JP2007534755A - ケモカイン受容体活性のモジュレーターとなる３，３−ジ置換テトラヒドロピラニルシクロペンチルアミド - Google Patents

ケモカイン受容体活性のモジュレーターとなる３，３−ジ置換テトラヒドロピラニルシクロペンチルアミド Download PDF

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JP2007534755A
JP2007534755A JP2007510818A JP2007510818A JP2007534755A JP 2007534755 A JP2007534755 A JP 2007534755A JP 2007510818 A JP2007510818 A JP 2007510818A JP 2007510818 A JP2007510818 A JP 2007510818A JP 2007534755 A JP2007534755 A JP 2007534755A
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alkyl
substituted
fluoro
unsubstituted
hydroxy
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JP2007534755A5 (enExample
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ヤン，リフー
ミルズ，サンダー・ジー
シヤンカラン，コサンダラマン
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Merck and Co Inc
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Merck and Co Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
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    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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    • A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
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  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Pulmonology (AREA)
  • Neurology (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Virology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Cardiology (AREA)
  • Obesity (AREA)
  • Dermatology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Endocrinology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Neurosurgery (AREA)
  • Communicable Diseases (AREA)
  • Emergency Medicine (AREA)
  • Molecular Biology (AREA)
  • AIDS & HIV (AREA)
  • Child & Adolescent Psychology (AREA)
JP2007510818A 2004-04-28 2005-04-22 ケモカイン受容体活性のモジュレーターとなる３，３−ジ置換テトラヒドロピラニルシクロペンチルアミド Withdrawn JP2007534755A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US56601204P 2004-04-28 2004-04-28
PCT/US2005/013752 WO2005105092A2 (en) 2004-04-28 2005-04-22 3,3-disubstituted tetrahydropyranyl cyclopentyl amide modulators of chemokine receptor activity

Publications (2)

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JP2007534755A true JP2007534755A (ja) 2007-11-29
JP2007534755A5 JP2007534755A5 (enExample) 2008-06-05

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JP2007510818A Withdrawn JP2007534755A (ja) 2004-04-28 2005-04-22 ケモカイン受容体活性のモジュレーターとなる３，３−ジ置換テトラヒドロピラニルシクロペンチルアミド

Country Status (7)

Country Link
US (1) US7566726B2 (enExample)
EP (1) EP1755603A4 (enExample)
JP (1) JP2007534755A (enExample)
CN (1) CN101103027A (enExample)
AU (1) AU2005237500A1 (enExample)
CA (1) CA2564561A1 (enExample)
WO (1) WO2005105092A2 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2015516968A (ja) * 2012-04-06 2015-06-18 ヤンセン ファーマシューティカ エヌ．ベー． Ｃｃｒ２の縮合シクロペンチル拮抗薬

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JO2479B1 (en) 2002-04-29 2009-01-20 ميرك شارب اند دوم ليمتد Rates for the activity of the chemokine receptor of tetrahydrobranyl cycloneptil tetrahydrobredo predine
US20060030582A1 (en) * 2002-04-29 2006-02-09 Demartino Julie Tetrahydropyranyl cyclopentyl tetrahydropyridopyridine modulators of chemokine receptor activity
US20060205761A1 (en) * 2003-06-06 2006-09-14 Catherine Abbadie Ccr-2 antagonists for treatment of neuropathic pain
US8067415B2 (en) 2005-11-01 2011-11-29 Millennium Pharmaceuticals, Inc. Compounds useful as antagonists of CCR2
US8067457B2 (en) 2005-11-01 2011-11-29 Millennium Pharmaceuticals, Inc. Compounds useful as antagonists of CCR2
PT2370442E (pt) 2008-11-26 2013-06-27 Pfizer 3-aminociclopentanocarboxamidas como moduladores de receptor de quimiocina
EP2534158B1 (en) 2010-02-09 2014-01-08 Bristol-Myers Squibb Company Benzylpyrrolidinone derivatives as modulators of chemokine receptor activity
EP2685978A2 (en) * 2011-03-17 2014-01-22 Merck Sharp & Dohme Corp. Cyclohexane substituted amino cyclopentane derivatives as useful ccr2 antagonists
CN104781257A (zh) 2012-06-14 2015-07-15 第一三共株式会社 哌啶基吡唑并吡啶衍生物
EP3515889A1 (en) 2016-09-20 2019-07-31 GlaxoSmithKline Intellectual Property (No. 2) Limited Trpv4 antagonists
JP7106528B2 (ja) 2016-09-20 2022-07-26 グラクソスミスクライン、インテレクチュアル、プロパティー、（ナンバー２）、リミテッド Ｔｒｐｖ４拮抗薬
TW201825458A (zh) 2016-09-20 2018-07-16 英商葛蘭素史克智慧財產（第二）有限公司 Ｔｒｐｖ４拮抗劑
CN110028469B (zh) * 2019-04-28 2022-08-09 南京药石科技股份有限公司 一种非阿片类镇痛药的关键中间体的制备方法及应用

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3850920B2 (ja) * 1995-08-09 2006-11-29 壽製薬株式会社 アズレン誘導体およびその製造方法ならびにタキキニン受容体拮抗剤
JO2479B1 (en) * 2002-04-29 2009-01-20 ميرك شارب اند دوم ليمتد Rates for the activity of the chemokine receptor of tetrahydrobranyl cycloneptil tetrahydrobredo predine
ES2306867T3 (es) * 2002-04-29 2008-11-16 MERCK & CO., INC. Moduladores de la actividad receptora de quimiocinas de tetrahidro-piranil-ciclopentil-tetrahidropiridopiridina.
EP1501803B1 (en) * 2002-04-29 2008-08-13 Merck & Co., Inc. Tetrahydropyranyl cyclopentyl tetrahydroisoquinoline modulators of chemokine receptor activity
US20060205761A1 (en) * 2003-06-06 2006-09-14 Catherine Abbadie Ccr-2 antagonists for treatment of neuropathic pain

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2015516968A (ja) * 2012-04-06 2015-06-18 ヤンセン ファーマシューティカ エヌ．ベー． Ｃｃｒ２の縮合シクロペンチル拮抗薬

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Publication number Publication date
US20080021057A1 (en) 2008-01-24
US7566726B2 (en) 2009-07-28
EP1755603A2 (en) 2007-02-28
WO2005105092A3 (en) 2007-07-26
CN101103027A (zh) 2008-01-09
WO2005105092A2 (en) 2005-11-10
CA2564561A1 (en) 2005-11-10
AU2005237500A1 (en) 2005-11-10
EP1755603A4 (en) 2009-03-11

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