JP2007500730A - 固形癌の増殖状態を画像化するためのシグマ−２受容体ラジオトレーサー - Google Patents
固形癌の増殖状態を画像化するためのシグマ−２受容体ラジオトレーサー Download PDFInfo
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- C07—ORGANIC CHEMISTRY
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- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
- C07D295/125—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/13—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/0497—Organic compounds conjugates with a carrier being an organic compounds
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
- C07C323/39—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton at least one of the nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom
- C07C323/40—Y being a hydrogen or a carbon atom
- C07C323/41—Y being a hydrogen or an acyclic carbon atom
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
- C07D217/04—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
- C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
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- Organic Chemistry (AREA)
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- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
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| Application Number | Priority Date | Filing Date | Title |
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| US49158203P | 2003-07-31 | 2003-07-31 | |
| PCT/US2004/025304 WO2005048810A2 (en) | 2003-07-31 | 2004-07-30 | Sigma-2 receptor radiotracers for imaging the proliferative status of solid tumors |
Publications (2)
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| JP2007500730A true JP2007500730A (ja) | 2007-01-18 |
| JP2007500730A5 JP2007500730A5 (enExample) | 2007-09-13 |
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| JP2006522145A Pending JP2007500730A (ja) | 2003-07-31 | 2004-07-30 | 固形癌の増殖状態を画像化するためのシグマ−２受容体ラジオトレーサー |
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| Country | Link |
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| US (3) | US7390902B2 (enExample) |
| EP (1) | EP1660137A4 (enExample) |
| JP (1) | JP2007500730A (enExample) |
| WO (1) | WO2005048810A2 (enExample) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2010529044A (ja) * | 2007-06-01 | 2010-08-26 | ワシントン・ユニバーシティ | 画像診断における放射性標識フルオロベンズアミドアナログ、それらの合成および使用 |
| US8758724B2 (en) | 2005-11-29 | 2014-06-24 | Nihon Medi-Physics Co., Ltd. | Unnatural amino acid radiolabeling precursor |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7390902B2 (en) | 2003-07-31 | 2008-06-24 | Washington University | Sigma-2 receptor radiotracers for imaging the proliferative status of solid tumors |
| MX2008000447A (es) * | 2005-07-12 | 2008-03-10 | Bayer Cropscience Sa | Nuevos derivados de benzoheterocicliletilbenzamida. |
| US8143222B2 (en) * | 2007-10-22 | 2012-03-27 | Washington University | Modular platform for targeted therapeutic delivery |
| US20090324496A1 (en) * | 2008-06-27 | 2009-12-31 | Tang I-Chung | Radioactive material for inhibiting cancer and preparation method thereof |
| US8506927B2 (en) | 2011-01-05 | 2013-08-13 | Washington University | Pegylated fluorobenzamide analogues, their synthesis and use in diagnostic imaging |
| EP3189041B1 (en) | 2014-09-03 | 2021-04-28 | Ctxt Pty Ltd | Tetrahydroisoquinoline derived prmt5-inhibitors |
| GB201415573D0 (en) | 2014-09-03 | 2014-10-15 | Cancer Therapeutics Crc Pty Ltd | Compounds |
| EP3189048B1 (en) | 2014-09-03 | 2021-03-17 | Ctxt Pty Ltd | Aminoindane-, aminotetrahydronaphthalene- and aminobenzocyclobutane-derived prmt5-inhibitors |
| WO2016178852A1 (en) * | 2015-05-04 | 2016-11-10 | The Trustees Of The University Of Pennsylvania | 211-astatine containing radiotherapeutics for the treatment of cancer |
| GB201604029D0 (en) | 2016-03-09 | 2016-04-20 | Ctxt Pty Ltd | Compounds |
| GB201604020D0 (en) | 2016-03-09 | 2016-04-20 | Ctxt Pty Ltd | Compounds |
| GB201604022D0 (en) | 2016-03-09 | 2016-04-20 | Ctxt Pty Ltd | Compounds |
| GB201604027D0 (en) | 2016-03-09 | 2016-04-20 | Ctxt Pty Ltd | Compounds |
| GB201604031D0 (en) | 2016-03-09 | 2016-04-20 | Ctxt Pty Ltd | Compounds |
| GB201604030D0 (en) | 2016-03-09 | 2016-04-20 | Ctxt Pty Ltd | Compounds |
| CN112898278B (zh) * | 2019-11-19 | 2022-05-13 | 广东医科大学 | Sigma-2荧光配体的制备及应用 |
| EP4202425A1 (en) * | 2021-12-23 | 2023-06-28 | King Faisal Specialist Hospital & Research Centre | Phantom for testing drug-cell interaction |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4197243A (en) * | 1975-04-02 | 1980-04-08 | Yamanouchi Pharmaceutical Co., Ltd. | N-1-Benzyl-3-pyrrolidinyl-4-dimethylamino benzamide derivatives |
| US5294621A (en) * | 1992-10-07 | 1994-03-15 | Ortho Pharmaceutical Corporation | Thieno tetrahydropyridines useful as class III antiarrhythmic agents |
| JP2001502683A (ja) * | 1996-10-18 | 2001-02-27 | ゼノバ リミテッド | 多剤耐性モジュレーターとしてのアントラニル酸誘導体 |
| JP2001522366A (ja) * | 1997-04-30 | 2001-11-13 | スミスクライン・ビーチャム・パブリック・リミテッド・カンパニー | ドーパミンｄ▲上３▼受容体のモジュレーターとしての置換テトラヒドロイソキノリン誘導体 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5911970A (en) * | 1993-05-06 | 1999-06-15 | Research Corporation Technologies, Inc. | Methods for cancer imaging and therapy using benzamine compounds |
| AU724780B2 (en) * | 1996-03-20 | 2000-09-28 | Wake Forest University | Sigma-2 receptors as biomarkers of tumor cell proliferation |
| IL126747A0 (en) * | 1996-05-11 | 1999-08-17 | Smithkline Beecham Plc | Tetrahydroisoquinoline derivatives as modulators of dopamine D3 receptors |
| US7390902B2 (en) | 2003-07-31 | 2008-06-24 | Washington University | Sigma-2 receptor radiotracers for imaging the proliferative status of solid tumors |
| US7612085B2 (en) | 2006-07-11 | 2009-11-03 | Washington University | Sigma 2 receptor ligands and therapeutic uses therefor |
-
2004
- 2004-07-30 US US10/903,771 patent/US7390902B2/en not_active Expired - Fee Related
- 2004-07-30 JP JP2006522145A patent/JP2007500730A/ja active Pending
- 2004-07-30 WO PCT/US2004/025304 patent/WO2005048810A2/en not_active Ceased
- 2004-07-30 EP EP04817745A patent/EP1660137A4/en not_active Withdrawn
-
2008
- 2008-03-08 US US12/044,952 patent/US7612206B2/en not_active Expired - Fee Related
-
2009
- 2009-08-28 US US12/550,220 patent/US7893266B2/en not_active Expired - Fee Related
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4197243A (en) * | 1975-04-02 | 1980-04-08 | Yamanouchi Pharmaceutical Co., Ltd. | N-1-Benzyl-3-pyrrolidinyl-4-dimethylamino benzamide derivatives |
| US5294621A (en) * | 1992-10-07 | 1994-03-15 | Ortho Pharmaceutical Corporation | Thieno tetrahydropyridines useful as class III antiarrhythmic agents |
| JP2001502683A (ja) * | 1996-10-18 | 2001-02-27 | ゼノバ リミテッド | 多剤耐性モジュレーターとしてのアントラニル酸誘導体 |
| JP2001522366A (ja) * | 1997-04-30 | 2001-11-13 | スミスクライン・ビーチャム・パブリック・リミテッド・カンパニー | ドーパミンｄ▲上３▼受容体のモジュレーターとしての置換テトラヒドロイソキノリン誘導体 |
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8758724B2 (en) | 2005-11-29 | 2014-06-24 | Nihon Medi-Physics Co., Ltd. | Unnatural amino acid radiolabeling precursor |
| JP5635225B2 (ja) * | 2005-11-29 | 2014-12-03 | 日本メジフィジックス株式会社 | 放射性ハロゲン標識有機化合物の前駆体化合物 |
| US9381259B2 (en) | 2005-11-29 | 2016-07-05 | Nihon Medi-Physics Co., Ltd. | Precursor compound of radioactive halogen-labeled organic compound |
| US9387266B2 (en) | 2005-11-29 | 2016-07-12 | Nihon Medi-Physics Co., Ltd. | Precursor compound of radioactive halogen-labeled organic compound |
| US10010632B2 (en) | 2005-11-29 | 2018-07-03 | Nihon Medi-Physics Co., Ltd. | Precursor compound of radioactive halogen-labeled organic compound |
| US10953112B2 (en) | 2005-11-29 | 2021-03-23 | Nihon Medi-Physics Co., Ltd. | Precursor compound of radioactive halogen-labeled organic compound |
| US11083804B2 (en) | 2005-11-29 | 2021-08-10 | Nihon Medi-Physics Co., Ltd. | Precursor compound of radioactive halogen-labeled organic compound |
| JP2010529044A (ja) * | 2007-06-01 | 2010-08-26 | ワシントン・ユニバーシティ | 画像診断における放射性標識フルオロベンズアミドアナログ、それらの合成および使用 |
Also Published As
| Publication number | Publication date |
|---|---|
| US20050107398A1 (en) | 2005-05-19 |
| WO2005048810A3 (en) | 2005-09-09 |
| US20090041663A1 (en) | 2009-02-12 |
| WO2005048810A2 (en) | 2005-06-02 |
| US7390902B2 (en) | 2008-06-24 |
| EP1660137A2 (en) | 2006-05-31 |
| EP1660137A4 (en) | 2008-11-12 |
| US7893266B2 (en) | 2011-02-22 |
| US7612206B2 (en) | 2009-11-03 |
| US20100028936A1 (en) | 2010-02-04 |
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