CN1871005B - 雄激素受体调节剂21-杂环-4-氮杂甾体衍生物 - Google Patents

雄激素受体调节剂21-杂环-4-氮杂甾体衍生物 Download PDF

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Publication number
CN1871005B
CN1871005B CN2004800315580A CN200480031558A CN1871005B CN 1871005 B CN1871005 B CN 1871005B CN 2004800315580 A CN2004800315580 A CN 2004800315580A CN 200480031558 A CN200480031558 A CN 200480031558A CN 1871005 B CN1871005 B CN 1871005B
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alkyl
methyl
aza
androst
aryl
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Expired - Fee Related
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CN2004800315580A
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Chinese (zh)
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CN1871005A (zh
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W·P·丹库利奇
H·J·米切尔
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Merck Sharp and Dohme LLC
Merck and Co Inc
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Merck Sharp and Dohme LLC
Merck and Co Inc
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    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J73/00—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms
    • C07J73/001—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms by one hetero atom
    • C07J73/005—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms by one hetero atom by nitrogen as hetero atom
    • A—HUMAN NECESSITIES
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CN2004800315580A 2003-10-31 2004-10-27 雄激素受体调节剂21-杂环-4-氮杂甾体衍生物 Expired - Fee Related CN1871005B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US51642503P 2003-10-31 2003-10-31
US60/516,425 2003-10-31
PCT/US2004/035838 WO2005044988A2 (en) 2003-10-31 2004-10-27 21-heterocyclic-4-azasteroid derivatives as androgen receptor modulators

Publications (2)

Publication Number Publication Date
CN1871005A CN1871005A (zh) 2006-11-29
CN1871005B true CN1871005B (zh) 2010-10-27

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Country Link
US (1) US7312229B2 (enExample)
EP (1) EP1696925A4 (enExample)
JP (1) JP2007509962A (enExample)
CN (1) CN1871005B (enExample)
AU (1) AU2004288196B2 (enExample)
CA (1) CA2543956A1 (enExample)
WO (1) WO2005044988A2 (enExample)

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WO2006110683A1 (en) 2005-04-11 2006-10-19 Abbott Laboratories 2-substituted-1h-benzimidazole-4-carboxamides are parp inhibitors
RU2329035C1 (ru) * 2006-11-28 2008-07-20 ГУ Научно-исследовательский институт фармакологии Томского научного центра Сибирского отделения Российской академии медицинских наук Лекарственные средства для профилактики и лечения анемии при невротических воздействиях
US20160331729A9 (en) 2007-04-11 2016-11-17 Omeros Corporation Compositions and methods for prophylaxis and treatment of addictions
US11241420B2 (en) 2007-04-11 2022-02-08 Omeros Corporation Compositions and methods for prophylaxis and treatment of addictions
ES2830073T3 (es) * 2007-04-11 2021-06-02 Omeros Corp Composiciones y métodos para la profilaxis y el tratamiento de adicciones
MX2012014431A (es) 2010-06-10 2013-02-26 Aragon Pharmaceuticals Inc Modulares del receptor de estrogenos y usos de los mismos.
MX357496B (es) 2011-12-14 2018-07-11 Seragon Pharmaceuticals Inc Moduladores del receptor de estrógenos fluorados y sus usos.
CN105820206B (zh) * 2016-04-18 2017-08-01 广西师范学院 22‑降‑豆甾苯并咪唑化合物及其制备方法和应用

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5510351A (en) * 1992-05-20 1996-04-23 Merck & Co., Inc. Delta-17 and delta-20 olefinic and saturated 17 beta-substituted 4-aza-5 alpha-androstan-ones as 5 alpha reductase inhibitors useful in the prevention and treatment of hyperandrogenic disorders
US5629318A (en) * 1992-12-18 1997-05-13 Merck & Co., Inc. Method of treatment of chronic prostatitis with 17β-N-monosubstituted-carbamoyl-4-aza-5α-androst-1-en-3-ones

Family Cites Families (3)

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Publication number Priority date Publication date Assignee Title
US5525608A (en) * 1994-04-20 1996-06-11 Merck & Co., Inc. 17b-aryl-4-aza-steroid derivatives useful as 5-alpha-reductase inhibitors
CA2478186C (en) * 2002-03-13 2011-08-23 Merck & Co., Inc. Fluorinated 4-azasteroid derivatives as androgen receptor modulators
JP2007505118A (ja) 2003-09-10 2007-03-08 メルク　エンド　カムパニー　インコーポレーテッド アンドロゲン受容体調節剤としての１７−複素環−４−アザステロイド誘導体

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5510351A (en) * 1992-05-20 1996-04-23 Merck & Co., Inc. Delta-17 and delta-20 olefinic and saturated 17 beta-substituted 4-aza-5 alpha-androstan-ones as 5 alpha reductase inhibitors useful in the prevention and treatment of hyperandrogenic disorders
US5629318A (en) * 1992-12-18 1997-05-13 Merck & Co., Inc. Method of treatment of chronic prostatitis with 17β-N-monosubstituted-carbamoyl-4-aza-5α-androst-1-en-3-ones

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EP1696925A2 (en) 2006-09-06
JP2007509962A (ja) 2007-04-19
WO2005044988A2 (en) 2005-05-19
US20070088047A1 (en) 2007-04-19
CN1871005A (zh) 2006-11-29
AU2004288196B2 (en) 2009-11-26
CA2543956A1 (en) 2005-05-19
US7312229B2 (en) 2007-12-25
AU2004288196A1 (en) 2005-05-19
EP1696925A4 (en) 2009-11-18
WO2005044988A3 (en) 2005-10-27

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