JP2007502287A5 - - Google Patents

Download PDF

Info

Publication number
JP2007502287A5
JP2007502287A5 JP2006523335A JP2006523335A JP2007502287A5 JP 2007502287 A5 JP2007502287 A5 JP 2007502287A5 JP 2006523335 A JP2006523335 A JP 2006523335A JP 2006523335 A JP2006523335 A JP 2006523335A JP 2007502287 A5 JP2007502287 A5 JP 2007502287A5
Authority
JP
Japan
Prior art keywords
therapeutic
prophylactic agent
tautomer
prodrug
pharmaceutically acceptable
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
JP2006523335A
Other languages
English (en)
Japanese (ja)
Other versions
JP2007502287A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2004/026021 external-priority patent/WO2005019167A2/en
Publication of JP2007502287A publication Critical patent/JP2007502287A/ja
Publication of JP2007502287A5 publication Critical patent/JP2007502287A5/ja
Withdrawn legal-status Critical Current

Links

JP2006523335A 2003-08-13 2004-08-11 メラニン凝集ホルモン受容体アンタゴニスト Withdrawn JP2007502287A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US49473503P 2003-08-13 2003-08-13
PCT/US2004/026021 WO2005019167A2 (en) 2003-08-13 2004-08-11 Melanin concentrating hormone receptor antagonist

Publications (2)

Publication Number Publication Date
JP2007502287A JP2007502287A (ja) 2007-02-08
JP2007502287A5 true JP2007502287A5 (OSRAM) 2007-06-28

Family

ID=34215897

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2006523335A Withdrawn JP2007502287A (ja) 2003-08-13 2004-08-11 メラニン凝集ホルモン受容体アンタゴニスト

Country Status (7)

Country Link
US (2) US7514438B2 (OSRAM)
EP (1) EP1653960A4 (OSRAM)
JP (1) JP2007502287A (OSRAM)
AU (1) AU2004266233A1 (OSRAM)
CA (1) CA2533112A1 (OSRAM)
MX (1) MXPA06001636A (OSRAM)
WO (1) WO2005019167A2 (OSRAM)

Families Citing this family (51)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RS20060035A (sr) 2003-07-22 2008-08-07 Arena Pharmaceuticals Inc., Derivati diaril i arilheteroaril uree kao modulatori receptora 5-ht2a serotonina korisni u profilaksi i lečenju poremećaja u vezi sa njima
KR20080031379A (ko) 2005-07-11 2008-04-08 와이어쓰 글루타메이트 아그레카나제 저해제
TW200800306A (en) * 2005-09-12 2008-01-01 Wyeth Corp Sustained-release formulation and uses thereof
GT200600414A (es) * 2005-09-12 2007-09-20 Sal de glucuranato de compuesto de piperazine
GT200600416A (es) * 2005-09-12 2007-09-20 Sales salicilato y gentisato de un compuesto de piperazina
KR101020333B1 (ko) 2005-09-30 2011-03-09 에프. 호프만-라 로슈 아게 Mch 수용체 길항제로서의 인단 유도체
WO2007044100A1 (en) 2005-10-13 2007-04-19 Wyeth Methods for preparing glutamic acid derivatives
US20090018142A9 (en) * 2006-05-02 2009-01-15 Zhengping Zhuang Use of phosphatases to treat tumors overexpressing N-CoR
JP5682051B2 (ja) 2006-05-18 2015-03-11 ファーマサイクリックス,インク. 細胞内キナーゼ阻害剤
TWI415845B (zh) 2006-10-03 2013-11-21 Arena Pharm Inc 用於治療與5-ht2a血清素受體相關聯病症之作為5-ht2a血清素受體之調節劑的吡唑衍生物
WO2008086069A1 (en) * 2007-01-03 2008-07-17 The General Hospital Corporation Methods of treating itch
MX2009008347A (es) 2007-02-06 2009-10-19 Lixte Biotechnology Holdings I Oxabicicloheptanos y oxabicicloheptenos, su preparacion y uso.
EP2190844B3 (en) 2007-08-15 2013-07-17 Arena Pharmaceuticals, Inc. Imidazo[1,2-a]pyridine derivatives as modulators of the 5-ht2a serotonin receptor useful for the treatment of disorders related thereto
MX2010003417A (es) * 2007-10-01 2010-09-10 Lixte Biotechnology Inc Inhibidores de histona desacetilasa.
WO2009123714A2 (en) 2008-04-02 2009-10-08 Arena Pharmaceuticals, Inc. Processes for the preparation of pyrazole derivatives useful as modulators of the 5-ht2a serotonin receptor
AU2009277086B2 (en) 2008-08-01 2015-12-10 Lixte Biotechnology, Inc. Neuroprotective agents for the prevention and treatment of neurodegenerative diseases
US8227473B2 (en) 2008-08-01 2012-07-24 Lixte Biotechnology, Inc. Oxabicycloheptanes and oxabicycloheptenes, their preparation and use
RS57110B1 (sr) 2008-10-28 2018-06-29 Arena Pharm Inc Sastavi modulatora 5-ht2a serotoninskog receptora korisni za tretiranje poremećaja povezanih sa njim
US9126946B2 (en) 2008-10-28 2015-09-08 Arena Pharmaceuticals, Inc. Processes useful for the preparation of 1-[3-(4-bromo-2-methyl-2H-pyrazol-3-yl)-4-methoxy-phenyl]-3-(2,4-difluoro-phenyl)urea and crystalline forms related thereto
US8673920B2 (en) 2009-05-06 2014-03-18 Merck Sharp & Dohme Corp. Inhibitors of the renal outer medullary potassium channel
EP2632465B1 (en) 2010-10-27 2015-12-30 Merck Sharp & Dohme Corp. Inhibitors of the renal outer medullary potassium channel
WO2012058134A1 (en) 2010-10-29 2012-05-03 Merck Sharp & Dohme Corp. Inhibitors of the renal outer medullary potassium channel
GB201106817D0 (en) 2011-04-21 2011-06-01 Astex Therapeutics Ltd New compound
CA2844310A1 (en) 2011-08-19 2013-02-28 Merck Sharp & Dohme Corp. Inhibitors of the renal outer medullary potassium channel
TW201317213A (zh) 2011-09-16 2013-05-01 Merck Sharp & Dohme 腎外髓質鉀通道抑制劑
WO2013062900A1 (en) 2011-10-25 2013-05-02 Merck Sharp & Dohme Corp. Inhibitors of the renal outer medullary potassium channel
EP2771005B1 (en) 2011-10-25 2016-05-18 Merck Sharp & Dohme Corp. Inhibitors of the renal outer medullary potassium channel
US9139585B2 (en) 2011-10-31 2015-09-22 Merck Sharp & Dohme Corp. Inhibitors of the Renal Outer Medullary Potassium channel
US9108947B2 (en) 2011-10-31 2015-08-18 Merck Sharp & Dohme Corp. Inhibitors of the Renal Outer Medullary Potassium channel
EP2773351B1 (en) 2011-10-31 2017-08-23 Merck Sharp & Dohme Corp. Inhibitors of the renal outer medullary potassium channel
WO2013090271A1 (en) 2011-12-16 2013-06-20 Merck Sharp & Dohme Corp. Inhibitors of the renal outer medullary potassium channel
US9073864B2 (en) 2012-03-29 2015-07-07 Takeda Pharmaceutical Company Limted Aromatic ring compound
AR092031A1 (es) 2012-07-26 2015-03-18 Merck Sharp & Dohme Inhibidores del canal de potasio medular externo renal
US9980973B2 (en) 2012-10-19 2018-05-29 Astex Therapeutics Limited Bicyclic heterocycle compounds and their uses in therapy
GB201218864D0 (en) 2012-10-19 2012-12-05 Astex Therapeutics Ltd Bicyclic heterocycle compounds and their uses in therapy
GB201218862D0 (en) 2012-10-19 2012-12-05 Astex Therapeutics Ltd Bicyclic heterocycle compounds and their uses in therapy
GB201218850D0 (en) 2012-10-19 2012-12-05 Astex Therapeutics Ltd Bicyclic heterocycle compounds and their uses in therapy
WO2014085210A1 (en) 2012-11-29 2014-06-05 Merck Sharp & Dohme Corp. Inhibitors of the renal outer medullary potassium channel
WO2014099633A2 (en) 2012-12-19 2014-06-26 Merck Sharp & Dohme Corp. Inhibitors of the renal outer medullary potassium channel
EP2956142B1 (en) 2013-02-18 2017-09-20 Merck Sharp & Dohme Corp. Inhibitors of the renal outer medullary potassium channel
EP2968288B1 (en) 2013-03-15 2018-07-04 Merck Sharp & Dohme Corp. Inhibitors of the renal outer medullary potassium channel
BR112015025852A2 (pt) 2013-04-09 2017-07-25 Lixte Biotechnology Inc as formulações de oxabicicloheptanos e oxabicicloheptenos
WO2015017305A1 (en) 2013-07-31 2015-02-05 Merck Sharp & Dohme Corp Inhibitors of the renal outer medullary potassium channel
WO2015065866A1 (en) 2013-10-31 2015-05-07 Merck Sharp & Dohme Corp. Inhibitors of the renal outer medullary potassium channel
ES2883289T3 (es) 2013-12-20 2021-12-07 Astex Therapeutics Ltd Compuestos heterocíclicos bicíclicos y sus usos en terapia
WO2016118632A1 (en) 2015-01-20 2016-07-28 The General Hospital Corporation Prevention and treatment of itch with an mrgpr antagonist
WO2016127358A1 (en) 2015-02-12 2016-08-18 Merck Sharp & Dohme Corp. Inhibitors of renal outer medullary potassium channel
AU2016276966A1 (en) 2015-06-12 2018-01-18 Axovant Sciences Gmbh Diaryl and arylheteroaryl urea derivatives useful for the prophylaxis and treatment of REM sleep behavior disorder
EP3322415A4 (en) 2015-07-15 2019-03-13 Axovant Sciences GmbH DIARYL AND ARYLHETEROARYL UREA DERIVATIVES AS MODULATORS OF THE 5-HT2A SEROTONIN RECEPTOR FOR PROPHYLAXIS AND TREATMENT OF HALLUCINATIONS RELATED TO A NEUROGENERATIVE DISEASE
US12168008B2 (en) 2016-12-08 2024-12-17 Lixte Biotechnology, Inc. Oxabicycloheptanes for modulation of immune response
CN119219575B (zh) * 2024-12-03 2025-03-11 天津科技大学 一种抗肿瘤肉桂基哌嗪白藜芦醇偶联物或其药学上可接受的盐及其制备方法和应用

Family Cites Families (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE276541C (OSRAM) *
ZA843899B (en) 1983-05-23 1984-12-24 Usv Pharma Corp Compounds for treating hypertension
US6100048A (en) 1992-04-10 2000-08-08 Oregon Health Sciences University Methods and reagents for discovering and using mammalian melanocortin receptor agonists and antagonists to modulate feeding behavior in animals
SK57097A3 (en) 1994-11-07 1998-10-07 Pfizer Certain substituted benzylamine derivatives; a new class of neuropeptide y1 specific ligands
DK0918761T3 (da) 1996-07-23 2003-08-25 Neurogen Corp Visse amido- og aminosubstituerede benzylaminderivater, en ny klasse af neuropeptid Y1-specifikke ligander
EP0915859B1 (en) 1996-07-23 2003-01-02 Neurogen Corporation Certain substituted benzylamine derivatives; a new class of neuropeptide y1 specific ligands
EP0915860A1 (en) 1996-07-23 1999-05-19 Neurogen Corporation Certain substituted benzylamine derivatives; a new class of neuropeptide-y1 specific ligands
CN1344321A (zh) 1998-12-28 2002-04-10 武田药品工业株式会社 筛选方法
US6221613B1 (en) 1998-12-31 2001-04-24 Synaptic Pharmaceutical Corporation DNA encoding a human melanin concentrating hormone receptor (MCH1) and uses thereof
US7198910B1 (en) 1999-07-14 2007-04-03 Merck & Co., Inc. Nucleic acid encoding melanin-concentrating hormone receptor
AU7315800A (en) 1999-09-20 2001-04-24 Takeda Chemical Industries Ltd. Mch antagonists
AU7315700A (en) 1999-09-20 2001-04-24 Takeda Chemical Industries Ltd. Melanin concentrating hormone antagonist
GB0001447D0 (en) * 2000-01-21 2000-03-08 Novartis Ag Organic compounds
CA2414198A1 (en) * 2000-07-06 2002-01-17 Neurogen Corporation Melanin concentrating hormone receptor ligands
AR031930A1 (es) * 2000-12-22 2003-10-08 Schering Corp Antagonistas de mch y su uso en el tratamiento de la obesidad
DE10123958A1 (de) * 2001-05-17 2002-11-28 Aventis Pharma Gmbh Verfahren zur Identifizierung von Liganden für G protein coupled receptors
EP1389189A2 (en) 2001-05-22 2004-02-18 Neurogen Corporation Melanin concentrating hormone receptor ligands: substituted 1-benzyl-4-aryl piperazine analogues
US6552188B2 (en) * 2001-06-29 2003-04-22 Kowa Co., Ltd. Unsymmetrical cyclic diamine compound
DE10139416A1 (de) 2001-08-17 2003-03-06 Aventis Pharma Gmbh Aminoalkyl substituierte aromatische Bicyclen, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
AU2002352878B2 (en) 2001-11-27 2007-11-22 Merck Sharp & Dohme Corp. 2-Aminoquinoline compounds
US6818772B2 (en) * 2002-02-22 2004-11-16 Abbott Laboratories Antagonists of melanin concentrating hormone effects on the melanin concentrating hormone receptor
US20040180889A1 (en) * 2002-03-01 2004-09-16 Pintex Pharmaceuticals, Inc. Pin1-modulating compounds and methods of use thereof
WO2003087046A1 (en) 2002-04-09 2003-10-23 7Tm Pharma A/S Novel aminotetraline compounds for use in mch receptor related disorders
WO2003087044A2 (en) 2002-04-09 2003-10-23 7Tm Pharma A/S Novel carboxamide compounds for use in mch receptor related disorders
US7078430B2 (en) * 2002-07-08 2006-07-18 Ranbaxy Laboratories Limited HMG CoA-reductase inhibitors
FR2842524B1 (fr) * 2002-07-16 2005-04-22 Aventis Pharma Sa Compositions pharmaceutiques contenant un derive de 3-guanidinocarbonyl-1-heteroaryl-pyrrole, leur procede de preparation a titre de medicaments
US7091235B2 (en) * 2002-10-15 2006-08-15 Signal Pharmaceuticals, Llc Benzopyranone compounds, compositions thereof, and methods for treating or preventing cancer

Similar Documents

Publication Publication Date Title
JP2007502287A5 (OSRAM)
HK1054333A1 (zh) 杂芳基脲神经肽yy5受体拮抗剂
HK1054225A1 (zh) Mch拮抗剂和它们在治疗肥胖中的用途
WO2006098918A3 (en) Substituted gamma lactams as therapeutic agents
JP2005506370A5 (OSRAM)
JP2006526031A5 (OSRAM)
JP2005523254A5 (OSRAM)
CA2503767A1 (en) Pyridopyrrolizine and pyridoindolizine derivatives
WO2007146758A3 (en) Novel mch receptor antagonists
JP2007514005A5 (OSRAM)
WO2006023460A3 (en) COMPOUNDS HAVING β2 ADRENERGIC RECEPTOR AGONIST AND MUSCARINIC RECEPTOR ANTAGONIST ACTIVITY
WO2005082871A3 (de) Guanidinverbindungen und ihre verwendung als bindungspartner für 5-ht5-rezeptoren
LU92602I2 (fr) Trametinib, optionnellement sous la forme d'un sel, hydrate ou solvate pharmaceutiquement acceptablede celui-ci
EP2397476A3 (en) Indole derivative having PGD2 receptor antagonist activity
WO2003024401A3 (en) Piperizinones as modulators of chemokine receptor activity
CA2472954A1 (en) Aza-arylpiperazines
WO2009010871A3 (en) Pyrazole derivatives as antagonists of adenosine a3 receptor
CA2503718A1 (en) Use of serotonin receptor antagonists for the treatment of sleep apnea
WO2007062999A3 (en) 1,5-substituted indol-2-yl amide derivatives
WO2006066173A3 (en) Novel mch receptor antagonists
JP2008513510A5 (OSRAM)
EP1398029A8 (en) NR3B1 nuclear receptor binding 3-substituted pyrazole derivatives
WO2002060423A3 (en) Substituted carbostyril derivatives as 5-ht1a receptor subtype agonists
WO2007039462A3 (en) Indane derivatives as mch receptor antagonists
WO2005040157A3 (en) Novel mch receptor antagonists