JP2007509962A - アンドロゲン受容体調節剤としての２１−複素環−４−アザステロイド誘導体 - Google Patents

アンドロゲン受容体調節剤としての２１−複素環−４−アザステロイド誘導体 Download PDF

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Publication number
JP2007509962A
JP2007509962A JP2006538255A JP2006538255A JP2007509962A JP 2007509962 A JP2007509962 A JP 2007509962A JP 2006538255 A JP2006538255 A JP 2006538255A JP 2006538255 A JP2006538255 A JP 2006538255A JP 2007509962 A JP2007509962 A JP 2007509962A
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alkyl
aryl
compound
alkylamino
cycloalkyl
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JP2007509962A5 (enExample
Inventor
ダンクーリツチ，ウイリアム・ピー
ミツチエル，ヘレン・ジエイ
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Merck and Co Inc
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Merck and Co Inc
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Publication of JP2007509962A publication Critical patent/JP2007509962A/ja
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J73/00—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms
    • C07J73/001—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms by one hetero atom
    • C07J73/005—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms by one hetero atom by nitrogen as hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
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    • A61P13/08—Drugs for disorders of the urinary system of the prostate
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
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    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
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    • A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
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    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
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    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

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  • Gynecology & Obstetrics (AREA)
  • Urology & Nephrology (AREA)
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JP2006538255A 2003-10-31 2004-10-27 アンドロゲン受容体調節剤としての２１−複素環−４−アザステロイド誘導体 Pending JP2007509962A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US51642503P 2003-10-31 2003-10-31
PCT/US2004/035838 WO2005044988A2 (en) 2003-10-31 2004-10-27 21-heterocyclic-4-azasteroid derivatives as androgen receptor modulators

Publications (2)

Publication Number Publication Date
JP2007509962A true JP2007509962A (ja) 2007-04-19
JP2007509962A5 JP2007509962A5 (enExample) 2007-12-13

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JP2006538255A Pending JP2007509962A (ja) 2003-10-31 2004-10-27 アンドロゲン受容体調節剤としての２１−複素環−４−アザステロイド誘導体

Country Status (7)

Country Link
US (1) US7312229B2 (enExample)
EP (1) EP1696925A4 (enExample)
JP (1) JP2007509962A (enExample)
CN (1) CN1871005B (enExample)
AU (1) AU2004288196B2 (enExample)
CA (1) CA2543956A1 (enExample)
WO (1) WO2005044988A2 (enExample)

Families Citing this family (8)

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Publication number Priority date Publication date Assignee Title
WO2006110683A1 (en) 2005-04-11 2006-10-19 Abbott Laboratories 2-substituted-1h-benzimidazole-4-carboxamides are parp inhibitors
RU2329035C1 (ru) * 2006-11-28 2008-07-20 ГУ Научно-исследовательский институт фармакологии Томского научного центра Сибирского отделения Российской академии медицинских наук Лекарственные средства для профилактики и лечения анемии при невротических воздействиях
US20160331729A9 (en) 2007-04-11 2016-11-17 Omeros Corporation Compositions and methods for prophylaxis and treatment of addictions
US11241420B2 (en) 2007-04-11 2022-02-08 Omeros Corporation Compositions and methods for prophylaxis and treatment of addictions
ES2830073T3 (es) * 2007-04-11 2021-06-02 Omeros Corp Composiciones y métodos para la profilaxis y el tratamiento de adicciones
MX2012014431A (es) 2010-06-10 2013-02-26 Aragon Pharmaceuticals Inc Modulares del receptor de estrogenos y usos de los mismos.
MX357496B (es) 2011-12-14 2018-07-11 Seragon Pharmaceuticals Inc Moduladores del receptor de estrógenos fluorados y sus usos.
CN105820206B (zh) * 2016-04-18 2017-08-01 广西师范学院 22‑降‑豆甾苯并咪唑化合物及其制备方法和应用

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5510351A (en) * 1992-05-20 1996-04-23 Merck & Co., Inc. Delta-17 and delta-20 olefinic and saturated 17 beta-substituted 4-aza-5 alpha-androstan-ones as 5 alpha reductase inhibitors useful in the prevention and treatment of hyperandrogenic disorders
US5525608A (en) * 1994-04-20 1996-06-11 Merck & Co., Inc. 17b-aryl-4-aza-steroid derivatives useful as 5-alpha-reductase inhibitors
US5629318A (en) * 1992-12-18 1997-05-13 Merck & Co., Inc. Method of treatment of chronic prostatitis with 17β-N-monosubstituted-carbamoyl-4-aza-5α-androst-1-en-3-ones
WO2003077919A1 (en) * 2002-03-13 2003-09-25 Merck & Co., Inc. Fluorinated 4-azasteroid derivatives as androgen receptor modulators

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2007505118A (ja) 2003-09-10 2007-03-08 メルク　エンド　カムパニー　インコーポレーテッド アンドロゲン受容体調節剤としての１７−複素環−４−アザステロイド誘導体

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5510351A (en) * 1992-05-20 1996-04-23 Merck & Co., Inc. Delta-17 and delta-20 olefinic and saturated 17 beta-substituted 4-aza-5 alpha-androstan-ones as 5 alpha reductase inhibitors useful in the prevention and treatment of hyperandrogenic disorders
US5629318A (en) * 1992-12-18 1997-05-13 Merck & Co., Inc. Method of treatment of chronic prostatitis with 17β-N-monosubstituted-carbamoyl-4-aza-5α-androst-1-en-3-ones
US5525608A (en) * 1994-04-20 1996-06-11 Merck & Co., Inc. 17b-aryl-4-aza-steroid derivatives useful as 5-alpha-reductase inhibitors
WO2003077919A1 (en) * 2002-03-13 2003-09-25 Merck & Co., Inc. Fluorinated 4-azasteroid derivatives as androgen receptor modulators

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EP1696925A2 (en) 2006-09-06
WO2005044988A2 (en) 2005-05-19
US20070088047A1 (en) 2007-04-19
CN1871005A (zh) 2006-11-29
CN1871005B (zh) 2010-10-27
AU2004288196B2 (en) 2009-11-26
CA2543956A1 (en) 2005-05-19
US7312229B2 (en) 2007-12-25
AU2004288196A1 (en) 2005-05-19
EP1696925A4 (en) 2009-11-18
WO2005044988A3 (en) 2005-10-27

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