JP2007500740A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2007500740A5 JP2007500740A5 JP2006530499A JP2006530499A JP2007500740A5 JP 2007500740 A5 JP2007500740 A5 JP 2007500740A5 JP 2006530499 A JP2006530499 A JP 2006530499A JP 2006530499 A JP2006530499 A JP 2006530499A JP 2007500740 A5 JP2007500740 A5 JP 2007500740A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- optionally substituted
- cycloalkyl
- phenyl
- heterocyclyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 125000000217 alkyl group Chemical group 0.000 claims 27
- 150000001875 compounds Chemical class 0.000 claims 11
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims 8
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 6
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 5
- 125000000623 heterocyclic group Chemical group 0.000 claims 5
- 229910052739 hydrogen Inorganic materials 0.000 claims 5
- 239000001257 hydrogen Substances 0.000 claims 5
- KXDAEFPNCMNJSK-UHFFFAOYSA-N Benzamide Chemical compound NC(=O)C1=CC=CC=C1 KXDAEFPNCMNJSK-UHFFFAOYSA-N 0.000 claims 4
- 150000002431 hydrogen Chemical class 0.000 claims 4
- 125000003545 alkoxy group Chemical group 0.000 claims 3
- 125000001246 bromo group Chemical group Br* 0.000 claims 3
- 125000001309 chloro group Chemical group Cl* 0.000 claims 3
- 125000001153 fluoro group Chemical group F* 0.000 claims 3
- 125000002346 iodo group Chemical group I* 0.000 claims 3
- 238000004519 manufacturing process Methods 0.000 claims 3
- -1 piperidin-4-ylidene Chemical group 0.000 claims 3
- 125000003118 aryl group Chemical group 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 claims 1
- 125000000094 2-phenylethyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])* 0.000 claims 1
- 125000005975 2-phenylethyloxy group Chemical group 0.000 claims 1
- ADKFEPXDKPTJPI-UHFFFAOYSA-N 4-[(3-cyclohexyloxyphenyl)-piperidin-4-ylidenemethyl]-n,n-diethylbenzamide Chemical compound C1=CC(C(=O)N(CC)CC)=CC=C1C(C=1C=C(OC2CCCCC2)C=CC=1)=C1CCNCC1 ADKFEPXDKPTJPI-UHFFFAOYSA-N 0.000 claims 1
- IPKSXPQDHACCNZ-UHFFFAOYSA-N 4-[(3-cyclopentyloxyphenyl)-piperidin-4-ylidenemethyl]-n,n-diethylbenzamide Chemical compound C1=CC(C(=O)N(CC)CC)=CC=C1C(C=1C=C(OC2CCCC2)C=CC=1)=C1CCNCC1 IPKSXPQDHACCNZ-UHFFFAOYSA-N 0.000 claims 1
- 208000019901 Anxiety disease Diseases 0.000 claims 1
- 208000018522 Gastrointestinal disease Diseases 0.000 claims 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 1
- 208000027520 Somatoform disease Diseases 0.000 claims 1
- 230000036506 anxiety Effects 0.000 claims 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 1
- 125000000753 cycloalkyl group Chemical group 0.000 claims 1
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims 1
- 125000001511 cyclopentyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- QZNQCUCDFBHLSR-UHFFFAOYSA-N n,n-diethyl-4-[(3-phenylmethoxyphenyl)-piperidin-4-ylidenemethyl]benzamide Chemical compound C1=CC(C(=O)N(CC)CC)=CC=C1C(C=1C=C(OCC=2C=CC=CC=2)C=CC=1)=C1CCNCC1 QZNQCUCDFBHLSR-UHFFFAOYSA-N 0.000 claims 1
- 208000027753 pain disease Diseases 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 0 *N(*)C(c(cc1)ccc1C(c1cccc(OI)c1)=C1CCN(*)CC1)=O Chemical compound *N(*)C(c(cc1)ccc1C(c1cccc(OI)c1)=C1CCN(*)CC1)=O 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE0301443A SE0301443D0 (sv) | 2003-05-16 | 2003-05-16 | Diarylmethylidene piperidine derivatives, preparations thereof and uses thereof |
| PCT/GB2004/002073 WO2004101521A1 (en) | 2003-05-16 | 2004-05-13 | Diarylmethylidene piperidine derivatives, preparations thereof and uses thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2007500740A JP2007500740A (ja) | 2007-01-18 |
| JP2007500740A5 true JP2007500740A5 (https=) | 2007-05-31 |
Family
ID=20291332
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006530499A Abandoned JP2007500740A (ja) | 2003-05-16 | 2004-05-13 | ジアリールメチリデンピペリジン誘導体、その製造およびその使用 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US20070066653A1 (https=) |
| EP (1) | EP1628960A1 (https=) |
| JP (1) | JP2007500740A (https=) |
| AR (1) | AR044344A1 (https=) |
| SE (1) | SE0301443D0 (https=) |
| TW (1) | TW200507842A (https=) |
| UY (1) | UY28319A1 (https=) |
| WO (1) | WO2004101521A1 (https=) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE602007011793D1 (de) | 2006-10-18 | 2011-02-17 | Pfizer Prod Inc | Biaryl-ether-harnstoffverbindungen |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2898339A (en) * | 1957-07-29 | 1959-08-04 | Wm S Merrell Co | N-substituted benzhydrol, benzhydryl, and benzhydrylidene piperidine |
| US4581171A (en) * | 1983-07-27 | 1986-04-08 | Janssen Pharmaceutica, N.V. | [[Bis(aryl)methylene]-1-piperidinyl]alkyl-pyrimidinones useful for treating psychotropic disorders |
| US4816586A (en) * | 1987-07-29 | 1989-03-28 | Regents Of The University Of Minnesota | Delta opioid receptor antagonists |
| US5140029A (en) * | 1989-01-09 | 1992-08-18 | Janssen Pharmaceutica N.V. | 2-aminopyrimidinone derivatives |
| US4939137A (en) * | 1989-06-28 | 1990-07-03 | Ortho Pharmaceutical Corporation | Ring-fused thienopyrimidinedione derivatives |
| US5683998A (en) * | 1991-04-23 | 1997-11-04 | Toray Industries, Inc. | Tricyclic triazolo derivatives, processes for producing the same and the uses of the same |
| US5574159A (en) * | 1992-02-03 | 1996-11-12 | Delta Pharmaceuticals, Inc. | Opioid compounds and methods for making therefor |
| TW548271B (en) * | 1996-12-20 | 2003-08-21 | Astra Pharma Inc | Novel piperidine derivatives having an exocyclic double bond with analgesic effects |
| IL151550A0 (en) * | 2000-03-03 | 2003-04-10 | Ortho Mcneil Pharm Inc | 3-(diarylmethylene)-8-azabicyclo [3.2.1] octane derivatives |
| US6556387B1 (en) * | 2000-03-31 | 2003-04-29 | Seagate Technology Llc | Controlling mechanical response characteristics of a disc drive actuator by adjusting a fastener engaging the actuator shaft to vary axial force on the bearing assembly |
| SE0001207D0 (sv) * | 2000-04-04 | 2000-04-04 | Astrazeneca Canada Inc | Novel compounds |
| SE0101767D0 (sv) * | 2001-05-18 | 2001-05-18 | Astrazeneca Ab | Novel compounds |
| SE0301441D0 (sv) * | 2003-05-16 | 2003-05-16 | Astrazeneca Ab | Diarylmethylidene piperidine derivatives, preparations thereof and uses thereof |
| SE0301442D0 (sv) * | 2003-05-16 | 2003-05-16 | Astrazeneca Ab | Diarylmethylidene piperidine derivatives, preparations therof and uses thereof |
-
2003
- 2003-05-16 SE SE0301443A patent/SE0301443D0/xx unknown
-
2004
- 2004-05-13 EP EP04732652A patent/EP1628960A1/en not_active Withdrawn
- 2004-05-13 JP JP2006530499A patent/JP2007500740A/ja not_active Abandoned
- 2004-05-13 WO PCT/GB2004/002073 patent/WO2004101521A1/en not_active Ceased
- 2004-05-13 US US10/557,068 patent/US20070066653A1/en not_active Abandoned
- 2004-05-14 UY UY28319A patent/UY28319A1/es not_active Application Discontinuation
- 2004-05-14 AR ARP040101661A patent/AR044344A1/es unknown
- 2004-05-14 TW TW093113747A patent/TW200507842A/zh unknown
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| RU2317294C2 (ru) | (имидазол-1-илметил)пиридазин в качестве блокатора nmda рецептора | |
| JP2002520416A5 (https=) | ||
| JP2004137288A5 (https=) | ||
| JP2005508349A5 (https=) | ||
| JP2005053931A5 (https=) | ||
| JP2010539151A5 (https=) | ||
| JP2009534471A5 (https=) | ||
| JP2005511547A5 (https=) | ||
| JP2007507494A5 (https=) | ||
| JP2010522710A5 (https=) | ||
| CA2702482A1 (en) | Substituted n-phenyl-bipyrrolidine carboxamides and therapeutic use thereof | |
| JP2002520316A5 (https=) | ||
| JP2003506426A5 (https=) | ||
| JP2004509837A5 (https=) | ||
| JP2003502367A5 (https=) | ||
| JP2023518044A5 (https=) | ||
| JP2005510457A5 (https=) | ||
| JP2005505583A5 (https=) | ||
| RU2005121908A (ru) | Производные зн-хиназолин-4-она | |
| JP2004525184A5 (https=) | ||
| JP2004525178A5 (https=) | ||
| JP2009539874A5 (https=) | ||
| JP2015536965A5 (https=) | ||
| JP2005516898A5 (https=) | ||
| JP2003529597A5 (https=) |