JP2007536220A5 - - Google Patents

Info

Publication number

JP2007536220A5

JP2007536220A5 JP2007511320A JP2007511320A JP2007536220A5 JP 2007536220 A5 JP2007536220 A5 JP 2007536220A5 JP 2007511320 A JP2007511320 A JP 2007511320A JP 2007511320 A JP2007511320 A JP 2007511320A JP 2007536220 A5 JP2007536220 A5 JP 2007536220A5

Authority

JP

Japan

Prior art keywords

eye

stabilized

viscoelastic medium

medium

derivatives

Prior art date

2005-05-04

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
• Discuss

• 238000000034 method Methods 0.000 claims 11
• 230000035515 penetration Effects 0.000 claims 10
• 241001465754 Metazoa Species 0.000 claims 7
• KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims 4
• 229920002674 hyaluronan Polymers 0.000 claims 4
• 229960003160 hyaluronic acid Drugs 0.000 claims 4
• 201000002287 Keratoconus Diseases 0.000 claims 3
• 230000004410 intraocular pressure Effects 0.000 claims 3
• SQDAZGGFXASXDW-UHFFFAOYSA-N 5-bromo-2-(trifluoromethoxy)pyridine Chemical compound FC(F)(F)OC1=CC=C(Br)C=N1 SQDAZGGFXASXDW-UHFFFAOYSA-N 0.000 claims 2
• 229920001287 Chondroitin sulfate Polymers 0.000 claims 2
• 208000010412 Glaucoma Diseases 0.000 claims 2
• 229920002683 Glycosaminoglycan Polymers 0.000 claims 2
• HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 claims 2
• 210000002159 anterior chamber Anatomy 0.000 claims 2
• 239000003795 chemical substances by application Substances 0.000 claims 2
• 229940059329 chondroitin sulfate Drugs 0.000 claims 2
• 210000004087 cornea Anatomy 0.000 claims 2
• 239000003814 drug Substances 0.000 claims 2
• 239000007863 gel particle Substances 0.000 claims 2
• 150000004676 glycans Chemical class 0.000 claims 2
• 229920000669 heparin Polymers 0.000 claims 2
• 229960002897 heparin Drugs 0.000 claims 2
• 229920001282 polysaccharide Polymers 0.000 claims 2
• 239000005017 polysaccharide Substances 0.000 claims 2
• 230000015572 biosynthetic process Effects 0.000 claims 1
• 238000002347 injection Methods 0.000 claims 1
• 239000007924 injection Substances 0.000 claims 1
• 238000004519 manufacturing process Methods 0.000 claims 1