JP2007521860A - 過分極化原子核の富化法および該方法を実施するための装置 - Google Patents
過分極化原子核の富化法および該方法を実施するための装置 Download PDFInfo
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- JP2007521860A JP2007521860A JP2006548093A JP2006548093A JP2007521860A JP 2007521860 A JP2007521860 A JP 2007521860A JP 2006548093 A JP2006548093 A JP 2006548093A JP 2006548093 A JP2006548093 A JP 2006548093A JP 2007521860 A JP2007521860 A JP 2007521860A
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- solvent
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- nuclei
- hyperpolarized
- enriched
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- 238000000034 method Methods 0.000 title claims abstract description 56
- 239000002904 solvent Substances 0.000 claims abstract description 108
- 238000007872 degassing Methods 0.000 claims abstract description 28
- 230000005291 magnetic effect Effects 0.000 claims abstract description 21
- 239000000203 mixture Substances 0.000 claims abstract description 19
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 claims description 42
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 29
- 229910052756 noble gas Inorganic materials 0.000 claims description 17
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims description 15
- 238000001816 cooling Methods 0.000 claims description 15
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 claims description 12
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 claims description 12
- OFBQJSOFQDEBGM-UHFFFAOYSA-N Pentane Chemical compound CCCCC OFBQJSOFQDEBGM-UHFFFAOYSA-N 0.000 claims description 12
- LRHPLDYGYMQRHN-UHFFFAOYSA-N N-Butanol Chemical compound CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 claims description 8
- 238000002844 melting Methods 0.000 claims description 6
- 230000008018 melting Effects 0.000 claims description 6
- 238000004090 dissolution Methods 0.000 claims description 4
- 239000004006 olive oil Substances 0.000 claims description 4
- 235000008390 olive oil Nutrition 0.000 claims description 4
- 239000011903 deuterated solvents Substances 0.000 claims description 3
- 229930195733 hydrocarbon Natural products 0.000 claims description 3
- 150000002430 hydrocarbons Chemical class 0.000 claims description 3
- KOPOQZFJUQMUML-UHFFFAOYSA-N chlorosilane Chemical class Cl[SiH3] KOPOQZFJUQMUML-UHFFFAOYSA-N 0.000 claims description 2
- 239000002872 contrast media Substances 0.000 claims description 2
- 230000009969 flowable effect Effects 0.000 claims description 2
- 239000004215 Carbon black (E152) Substances 0.000 claims 2
- 239000007789 gas Substances 0.000 description 53
- 230000010287 polarization Effects 0.000 description 18
- 239000003513 alkali Substances 0.000 description 15
- 229910052724 xenon Inorganic materials 0.000 description 13
- FHNFHKCVQCLJFQ-UHFFFAOYSA-N xenon atom Chemical compound [Xe] FHNFHKCVQCLJFQ-UHFFFAOYSA-N 0.000 description 13
- 239000007788 liquid Substances 0.000 description 11
- 210000004027 cell Anatomy 0.000 description 10
- 150000002835 noble gases Chemical class 0.000 description 7
- 239000011521 glass Substances 0.000 description 5
- 230000003287 optical effect Effects 0.000 description 5
- 238000005086 pumping Methods 0.000 description 5
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 4
- 238000010438 heat treatment Methods 0.000 description 4
- 230000000694 effects Effects 0.000 description 3
- 230000003993 interaction Effects 0.000 description 3
- 229910052757 nitrogen Inorganic materials 0.000 description 3
- 239000012071 phase Substances 0.000 description 3
- 229910052701 rubidium Inorganic materials 0.000 description 3
- IGLNJRXAVVLDKE-UHFFFAOYSA-N rubidium atom Chemical compound [Rb] IGLNJRXAVVLDKE-UHFFFAOYSA-N 0.000 description 3
- 238000003325 tomography Methods 0.000 description 3
- 239000002699 waste material Substances 0.000 description 3
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 2
- 210000004556 brain Anatomy 0.000 description 2
- 229910052799 carbon Inorganic materials 0.000 description 2
- 230000007423 decrease Effects 0.000 description 2
- 238000011067 equilibration Methods 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 239000003574 free electron Substances 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 238000005259 measurement Methods 0.000 description 2
- 238000011084 recovery Methods 0.000 description 2
- 229920001774 Perfluoroether Polymers 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 150000001340 alkali metals Chemical group 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 210000002421 cell wall Anatomy 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 230000018109 developmental process Effects 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 238000009792 diffusion process Methods 0.000 description 1
- 238000006073 displacement reaction Methods 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 238000007710 freezing Methods 0.000 description 1
- 230000008014 freezing Effects 0.000 description 1
- 229910052734 helium Inorganic materials 0.000 description 1
- 239000001307 helium Substances 0.000 description 1
- SWQJXJOGLNCZEY-UHFFFAOYSA-N helium atom Chemical compound [He] SWQJXJOGLNCZEY-UHFFFAOYSA-N 0.000 description 1
- 230000002102 hyperpolarization Effects 0.000 description 1
- 238000005372 isotope separation Methods 0.000 description 1
- 239000007791 liquid phase Substances 0.000 description 1
- 210000004072 lung Anatomy 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 230000005414 paramagnetic center Effects 0.000 description 1
- 238000000819 phase cycle Methods 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- KDLCSNRLYFANOE-UHFFFAOYSA-N rubidium xenon Chemical compound [Rb].[Xe] KDLCSNRLYFANOE-UHFFFAOYSA-N 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 238000004611 spectroscopical analysis Methods 0.000 description 1
- 230000003068 static effect Effects 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000010257 thawing Methods 0.000 description 1
- 238000002604 ultrasonography Methods 0.000 description 1
Images
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
- G01R33/00—Arrangements or instruments for measuring magnetic variables
- G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
- G01R33/28—Details of apparatus provided for in groups G01R33/44 - G01R33/64
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/18—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
- A61K49/1806—Suspensions, emulsions, colloids, dispersions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/18—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
- A61K49/1806—Suspensions, emulsions, colloids, dispersions
- A61K49/1815—Suspensions, emulsions, colloids, dispersions compo-inhalant, e.g. breath tests
-
- C—CHEMISTRY; METALLURGY
- C01—INORGANIC CHEMISTRY
- C01B—NON-METALLIC ELEMENTS; COMPOUNDS THEREOF; METALLOIDS OR COMPOUNDS THEREOF NOT COVERED BY SUBCLASS C01C
- C01B23/00—Noble gases; Compounds thereof
- C01B23/001—Purification or separation processes of noble gases
- C01B23/0036—Physical processing only
- C01B23/0089—Physical processing only by absorption in liquids
-
- C—CHEMISTRY; METALLURGY
- C01—INORGANIC CHEMISTRY
- C01B—NON-METALLIC ELEMENTS; COMPOUNDS THEREOF; METALLOIDS OR COMPOUNDS THEREOF NOT COVERED BY SUBCLASS C01C
- C01B2210/00—Purification or separation of specific gases
- C01B2210/0029—Obtaining noble gases
- C01B2210/0037—Xenon
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Physics & Mathematics (AREA)
- Radiology & Medical Imaging (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Dispersion Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Inorganic Chemistry (AREA)
- Condensed Matter Physics & Semiconductors (AREA)
- Magnetic Resonance Imaging Apparatus (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102004002639A DE102004002639A1 (de) | 2004-01-19 | 2004-01-19 | Verfahren zur Anreicherung von hyperpolarisierten Atomkernen und Vorrichtung zur Durchführung des Verfahrens |
| PCT/DE2004/002689 WO2005068359A2 (de) | 2004-01-19 | 2004-12-08 | Verfahren zur anreicherung von hyperpolarisierten atomkernen und vorrichtung zur durchführung des verfahrens |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2007521860A true JP2007521860A (ja) | 2007-08-09 |
| JP2007521860A5 JP2007521860A5 (https=) | 2008-01-10 |
Family
ID=34778083
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006548093A Withdrawn JP2007521860A (ja) | 2004-01-19 | 2004-12-08 | 過分極化原子核の富化法および該方法を実施するための装置 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US20070156046A1 (https=) |
| EP (1) | EP1706355A2 (https=) |
| JP (1) | JP2007521860A (https=) |
| DE (1) | DE102004002639A1 (https=) |
| WO (1) | WO2005068359A2 (https=) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2007309915A (ja) * | 2006-05-18 | 2007-11-29 | Honeywell Internatl Inc | チップスケールの原子ジャイロスコープ |
| JP2011530319A (ja) * | 2008-08-08 | 2011-12-22 | コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ | 対象者を落ち着かせる装置 |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007136439A2 (en) * | 2006-02-21 | 2007-11-29 | Avrum Belzer | Hyperpolarization methods, systems and compositions |
| US8703102B2 (en) * | 2008-04-04 | 2014-04-22 | Millikelvin Technologies Llc | Systems and methods for producing hyperpolarized materials and mixtures thereof |
| US7576538B2 (en) * | 2006-03-14 | 2009-08-18 | Thomas Meersmann | Nuclear electric quadrupolar properties of hyperpolarized gases to probe surfaces and interfaces |
| AU2009251528B2 (en) * | 2008-04-04 | 2014-09-18 | Millikelvin Technologies Llc | Manufacture, transport and delivery of material containing highly polarized nuclei |
| WO2009143368A2 (en) * | 2008-05-23 | 2009-11-26 | University Of Utah | Non-cryogenic storage cell for hyperpolarized 129xe |
| WO2010013743A1 (ja) * | 2008-08-01 | 2010-02-04 | 国立大学法人大阪大学 | 偏極キセノンガスの濃縮方法、偏極キセノンガスの製造供給装置及びmriシステム |
| US9289518B2 (en) * | 2008-08-22 | 2016-03-22 | The Brigham And Women's Hospital | Enhanced 13C NMR by thermal mixing with hyperpolarized 129XE |
| EP2473198A4 (en) * | 2009-08-31 | 2015-06-24 | Millikelvin Technologies Llc | SYSTEMS AND METHOD FOR THE PRODUCTION OF HYPERPOLARIZED MATERIALS AND MIXTURES THEREOF |
| US9222995B2 (en) * | 2010-02-16 | 2015-12-29 | Koninklijke Philips N.V. | Apparatus and method for dispensing a hyperpolarized fluid |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU1742795A (en) * | 1994-02-04 | 1995-08-21 | University Of Chicago, The | Apparatus for detection and separation of heavy noble gases |
| US6123919A (en) * | 1994-04-08 | 2000-09-26 | The Trustees Of Princeton University | Magnetic resonance imaging using hyperpolarized noble gases |
| IL126347A (en) * | 1996-03-29 | 2003-11-23 | Lawrence Berkeley National Lab | Enhancement of nmr and mri in the presence of hyperpolarized noble gases |
| US5809801A (en) * | 1996-03-29 | 1998-09-22 | The Trustees Of Princeton University | Cryogenic accumulator for spin-polarized xenon-129 |
-
2004
- 2004-01-19 DE DE102004002639A patent/DE102004002639A1/de not_active Withdrawn
- 2004-12-08 WO PCT/DE2004/002689 patent/WO2005068359A2/de not_active Ceased
- 2004-12-08 JP JP2006548093A patent/JP2007521860A/ja not_active Withdrawn
- 2004-12-08 EP EP04802897A patent/EP1706355A2/de not_active Withdrawn
- 2004-12-08 US US10/586,569 patent/US20070156046A1/en not_active Abandoned
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2007309915A (ja) * | 2006-05-18 | 2007-11-29 | Honeywell Internatl Inc | チップスケールの原子ジャイロスコープ |
| JP2011191323A (ja) * | 2006-05-18 | 2011-09-29 | Honeywell Internatl Inc | チップスケールの原子ジャイロスコープ |
| JP2011530319A (ja) * | 2008-08-08 | 2011-12-22 | コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ | 対象者を落ち着かせる装置 |
Also Published As
| Publication number | Publication date |
|---|---|
| DE102004002639A1 (de) | 2005-09-15 |
| WO2005068359A3 (de) | 2006-12-21 |
| EP1706355A2 (de) | 2006-10-04 |
| US20070156046A1 (en) | 2007-07-05 |
| WO2005068359A2 (de) | 2005-07-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20071114 |
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| A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20071114 |
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| A761 | Written withdrawal of application |
Free format text: JAPANESE INTERMEDIATE CODE: A761 Effective date: 20091208 |