JP2007516218A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2007516218A5 JP2007516218A5 JP2006528067A JP2006528067A JP2007516218A5 JP 2007516218 A5 JP2007516218 A5 JP 2007516218A5 JP 2006528067 A JP2006528067 A JP 2006528067A JP 2006528067 A JP2006528067 A JP 2006528067A JP 2007516218 A5 JP2007516218 A5 JP 2007516218A5
- Authority
- JP
- Japan
- Prior art keywords
- methoxy
- pharmaceutical composition
- methyl
- composition according
- phenylisoquinolin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US50510103P | 2003-09-23 | 2003-09-23 | |
| US60/505,101 | 2003-09-23 | ||
| PCT/US2004/030431 WO2005030791A2 (en) | 2003-09-23 | 2004-09-17 | Isoquinolinone potassium channel inhibitors |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2007516218A JP2007516218A (ja) | 2007-06-21 |
| JP2007516218A5 true JP2007516218A5 (https=) | 2007-08-02 |
| JP4718467B2 JP4718467B2 (ja) | 2011-07-06 |
Family
ID=34392976
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006528067A Expired - Fee Related JP4718467B2 (ja) | 2003-09-23 | 2004-09-17 | イソキノリノンカリウムチャネル阻害剤 |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US7723352B2 (https=) |
| EP (1) | EP1667982B1 (https=) |
| JP (1) | JP4718467B2 (https=) |
| CN (1) | CN1856476A (https=) |
| AU (1) | AU2004276236B2 (https=) |
| CA (1) | CA2539814C (https=) |
| WO (1) | WO2005030791A2 (https=) |
Families Citing this family (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005030729A1 (en) * | 2003-09-23 | 2005-04-07 | Merck & Co., Inc. | Isoquinoline potassium channel inhibitors |
| EP1667976B1 (en) * | 2003-09-23 | 2010-08-04 | Merck Sharp & Dohme Corp. | Isoquinolinone potassium channel inhibitors |
| US7723352B2 (en) * | 2003-09-23 | 2010-05-25 | Merck Sharp & Dohme | Isoquinolinone potassium channel inhibitors |
| JP4719152B2 (ja) * | 2003-09-23 | 2011-07-06 | メルク・シャープ・エンド・ドーム・コーポレイション | イソキノリノンカリウムチャネル阻害剤 |
| AU2004289186B2 (en) * | 2003-09-23 | 2010-12-16 | Merck Sharp & Dohme Corp. | Isoquinolinone potassium channel inhibitors |
| US7723290B2 (en) | 2004-10-22 | 2010-05-25 | Bioincept, Llc | Compositions and methods for modulating the immune system |
| US7569589B2 (en) | 2004-07-29 | 2009-08-04 | Merck & Co., Inc. | Potassium channel inhibitors |
| CN1993347A (zh) | 2004-07-29 | 2007-07-04 | 默克公司 | 钾通道抑制剂 |
| DE102005028862A1 (de) * | 2005-06-22 | 2007-01-11 | Sanofi-Aventis Deutschland Gmbh | Substituierte Heterocyclen, ihre Verwendung als Medikament sowie sie enthaltende pharmazeutische Zubereitungen |
| CN101213187B (zh) | 2005-06-28 | 2012-06-06 | 塞诺菲-安万特股份有限公司 | 作为rho-激酶抑制剂的异喹啉衍生物 |
| RS52241B (sr) | 2005-07-26 | 2012-10-31 | Sanofi | Derivati cikloheksilamin izohinolona kao inhibitori rho-kinaze |
| CA2615577C (en) | 2005-07-26 | 2014-09-09 | Sanofi-Aventis | Piperidinyl-substituted isoquinolone derivatives as rho-kinase inhibitors |
| GB0525164D0 (en) | 2005-12-09 | 2006-01-18 | Xention Discovery Ltd | Compounds |
| AU2007217099A1 (en) * | 2006-02-17 | 2007-08-30 | Janssen Pharmaceutica N.V. | Pyrazolylquinazolinones as potassium channel openers |
| MY148902A (en) | 2006-12-27 | 2013-06-14 | Sanofi Aventis | Substituted isoquinolines and their use as rho-kinase inhibitors |
| MX2009005964A (es) | 2006-12-27 | 2009-06-15 | Sanofi Aventis | Derivados de isoquinolina sustituidos con cicloalquilamina. |
| RU2468011C2 (ru) | 2006-12-27 | 2012-11-27 | Санофи-Авентис | Замещенные циклоалкиламином производные изохинолина и изохинолинона |
| NZ577980A (en) | 2006-12-27 | 2012-01-12 | Sanofi Aventis | Cycloalkylamine substituted isoquinolone derivatives |
| BRPI0720986A2 (pt) | 2006-12-27 | 2014-03-11 | Sanofi Aventis | Derivados de isoquinolina e isoquinolinona substituídos |
| JP5421783B2 (ja) | 2006-12-27 | 2014-02-19 | サノフイ | Ｒｈｏキナーゼ阻害剤としての置換イソキノロン及びイソキノリノン誘導体 |
| PT2125744E (pt) * | 2006-12-27 | 2011-07-01 | Sanofi Aventis | Derivados de isoquinolona e isoquinolinona substituídos com cicloalquilamina |
| EA026578B1 (ru) | 2007-01-22 | 2017-04-28 | ДЖиТиЭкс, ИНК. | Вещества, связывающие ядерные рецепторы |
| US9604931B2 (en) | 2007-01-22 | 2017-03-28 | Gtx, Inc. | Nuclear receptor binding agents |
| US9623021B2 (en) * | 2007-01-22 | 2017-04-18 | Gtx, Inc. | Nuclear receptor binding agents |
| CA2728137C (en) | 2008-06-24 | 2016-10-18 | Sanofi-Aventis | Substituted isoquinolines and isoquinolinones as rho kinase inhibitors |
| MY153756A (en) | 2008-06-24 | 2015-03-13 | Sanofi Aventis | Bi-and polycyclic substituted isoquinoline and isoquinoline derivatives as rho kinase inhibitors |
| MY153615A (en) | 2008-06-24 | 2015-02-27 | Sanofi Aventis | 6-substituted isoquinolines and isoquinolinones |
| GB0815782D0 (en) | 2008-08-29 | 2008-10-08 | Xention Ltd | Novel potassium channel blockers |
| GB0815784D0 (en) | 2008-08-29 | 2008-10-08 | Xention Ltd | Novel potassium channel blockers |
| GB0815781D0 (en) | 2008-08-29 | 2008-10-08 | Xention Ltd | Novel potassium channel blockers |
| US9737585B2 (en) | 2011-03-02 | 2017-08-22 | Bioincept, Llc | Compositions and methods for treatment of intracellular damage and bacterial infection |
| WO2013142390A1 (en) * | 2012-03-21 | 2013-09-26 | Gtx, Inc. | Aldo-keto reductase subfamily 1c3 (akr1c3) inhibitors |
| WO2017039751A1 (en) | 2015-08-28 | 2017-03-09 | Bioincept, Llc | Mutant peptides and methods of treating subjects using the same |
| SG10201804471PA (en) * | 2013-10-18 | 2018-07-30 | Celgene Quanticel Research Inc | Bromodomain inhibitors |
| EA038715B1 (ru) * | 2014-01-24 | 2021-10-08 | Селджен Квонтисел Рисёрч, Инк. | Ингибиторы бромодомена |
| AR104259A1 (es) | 2015-04-15 | 2017-07-05 | Celgene Quanticel Res Inc | Inhibidores de bromodominio |
| EP3341006A4 (en) | 2015-08-28 | 2019-03-13 | BioIncept LLC | COMPOSITIONS AND METHODS FOR TREATING NERVE DAMAGE |
| EP3445750A4 (en) | 2016-04-18 | 2019-11-27 | Celgene Quanticel Research, Inc. | THERAPEUTIC COMPOUNDS |
| US10150754B2 (en) | 2016-04-19 | 2018-12-11 | Celgene Quanticel Research, Inc. | Histone demethylase inhibitors |
| JP7732999B2 (ja) | 2020-04-03 | 2025-09-02 | バーテックス ファーマシューティカルズ インコーポレイテッド | アルファ１－アンチトリプシンのモジュレーター |
| CN115697969A (zh) * | 2020-04-03 | 2023-02-03 | 弗特克斯药品有限公司 | 作为用于治疗α-1抗胰蛋白酶缺乏症(AATD)的α-1抗胰蛋白酶调节剂的7-或8-羟基-异喹啉和7-或8-羟基-喹啉衍生物 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3594380A (en) * | 1969-02-18 | 1971-07-20 | American Home Prod | Isoquinolin-1(2h)-ones |
| US3878215A (en) * | 1971-12-01 | 1975-04-15 | Sandoz Ag | 2-Alkyl-3-substituted-4-aryl isoquinolines |
| US4897391A (en) * | 1988-06-17 | 1990-01-30 | Schering Corporation | Tricyclic anti-allergy, antiinflammatory and anti-hyperproliferative compounds |
| EP0585913B1 (en) | 1992-09-04 | 1997-12-29 | Takeda Chemical Industries, Ltd. | Condensed heterocyclic compounds, their production and use |
| AU5772196A (en) * | 1995-05-19 | 1996-11-29 | Chiroscience Limited | 3,4-disubstituted-phenylsulphonamides and their therapeutic use |
| AU2002212969B2 (en) * | 2000-09-20 | 2006-07-06 | Merck Sharp & Dohme Corp. | Isoquinolinone potassium channel inhibitors |
| EP1396488A1 (en) * | 2001-05-23 | 2004-03-10 | Mitsubishi Pharma Corporation | Fused heterocyclic compound and medicinal use thereof |
| WO2003068750A1 (en) * | 2002-02-13 | 2003-08-21 | Takeda Chemical Industries, Ltd. | Jnk inhibitor |
| WO2005030729A1 (en) * | 2003-09-23 | 2005-04-07 | Merck & Co., Inc. | Isoquinoline potassium channel inhibitors |
| AU2004289186B2 (en) * | 2003-09-23 | 2010-12-16 | Merck Sharp & Dohme Corp. | Isoquinolinone potassium channel inhibitors |
| US7723352B2 (en) * | 2003-09-23 | 2010-05-25 | Merck Sharp & Dohme | Isoquinolinone potassium channel inhibitors |
| EP1667976B1 (en) * | 2003-09-23 | 2010-08-04 | Merck Sharp & Dohme Corp. | Isoquinolinone potassium channel inhibitors |
| JP4719152B2 (ja) * | 2003-09-23 | 2011-07-06 | メルク・シャープ・エンド・ドーム・コーポレイション | イソキノリノンカリウムチャネル阻害剤 |
-
2004
- 2004-09-17 US US10/571,870 patent/US7723352B2/en not_active Expired - Fee Related
- 2004-09-17 EP EP04788811.0A patent/EP1667982B1/en not_active Expired - Lifetime
- 2004-09-17 JP JP2006528067A patent/JP4718467B2/ja not_active Expired - Fee Related
- 2004-09-17 AU AU2004276236A patent/AU2004276236B2/en not_active Ceased
- 2004-09-17 CA CA2539814A patent/CA2539814C/en not_active Expired - Fee Related
- 2004-09-17 WO PCT/US2004/030431 patent/WO2005030791A2/en not_active Ceased
- 2004-09-17 CN CNA2004800273696A patent/CN1856476A/zh active Pending
-
2010
- 2010-04-02 US US12/753,572 patent/US8338449B2/en not_active Expired - Fee Related
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2007516218A5 (https=) | ||
| JP2007506748A5 (https=) | ||
| JP2007506742A5 (https=) | ||
| CA2539814A1 (en) | Isoquinolinone potassium channel inhibitors | |
| WO2001032624A1 (en) | 4-phenyl-substituted tetrahydroisoquinolines and use thereof to block reuptake of norepinephrine, dopamine and serotonin | |
| JP2009120619A (ja) | 心不全の予防又は治療のための医薬組成物 | |
| AU2008274201A1 (en) | Compounds and methods for modulating Rho GTPases | |
| EP1246806A1 (en) | Arly- and heteroaryl-substituted tetrahydroisoquinolines and use thereof to block reuptake of norepinephrine, dopamine and serotonin | |
| Rowland et al. | The Comparativee Effects of Diltiazem and Verapamil on Atrioventricular Conduction and Atrioventricular Reentry Tachycardia | |
| Fiala et al. | Termination of long‐lasting persistent versus short‐lasting persistent and paroxysmal atrial fibrillation by ablation | |
| US20090215745A1 (en) | Association of a sinus node If current inhibitor and a calcium inhibitor, and pharmaceutical compositions containing it | |
| JP2007527904A5 (https=) | ||
| ES2296964T3 (es) | Compuestos a base de nitrato organico para el tratamiento de ateroesclerosis y enfermedades vasculares. | |
| Aizawa et al. | Conductive property of the zone of slow conduction of reentrant ventricular tachycardia and its relation to pacing induced terminability | |
| CA2766533A1 (en) | Otamixaban for treatment of elderly and renal impaired non-st elevation myocardial infarction patients | |
| US6110927A (en) | Loratadine for use as an antiarrhythmic | |
| JP2007527903A5 (https=) | ||
| JP2934323B2 (ja) | 抗血栓性化合物 | |
| Menezes Júnior et al. | Management of an Electrical Storm: Definitions, Mechanisms, Diagnosis, and Treatment Strategies | |
| JP2008516952A5 (https=) | ||
| MY138896A (en) | Derivatives of 3-(guanidinocarbonyl) heterocycle, methods of preparation and intermediates thereof, their use as medicaments, and pharmaceutical compositions therefrom | |
| Wijffels et al. | Non-invasive characteristics of atrial fibrillation: the value of Holter recordings for the treatment of AF | |
| Kocić | Direct inotropic action of WB-4101 and prazosin in the guinea pig papillary muscle. Comparison with HOE-234, the new activator of ATP-sensitive K+ channels | |
| Garg et al. | Atrial flutter | |
| Kołodziej et al. | Case report Brugada syndrome–underestimated cause of sudden cardiac death in patients without an organic cardiac disease–a case report |