JP2007518462A - 椎間板髄核を置換するための方法および装置 - Google Patents
椎間板髄核を置換するための方法および装置 Download PDFInfo
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- JP2007518462A JP2007518462A JP2006533983A JP2006533983A JP2007518462A JP 2007518462 A JP2007518462 A JP 2007518462A JP 2006533983 A JP2006533983 A JP 2006533983A JP 2006533983 A JP2006533983 A JP 2006533983A JP 2007518462 A JP2007518462 A JP 2007518462A
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- Prior art keywords
- nucleus pulposus
- sis
- elongated shape
- cells
- intervertebral disc
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
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Abstract
【解決手段】小腸粘膜下組織(SIS)を有し、低侵襲で髄核を増補もしくは置換する方法およびこれに対応する装置が開示される。この方法は、椎間板の高さ維持を支援し、元来の髄核構造の再生を促進する、小腸粘膜下組織(SIS)を備えた、椎間板の髄核を増補もしくは置換する材料の注入に関する。この装置は、ストリップ、コード、紐、チューブ、巻物もしくはペレットのような細長い形状をもって構成される。これらは、生体活性因子や播種細胞を備えていてもよい。
【選択図】図1
Description
本発明は、髄核を修復かつ/または回復させることによって、椎間板の障害を原因とする背痛を治療するための方法および器具に関する。
椎間板の損傷および/もしくは変性は、椎間板ヘルニア、椎間板線維輪の破裂および/もしくは髄核脱出の結果として背痛の原因となる。ヘルニアや髄核脱出は、脊柱管および椎孔の狭窄原因となる。いずれにしても脊髄を刺激する化学走化性因子を放出させることになる。線維輪および/もしくは髄核に対する急性の損傷は、椎間板の生体力学的機能に異常を来し、その結果椎間板の変性を引き起こす。
本発明の実施例は、
1)椎間板の治療部位を備える工程と、
2)椎間板の線維輪の側壁にカニューレ状の挿入具を突き挿す工程と、
3)小腸粘膜下組織(SIS)をこのカニューレ状の挿入具を通して髄核へ挿入する工程と、
を含む、椎間板の髄核を増補もしくは置換する低侵襲の方法に関する。
1)椎間板の治療部位を備える工程と、
2)椎間板の線維輪の側壁にカニューレ状の挿入具を突き挿す工程と、
3)延ばされた髄核の増補もしくは置換の材料をこのカニューレ状の挿入具を通して髄核へ挿入する工程と、
を含む、椎間板の髄核を増補もしくは置換する低侵襲の方法に関する。
本発明の実施例は、椎間板の髄核を小腸粘膜下組織(SIS)で増補もしくは置換するための装置および方法に関する。
1)SISの元を準備する工程と、
2)SISをシート状に切り開く工程と、
3)所望の直径にSISシートを巻く工程と、
を備えた小腸粘膜下組織(SIS)の移植片を準備する方法に関する。
1)椎間板の治療部位を備える工程と、
2)椎間板の線維輪の側壁にカニューレ状の挿入具を突き挿す工程と、
3)小腸粘膜下組織(SIS)をこのカニューレ状の挿入具を通して髄核へ挿入する工程と、
を含む。
1)椎間板の治療部位を備える工程と、
2)椎間板の線維輪の側壁にカニューレ状の挿入具を突き挿す工程と、
3)延ばされた髄核の増補もしくは置換する材料をこのカニューレ状の挿入具を通して髄核へ挿入する工程と、
を含む、低侵襲法に関する。
(1)小腸粘膜下組織(SIS)を有し、椎間板の髄核を増補もしくは置換するための装置。
(2)実施態様1に記載の装置において、
前記SISは細長い形状である、装置。
(3)実施態様2に記載の装置において、
前記細長い形状は、ストリップ、コード、紐、チューブ、巻物、ペレットおよびこれらの組み合わせからなるグループから選択される、装置。
(4)実施態様3に記載の装置において、
前記細長い形状はペレットである、装置。
(5)実施態様3に記載の装置において、
前記細長い形状はストリップである、装置。
(6)実施態様3に記載の装置において、
前記細長い形状はコードである、装置。
(7)実施態様3に記載の装置において、
前記細長い形状は紐である、装置。
(8)実施態様3に記載の装置において、
前記細長い形状はチューブである、装置。
(9)実施態様3に記載の装置において、
前記細長い形状は巻物である、装置。
(10)実施態様9に記載の装置において、
前記巻物内に、微粒子もしくは方向の揃えられた小腸粘膜下組織の形状を更に含む、装置。
(11)実施態様1〜10のいずれかに記載の装置において、
生体活性因子もしくは播種細胞を更に含む、装置。
(12)実施態様11に記載の装置において、
前記生体活性因子は、形質転換成長因子β、成長因子と同分類に属するエージェント、血小板由来増殖因子、線維芽細胞増殖因子、インスリン様増殖因子、RGD−ペプチドやインディアンヘッジホッグタンパク質のようなタンパク質重合体、抗炎症剤、血管新生因子、ホルモン、ヒアルロン酸、およびこれらの組合せからなるグループから選択される、装置。
(13)実施態様12に記載の装置において、
前記形質転換成長因子βおよび前記成長因子と同分類に属するエージェントは、TGF−β1、TGF−β2、TGF−β3、GDF−5、MP−52、BMP(骨形成タンパク質)に限定されない、装置。
(14)実施態様11に記載の装置において、
前記播種細胞は、幹細胞、骨髄細胞、線維細胞、含脂肪細胞、軟骨細胞、髄核細胞や線維輪細胞のような、身体の椎間板から採取した細胞、およびこれらの組合せからなるグループから選択される、装置。
(15)実施態様14に記載の装置において、
前記播種細胞は幹細胞である、装置。
(16)椎間板の髄核を増補もしくは置換する材料を低侵襲で供給する装置において、
近位端および遠位端を有するカニューレ状の送出管と、
前記送出管の前記近位端に挿入するためのプランジャーであって、前記プランジャーが前記送出管の前記近位端から前記遠位端に押し進められるにつれて、前記増補もしくは置換する材料の注入を行う、プランジャーと、
前記カニューレ状の送出管に挿入するための、椎間板の髄核を増補もしくは置換する材料と、を更に備えた、装置。
Claims (16)
- 小腸粘膜下組織(SIS)を含み、椎間板の髄核を増補もしくは置換するための装置。
- 請求項1に記載の装置において、
前記SISは細長い形状である、装置。 - 請求項2に記載の装置において、
前記細長い形状は、ストリップ、コード、紐、チューブ、巻物、ペレットおよびこれらの組み合わせからなるグループから選択される、装置。 - 請求項3に記載の装置において、
前記細長い形状はペレットである、装置。 - 請求項3に記載の装置において、
前記細長い形状はストリップである、装置。 - 請求項3に記載の装置において、
前記細長い形状はコードである、装置。 - 請求項3に記載の装置において、
前記細長い形状は紐である、装置。 - 請求項3に記載の装置において、
前記細長い形状はチューブである、装置。 - 請求項3に記載の装置において、
前記細長い形状は巻物である、装置。 - 請求項9に記載の装置において、
前記巻物内に、微粒子もしくは方向の揃えられた小腸粘膜下組織の形状を更に含む、装置。 - 請求項1〜10のいずれかに記載の装置において、
生体活性因子もしくは播種細胞を更に含む、装置。 - 請求項11に記載の装置において、
前記生体活性因子は、形質転換成長因子β、成長因子と同分類に属するエージェント、血小板由来増殖因子、線維芽細胞増殖因子、インスリン様増殖因子、RGD−ペプチドやインディアンヘッジホッグタンパク質のようなタンパク質重合体、抗炎症剤、血管新生因子、ホルモン、ヒアルロン酸、およびこれらの組合せからなるグループから選択される、装置。 - 請求項12に記載の装置において、
前記形質転換成長因子βおよび前記成長因子と同分類に属するエージェントは、TGF−β1、TGF−β2、TGF−β3、GDF−5、MP−52、BMP(骨形成タンパク質)に限定されない、装置。 - 請求項11に記載の装置において、
前記播種細胞は、幹細胞、骨髄細胞、線維細胞、含脂肪細胞、軟骨細胞、髄核細胞や線維輪細胞のような、身体の椎間板から採取した細胞、およびこれらの組合せからなるグループから選択される、装置。 - 請求項14に記載の装置において、
前記播種細胞は幹細胞である、装置。 - 椎間板の髄核を増補もしくは置換する材料を低侵襲で供給する装置において、
近位端および遠位端を有するカニューレ状の送出管と、
前記送出管の前記近位端に挿入するためのプランジャーであって、前記プランジャーが前記送出管の前記近位端から前記遠位端に押し進められるにつれて、前記増補もしくは置換する材料の注入を行う、プランジャーと、
前記カニューレ状の送出管に挿入するための、椎間板の髄核を増補もしくは置換する材料と、を更に備えた、装置。
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-
2003
- 2003-09-30 US US10/676,869 patent/US20050071012A1/en not_active Abandoned
-
2004
- 2004-09-24 KR KR1020067006230A patent/KR20060092233A/ko not_active Application Discontinuation
- 2004-09-24 WO PCT/US2004/031462 patent/WO2005032434A1/en active Application Filing
- 2004-09-24 EP EP04785021A patent/EP1673047A1/en not_active Withdrawn
- 2004-09-24 JP JP2006533983A patent/JP2007518462A/ja not_active Abandoned
- 2004-09-24 CN CNA2004800349163A patent/CN1956687A/zh active Pending
- 2004-09-24 CA CA002540675A patent/CA2540675A1/en not_active Abandoned
- 2004-09-24 BR BRPI0414940-8A patent/BRPI0414940A/pt not_active IP Right Cessation
- 2004-09-24 AU AU2004277939A patent/AU2004277939A1/en not_active Abandoned
Also Published As
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CA2540675A1 (en) | 2005-04-14 |
US20050071012A1 (en) | 2005-03-31 |
BRPI0414940A (pt) | 2006-11-07 |
EP1673047A1 (en) | 2006-06-28 |
AU2004277939A1 (en) | 2005-04-14 |
KR20060092233A (ko) | 2006-08-22 |
CN1956687A (zh) | 2007-05-02 |
WO2005032434A1 (en) | 2005-04-14 |
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