JP2008001687A - Compression molding product and method for producing the same - Google Patents
Compression molding product and method for producing the same Download PDFInfo
- Publication number
- JP2008001687A JP2008001687A JP2007137305A JP2007137305A JP2008001687A JP 2008001687 A JP2008001687 A JP 2008001687A JP 2007137305 A JP2007137305 A JP 2007137305A JP 2007137305 A JP2007137305 A JP 2007137305A JP 2008001687 A JP2008001687 A JP 2008001687A
- Authority
- JP
- Japan
- Prior art keywords
- flavoring agent
- compression
- coating
- coated
- compression molding
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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Abstract
Description
本発明は圧縮成型物およびその製造方法に関する。更に詳しくは、成型と同時に表面のみに微量の矯味剤または矯臭剤を添加し、成型物の形状や大きさを変化させることなく簡便に風味、香りを改善することができる圧縮成型物およびその製造方法に関する。 The present invention relates to a compression molded product and a method for producing the same. More specifically, a compact molded product that can be easily improved in flavor and aroma without changing the shape and size of the molded product by adding a small amount of a flavoring agent or flavoring agent to the surface at the same time as molding and its production Regarding the method.
医薬品や食品には苦味、辛味の強いものや臭気、香気の強いものなどがあり、これらの医薬品や食品の矯味矯臭方法として、一般的に矯味剤や矯臭剤を圧縮成型用物質に混合して成型する方法（特許文献１参照）、フィルムコーティング方法（特許文献２参照）、糖衣による方法（非特許文献１参照）などが知られている。 Drugs and foods include bitter, pungent, odors, and fragrances. As a method of flavoring these drugs and foods, generally, a flavoring agent or flavoring agent is mixed with a compression molding substance. A molding method (see Patent Document 1), a film coating method (see Patent Document 2), a sugar coating method (see Non-Patent Document 1), and the like are known.
また、コーティング機を使用せずに錠剤をコーティングする技術として有核錠にする方法（特許文献３参照）、２重杵を用いる方法（特許文献４参照）が開示されている。 Further, as a technique for coating tablets without using a coating machine, a method of making a dry tablet (see Patent Document 3) and a method of using a double basket (see Patent Document 4) are disclosed.
さらに、苦味を有する薬物層よりも早い段階で水不溶性物質を溶出できる部位に配置することによる苦味マスキング方法が開示されている。 Furthermore, a bitterness masking method by disposing at a site where a water-insoluble substance can be eluted at an earlier stage than a drug layer having a bitter taste is disclosed.
また、打錠の際に錠剤が金型に付着することを防止するために滑沢剤を臼と杵に塗布する方法が一般的に知られており、例えば、滑沢剤を均一に散布する外部滑沢式打錠機が開示されている（特許文献６参照）。 In addition, a method of applying a lubricant to the mortar and the punch to prevent the tablet from adhering to the mold during tableting is generally known. For example, the lubricant is uniformly sprayed. An external lubrication type tableting machine is disclosed (see Patent Document 6).
医薬品の矯味矯臭のために矯味剤や矯臭剤を圧縮成型用物質に混合して成型する方法では、矯味剤や矯臭剤と相互作用を起こして、有効成分が分解してしまうことや、矯味剤または矯臭剤の添加により極端に圧縮成型物の硬度が下がることがあるため、圧縮成型物中に矯味剤や矯臭剤を含有できない場合がある。また、圧縮成型物が大きくなってしまうことがあり服用性の点でも満足できないことがあった。 In the method of mixing a flavoring agent or a flavoring agent with a compression molding substance for the flavoring of a pharmaceutical product, the active ingredient may be decomposed by interacting with the flavoring agent or the flavoring agent. Or, since the hardness of the compression molded product may be extremely lowered by the addition of the flavoring agent, the compression molding product may not contain a corrigent or a flavoring agent. In addition, the compression-molded product may become large, and it may not be satisfactory in terms of ingestion.
次に、通常のフィルムコーティング方法や糖衣を施す方法では、圧縮成型と同時にフィルムコーティングや糖衣をすることができず、別工程にて実施する必要がある。また、フィルムコーティングを行う場合、通常、ドラム回転型通気式フィルムコーティング機が使用されるが、多量の被コーティング物を容器に投入し、激しく流動させるため、被コーティング物である圧縮成形物は容器内部との衝突や圧縮成形物同士の衝突が繰り返され、圧縮成形物の摩損や破損が発生することがあり、口腔内速崩壊型錠剤やチュアブル錠、あるいは、突起があるような異形錠などの比較的壊れ易い圧縮成型物にコーティングを施すことは難しい。さらに、被コーティング物の凹凸により、コーティングに斑ができてしまうことがある。一般的に凸部ではフィルムが薄くなり、凹部ではフィルムが厚くなり、条件によっては凹部がフィルムにより埋まってしまうことがある。 Next, in a normal film coating method or sugar coating method, film coating or sugar coating cannot be performed simultaneously with compression molding, and it is necessary to carry out in a separate process. In addition, when film coating is performed, a drum rotating type air-permeable film coating machine is usually used. However, since a large amount of coating material is charged into the container and fluidized vigorously, the compression molding material to be coated is a container. Collisions with the inside and compression moldings may be repeated, and the compression moldings may be worn or damaged, such as intraoral quick disintegrating tablets, chewable tablets, or irregular tablets with protrusions It is difficult to apply a coating to a compression product that is relatively fragile. Furthermore, unevenness of the coating object may cause spots on the coating. In general, the film is thin at the convex portion, the film is thick at the concave portion, and the concave portion may be filled with the film depending on conditions.
ここで、矯味矯臭方法としては、圧縮成型により糖衣を施す有核二重錠にする方法があげられるが、圧縮成型の際に障害のないコーティング剤を使用しなければならないことや、コーティング層を薄くした場合にコーティング層が割れやすいなどの問題が発生することがある。 Here, as a flavoring method, there is a method of making a dry double tablet that is sugar-coated by compression molding, but it is necessary to use a coating agent that does not hinder the compression molding, When the thickness is reduced, the coating layer may be easily broken.
従って、従来のコーティング技術や有核二重錠とする技術を用いても、複雑な形状の成型物の風味改善に対応することは困難であった。 Therefore, it has been difficult to cope with the flavor improvement of a molded product having a complicated shape even by using a conventional coating technique or a technique for making a dry double tablet.
さらに、苦味を有する薬物層よりも早い段階で水不溶性物質を溶出できる部位に配置することによる苦味マスキング方法は三層錠にする必要があるなど作業効率が悪いものであった。 Furthermore, the bitterness masking method by arranging the water-insoluble substance at a site where the water-insoluble substance can be eluted at an earlier stage than the drug layer having a bitter taste is inferior in work efficiency because it is necessary to use a three-layer tablet.
すなわち本発明は、配合される成分の苦味、辛味、臭気または香気などの矯味矯臭方法として、コーティングなどの特別な製造工程を踏むことなく、簡便な方法で製造できる矯味矯臭された圧縮成形物およびその製造方法を提供することをその課題とする。 That is, the present invention is a flavored compression-molded product that can be produced by a simple method without taking a special production process such as coating as a flavoring method such as bitterness, pungent taste, odor or fragrance of the ingredients to be blended, and It is an object to provide a manufacturing method thereof.
本発明者らは、上記課題を解決するために鋭意検討を重ねた結果、矯味剤または矯臭剤を噴霧または塗布した金型を用いて圧縮成型をすることによって、圧縮工程のみで表面に剥離しない矯味剤または矯臭剤層を成型することができ、優れた矯味矯臭効果を付与した圧縮成形物が得られることを見出し、本発明を完成させた。 As a result of intensive studies to solve the above-mentioned problems, the present inventors do not peel off the surface only by the compression process by performing compression molding using a mold sprayed or coated with a flavoring agent or flavoring agent. The present inventors have found that a flavoring agent or a flavoring agent layer can be molded, and that a compression-molded product having an excellent flavoring effect can be obtained, and the present invention has been completed.
すなわち本発明は、
１．圧縮成型物において、矯味剤及び矯臭剤から選ばれる少なくとも１種を含む被覆剤を噴霧または塗布した金型を用いて、表面を被覆剤で被覆したことを特徴とする圧縮成型物、
２．圧縮成型物において、矯味剤及び矯臭剤から選ばれる少なくとも１種並びに滑沢剤を含む被覆剤を噴霧または塗布した金型を用いて、表面を被覆剤で被覆したことを特徴とする圧縮成型物、
３．矯味剤及び矯臭剤から選ばれる少なくとも１種を含む被覆剤を噴霧または塗布した金型を用いて被圧縮物を圧縮成型することを特徴とする、表面を被覆剤で被覆した圧縮成型物の製造方法、
４．矯味剤及び矯臭剤から選ばれる少なくとも１種並びに滑沢剤を含む被覆剤を噴霧または塗布した金型を用いて被圧縮物を圧縮成型することを特徴とする、表面を被覆剤で被覆した圧縮成型物の製造方法、
である。
That is, the present invention
1. In a compression molded product, a compression molded product characterized in that the surface is coated with a coating agent using a mold sprayed or coated with a coating agent containing at least one selected from a corrigent and a flavoring agent,
2. A compression molded article characterized in that the surface is coated with a coating agent using a mold sprayed or coated with a coating agent containing at least one selected from a flavoring agent and a flavoring agent and a lubricant. ,
3. Production of a compression-molded article having a surface coated with a coating, characterized in that the article to be compressed is compression-molded using a mold sprayed or coated with a coating containing at least one selected from a corrigent and a flavoring agent. Method,
4). Compression with a surface coated with a coating material, characterized in that the object to be compressed is compression-molded using a mold sprayed or coated with a coating material containing at least one selected from a corrigent and a flavoring agent and a lubricant. Manufacturing method of moldings,
It is.
本発明により、簡便な方法で表面に矯味剤または矯臭剤を含有する剥離しにくい層を有し、風味、香りを改善した圧縮成型物を得ることができた。また、コーティング工程などの特別な製造工程が必要なく、更に錠剤の形状や大きさを変化させることもない、簡便な圧縮成型物およびその製造方法を得ることができた。 According to the present invention, it is possible to obtain a compression-molded product having a layer that contains a flavoring agent or a flavoring agent on the surface and that is difficult to peel, and has improved flavor and aroma. In addition, a simple compression-molded product and a method for producing the same that do not require a special manufacturing process such as a coating process and that do not change the shape or size of the tablet can be obtained.
また、薬物と相互作用を有する矯味剤又は矯臭剤を選択しても薬物の安定性に影響を及ぼさない圧縮成型物を得ることができた。 Moreover, even if a flavoring agent or a flavoring agent that interacts with the drug was selected, a compression molded product that did not affect the stability of the drug could be obtained.
本発明に用いる矯味剤または矯臭剤とは、風味の改善や、においなどを抑制するために添加する物質であれば使用することができるが、圧縮成型物全体に対して０．０１質量％から１質量％の微量で矯味、矯臭効果のある物質が好ましい。 The flavoring agent or flavoring agent used in the present invention can be used as long as it is a substance added to improve flavor and suppress odors, but from 0.01% by mass relative to the entire compression molded product. A substance having a taste-masking and flavoring effect in a minute amount of 1% by mass is preferred.
矯味剤または矯臭剤としては、甘味剤、酸味を呈する物質、香料、芳香剤などが挙げられる。矯味剤または矯臭剤は1種だけでなく２種以上組み合わせて使用することができる。 Examples of the flavoring agent or flavoring agent include sweeteners, sour substances, fragrances, and fragrances. A flavoring agent or a flavoring agent can be used alone or in combination of two or more.
本発明に用いる甘味剤として具体的には、ショ糖、ブドウ糖、果糖、乳糖、転化糖、異性化糖、水飴、Ｄ-キシロース、メイプルシュガー、ハチミツ、ソルビトール、マルチトール、グリチルリチン、スクラロース、アセスルファムＫ、アスパルテーム、ソーマチン、ステビア、サッカリン等があげられ、特に微量で甘味を有する物質、例えばスクラロース、アセスルファムＫ、アスパルテーム、ソーマチン、ステビア、サッカリン、サッカリンの塩などの高甘味度甘味料であることが好ましい。本発明では、これらの中の１種または２種以上を併用することもできる。 Specific examples of sweeteners used in the present invention include sucrose, glucose, fructose, lactose, invert sugar, isomerized sugar, starch syrup, D-xylose, maple sugar, honey, sorbitol, maltitol, glycyrrhizin, sucralose, and acesulfame K. , Aspartame, thaumatin, stevia, saccharin and the like, and a particularly sweet substance such as sucralose, acesulfame K, aspartame, thaumatin, stevia, saccharin, saccharin and the like is preferable. . In the present invention, one or more of these may be used in combination.
本発明で用いる酸味を呈する物質としては、服用して酸味を感じられるものであれば無機酸でも有機酸でもよいが、好ましくはクエン酸、無水クエン酸、リンゴ酸、酒石酸、コハク酸、フマル酸、アスコルビン酸、乳酸、マレイン酸、エリソルビン酸などの水溶性有機酸である。さらに好ましくはクエン酸、無水クエン酸、リンゴ酸、アスコルビン酸、エリソルビン酸である。これらの酸味を呈する物質は、単独で使用しても、２種以上の併用により使用してもよい。 The sour substance used in the present invention may be an inorganic acid or an organic acid as long as it can be taken and feels sour, but preferably citric acid, anhydrous citric acid, malic acid, tartaric acid, succinic acid, fumaric acid Water-soluble organic acids such as ascorbic acid, lactic acid, maleic acid and erythorbic acid. More preferred are citric acid, anhydrous citric acid, malic acid, ascorbic acid, and erythorbic acid. These substances exhibiting sourness may be used alone or in combination of two or more.
香料、芳香剤としては、天然香料、合成香料など香気を有する香味成分であれば特に限定されない。香味成分としては、例えば、テルペン系炭化水素、テルペン系アルコール、その他のアルコール、フェノール及びその誘導体、脂肪族アルデヒド、テルペン系アルデヒド、芳香族アルデヒド、アセタール類、脂肪族ケトン、テルペン系ケトン、芳香族ケトン、脂環式ケトン・エーテル・ラクトン、大環状ケトン・ラクトン、合成ムスク、環状エーテル、複素環式化合物、脂肪族酸のエステルまたは芳香族酸のエステルからなる群から選ばれる１種または２種以上を含む香味成分があげられる。 A fragrance | flavor and an aromatic agent will not be specifically limited if it is a flavor component which has fragrances, such as a natural fragrance | flavor and a synthetic fragrance | flavor. Examples of flavor components include terpene hydrocarbons, terpene alcohols, other alcohols, phenols and derivatives thereof, aliphatic aldehydes, terpene aldehydes, aromatic aldehydes, acetals, aliphatic ketones, terpene ketones, and aromatics. One or two selected from the group consisting of ketones, alicyclic ketones / ethers / lactones, macrocyclic ketones / lactones, synthetic musks, cyclic ethers, heterocyclic compounds, esters of aliphatic acids or esters of aromatic acids The flavor component containing the above is mention | raise | lifted.
脂肪族酸のエステルまたは芳香族酸エステルとしては、例えば、酢酸リナリル、酢酸ゲラニル、酢酸ボルニル、酢酸−α−テルピニル、酢酸−４−テルピニル、酢酸ネリル、酢酸ミルテニル、酢酸ツヤン−４−イル、酢酸ラバンジュリル、酢酸シトロネリル、酢酸オイゲイル、酢酸ベンジル、酢酸ファルネシル、酢酸シンナミル等の酢酸エステル、プロピオン酸ネリル、プロピオン酸シトロネリル等のプロピオン酸エステル、サリチル酸メチル、サリチル酸ベンジル等のサリチル酸エステル、ギ酸シトロネイル、ギ酸ゲラニル等のギ酸エステル、イソ酪酸ボルニル、イソ酪酸シトロネリル、イソ酪酸イソブチル、イソ酪酸−２− メチルブチル等のイソ酪酸エステル、２−メチル酢酸−２−メチルブチル、２−メチル酢酸イソブチル等の２−メチル酢酸エステル、アンゲリカ酸イソブチル、アンゲリカ酸イソアミル、アンゲリカ酸−β−メサリル等のアンゲリカ酸エステル、アンゼリカ酸イソブチレン等のアンゼリカ酸エステル、ケイ皮酸メチル等のケイ皮酸エステルまたは安息香酸ベンジル等の安息香酸エステルが挙げられる。 Examples of the aliphatic acid ester or aromatic acid ester include linalyl acetate, geranyl acetate, bornyl acetate, acetic acid-α-terpinyl, acetic acid-4-terpinyl, neryl acetate, mirtenyl acetate, thuan-4-yl acetate, acetic acid. Labandulyl, citronellyl acetate, eugeyl acetate, benzyl acetate, farnesyl acetate, cinnamyl acetate, propionate such as neryl propionate, citronellyl propionate, salicylate such as methyl salicylate and benzyl salicylate, citronellate formate, geranyl formate, etc. Formate, bornyl isobutyrate, citronellyl isobutyrate, isobutyl isobutyrate, 2-methylbutyl isobutyrate, 2-methyl acetate, 2-methyl acetate, 2-methyl acetate, Benzoic acid esters such as lactic acid ester, angelic acid isobutyl, angelic acid isoamyl, angelic acid ester such as angelic acid-β-mesalyl, angelic acid ester such as angelic acid isobutylene, cinnamate such as methyl cinnamate or benzyl benzoate Examples include acid esters.
環状エーテルとしては、例えば、メチルカビコール、アネトール、サフロール、アピオール、エレミシン− ミリスチシン、メチル・オイゲノール、メチル・イソオイゲノール、アサロン、テトラメトキシアリルベンゼン、メチル・パラクレゾール、メチル・カルバクロール、メチル・チモール、またはメチル・ミルテノールが挙げられる。 Examples of the cyclic ether include methyl cavicol, anethole, safrole, apiol, elemicin-myristicin, methyl eugenol, methyl isoeugenol, asarone, tetramethoxyallylbenzene, methyl paracresol, methyl carvacrol, methyl thymol. Or methyl myrtenol.
脂肪族アルデヒド、テルペン系アルデヒドまたは芳香族アルデヒドとしては、例えば、シトラール、シトロネラール、デカナール、ウンデカナール、ドデカナール、デセナール、オクタナール、クミナール、ノナナール、ミルテナール、フェランドラール、カンフォレン・アルデヒド等のモノテルペンアルデヒド、ファルネサール、α−シネンサール、β−シネンサール等のセスキテルペンアルデヒド、シンナムアルデヒド、ベンズアルデヒド、サリチルアルデヒドまたはアニスアルデヒド等のフェニルプロパンアルデヒドが挙げられる。 Examples of the aliphatic aldehyde, terpene aldehyde or aromatic aldehyde include monoterpene aldehyde such as citral, citronellal, decanal, undecanal, dodecanal, decenal, octanal, cuminal, nonanal, mirutenal, ferrandar, camphorene aldehyde, and farnesal. , Sesquiterpene aldehydes such as α-sinensal and β-sinensal, and phenylpropanaldehydes such as cinnamaldehyde, benzaldehyde, salicylaldehyde and anisaldehyde.
脂肪族ケトン、テルペン系ケトンまたは芳香族ケトンとしては、例えば、ピノカンフォン、イソピノカンフォン、α−ツヨン、β−ツヨン、ボルナノン、プレゴン、メントン、イソメントン、ベルベノン、フェンコン、ｌ−カルボン、ｄ−カルボン、ピペリトン、ピノカルボン、クリプトン、クマリン、オーラプテン、ヘルニアリン、セレリン、シトロプテン、オストール、アンゲリシン、ベルガモッチン、ベルガプテン、ベルガプトール、インペラトリン、ビスナジン、S−メチル・チオ安息香酸、ミントサルファイドまたはｐ−メントン−８−チオールが挙げられる。 Examples of the aliphatic ketone, terpene-based ketone or aromatic ketone include, for example, pinocamphone, isopinocamphorphone, α-thuyon, β-thuyong, bornanone, pregon, menthone, isomenton, berbenone, fenkon, l-carvone, d-carvone , Piperitone, pinocarbon, krypton, coumarin, aurapten, hernialine, selelin, citropten, ostole, angelicin, bergamottin, bergapten, bergaptol, imperatorin, bisnadin, S-methylthiobenzoic acid, mintsulfide or p-menton-8 -Thiols are mentioned.
テルペン系炭化水素としては、例えば、リモネン、α−ピネン、β−ピネン、α−フェランドレン、ｐ−シメン、ミルセン、サビネン、γ−テルピネン、テルピノーレン、カンフェン等のモノテルペン、β−カリオフェン、β−セスキフェランドレン、サンタレン等のセスキテルペン、カマズレン等のアズレン、β−エレメン、ファルネセン、α−パチュレン、β−パチュレンまたはγ−パチュレン等のジテルペンが挙げられる。 Examples of terpene hydrocarbons include monoterpenes such as limonene, α-pinene, β-pinene, α-ferrandrene, p-cymene, myrcene, sabinene, γ-terpinene, terpinolene, camphene, β-caryophene, β- Examples thereof include sesquiterpenes such as sesquiferlandrene and santalen, azulene such as camazulene, and diterpenes such as β-elemene, farnesene, α-patulene, β-patulene, and γ-patulene.
テルペン系アルコールとしては、例えば、リナロール、ゲラニオール、メントール、α−テレピネオール、ボルネオール、シトロネロール等のモノテルペンアルコール、α−サンタロール、セドロール、カトロール等のセスキテルペンアルコールまたはスクラレオール等のジテルペンアルコールが挙げられる。 Examples of the terpene alcohol include monoterpene alcohols such as linalool, geraniol, menthol, α-terpineol, borneol and citronellol, sesquiterpene alcohols such as α-santalol, cedrol and catrol, and diterpene alcohols such as sclareol.
本発明において香味成分は、上記化合物を単独または組み合わせて使用しても良いが、
これらを含有する生薬やハーブなどの植物の乾燥末、抽出末、精油、抽出油、抽出液等として、あるいは、これらを含有する生薬やハーブなどの植物の抽出物を用いることもできる。
In the present invention, the flavor component may be used alone or in combination,
Extracts of plants such as herbal medicines and herbs containing these may be used as dry powder, extracted powder, essential oils, extracted oils, extracts, etc. of plants such as herbal medicines and herbs.
具体的には、エステル類を多く含むものとして、ラベンダー、ローマンカモミール、クラリセージ、ネロリ、プチグレイン、パルマローザ、ベルガモット等の植物の乾燥末、抽出末、精油、抽出油、抽出液等が挙げられる。 Specifically, those containing a large amount of esters include dry powder, extracted powder, essential oil, extract oil, extract liquid of plants such as lavender, roman chamomile, clary sage, neroli, petit grain, palmarosa, and bergamot.
エーテル類を多く含むものとして、バジル、タラゴン等の植物の乾燥末、抽出末、精油、抽出油、抽出液等が挙げられる。 Examples of those containing a large amount of ethers include dried powder, extracted powder, essential oil, extracted oil, and extract of plants such as basil and tarragon.
アルデヒド類を多く含むものとして、メリッサ、レモングラス、レモンユーカリ、シトロネラ、コリアンダー、ミカン属、マンダリン、ネロリ等の植物の乾燥末、抽出末、精油、抽出油、抽出液等が挙げられる。 Examples of those containing a large amount of aldehydes include dried powder, extracted powder, essential oil, extracted oil, and extract of plants such as Melissa, lemongrass, lemon eucalyptus, citronella, coriander, mandarin, mandarin, and neroli.
ケトン類を多く含むものとして、ヒソップ、セージ、ホワイトマグワート、アルボレセンスマグワート、ローズマリー、ラベンダー、ラバンジン、ペニーロイヤル、ペパーミント、コーンミント、フェンネル(ウイキョウ)、スペアミント、キャラウェイ、ディル、ユーカリ、ローマンカモミール等の植物の乾燥末、抽出末、精油、抽出油、抽出液等が挙げられる。 Contains a lot of ketones, including hyssop, sage, white mugwort, arborescence mugwort, rosemary, lavender, lavandine, penny royal, peppermint, corn mint, fennel (fennel), spearmint, caraway, dill, eucalyptus, roman Examples include dry powder, extracted powder, essential oil, extracted oil, and extract of plants such as chamomile.
クマリン類を多く含むものとして、ベルガモット、レモン、グレープフルーツ、セロリ、アンゼリカ、ライム、シナモン、シナモンカシャ、エストラゴン等の植物の乾燥末、抽出末、精油、抽出油、抽出液等が挙げられる。 Examples of substances that contain a large amount of coumarins include dried powder, extracted powder, essential oil, extracted oil, and extract of plants such as bergamot, lemon, grapefruit, celery, angelica, lime, cinnamon, cinnamon cacha, and estragon.
含窒素化合物を多く含むものとして、ニアウリ、ペパーミント等の植物の乾燥末、抽出末、精油、抽出油、抽出液等が挙げられる。 Examples of substances containing a large amount of nitrogen-containing compounds include dried powder, extracted powder, essential oil, extracted oil, and extract of plants such as near cucumber and peppermint.
テルペン系炭化水素を多く含むものとして、レモン、オレンジ、ネロリ、プチグレイン、オレンジ、オレンジピール（トウヒ）、グレープフルーツ、マンダリン、ベルガモット、ライム、ユズなどの柑橘類、サイプレス、システ、マートル、ローズマリー、タイム、ディル、パイン、イランイラン、ブラックペッパー、ペッパー、メリッサ、ラベンダー、ジンジャー、ジャーマンカモミール、ミルラ、パチュリー等の植物の乾燥末、抽出末、精油、抽出油、抽出液等が挙げられる。 Citruses such as lemon, orange, neroli, petit grain, orange, orange peel (spruce), grapefruit, mandarin, bergamot, lime, yuzu, cypress, system, myrtle, rosemary, thyme , Dried powder, extracted powder, essential oil, extracted oil, extract of plants such as dill, pine, ylang ylang, black pepper, pepper, melissa, lavender, ginger, german chamomile, myrrh, patchouli, etc.
テルペンアルコールを多く含むものとして、ラバンジン、タイム、ネロリ、ラベンダー、オレンジ、レモングラス、イランイラン、ゼラニウム、クラリセージ、ローリエ、パルマローザ、サンダルウッド、ローズ等の植物の乾燥末、抽出末、精油、抽出油、抽出液等が挙げられる。 Contains a lot of terpene alcohol, such as lavandin, thyme, neroli, lavender, orange, lemongrass, ylang ylang, geranium, clary sage, bay leaf, dried powder, extracted powder, essential oil, extracted oil of plants such as palmarosa, sandalwood, rose , Extract and the like.
なお、これら香味成分を含包するマイクロカプセルやマイクロスフェアーの形態で添加してもよい。粉末香料だけでなくオイルフレーバーを適当な吸着剤などの担体に担持させることにより使用することもできる。 In addition, you may add in the form of the microcapsule and microsphere which include these flavor components. Not only powder flavor but also oil flavor can be used by supporting it on a carrier such as an appropriate adsorbent.
また、矯味剤または矯臭剤には、圧縮成形に用いられる種々の添加剤を混合しても良い。添加剤としては、滑沢剤、賦形剤、基剤、糖衣剤、崩壊剤、崩壊補助剤、泡剤、防湿剤、吸着剤、界面活性剤、可溶化剤、緩衝剤、溶解剤、溶解補助剤、溶剤、安定化剤、乳化剤、懸濁剤、分散剤、抗酸化剤、充填剤、粘稠剤、粘稠化剤、ｐＨ調整剤、防腐剤、保存剤、清涼化剤、着色剤などが挙げられる。 Moreover, you may mix the various additives used for compression molding with a corrigent or a corrigent. Additives include lubricants, excipients, bases, sugar coatings, disintegrants, disintegration aids, foams, moisture-proofing agents, adsorbents, surfactants, solubilizers, buffering agents, solubilizers, dissolution agents Auxiliaries, solvents, stabilizers, emulsifiers, suspending agents, dispersants, antioxidants, fillers, thickeners, thickeners, pH adjusters, preservatives, preservatives, cooling agents, colorants Etc.
特に矯味剤または矯臭剤と滑沢剤とを混合して用いると、圧縮成型する際に圧縮成型物が金型からはがれやすいことから好ましい。 In particular, it is preferable to use a mixture of a flavoring agent or a flavoring agent and a lubricant because the compression-molded product is easily peeled off from the mold during compression molding.
本発明で用いられる滑沢剤としては一般的なものを使用することができ、ステアリン酸マグネシウム、ステアリン酸カルシウム、日局硬化油、タルクなどをあげることができる。 As the lubricant used in the present invention, a general lubricant can be used, and examples thereof include magnesium stearate, calcium stearate, JP hardened oil, and talc.
また、本発明に用いる矯味剤または矯臭剤は金型に噴霧または塗布できるものであれば、固体、ゲル、液体など何を用いてもよく、その形態を問わないが、製造工程等での取り扱いの面から固体が好ましく、特に金型への付着性を考慮し、粉砕したものがさらに好ましい。 Further, the flavoring agent or flavoring agent used in the present invention may be any solid, gel, liquid, etc., as long as it can be sprayed or applied to the mold, regardless of its form, but it is handled in the manufacturing process etc. From this aspect, a solid is preferable, and a pulverized product is more preferable in consideration of adhesion to a mold.
金型に矯味剤または矯臭剤を噴霧または塗布する方法としては、（１）金型を矯味剤または矯臭剤に浸漬する方法、（２）矯味剤または矯臭剤を刷毛などで金型に塗る方法、（３）金型にスプレーなどで矯味剤または矯臭剤を噴霧塗布する方法、（４）矯味剤または矯臭剤を分散させた気相または液相に金型を通過あるいは静置する方法などがあるが、金型に矯味剤または矯臭剤を付着させることができればその他のいずれの方法も用いることができる。特に外部滑沢噴霧システムを用いて、滑沢剤に換えて、もしくは滑沢剤に加えて矯味剤又は矯臭剤を用いると製造が容易である。 As a method of spraying or applying a flavoring agent or a flavoring agent to the mold, (1) a method of immersing the mold in the flavoring agent or the flavoring agent, and (2) a method of applying the flavoring agent or the flavoring agent to the mold with a brush or the like. (3) A method of spraying a flavoring agent or a flavoring agent to the mold by spraying or the like, (4) A method of passing or leaving the mold in a gas phase or a liquid phase in which the flavoring agent or the flavoring agent is dispersed. However, any other method can be used as long as a flavoring agent or a flavoring agent can be attached to the mold. In particular, when an external lubricant spray system is used, a flavoring agent or a flavoring agent is used instead of the lubricant or in addition to the lubricant.
本発明において被圧縮物とは粉体、顆粒などの圧縮することにより圧縮成型物となるものであり、種々の成分の混合物も含む。 In the present invention, the material to be compressed is a compression molded product by compressing powder, granules, etc., and includes a mixture of various components.
本発明の圧縮成型物としては、錠剤、また特に、比較的壊れ易い圧縮成型物である口腔内速崩壊型錠剤やチュアブル錠、あるいは、突起があるような異形錠などが挙げられ、医薬品、医薬部外品、食品、飼料、化粧品、洗剤、入浴剤又は肥料などで一般的に用いられる圧縮成型物をすべて含む。 Examples of the compression-molded product of the present invention include tablets and, in particular, intraoral quick-disintegrating tablets and chewable tablets that are relatively easy-to-break compression products, or deformed tablets with protrusions. It includes all compression moldings commonly used in quasi-drugs, foods, feeds, cosmetics, detergents, bath additives or fertilizers.
本発明で矯味剤または矯臭剤を噴霧または塗布した金型で圧縮成型に使用する圧縮成型機は、一般的に使用されている油圧プレス機、エアプレス機、ロールプレス機、螺旋式プレス機、単発打錠機、ロータリー打錠機などの圧縮成型機を挙げられるが圧縮成型する際に使用することができればその他のいずれの圧縮成型機も使用することができる。 The compression molding machine used for compression molding with a mold sprayed or coated with a flavoring agent or flavoring agent in the present invention is a generally used hydraulic press machine, air press machine, roll press machine, spiral press machine, Although compression molding machines, such as a single tableting machine and a rotary tableting machine, are mentioned, any other compression molding machine can be used as long as it can be used for compression molding.
以下に実施例及び試験例により本発明をさらに詳細に説明する。 Hereinafter, the present invention will be described in more detail with reference to Examples and Test Examples.
表１に示した酸味の強いアスコルビン酸と苦味のあるリボフラビンを含む処方で、精密万能試験機（オートグラフ／島津製作所製）を使用して、矯味剤を臼杵表面に刷毛を用いて塗布し、15000Nの圧力で圧縮成型して錠剤を製造した。なお、臼杵表面に刷毛を用いて塗布した矯味剤の量は０.５質量％以下であることを確認した。その際、矯味剤はスクラロース（三栄源エフ・エフ・アイ製）、香料（カシスオレンジパウダー／長岡香料製）、ラブリワックス（川研ファインケミカル製）をそれぞれ６：３：１の割合で混合したものを用いた。 Using a precision universal testing machine (manufactured by Autograph / Shimadzu Corporation) with a formulation containing strong sour ascorbic acid and bitter riboflavin shown in Table 1, the taste-masking agent was applied to the surface of the mortar using a brush, Tablets were produced by compression molding at a pressure of 15000 N. It was confirmed that the amount of the corrigent applied to the surface of the mortar using a brush was 0.5% by mass or less. At that time, the flavoring agent was a mixture of sucralose (manufactured by Saneigen F.F.I.), fragrance (cassis orange powder / manufactured by Nagaoka fragrance), and love wax (manufactured by Kawaken Fine Chemical) in a ratio of 6: 3: 1. Was used.
比較例１
実施例１の表１に示した処方で、矯味剤及び矯臭剤は何も添加せず、実施例１と同様にして錠剤を製造した。
Comparative Example 1
Tablets were produced in the same manner as in Example 1 except that no flavoring agents and flavoring agents were added in the formulation shown in Table 1 of Example 1.
試験例１
パネラー１０人に、実施例１及び比較例１の錠剤について、何れか甘味の強い方、香気の良い方及び飲み易い方を選択させた。その結果を表２に示した。表２から明らかなように、本発明の方が、香気及び甘味がよく、飲み易くなっているとの評価が得られた。
Test example 1
Ten panelists were asked to select one of the sweeter, the more fragrant and the easier to drink for the tablets of Example 1 and Comparative Example 1. The results are shown in Table 2. As is clear from Table 2, the present invention was evaluated as having better aroma and sweetness and being easier to drink.
表３に示した苦味の強いイブプロフェンを含有する処方で、流動層造粒機（パウレック製）を用いて顆粒を製造した。 Granules were produced using a fluid bed granulator (manufactured by POWREC) with a formulation containing ibuprofen having a strong bitter taste shown in Table 3.
矯味剤を圧縮エアーで気中にまきあげ、分散させたところに臼杵を置き臼杵表面に矯味剤を付着させた後、顆粒をオートグラフ（島津製作所）を使用して10000Nの圧力で圧縮成型し錠剤を得た。なお、矯味剤は１錠あたり０.５質量％であった。矯味剤はアセスルファムＫ（サネット／武田キリン食品製）、クエン酸（磐田化学製）、香料（グレープフルーツフレーバー／長谷川香料製）を１：７：２の割合で混合したものを使用した。クエン酸はヤリヤ粉砕機にて粉砕したものを使用した。 Sprinkle the corrigant in the air with compressed air, place the mortar in the dispersed place, attach the corrigent to the surface of the mortar, and then compress the granules using an autograph (Shimadzu Corporation) at a pressure of 10000 N to make tablets Got. The taste-masking agent was 0.5% by mass per tablet. The flavoring agent used was a mixture of acesulfame K (Sanet / Takeda Kirin Foods Co., Ltd.), citric acid (Mutada Chemical Co., Ltd.), and fragrance (Grapefruit Flavor / Hasegawa Fragrance) in a ratio of 1: 7: 2. The citric acid used was pulverized with a Yarya pulverizer.
比較例２
実施例２の表３に示した処方で、矯味剤及び矯臭剤を使用せずに実施例２と同様の方法で製造して比較用錠剤を得た。
Comparative Example 2
The tablet shown in Table 3 of Example 2 was manufactured in the same manner as in Example 2 without using a corrigent and a corrigent, and a comparative tablet was obtained.
試験例２
パネラー９人に、この実施例２と比較例２の錠剤について、苦味の弱い方、香気の良い方及び飲み易い方を選択させた。その結果を表４に示した。表４から明らかなように、本発明の錠剤は、香気がよく、甘味があり、飲み易くなっているとの評価が得られた。
Test example 2
Nine panelists were asked to select the less bitter, fragrant and easy to drink for the tablets of Example 2 and Comparative Example 2. The results are shown in Table 4. As is clear from Table 4, the tablet of the present invention was evaluated as having a good aroma, sweetness and easy to drink.
表５に示した酸味の強いアスコルビン酸と苦味のあるリボフラビンを含む処方で、ロータリー式打錠機（コレクト／菊水製作所製）を使用し、矯味剤及び滑沢剤から成る粉体を外部滑沢噴霧システム（ＥＬＳ−Ｐ１／菊水製作所製）を用い、素錠重量に対し約０．１質量％分を臼杵表面に付着させ、９ｍｍ糖衣面にて8000Nの圧力で圧縮成型して錠剤を製造した。 A formulation containing strong ascorbic acid and bitter riboflavin as shown in Table 5, using a rotary tableting machine (collect / manufactured by Kikusui Seisakusho). Using a spray system (ELS-P1 / manufactured by Kikusui Seisakusho), about 0.1% by mass with respect to the uncoated tablet weight was adhered to the surface of the mortar and compression-molded at a pressure of 8000 N on a 9 mm sugar-coated surface to produce a tablet. .
表６に示した処方で、ロータリー式打錠機（コレクト／菊水製作所製）を使用し、滑沢剤を外部滑沢噴霧システム（ＥＬＳ−Ｐ１／菊水製作所製）を用い、素錠重量に対し約０．１質量％分を臼杵表面に付着させ、8000Nの圧力で圧縮成型して錠剤を製造した。
With the formulation shown in Table 6, using a rotary tableting machine (collect / manufactured by Kikusui Seisakusho), using an external lubricant spray system (ELS-P1 / manufactured by Kikusui Seisakusho), About 0.1% by mass was attached to the surface of the mortar and compression molded at a pressure of 8000 N to produce a tablet.
試験例３
実施例３及び比較例３の錠剤を乾燥減量約１.０％に調製し、５０℃に密閉保存することでアスコルビン酸とアスパルテームによる変色を促進させた。１週間保存後の色調変化を下記基準で５℃保存品と比較して９名による５段階評価で評価し、平均値によるスコア化で比較した。
Test example 3
The tablets of Example 3 and Comparative Example 3 were prepared to a loss on drying of about 1.0% and stored in a sealed state at 50 ° C. to promote discoloration due to ascorbic acid and aspartame. The change in color tone after storage for 1 week was evaluated by a five-step evaluation by 9 people in comparison with a product stored at 5 ° C. according to the following criteria, and compared by scoring with an average value.
＜判断基準＞０：変化無し １：僅かに変化を認める ２：変化を認めるが許容できる ３：明らかな変化を認める ４：著しい変化を認める
その結果を表７に示した。実施例３（本発明）の方がスコア値が低く、色調変化が少ないとの評価が得られた。
<Judgment criteria> 0: No change 1: A slight change is observed 2: A change is recognized but acceptable 3: A clear change is recognized 4: A remarkable change is recognized The results are shown in Table 7. Evaluation that Example 3 (this invention) had a lower score value and there were few color tone changes was obtained.
表から明らかな通り、内容物と相互作用を起こす矯味剤を用いても、変色の少ない錠剤を製造できることが明らかになった。 As is apparent from the table, it was revealed that tablets with little discoloration can be produced even by using a corrigent that interacts with the contents.
本発明の圧縮成型物は、医薬品、医薬部外品、食品、飼料などの風味を改善することに加えて、化粧品、洗剤、入浴剤、肥料などの矯臭、賦香にも利用でき、幅広く利用することができる。 The compression molded product of the present invention can be used not only for improving the flavor of pharmaceuticals, quasi drugs, foods, feeds, etc., but also for flavoring and flavoring of cosmetics, detergents, bathing agents, fertilizers, etc. can do.
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| JP2015164740A (en) * | 2014-02-04 | 2015-09-17 | 株式会社菊水製作所 | Powder compression molding machine, and manufacturing method for compression molding |
| JP6284136B1 (en) * | 2017-11-08 | 2018-02-28 | 長岡香料株式会社 | Bitter taste inhibitor |
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| WO2006013447A1 (en) * | 2004-07-29 | 2006-02-09 | Cephalon France | Modafinil oral lyophilizate |
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| JPH11349473A (en) * | 1998-06-03 | 1999-12-21 | Otsuka Pharmaceut Co Ltd | Taste-masked pharmaceutical preparation |
| WO2001026632A1 (en) * | 1999-10-13 | 2001-04-19 | Kyowa Hakko Kogyo Co., Ltd. | Compression molded product and production method therefor |
| JP2001288117A (en) * | 2000-04-05 | 2001-10-16 | Otsuka Pharmaceut Co Ltd | Composition for medicinal preparation |
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| JP6284136B1 (en) * | 2017-11-08 | 2018-02-28 | 長岡香料株式会社 | Bitter taste inhibitor |
| JP2019083762A (en) * | 2017-11-08 | 2019-06-06 | 長岡香料株式会社 | Bitterness inhibitor |
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