JP2007522147A5 - - Google Patents
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- Publication number
- JP2007522147A5 JP2007522147A5 JP2006552169A JP2006552169A JP2007522147A5 JP 2007522147 A5 JP2007522147 A5 JP 2007522147A5 JP 2006552169 A JP2006552169 A JP 2006552169A JP 2006552169 A JP2006552169 A JP 2006552169A JP 2007522147 A5 JP2007522147 A5 JP 2007522147A5
- Authority
- JP
- Japan
- Prior art keywords
- modafinil
- composition
- ray diffraction
- diffraction pattern
- solvate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 claims 52
- 239000012453 solvate Substances 0.000 claims 37
- 238000002441 X-ray diffraction Methods 0.000 claims 35
- YFGHCGITMMYXAQ-LJQANCHMSA-N armodafinil Chemical compound C=1C=CC=CC=1C([S@](=O)CC(=O)N)C1=CC=CC=C1 YFGHCGITMMYXAQ-LJQANCHMSA-N 0.000 claims 32
- YFGHCGITMMYXAQ-UHFFFAOYSA-N 2-[(diphenylmethyl)sulfinyl]acetamide Chemical compound C=1C=CC=CC=1C(S(=O)CC(=O)N)C1=CC=CC=C1 YFGHCGITMMYXAQ-UHFFFAOYSA-N 0.000 claims 18
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims 18
- 229960001165 modafinil Drugs 0.000 claims 18
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 claims 12
- MVPPADPHJFYWMZ-UHFFFAOYSA-N chlorobenzene Chemical compound ClC1=CC=CC=C1 MVPPADPHJFYWMZ-UHFFFAOYSA-N 0.000 claims 12
- 239000008194 pharmaceutical composition Substances 0.000 claims 8
- 238000000634 powder X-ray diffraction Methods 0.000 claims 7
- 239000004480 active ingredient Substances 0.000 claims 6
- 238000001938 differential scanning calorimetry curve Methods 0.000 claims 6
- 239000002904 solvent Substances 0.000 claims 6
- 239000011877 solvent mixture Substances 0.000 claims 4
- 238000009472 formulation Methods 0.000 claims 3
- 238000004519 manufacturing process Methods 0.000 claims 3
- 230000007704 transition Effects 0.000 claims 3
- 208000006096 Attention Deficit Disorder with Hyperactivity Diseases 0.000 claims 2
- 208000007590 Disorders of Excessive Somnolence Diseases 0.000 claims 2
- 206010041349 Somnolence Diseases 0.000 claims 2
- 208000010513 Stupor Diseases 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 201000003631 narcolepsy Diseases 0.000 claims 2
- 201000002859 sleep apnea Diseases 0.000 claims 2
- 206010021639 Incontinence Diseases 0.000 claims 1
- 208000021642 Muscular disease Diseases 0.000 claims 1
- 201000009623 Myopathy Diseases 0.000 claims 1
- 208000018737 Parkinson disease Diseases 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 208000035475 disorder Diseases 0.000 claims 1
- 206010016256 fatigue Diseases 0.000 claims 1
- 208000000509 infertility Diseases 0.000 claims 1
- 230000036512 infertility Effects 0.000 claims 1
- 231100000535 infertility Toxicity 0.000 claims 1
- 201000006417 multiple sclerosis Diseases 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
Applications Claiming Priority (19)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US54275204P | 2004-02-06 | 2004-02-06 | |
| US60/542,752 | 2004-02-06 | ||
| US56041104P | 2004-04-06 | 2004-04-06 | |
| US60/560,411 | 2004-04-06 | ||
| US57341204P | 2004-05-21 | 2004-05-21 | |
| US60/573,412 | 2004-05-21 | ||
| US57917604P | 2004-06-12 | 2004-06-12 | |
| US60/579,176 | 2004-06-12 | ||
| US58199204P | 2004-06-22 | 2004-06-22 | |
| US60/581,992 | 2004-06-22 | ||
| US58675204P | 2004-07-09 | 2004-07-09 | |
| US60/586,752 | 2004-07-09 | ||
| US58823604P | 2004-07-15 | 2004-07-15 | |
| US60/588,236 | 2004-07-15 | ||
| PCT/US2004/029013 WO2005023198A2 (en) | 2003-09-04 | 2004-09-04 | Modafinil compositions |
| USPCT/US04/29013 | 2004-09-04 | ||
| US63178604P | 2004-11-30 | 2004-11-30 | |
| US60/631,786 | 2004-11-30 | ||
| PCT/US2005/002782 WO2005077894A1 (en) | 2004-02-06 | 2005-02-01 | Modafinil compositions |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2007522147A JP2007522147A (ja) | 2007-08-09 |
| JP2007522147A5 true JP2007522147A5 (enrdf_load_stackoverflow) | 2008-03-06 |
| JP4917441B2 JP4917441B2 (ja) | 2012-04-18 |
Family
ID=38456572
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006552169A Expired - Fee Related JP4917441B2 (ja) | 2004-02-06 | 2005-02-01 | モダフィニル組成物 |
Country Status (7)
| Country | Link |
|---|---|
| EP (1) | EP1718607A4 (enrdf_load_stackoverflow) |
| JP (1) | JP4917441B2 (enrdf_load_stackoverflow) |
| AU (1) | AU2005212229B2 (enrdf_load_stackoverflow) |
| CA (1) | CA2556106A1 (enrdf_load_stackoverflow) |
| EA (1) | EA009949B1 (enrdf_load_stackoverflow) |
| IL (1) | IL176934A (enrdf_load_stackoverflow) |
| WO (1) | WO2005077894A1 (enrdf_load_stackoverflow) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4906233B2 (ja) | 2002-03-01 | 2012-03-28 | ユニバーシティー オブ サウス フロリダ | 少なくとも１種の有効薬剤成分を含有する多構成要素固相 |
| CA2489984A1 (en) | 2002-06-21 | 2003-12-31 | Transform Pharmaceuticals, Inc. | Pharmaceutical compositions with improved dissolution |
| FR2849029B1 (fr) | 2002-12-20 | 2005-03-18 | Lafon Labor | Procede de preparation et formes cristallines des enantiomeres optiques du modafinil. |
| US8183290B2 (en) | 2002-12-30 | 2012-05-22 | Mcneil-Ppc, Inc. | Pharmaceutically acceptable propylene glycol solvate of naproxen |
| WO2005099822A2 (en) * | 2004-04-13 | 2005-10-27 | Cephalon, Inc. | Reduction of drug / drug interactions with modafinil |
| CA2625299A1 (en) * | 2005-11-22 | 2007-05-31 | Teva Pharmaceutical Industries Ltd. | Crystal forms of cinacalcet hci and processes for their preparation |
| CN100343228C (zh) * | 2006-02-17 | 2007-10-17 | 中国科学院上海有机化学研究所 | 高对映体选择性制备 2－二苯甲基亚磺酰基－乙酰胺单一对映体的方法 |
| MX2007012605A (es) * | 2006-02-21 | 2008-01-11 | Teva Pharma | Formas cristalinas novedosas de armodafinil y preparacion de ellas. |
| CA2688430A1 (en) * | 2007-06-04 | 2008-12-11 | Generics [Uk] Limited | Novel process |
| US7960586B2 (en) | 2007-08-16 | 2011-06-14 | Teva Pharmaceutical Industries Ltd. | Purification of armodafinil |
| WO2009045488A2 (en) * | 2007-10-02 | 2009-04-09 | Teva Pharmaceutical Industries Ltd. | Novel crystalline forms of armodafinil and preparation thereof |
| WO2009090663A1 (en) * | 2008-01-15 | 2009-07-23 | Lupin Limited | Novel crystalline polymorph of armodafinil and an improved process for preparation thereof |
| KR102126389B1 (ko) * | 2018-09-14 | 2020-06-25 | 셀라이온바이오메드 주식회사 | 벤즈히드릴티오 아세트아미드 화합물을 유효성분으로 포함하는 간 질환의 예방 또는 치료용 조성물 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2593809B1 (fr) * | 1986-01-31 | 1988-07-22 | Lafon Labor | Benzhydrylsulfinylacetamide, procede de preparation et utilisation en therapeutique |
| FR2804322B1 (fr) * | 2000-01-31 | 2002-04-19 | Lafon Labor | Utilisation du modafinil pour la fabrication d'un medicament destine a corriger les troubles de la vigilance associes aux myopathies |
| DK1309547T3 (da) * | 2000-07-27 | 2007-05-21 | Teva Pharma | Krystallinsk og ren modafinil og fremgangsmåde til fremstilling af samme |
| FR2849029B1 (fr) * | 2002-12-20 | 2005-03-18 | Lafon Labor | Procede de preparation et formes cristallines des enantiomeres optiques du modafinil. |
-
2005
- 2005-02-01 JP JP2006552169A patent/JP4917441B2/ja not_active Expired - Fee Related
- 2005-02-01 EP EP05712282A patent/EP1718607A4/en not_active Ceased
- 2005-02-01 EA EA200601390A patent/EA009949B1/ru not_active IP Right Cessation
- 2005-02-01 CA CA002556106A patent/CA2556106A1/en not_active Abandoned
- 2005-02-01 WO PCT/US2005/002782 patent/WO2005077894A1/en active Application Filing
- 2005-02-01 AU AU2005212229A patent/AU2005212229B2/en not_active Ceased
-
2006
- 2006-07-18 IL IL176934A patent/IL176934A/en not_active IP Right Cessation
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