JP2007522096A5 - - Google Patents
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- Publication number
- JP2007522096A5 JP2007522096A5 JP2006533638A JP2006533638A JP2007522096A5 JP 2007522096 A5 JP2007522096 A5 JP 2007522096A5 JP 2006533638 A JP2006533638 A JP 2006533638A JP 2006533638 A JP2006533638 A JP 2006533638A JP 2007522096 A5 JP2007522096 A5 JP 2007522096A5
- Authority
- JP
- Japan
- Prior art keywords
- epha4
- antibody
- antibodies
- scfv
- provides
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US47690903P | 2003-06-06 | 2003-06-06 | |
| US50335603P | 2003-09-16 | 2003-09-16 | |
| PCT/US2004/018279 WO2005048917A2 (en) | 2003-06-06 | 2004-06-07 | Use of epha4 and modulator or epha4 for diagnosis, treatment and prevention of cancer |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2007522096A JP2007522096A (ja) | 2007-08-09 |
| JP2007522096A5 true JP2007522096A5 (enExample) | 2008-06-19 |
Family
ID=34622735
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006533638A Abandoned JP2007522096A (ja) | 2003-06-06 | 2004-06-07 | 癌の診断、治療、及び予防のためのＥｐｈＡ４及びＥｐｈＡ４変調因子の使用 |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US7604799B2 (enExample) |
| EP (1) | EP1638514A4 (enExample) |
| JP (1) | JP2007522096A (enExample) |
| KR (1) | KR20060034231A (enExample) |
| AU (1) | AU2004291026A1 (enExample) |
| CA (1) | CA2528549A1 (enExample) |
| WO (1) | WO2005048917A2 (enExample) |
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6887674B1 (en) | 1998-04-13 | 2005-05-03 | California Institute Of Technology | Artery- and vein-specific proteins and uses therefor |
| US6864227B1 (en) | 1998-04-13 | 2005-03-08 | California Institute Of Technology | Artery-and vein-specific proteins and uses therefor |
| US9032097B2 (en) * | 2001-04-26 | 2015-05-12 | Nokia Corporation | Data communication with remote network node |
| US7381410B2 (en) | 2003-03-12 | 2008-06-03 | Vasgene Therapeutics, Inc. | Polypeptide compounds for inhibiting angiogenesis and tumor growth |
| AU2004220459B2 (en) | 2003-03-12 | 2010-08-05 | Vasgene Therapeutics, Inc. | Polypeptide compounds for inhibiting angiogenesis and tumor growth |
| US20050147593A1 (en) * | 2003-05-22 | 2005-07-07 | Medimmune, Inc. | EphA2, EphA4 and LMW-PTP and methods of treatment of hyperproliferative cell disorders |
| KR20060034231A (ko) * | 2003-06-06 | 2006-04-21 | 메디뮨 인코포레이티드 | 암의 진단, 치료 및 예방에 있어서의 ｅｐｈａ４ 및ｅｐｈａ４ 조정제의 용도 |
| US20050153923A1 (en) * | 2003-12-04 | 2005-07-14 | Kinch Michael S. | Targeted drug delivery using EphA2 or EphA4 binding moieties |
| ATE492564T1 (de) | 2004-03-12 | 2011-01-15 | Vasgene Therapeutics Inc | Ephb4-bindende antikörper zur inhibierung von angiogenese und tumorwachstum |
| AU2005224081B2 (en) | 2004-03-12 | 2011-06-30 | Vasgene Therapeutics, Inc. | Polypeptide compounds for inhibiting angiogenesis and tumor growth |
| EP1799713B1 (en) | 2004-09-23 | 2014-11-05 | VasGene Therapeutics, Inc. | Polypeptide compounds for inhibiting angiogenesis and tumor growth |
| PL1874821T3 (pl) | 2005-04-26 | 2013-09-30 | Trion Pharma Gmbh | Kombinacja przeciwciał i glikokortykoidów do leczenia raka |
| WO2007002543A2 (en) | 2005-06-23 | 2007-01-04 | Medimmune, Inc. | Antibody formulations having optimized aggregation and fragmentation profiles |
| US20070128116A1 (en) * | 2005-07-27 | 2007-06-07 | Wang Zheng J | Multifunctional core for molecular imaging and targeted delivery of macromolecules and drugs |
| US7807459B2 (en) * | 2005-09-27 | 2010-10-05 | Reneuron, Inc. | EphA4-positive human adult pancreatic endocrine progenitor cells |
| CA2633718A1 (en) * | 2005-12-21 | 2007-07-05 | Medimmune, Llc | Affinity optimized epha2 agonistic antibodies and methods of use thereof |
| JP2009531273A (ja) | 2006-02-28 | 2009-09-03 | オンコセラピー・サイエンス株式会社 | 抗ＥｐｈＡ４抗体のエフェクター機能を用いて細胞を障害する方法 |
| US8975377B2 (en) | 2007-08-13 | 2015-03-10 | Vasgene Therapeutics, Inc | Cancer treatment using humanized antibodies that bind to EphB4 |
| WO2010114921A1 (en) * | 2009-04-02 | 2010-10-07 | Burnham Institute For Medical Research | Eph receptor ligands and methods of use |
| CN103237901B (zh) | 2010-03-01 | 2016-08-03 | 卡里斯生命科学瑞士控股有限责任公司 | 用于治疗诊断的生物标志物 |
| EP2366714A1 (en) * | 2010-03-03 | 2011-09-21 | Dr. Rentschler Holding GmbH & Co. KG | Naturally occuring autoantibodies against alpha-synuclein that inhibit the aggregation and cytotoxicity of alpha-synuclein |
| CA2795776A1 (en) | 2010-04-06 | 2011-10-13 | Caris Life Sciences Luxembourg Holdings, S.A.R.L. | Circulating biomarkers for disease |
| WO2012078703A2 (en) * | 2010-12-08 | 2012-06-14 | Fox Chase Cancer Center | Inhibiting chromosome instability in ovarian cancer |
| US20140302034A1 (en) * | 2010-12-08 | 2014-10-09 | Stem Centrx, Inc. | Novel modulators and methods of use |
| WO2012147798A1 (ja) * | 2011-04-25 | 2012-11-01 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | EphA4細胞外ドメインの測定による認知機能障害を伴う神経系疾患の検出方法 |
| CA2890427C (en) | 2012-11-06 | 2022-05-31 | Medimmune, Llc | Antibodies to s. aureus surface determinants |
| EP3065780A1 (en) | 2013-11-04 | 2016-09-14 | Pfizer Inc. | Anti-efna4 antibody-drug conjugates |
| EP3473271B1 (en) * | 2014-07-31 | 2022-07-20 | The Government of the United States of America as represented by the Secretary of the Department of Health and Human Services | Human monoclonal antibodies against epha4 and their use |
| CN107820495A (zh) * | 2015-04-29 | 2018-03-20 | 桑福德-伯纳姆医学研究院 | 靶向epha4的配体结合域的新型epha4抑制剂 |
| RU2019128192A (ru) * | 2015-09-08 | 2019-10-02 | Эйсай Ар Энд Ди Менеджмент Ко., Лтд. | Антитело к epha4 |
| CN108108589B (zh) * | 2017-12-29 | 2020-06-12 | 郑州轻工业学院 | 基于网络指标差异分析的食管鳞癌标记物的识别方法 |
| MA56466A (fr) | 2019-07-01 | 2022-05-11 | Eisai R&D Man Co Ltd | Anticorps anti-epha4 |
| EP4139326A4 (en) * | 2020-04-23 | 2024-05-29 | The Regents Of The University Of California | COMPOUNDS TARGETING EPHA4 AND METHODS OF USE THEREOF |
| US11732007B2 (en) | 2020-09-28 | 2023-08-22 | The Regents Of The University Of California | Therapeutic compounds and methods |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US224374A (en) * | 1880-02-10 | Extension-ladder | ||
| US622711A (en) * | 1899-04-11 | render | ||
| US180823A (en) * | 1876-08-08 | Improvement in farm-gates | ||
| US28685A (en) * | 1860-06-12 | Peed-water apparatus for steam-boilers | ||
| US476909A (en) * | 1892-06-14 | Rail-cleaning attachment for cars | ||
| US503356A (en) * | 1893-08-15 | Wire-netting machine | ||
| US952560A (en) * | 1909-06-28 | 1910-03-22 | Gewerkschaft Der Stein Kohlenzeche Mont Cenis | Process of obtaining ammonium sulfate from gases. |
| FI85768C (fi) | 1990-07-04 | 1992-05-25 | Valtion Teknillinen | Foerfarande foer utfoerning av ytplasmonresonansmaetning samt i foerfarandet anvaendbar givare. |
| DE69110032T2 (de) | 1991-06-08 | 1995-12-21 | Hewlett Packard Gmbh | Verfahren und Gerät zur Feststellung und/oder Konzentrationsbestimmung von Biomolekülen. |
| GB9623820D0 (en) | 1996-11-16 | 1997-01-08 | Secr Defence | Surface plasma resonance sensor |
| KR100508289B1 (ko) | 1998-04-21 | 2005-08-17 | 마이크로메트 에이지 | Ｃｄ１９×ｃｄ３ 특이 폴리펩티드 및 그의 용도 |
| DE19923820C2 (de) | 1998-05-20 | 2001-05-10 | Graffinity Pharm Design Gmbh | SPR-Sensor zur gleichzeitigen Erfassung einer Vielzahl von in fluider Form vorliegenden Proben |
| US6289286B1 (en) | 1998-05-29 | 2001-09-11 | Biacore Ab | Surface regeneration of biosensors and characterization of biomolecules associated therewith |
| WO2001000678A1 (en) * | 1999-06-30 | 2001-01-04 | The Government Of The United States Of America As Represented By The Secretary, Department Of Health And Human Services | Human monoclonal antibodies to hiv-1 envelope glycoprotein gp120 |
| EP1212422B1 (en) * | 1999-08-24 | 2007-02-21 | Medarex, Inc. | Human ctla-4 antibodies and their uses |
| EP1358349A2 (en) | 2000-06-05 | 2003-11-05 | Avalon Pharmaceuticals | Cancer gene determination and therapeutic screening using signature gene sets |
| AU2001271502A1 (en) * | 2000-06-26 | 2002-01-08 | Gpc Biotech Ag | Methods and compositions for isolating biologically active antibodies |
| US7396917B2 (en) * | 2000-12-05 | 2008-07-08 | Alexion Pharmaceuticals, Inc. | Rationally designed antibodies |
| DK1410011T3 (da) | 2001-06-18 | 2011-07-18 | Netherlands Cancer Inst | Diagnose og prognose for brystcancerpatienter |
| CA2485373A1 (en) | 2002-05-10 | 2003-11-20 | Medimmune, Inc. | Epha2 monoclonal antibodies and methods of use thereof |
| AU2003268345A1 (en) | 2002-09-24 | 2004-04-19 | The Burnham Institute | Novel agents that modulate eph receptor activity |
| US20050147593A1 (en) * | 2003-05-22 | 2005-07-07 | Medimmune, Inc. | EphA2, EphA4 and LMW-PTP and methods of treatment of hyperproliferative cell disorders |
| KR20060034231A (ko) * | 2003-06-06 | 2006-04-21 | 메디뮨 인코포레이티드 | 암의 진단, 치료 및 예방에 있어서의 ｅｐｈａ４ 및ｅｐｈａ４ 조정제의 용도 |
| WO2005056766A2 (en) * | 2003-12-04 | 2005-06-23 | Medimmune, Inc. | TARGETED DRUG DELIVERY USING EphA2 OR Eph4 BINDING MOIETIES |
-
2004
- 2004-06-07 KR KR1020057023460A patent/KR20060034231A/ko not_active Withdrawn
- 2004-06-07 AU AU2004291026A patent/AU2004291026A1/en not_active Abandoned
- 2004-06-07 WO PCT/US2004/018279 patent/WO2005048917A2/en not_active Ceased
- 2004-06-07 JP JP2006533638A patent/JP2007522096A/ja not_active Abandoned
- 2004-06-07 CA CA002528549A patent/CA2528549A1/en not_active Abandoned
- 2004-06-07 EP EP04816745A patent/EP1638514A4/en not_active Withdrawn
- 2004-06-07 US US10/863,729 patent/US7604799B2/en not_active Expired - Fee Related
-
2009
- 2009-09-11 US US12/558,052 patent/US20100166657A1/en not_active Abandoned
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