JP2007290992A - ハンセン病発症予防作用のある菌体含有組成物 - Google Patents
ハンセン病発症予防作用のある菌体含有組成物 Download PDFInfo
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- JP2007290992A JP2007290992A JP2006119175A JP2006119175A JP2007290992A JP 2007290992 A JP2007290992 A JP 2007290992A JP 2006119175 A JP2006119175 A JP 2006119175A JP 2006119175 A JP2006119175 A JP 2006119175A JP 2007290992 A JP2007290992 A JP 2007290992A
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- A—HUMAN NECESSITIES
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- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/135—Bacteria or derivatives thereof, e.g. probiotics
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Abstract
【解決手段】本発明による組成物は、ヒトを含む動物腸内または発酵食品から分離されるグラム陽性細菌の少なくとも1種以上を有効成分として含んでなるものであって、生体におけるらい菌の増殖抑制または低減に用いられるものである。
【選択図】なし
Description
本発明は、ハンセン(Hansen)病発症予防作用のある菌体含有組成物に関する。より詳しくは、本発明は、ヒトを含む動物腸内または発酵食品から分離されるグラム陽性細菌からなる群より選択される細菌を含んでなる組成物に関する。また本発明は、ハンセン病発症予防作用のある飲食品に関する。
ハンセン病とは、らい菌(Mycobacterium leprae)によって、主に皮膚や末梢神経が冒される感染症の一つである。我が国においては年間10名以下程度の発症例が報告される程度であるが、発展途上国においてはハンセン病罹患者がなお数百万人いるとも言われている。
エンテロコッカス・フェカリス・EC−12株(Enterococcus faecalis EC-12)は、平成17年(2005年)2月25日(原寄託日)付で独立行政法人産業技術総合研究所 特許生物寄託センター(〒305-5466 日本国茨城県つくば市東1丁目1番地1 中央第6)に寄託された。受託番号は、FERM BP−10284である。
本発明による組成物および飲食品の有効成分は、前記したように、少なくとも1種以上の、ヒトを含む動物腸内または発酵食品から分離されるグラム陽性細菌である。この細菌は、乳酸を生成するグラム陽性細菌、所謂、乳酸菌である。
なおここで「変異株」とは、特定の菌株に対し、当業者に周知の方法により当業者がその性質に変化を及ぼさない範囲で変異させたもの、あるいは、それと同等であると当業者が確認できるものを包含する意味である。
本発明による有効成分は、生体におけるらい菌の増殖抑制または低減させる効果を有する。すなわち、後述する実施例に示されるように、本発明による有効成分は、らい菌感染に対して感受性の高いラットに摂取させることによって、らい菌の感染における生体でのらい菌増殖を抑制する作用があるが実際に確認されている(実施例、図1および図2)。すなわち、本発明による有効成分の投与群と非投与群のラットの所見より、本発明による組成物によってらい菌感染に伴う病態の進行が軽減されたことが確認された。このように、本発明による有効成分は、ハンセン病またはこれに関連する状態を予防、進行抑制する効果を実際に示した。よって、本発明における有効成分は、らい菌に感染した患者または感染する可能性の高い者に対し、その感染に伴う症状、例えば腫脹の軽減等といった症状の進行抑制、症状の緩和、改善効果をもたらすことができ、さらには症状の治療効果も期待できる。また本発明の有効成分は、毒性も低く、哺乳動物に対し安全に用いることができる。
本発明による組成物は、前記した有効成分として含んでなるものである。
実験には、らい菌(Mycobacterium leprae(M.leprae))の感染に対して感受性の高いSHR/NCrj−rnuヌードラットを用いた。なお、このラットは、本発明者らを含む関連機関より容易に入手可能であるが、当業者であれば、必要に応じて公知文献("Leprosy in hypertensive nude rat(SHR/NCrj-run)", Yasuko Yogi et al., International Journal of Leprosy and Other Mycobacterial Diseases, 67:435-445,1999)を参照することによって、容易に作出することができる。また、本発明の有効成分に相当する成分としては、EC−12株の殺菌菌体粉末を使用した。このEC−12株の加熱処理による殺菌菌体粉末としては、EC−12(商品名)(コンビ株式会社製)を用いた。
したがって、これらの結果は、EC−12摂取によって、らい菌の増殖が抑制されることを強く示唆するものといえる。
Claims (13)
- ヒトを含む動物腸内または発酵食品から分離されるグラム陽性細菌の少なくとも1種以上を有効成分として含んでなる、生体におけるらい菌の増殖抑制または低減に用いられる、組成物。
- 細菌が、エンテロコッカス属(Enterococcus)、ビフィドバクテリウム属(Bifidobacterium)、ラクトバシルス属(Lactobacillus)、ストレプトコッカス属(Streptococcus)、および、ラクトコッカス属(Lactococcus)に属する細菌からなる群より選択される、請求項1に記載の組成物。
- 細菌が、エンテロコッカス属に属する細菌である、請求項1に記載の組成物。
- 細菌が、エンテロコッカス・フェカリス・EC−12株(Enterococcus faecalis EC-12)(受託番号FERM BP−10284)またはその変異株である、請求項1に記載の組成物。
- 細菌が死菌体である、請求項1〜4のいずれか一項に記載の組成物。
- ハンセン病またはこれに関連する状態の予防、進行抑制または改善に用いられる、請求項1〜5のいずれか一項に記載の組成物。
- らい菌に感染もしくは感染の疑いのある患者、またはらい菌に感染する可能性の高い環境に置かれた者における、ハンセン病またはこれに関連する状態の予防、進行抑制または改善に用いられる、請求項1〜5のいずれか一項に記載の組成物。
- 経口摂取されるものである、請求項1〜7のいずれか一項に記載の組成物。
- 医薬組成物である、請求項1〜8のいずれか一項に記載の組成物。
- 請求項1〜8のいずれか一項に記載の組成物を含んでなる、飲食品。
- 請求項1に記載の有効成分を有効量含んでなる、飲食品であって、
生体におけるらい菌の増殖抑制または低減に用いられる、飲食品。 - 請求項1に記載の有効成分を有効量含んでなる、飲食品であって、
ハンセン病またはこれに関連する状態を予防、進行抑制または改善する機能が表示された、飲食品。 - 健康食品、機能性食品、特定保健用食品、栄養補助食品、疾病リスク低減表示が付された食品、または病者用食品である、請求項10〜12のいずれか一項に記載の飲食品。
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