JP2007522096A5 - - Google Patents

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Publication number
JP2007522096A5
JP2007522096A5 JP2006533638A JP2006533638A JP2007522096A5 JP 2007522096 A5 JP2007522096 A5 JP 2007522096A5 JP 2006533638 A JP2006533638 A JP 2006533638A JP 2006533638 A JP2006533638 A JP 2006533638A JP 2007522096 A5 JP2007522096 A5 JP 2007522096A5
Authority
JP
Japan
Prior art keywords
epha4
antibody
antibodies
scfv
provides
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
JP2006533638A
Other languages
English (en)
Japanese (ja)
Other versions
JP2007522096A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2004/018279 external-priority patent/WO2005048917A2/en
Publication of JP2007522096A publication Critical patent/JP2007522096A/ja
Publication of JP2007522096A5 publication Critical patent/JP2007522096A5/ja
Abandoned legal-status Critical Current

Links

JP2006533638A 2003-06-06 2004-06-07 癌の診断、治療、及び予防のためのＥｐｈＡ４及びＥｐｈＡ４変調因子の使用 Abandoned JP2007522096A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US47690903P 2003-06-06 2003-06-06
US50335603P 2003-09-16 2003-09-16
PCT/US2004/018279 WO2005048917A2 (en) 2003-06-06 2004-06-07 Use of epha4 and modulator or epha4 for diagnosis, treatment and prevention of cancer

Publications (2)

Publication Number Publication Date
JP2007522096A JP2007522096A (ja) 2007-08-09
JP2007522096A5 true JP2007522096A5 (enExample) 2008-06-19

Family

ID=34622735

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2006533638A Abandoned JP2007522096A (ja) 2003-06-06 2004-06-07 癌の診断、治療、及び予防のためのＥｐｈＡ４及びＥｐｈＡ４変調因子の使用

Country Status (7)

Country Link
US (2) US7604799B2 (enExample)
EP (1) EP1638514A4 (enExample)
JP (1) JP2007522096A (enExample)
KR (1) KR20060034231A (enExample)
AU (1) AU2004291026A1 (enExample)
CA (1) CA2528549A1 (enExample)
WO (1) WO2005048917A2 (enExample)

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US6864227B1 (en) 1998-04-13 2005-03-08 California Institute Of Technology Artery-and vein-specific proteins and uses therefor
US9032097B2 (en) * 2001-04-26 2015-05-12 Nokia Corporation Data communication with remote network node
JP2006521111A (ja) 2003-03-12 2006-09-21 バスジーン セラピューティクス， インコーポレイテッド 血管形成及び腫瘍増殖阻害用ポリペプチド化合物及びその応用
US7381410B2 (en) 2003-03-12 2008-06-03 Vasgene Therapeutics, Inc. Polypeptide compounds for inhibiting angiogenesis and tumor growth
US20050147593A1 (en) * 2003-05-22 2005-07-07 Medimmune, Inc. EphA2, EphA4 and LMW-PTP and methods of treatment of hyperproliferative cell disorders
EP1638514A4 (en) * 2003-06-06 2009-11-18 Medimmune Inc USE OF EPHA4 AND MODULATOR OR EPHA4 FOR THE DIAGNOSIS, TREATMENT AND PREVENTION OF CANCER
US20050153923A1 (en) * 2003-12-04 2005-07-14 Kinch Michael S. Targeted drug delivery using EphA2 or EphA4 binding moieties
CN102718867A (zh) 2004-03-12 2012-10-10 瓦斯基因治疗公司 结合ephb4、抑制血管发生和肿瘤生长的抗体
US7977463B2 (en) 2004-03-12 2011-07-12 Vasgene Therapeutics, Inc. Polypeptide compounds for inhibiting angiogenesis and tumor growth
US20060204512A1 (en) 2004-09-23 2006-09-14 Vasgene Therapeutics, Inc. Polypeptide compounds for inhibiting angiogenesis and tumor growth
JP5129122B2 (ja) 2005-04-26 2013-01-23 トリオン ファーマ ゲーエムベーハー 癌治療のための抗体およびグルココルチコイドの組み合わせ
AU2006261920A1 (en) 2005-06-23 2007-01-04 Medimmune, Llc Antibody formulations having optimized aggregation and fragmentation profiles
US20070128116A1 (en) * 2005-07-27 2007-06-07 Wang Zheng J Multifunctional core for molecular imaging and targeted delivery of macromolecules and drugs
US7807459B2 (en) * 2005-09-27 2010-10-05 Reneuron, Inc. EphA4-positive human adult pancreatic endocrine progenitor cells
AU2006331775A1 (en) * 2005-12-21 2007-07-05 Medimmune, Llc Affinity optimized EphA2 agonistic antibodies and methods of use thereof
EP2004228A1 (en) 2006-02-28 2008-12-24 Oncotherapy Science, Inc. Methods for damaging cells using effector functions of anti-epha4 antibodies
US8975377B2 (en) 2007-08-13 2015-03-10 Vasgene Therapeutics, Inc Cancer treatment using humanized antibodies that bind to EphB4
US20100256214A1 (en) * 2009-04-02 2010-10-07 Burnham Institute For Medical Research Eph receptor ligands and methods of use
KR20130056855A (ko) 2010-03-01 2013-05-30 카리스 라이프 사이언스 룩셈부르크 홀딩스 치료진단용 생물학적 지표들
EP2366714A1 (en) * 2010-03-03 2011-09-21 Dr. Rentschler Holding GmbH & Co. KG Naturally occuring autoantibodies against alpha-synuclein that inhibit the aggregation and cytotoxicity of alpha-synuclein
KR20130043104A (ko) 2010-04-06 2013-04-29 카리스 라이프 사이언스 룩셈부르크 홀딩스 질병용 순환 생물학적 지표들
MX356400B (es) * 2010-12-08 2018-05-28 Abbvie Stemcentrx Llc Moduladores novedosos y metodos de uso.
WO2012078703A2 (en) * 2010-12-08 2012-06-14 Fox Chase Cancer Center Inhibiting chromosome instability in ovarian cancer
WO2012147798A1 (ja) * 2011-04-25 2012-11-01 エーザイ・アール・アンド・ディー・マネジメント株式会社 EphA4細胞外ドメインの測定による認知機能障害を伴う神経系疾患の検出方法
CN104968797B (zh) 2012-11-06 2018-11-30 米迪缪尼有限公司 金黄色葡萄球菌表面决定簇的抗体
WO2015065954A1 (en) 2013-11-04 2015-05-07 Pfizer, Inc. Anti-efna4 antibody-drug conjugates
ES2848857T3 (es) * 2014-07-31 2021-08-12 Us Gov Health & Human Services Anticuerpos monoclonales humanos contra EphA4 y su uso
CA2983277A1 (en) * 2015-04-29 2016-11-03 Sanford-Burnham Medical Research Institute Novel epha4 inhibitors targeting its ligand binding domain
CA2989993A1 (en) 2015-09-08 2017-03-16 Eisai R&D Management Co., Ltd. Anti-epha4 antibody
CN108108589B (zh) * 2017-12-29 2020-06-12 郑州轻工业学院 基于网络指标差异分析的食管鳞癌标记物的识别方法
WO2021002312A1 (ja) 2019-07-01 2021-01-07 エーザイ・アール・アンド・ディー・マネジメント株式会社 抗ＥｐｈＡ４抗体
WO2021217047A1 (en) * 2020-04-23 2021-10-28 The Regents Of The University Of California Epha4 targeting compounds and methods of use thereof
US11732007B2 (en) 2020-09-28 2023-08-22 The Regents Of The University Of California Therapeutic compounds and methods

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JP2004509612A (ja) 2000-06-05 2004-04-02 アバロン　ファーマシューティカルズ ガン遺伝子決定および特徴的な遺伝子群を用いた治療用スクリーニング
AU2001271502A1 (en) * 2000-06-26 2002-01-08 Gpc Biotech Ag Methods and compositions for isolating biologically active antibodies
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US20040028685A1 (en) 2002-05-10 2004-02-12 Kinch Michael S. EphA2 monoclonal antibodies and methods of use thereof
EP1553963A4 (en) 2002-09-24 2006-05-03 Burnham Inst NEW MEANS FOR MODULATING EPH RECEPTOR ACTIVITY
US20050147593A1 (en) * 2003-05-22 2005-07-07 Medimmune, Inc. EphA2, EphA4 and LMW-PTP and methods of treatment of hyperproliferative cell disorders
EP1638514A4 (en) * 2003-06-06 2009-11-18 Medimmune Inc USE OF EPHA4 AND MODULATOR OR EPHA4 FOR THE DIAGNOSIS, TREATMENT AND PREVENTION OF CANCER
WO2005056766A2 (en) * 2003-12-04 2005-06-23 Medimmune, Inc. TARGETED DRUG DELIVERY USING EphA2 OR Eph4 BINDING MOIETIES

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