JP2007527913A5 - - Google Patents
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- Publication number
- JP2007527913A5 JP2007527913A5 JP2007502988A JP2007502988A JP2007527913A5 JP 2007527913 A5 JP2007527913 A5 JP 2007527913A5 JP 2007502988 A JP2007502988 A JP 2007502988A JP 2007502988 A JP2007502988 A JP 2007502988A JP 2007527913 A5 JP2007527913 A5 JP 2007527913A5
- Authority
- JP
- Japan
- Prior art keywords
- independently selected
- cycloalkyl
- optionally substituted
- halogen
- substituents
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 125000000217 alkyl group Chemical group 0.000 claims 52
- 125000001424 substituent group Chemical group 0.000 claims 43
- 125000000753 cycloalkyl group Chemical group 0.000 claims 35
- 229910052736 halogen Inorganic materials 0.000 claims 35
- 150000002367 halogens Chemical class 0.000 claims 35
- -1 amino, hydroxy Chemical group 0.000 claims 33
- 125000001072 heteroaryl group Chemical group 0.000 claims 22
- 125000003118 aryl group Chemical group 0.000 claims 20
- 125000000623 heterocyclic group Chemical group 0.000 claims 15
- 150000001875 compounds Chemical class 0.000 claims 13
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims 10
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 10
- 125000003342 alkenyl group Chemical group 0.000 claims 10
- 125000003545 alkoxy group Chemical group 0.000 claims 10
- 125000000304 alkynyl group Chemical group 0.000 claims 10
- 125000003917 carbamoyl group Chemical class [H]N([H])C(*)=O 0.000 claims 10
- 125000001589 carboacyl group Chemical group 0.000 claims 10
- XNVMFDGFXSZPDU-UHFFFAOYSA-N cyano nitroformate Chemical compound [O-][N+](=O)C(=O)OC#N XNVMFDGFXSZPDU-UHFFFAOYSA-N 0.000 claims 10
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims 10
- 125000004438 haloalkoxy group Chemical group 0.000 claims 10
- 125000001188 haloalkyl group Chemical group 0.000 claims 10
- 229910052739 hydrogen Inorganic materials 0.000 claims 10
- 239000001257 hydrogen Substances 0.000 claims 10
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 10
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 6
- 150000003839 salts Chemical class 0.000 claims 6
- 229920001774 Perfluoroether Polymers 0.000 claims 5
- 201000010099 disease Diseases 0.000 claims 5
- 125000004663 dialkyl amino group Chemical group 0.000 claims 4
- 239000003814 drug Substances 0.000 claims 4
- 108090000312 Calcium Channels Proteins 0.000 claims 3
- 102000003922 Calcium Channels Human genes 0.000 claims 3
- 150000002148 esters Chemical class 0.000 claims 3
- 238000004519 manufacturing process Methods 0.000 claims 3
- 125000003386 piperidinyl group Chemical group 0.000 claims 3
- 208000024891 symptom Diseases 0.000 claims 3
- 125000003039 tetrahydroisoquinolinyl group Chemical group C1(NCCC2=CC=CC=C12)* 0.000 claims 3
- 125000000147 tetrahydroquinolinyl group Chemical group N1(CCCC2=CC=CC=C12)* 0.000 claims 3
- 230000000694 effects Effects 0.000 claims 2
- 206010002383 Angina Pectoris Diseases 0.000 claims 1
- 206010007559 Cardiac failure congestive Diseases 0.000 claims 1
- 101150047856 Cav2 gene Proteins 0.000 claims 1
- 206010019280 Heart failures Diseases 0.000 claims 1
- 101000935123 Homo sapiens Voltage-dependent N-type calcium channel subunit alpha-1B Proteins 0.000 claims 1
- 206010020772 Hypertension Diseases 0.000 claims 1
- 108090000862 Ion Channels Proteins 0.000 claims 1
- 102000004310 Ion Channels Human genes 0.000 claims 1
- 208000002193 Pain Diseases 0.000 claims 1
- 208000006011 Stroke Diseases 0.000 claims 1
- 208000030886 Traumatic Brain injury Diseases 0.000 claims 1
- 206010046543 Urinary incontinence Diseases 0.000 claims 1
- 102100025342 Voltage-dependent N-type calcium channel subunit alpha-1B Human genes 0.000 claims 1
- 206010003119 arrhythmia Diseases 0.000 claims 1
- 230000006793 arrhythmia Effects 0.000 claims 1
- 125000003785 benzimidazolyl group Chemical group N1=C(NC2=C1C=CC=C2)* 0.000 claims 1
- 125000004432 carbon atom Chemical group C* 0.000 claims 1
- 206010012601 diabetes mellitus Diseases 0.000 claims 1
- 208000035475 disorder Diseases 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 125000005842 heteroatom Chemical group 0.000 claims 1
- 125000002883 imidazolyl group Chemical group 0.000 claims 1
- 208000031225 myocardial ischemia Diseases 0.000 claims 1
- 230000001537 neural effect Effects 0.000 claims 1
- 229910052760 oxygen Inorganic materials 0.000 claims 1
- 230000036407 pain Effects 0.000 claims 1
- 125000003226 pyrazolyl group Chemical group 0.000 claims 1
- 125000000719 pyrrolidinyl group Chemical group 0.000 claims 1
- 125000003107 substituted aryl group Chemical group 0.000 claims 1
- 229910052717 sulfur Inorganic materials 0.000 claims 1
- 229940124597 therapeutic agent Drugs 0.000 claims 1
- 230000009529 traumatic brain injury Effects 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US55137104P | 2004-03-08 | 2004-03-08 | |
| PCT/US2005/007902 WO2005086895A2 (en) | 2004-03-08 | 2005-03-07 | Ion channel modulators |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2007527913A JP2007527913A (ja) | 2007-10-04 |
| JP2007527913A5 true JP2007527913A5 (https=) | 2008-04-24 |
Family
ID=34976220
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007502988A Pending JP2007527913A (ja) | 2004-03-08 | 2005-03-07 | イオンチャンネルモジュレーター |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US7368467B2 (https=) |
| EP (1) | EP1722783A4 (https=) |
| JP (1) | JP2007527913A (https=) |
| CN (1) | CN1946397A (https=) |
| AU (1) | AU2005221131A1 (https=) |
| BR (1) | BRPI0508556A (https=) |
| CA (1) | CA2557648A1 (https=) |
| WO (1) | WO2005086895A2 (https=) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005087747A1 (en) * | 2004-03-08 | 2005-09-22 | Wyeth | Ion channel modulators |
| WO2005086836A2 (en) * | 2004-03-08 | 2005-09-22 | Wyeth | Ion channel modulators |
| AU2005221683A1 (en) * | 2004-03-08 | 2005-09-22 | Wyeth | Ion channel modulators |
| EP1723123A4 (en) * | 2004-03-08 | 2009-12-02 | Wyeth Corp | ION CHANNEL MODULATORS |
| EP2392328A1 (en) * | 2005-05-09 | 2011-12-07 | Hydra Biosciences, Inc. | Compounds for modulating TRPV3 Function |
| US8916550B2 (en) * | 2005-05-09 | 2014-12-23 | Hydra Biosciences, Inc. | Compounds for modulating TRPV3 function |
| US7893260B2 (en) * | 2005-11-04 | 2011-02-22 | Hydra Biosciences, Inc. | Substituted quinazolin-4-one compounds for antagonizing TRPV3 function |
| US7998980B2 (en) | 2006-09-15 | 2011-08-16 | Hydra Biosciences, Inc. | Compounds for modulating TRPV3 function |
| EP1939181A1 (en) * | 2006-12-27 | 2008-07-02 | sanofi-aventis | Heteroaryl-substituted carboxamides and use thereof for the stimulation of the expression of NO synthase |
| WO2008140750A1 (en) * | 2007-05-10 | 2008-11-20 | Hydra Biosciences Inc. | Compounds for modulating trpv3 function |
| TWI501965B (zh) | 2008-06-20 | 2015-10-01 | Lundbeck & Co As H | 作為ｐｄｅ１０ａ酵素抑制劑之新穎苯基咪唑衍生物 |
| US8133897B2 (en) | 2008-06-20 | 2012-03-13 | H. Lundbeck A/S | Phenylimidazole derivatives as PDE10A enzyme inhibitors |
| CN107375284B (zh) * | 2008-08-26 | 2020-08-07 | 巴斯夫欧洲公司 | 冷薄荷醇受体trpm8的低分子量调节剂的检测和用途 |
| CA2736117C (en) * | 2008-09-04 | 2013-11-19 | Ardea Biosciences, Inc. | Compounds, compositions and methods of using same for modulating uric acid levels |
| AU2010221650B2 (en) * | 2009-03-04 | 2015-06-25 | Merck Sharp & Dohme Corp. | Imidazole derivatives useful as modulators of FAAH and as FAAH imaging agents |
| WO2013054338A1 (en) * | 2011-07-06 | 2013-04-18 | Cadila Healthcare Limited | 2-thio-imidazole derivatives as tgr5 modulators |
| WO2013102929A1 (en) * | 2011-12-26 | 2013-07-11 | Cadila Healthcare Limited | Novel compounds for treatment of diabetes, obesity or related disorders |
| WO2014130550A1 (en) * | 2013-02-20 | 2014-08-28 | Allergan, Inc. | Substituted diaryl derivatives as sphingosine receptor modulators |
| BR112017008594B1 (pt) * | 2014-10-29 | 2023-04-18 | Apoglyx Ab | Derivados de 2-(1,2,4-triazol-3-ilsulfanil)-n-1,3,4-tiadiazol-2- il acetamida que são úteis para o tratamento de diabetes inter alia |
| WO2021154966A1 (en) | 2020-01-29 | 2021-08-05 | Kamari Pharma Ltd. | Compounds and compositions for use in treating skin disorders |
| WO2023009347A1 (en) * | 2021-07-30 | 2023-02-02 | The Regents Of The University Of California | Compounds for modulating epithelial 15-(s)-lipoxygenase-2 and methods of use for same |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4734421A (en) * | 1986-10-29 | 1988-03-29 | Merck & Co., Inc. | Anti-inflammatory substituted 2-benzyl-mercapto-imidazole and pyrimidine derivatives compositions and method of use therefor |
| AU8757098A (en) | 1997-06-30 | 1999-02-10 | Ortho-Mcneil Pharmaceutical, Inc. | 2-substituted imidazoles useful in the treatment of inflammatory diseases |
| US20030199523A1 (en) * | 2002-02-28 | 2003-10-23 | Snutch Terrance P. | Heterocyclic calcium in channel blockers |
| WO2005086836A2 (en) * | 2004-03-08 | 2005-09-22 | Wyeth | Ion channel modulators |
-
2005
- 2005-03-07 EP EP05725210A patent/EP1722783A4/en not_active Withdrawn
- 2005-03-07 CN CNA2005800073209A patent/CN1946397A/zh active Pending
- 2005-03-07 WO PCT/US2005/007902 patent/WO2005086895A2/en not_active Ceased
- 2005-03-07 JP JP2007502988A patent/JP2007527913A/ja active Pending
- 2005-03-07 US US11/075,629 patent/US7368467B2/en not_active Expired - Fee Related
- 2005-03-07 BR BRPI0508556-0A patent/BRPI0508556A/pt not_active IP Right Cessation
- 2005-03-07 CA CA002557648A patent/CA2557648A1/en not_active Abandoned
- 2005-03-07 AU AU2005221131A patent/AU2005221131A1/en not_active Abandoned
-
2007
- 2007-12-12 US US11/954,894 patent/US20080090891A1/en not_active Abandoned
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