JP2007531750A - 血管運動症状（ｖｍｓ）を治療するためのモノアミン再取り込みの調節剤としての複素環式フェニルアミノプロパノール誘導体 - Google Patents

血管運動症状（ｖｍｓ）を治療するためのモノアミン再取り込みの調節剤としての複素環式フェニルアミノプロパノール誘導体 Download PDF

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JP2007531750A
JP2007531750A JP2007506468A JP2007506468A JP2007531750A JP 2007531750 A JP2007531750 A JP 2007531750A JP 2007506468 A JP2007506468 A JP 2007506468A JP 2007506468 A JP2007506468 A JP 2007506468A JP 2007531750 A JP2007531750 A JP 2007531750A
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methylamino
pain
dihydro
benzoxazin
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アン・ティエン・ブ
ペイジ・エリン・マヘイニー
スティーブン・トッド・コーン
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    • C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D279/10—1,4-Thiazines; Hydrogenated 1,4-thiazines
    • C07D279/14—1,4-Thiazines; Hydrogenated 1,4-thiazines condensed with carbocyclic rings or ring systems
    • C07D279/16—1,4-Thiazines; Hydrogenated 1,4-thiazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P25/00—Drugs for disorders of the nervous system
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    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
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    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
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    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/36—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems
    • C07D241/38—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems with only hydrogen or carbon atoms directly attached to the ring nitrogen atoms
    • C07D241/40—Benzopyrazines
    • C07D241/42—Benzopyrazines with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/34—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings
    • C07D265/36—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings condensed with one six-membered ring

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  • Urology & Nephrology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
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  • Physical Education & Sports Medicine (AREA)
  • Obesity (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pregnancy & Childbirth (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Indole Compounds (AREA)
JP2007506468A 2004-03-30 2005-03-29 血管運動症状（ｖｍｓ）を治療するためのモノアミン再取り込みの調節剤としての複素環式フェニルアミノプロパノール誘導体 Withdrawn JP2007531750A (ja)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US55783104P 2004-03-30 2004-03-30
US56986104P 2004-05-11 2004-05-11
US11/091,291 US7414052B2 (en) 2004-03-30 2005-03-28 Phenylaminopropanol derivatives and methods of their use
PCT/US2005/010510 WO2005097761A1 (en) 2004-03-30 2005-03-29 Heterocyclic phenylaminopropanol derivatives as modulators of the monoamine reuptake for the treatment of vasomotor symptoms (vms)

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JP2007531750A true JP2007531750A (ja) 2007-11-08
JP2007531750A5 JP2007531750A5 (https=) 2008-05-22

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JP2007506468A Withdrawn JP2007531750A (ja) 2004-03-30 2005-03-29 血管運動症状（ｖｍｓ）を治療するためのモノアミン再取り込みの調節剤としての複素環式フェニルアミノプロパノール誘導体

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US (2) US7414052B2 (https=)
EP (1) EP1730127B1 (https=)
JP (1) JP2007531750A (https=)
AR (1) AR048447A1 (https=)
AT (1) ATE399158T1 (https=)
AU (1) AU2005230899A1 (https=)
BR (1) BRPI0509513A (https=)
CA (1) CA2560966A1 (https=)
DE (1) DE602005007718D1 (https=)
PA (1) PA8628101A1 (https=)
PE (1) PE20060163A1 (https=)
TW (1) TW200538460A (https=)
WO (1) WO2005097761A1 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
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JP2014502979A (ja) * 2011-01-20 2014-02-06 メルク・シャープ・アンド・ドーム・コーポレーション ミネラルコルチコイド受容体拮抗薬

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2014502979A (ja) * 2011-01-20 2014-02-06 メルク・シャープ・アンド・ドーム・コーポレーション ミネラルコルチコイド受容体拮抗薬

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CA2560966A1 (en) 2005-10-20
DE602005007718D1 (de) 2008-08-07
US20080255102A1 (en) 2008-10-16
US7414052B2 (en) 2008-08-19
AU2005230899A1 (en) 2005-10-20
US20050222142A1 (en) 2005-10-06
BRPI0509513A (pt) 2007-09-11
WO2005097761A1 (en) 2005-10-20
PA8628101A1 (es) 2005-11-25
AR048447A1 (es) 2006-04-26
US7638512B2 (en) 2009-12-29
TW200538460A (en) 2005-12-01
EP1730127A1 (en) 2006-12-13
ATE399158T1 (de) 2008-07-15
PE20060163A1 (es) 2006-04-17
EP1730127B1 (en) 2008-06-25

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