JP2007524699A5 - - Google Patents
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- Publication number
- JP2007524699A5 JP2007524699A5 JP2007500220A JP2007500220A JP2007524699A5 JP 2007524699 A5 JP2007524699 A5 JP 2007524699A5 JP 2007500220 A JP2007500220 A JP 2007500220A JP 2007500220 A JP2007500220 A JP 2007500220A JP 2007524699 A5 JP2007524699 A5 JP 2007524699A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical formulation
- pharmaceutically acceptable
- glycopyrronium
- acceptable salt
- formulation according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 239000008194 pharmaceutical composition Substances 0.000 claims 17
- 150000003839 salts Chemical class 0.000 claims 13
- ANGKOCUUWGHLCE-HKUYNNGSSA-N [(3s)-1,1-dimethylpyrrolidin-1-ium-3-yl] (2r)-2-cyclopentyl-2-hydroxy-2-phenylacetate Chemical compound C1[N+](C)(C)CC[C@@H]1OC(=O)[C@](O)(C=1C=CC=CC=1)C1CCCC1 ANGKOCUUWGHLCE-HKUYNNGSSA-N 0.000 claims 11
- 229960002462 glycopyrronium bromide Drugs 0.000 claims 11
- MNDBXUUTURYVHR-UHFFFAOYSA-N roflumilast Chemical compound FC(F)OC1=CC=C(C(=O)NC=2C(=CN=CC=2Cl)Cl)C=C1OCC1CC1 MNDBXUUTURYVHR-UHFFFAOYSA-N 0.000 claims 8
- SYTBZMRGLBWNTM-SNVBAGLBSA-N (R)-flurbiprofen Chemical compound FC1=CC([C@H](C(O)=O)C)=CC=C1C1=CC=CC=C1 SYTBZMRGLBWNTM-SNVBAGLBSA-N 0.000 claims 7
- 229960002586 roflumilast Drugs 0.000 claims 7
- 239000000825 pharmaceutical preparation Substances 0.000 claims 6
- -1 3,5-dichloropyrid-4-yl Chemical group 0.000 claims 3
- 150000001875 compounds Chemical class 0.000 claims 3
- 239000012453 solvate Substances 0.000 claims 3
- KXDAEFPNCMNJSK-UHFFFAOYSA-N Benzamide Chemical compound NC(=O)C1=CC=CC=C1 KXDAEFPNCMNJSK-UHFFFAOYSA-N 0.000 claims 2
- 241000124008 Mammalia Species 0.000 claims 2
- 229940123932 Phosphodiesterase 4 inhibitor Drugs 0.000 claims 2
- 230000001078 anti-cholinergic effect Effects 0.000 claims 2
- 208000006673 asthma Diseases 0.000 claims 2
- 239000002587 phosphodiesterase IV inhibitor Substances 0.000 claims 2
- 239000000843 powder Substances 0.000 claims 2
- 208000035285 Allergic Seasonal Rhinitis Diseases 0.000 claims 1
- WSVLPVUVIUVCRA-KPKNDVKVSA-N Alpha-lactose monohydrate Chemical group O.O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O WSVLPVUVIUVCRA-KPKNDVKVSA-N 0.000 claims 1
- 206010003557 Asthma exercise induced Diseases 0.000 claims 1
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 claims 1
- 206010014561 Emphysema Diseases 0.000 claims 1
- 208000004657 Exercise-Induced Asthma Diseases 0.000 claims 1
- 206010057190 Respiratory tract infections Diseases 0.000 claims 1
- 206010039085 Rhinitis allergic Diseases 0.000 claims 1
- 206010047924 Wheezing Diseases 0.000 claims 1
- 239000004480 active ingredient Substances 0.000 claims 1
- 201000010105 allergic rhinitis Diseases 0.000 claims 1
- 206010006451 bronchitis Diseases 0.000 claims 1
- 125000000837 carbohydrate group Chemical group 0.000 claims 1
- 239000002552 dosage form Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 208000024695 exercise-induced bronchoconstriction Diseases 0.000 claims 1
- 239000004615 ingredient Substances 0.000 claims 1
- 229960001021 lactose monohydrate Drugs 0.000 claims 1
- 208000024696 nocturnal asthma Diseases 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 230000035790 physiological processes and functions Effects 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 206010039083 rhinitis Diseases 0.000 claims 1
- 230000001225 therapeutic effect Effects 0.000 claims 1
- 208000011479 upper respiratory tract disease Diseases 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP04004472 | 2004-02-27 | ||
| PCT/EP2005/050800 WO2005082361A1 (en) | 2004-02-27 | 2005-02-25 | Roflumilast and glycopryrronium combination |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2007524699A JP2007524699A (ja) | 2007-08-30 |
| JP2007524699A5 true JP2007524699A5 (https=) | 2008-04-03 |
Family
ID=34895963
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007500220A Withdrawn JP2007524699A (ja) | 2004-02-27 | 2005-02-25 | ロフルミラストとグリコピロニウムとの組合せ物 |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US20070167496A1 (https=) |
| EP (1) | EP1720543A1 (https=) |
| JP (1) | JP2007524699A (https=) |
| WO (1) | WO2005082361A1 (https=) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0523655D0 (en) * | 2005-11-21 | 2005-12-28 | Novartis Ag | Organic compounds |
| US20100055045A1 (en) * | 2008-02-26 | 2010-03-04 | William Gerhart | Method and system for the treatment of chronic obstructive pulmonary disease with nebulized anticholinergic administrations |
| GB2468073B (en) * | 2008-02-26 | 2012-09-05 | Elevation Pharmaceuticals Inc | Method and system for the treatment of chronic obstructive pulmonary disease with nebulized anticholinergic administrations |
| EP2948148B1 (en) | 2013-01-28 | 2020-07-29 | Incozen Therapeutics Pvt. Ltd. | Methods of treating autoimmune, respiratory and inflammatory disorders by inhalation of roflumilast n-oxide |
| EP3473615B1 (en) | 2013-02-28 | 2022-01-19 | Journey Medical Corporation | Glycopyrrolate salts |
| US8558008B2 (en) | 2013-02-28 | 2013-10-15 | Dermira, Inc. | Crystalline glycopyrrolate tosylate |
| US9006462B2 (en) | 2013-02-28 | 2015-04-14 | Dermira, Inc. | Glycopyrrolate salts |
| WO2015063669A1 (en) | 2013-10-30 | 2015-05-07 | Wockhardt Limited | Pharmaceutical compositions comprising combination of roflumilast and acebrophylline or pharmaceutically acceptable salts thereof |
| CN104800192A (zh) * | 2014-01-27 | 2015-07-29 | 成都英诺新科技有限公司 | 一种罗氟司特吸入粉雾剂及制备方法 |
| EP3958847A2 (en) * | 2018-08-10 | 2022-03-02 | Arven Ilac Sanayi Ve Ticaret Anonim Sirketi | Inhalation compositions comprising phosphodiesterase-4 inhibitor |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2176252T3 (es) * | 1993-07-02 | 2002-12-01 | Altana Pharma Ag | Benzamidas sustituidas con fluoro-alcoxi y su utilizacion como agentes inhibidores de fosfodiesterasas de nucleotidos ciclicos. |
| WO1998000016A1 (en) * | 1996-07-01 | 1998-01-08 | Sepracor, Inc. | Methods and compositions for treating urinary incontinence using enantiomerically enriched (r,r)-glycopyrrolate |
| US6397838B1 (en) * | 1998-12-23 | 2002-06-04 | Battelle Pulmonary Therapeutics, Inc. | Pulmonary aerosol delivery device and method |
| AU777169B2 (en) * | 1999-04-23 | 2004-10-07 | Battelle Memorial Institute | High mass transfer electrosprayer |
| JP4677102B2 (ja) * | 1999-04-23 | 2011-04-27 | バテル・メモリアル・インスティテュート | エーロゾル給送装置及びエーロゾル小滴を給送する方法 |
| US20040002548A1 (en) * | 1999-05-12 | 2004-01-01 | Boehringer Ingelheim Pharma Kg | Medicament compositions containing anticholinergically-effective compounds and betamimetics |
| DE10110772A1 (de) * | 2001-03-07 | 2002-09-12 | Boehringer Ingelheim Pharma | Neue Arzneimittelkompositionen auf der Basis von Anticholinergika und PDE-IV-Inhibitoren |
| DE10061137B4 (de) * | 2000-12-07 | 2016-10-06 | Takeda Gmbh | Neue pharmazeutische Zubereitung |
| WO2002072145A1 (en) * | 2001-03-14 | 2002-09-19 | Ono Pharmaceutical Co., Ltd. | Remedies for depression containing ep1 antagonist as the active ingredient |
| WO2005074982A2 (en) * | 2004-02-06 | 2005-08-18 | Meda Pharma Gmbh & Co. Kg | Combination of anticholinergics and inhibitors of phosphodiesterase type 4 for the treatment of respiratory diseases |
| CA2568834A1 (en) * | 2004-06-29 | 2006-01-12 | Boehringer Ingelheim International Gmbh | Medicaments for inhalation comprising steroids and an anticholinergic |
-
2005
- 2005-02-25 JP JP2007500220A patent/JP2007524699A/ja not_active Withdrawn
- 2005-02-25 EP EP05716794A patent/EP1720543A1/en not_active Withdrawn
- 2005-02-25 US US10/589,865 patent/US20070167496A1/en not_active Abandoned
- 2005-02-25 WO PCT/EP2005/050800 patent/WO2005082361A1/en not_active Ceased
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