JP2007289727A5 - - Google Patents
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- JP2007289727A5 JP2007289727A5 JP2007161999A JP2007161999A JP2007289727A5 JP 2007289727 A5 JP2007289727 A5 JP 2007289727A5 JP 2007161999 A JP2007161999 A JP 2007161999A JP 2007161999 A JP2007161999 A JP 2007161999A JP 2007289727 A5 JP2007289727 A5 JP 2007289727A5
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- JP
- Japan
- Prior art keywords
- replacement
- replacement structure
- region
- skeleton
- dimensional
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000000835 fiber Substances 0.000 claims 6
- 238000009954 braiding Methods 0.000 claims 5
- 238000000034 method Methods 0.000 claims 4
- 210000003041 ligament Anatomy 0.000 claims 3
- 229920000954 Polyglycolide Polymers 0.000 claims 2
- 238000002513 implantation Methods 0.000 claims 2
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 claims 2
- 229920000747 poly(lactic acid) Polymers 0.000 claims 2
- 239000004633 polyglycolic acid Substances 0.000 claims 2
- 239000004626 polylactic acid Substances 0.000 claims 2
- 210000001264 anterior cruciate ligament Anatomy 0.000 claims 1
- 229920001577 copolymer Polymers 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 150000002148 esters Chemical class 0.000 claims 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 1
- 235000014655 lactic acid Nutrition 0.000 claims 1
- 239000004310 lactic acid Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000011159 matrix material Substances 0.000 claims 1
- 238000010899 nucleation Methods 0.000 claims 1
- 229920001432 poly(L-lactide) Polymers 0.000 claims 1
- 229920000642 polymer Polymers 0.000 claims 1
- 239000011148 porous material Substances 0.000 claims 1
- 230000002062 proliferating effect Effects 0.000 claims 1
- 238000002054 transplantation Methods 0.000 claims 1
Claims (15)
- 三次元編組方法を用いて形成された、多孔性の、繊維ベース三次元編組骨格を含む靭帯のための置換構造物であって、前記編組骨格が、患者への移植のために前記骨格を付着させるための第１および第２の端面および中間領域を含み、前記中間領域は、サイズ、編組角、気孔率および機械強度の１または２以上において前記端面と異なる、前記置換構造物。
- 損傷位置への移植を含むヒトにおいて損傷した靭帯の修復に使用されることを特徴とする、請求項１に記載の置換構造物。
- （ａ）組織培養において、採取した前十字宿主細胞を増殖させることおよび継代すること、および
（ｂ）三次元編組方法を用いて形成された、多孔性の三次元編組骨格に培養前十字宿主細胞を播種すること（前記編組骨格が、患者への移植のために前記骨格を付着させるための第１および第２の端面および中間領域を含み、前記中間領域は、サイズ、編組角、気孔率および機械強度の１または２以上において前記端面と異なる）、
を含む、マトリックス中の生存細胞から構成される靭帯のための置換構造物を製造する方法。 - 少なくとも１つの領域の断面が実質環状である、請求項１に記載の置換構造物。
- 少なくとも１つの領域の断面が実質矩形である、請求項１に記載の置換構造物。
- 繊維がポリ（ヒドロキシ）エステルを含む、請求項１に記載の置換構造物。
- 繊維がポリ乳酸、ポリグリコール酸、またはポリ乳酸およびポリグリコール酸のコポリマーを含む、請求項１に記載の置換構造物。
- 繊維が少なくとも１種の乳酸ポリマーを含む、請求項１に記載の置換構造物。
- 繊維がポリ−Ｌ−乳酸を含む、請求項１に記載の置換構造物。
- 編組骨格が、束あたり１０〜６０繊維を含む複数の束から形成される、請求項１に記載の置換構造物。
- 少なくとも１つの領域が５４％〜６３％の平均気孔率を有する、請求項１に記載の置換構造物。
- 少なくとも１つの領域が平均１７７μｍ〜２５０μｍの孔の直径を有する、請求項１に記載の置換構造物。
- 三次元編組方法が、ロウとカラム配列の織機を使用する、請求項１に記載の置換構造物。
- 三次元編組方法が、環状編組機を使用する、請求項１に記載の置換構造物。
- 前十字靭帯の修復、復元または置換に適合する、請求項１に記載の置換構造物。
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US19199900P | 2000-03-24 | 2000-03-24 | |
| US60/191,999 | 2000-03-24 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001570204A Division JP4452426B2 (ja) | 2000-03-24 | 2001-03-22 | 靭帯置換構造物並びにその製造方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2007289727A JP2007289727A (ja) | 2007-11-08 |
| JP2007289727A5 true JP2007289727A5 (ja) | 2010-03-04 |
| JP4897583B2 JP4897583B2 (ja) | 2012-03-14 |
Family
ID=22707811
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001570204A Expired - Fee Related JP4452426B2 (ja) | 2000-03-24 | 2001-03-22 | 靭帯置換構造物並びにその製造方法 |
| JP2007161999A Expired - Fee Related JP4897583B2 (ja) | 2000-03-24 | 2007-06-20 | 靭帯置換構造物並びにその製造方法および使用 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001570204A Expired - Fee Related JP4452426B2 (ja) | 2000-03-24 | 2001-03-22 | 靭帯置換構造物並びにその製造方法 |
Country Status (9)
| Country | Link |
|---|---|
| EP (1) | EP1272127B1 (ja) |
| JP (2) | JP4452426B2 (ja) |
| AT (1) | ATE381912T1 (ja) |
| AU (2) | AU2001249322B2 (ja) |
| CA (1) | CA2403983C (ja) |
| DE (1) | DE60132079T2 (ja) |
| DK (1) | DK1272127T3 (ja) |
| ES (1) | ES2299481T3 (ja) |
| WO (1) | WO2001072241A1 (ja) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20020133229A1 (en) | 2000-03-24 | 2002-09-19 | Laurencin Cato T. | Ligament and tendon replacement constructs and methods for production and use thereof |
| US20030212456A1 (en) * | 2002-05-09 | 2003-11-13 | John Lipchitz | Implant for tissue repair |
| US8177839B2 (en) * | 2006-12-27 | 2012-05-15 | Shriners Hospitals For Children | Woven and/or braided fiber implants and methods of making same |
| EP2131880B1 (en) | 2007-02-20 | 2012-08-08 | Shriners Hospitals for Children | In vivo hydraulic fixation including bio-rivets using biocompatible expandable fibers |
| JP5492097B2 (ja) | 2008-02-22 | 2014-05-14 | マイメディクス，インコーポレイテッド | 手首、手及びその他の靱帯置換術又は修復術のために適切なバイオステープル |
| EP2291143B1 (en) | 2008-05-16 | 2020-07-08 | Mimedx, Inc. | Medical constructs of twisted lengths of collagen fibers and methods of making same |
| CA2740008C (en) | 2008-10-09 | 2017-01-31 | Mimedx, Inc. | Methods of making biocomposite medical constructs and related constructs including artificial tissues, vessels and patches |
| JP5653418B2 (ja) | 2009-05-22 | 2015-01-14 | ソフト ティシュー リジェネレイション， インコーポレイテッド | 靱帯および腱の再生のための力学的に応答可能な足場 |
| US9757132B2 (en) * | 2010-03-24 | 2017-09-12 | Biorez, Inc. | Mechanically competent scaffold for rotator cuff and tendon augmentation |
| CA2829339C (en) | 2011-03-08 | 2018-10-16 | Mimedx, Inc. | Collagen fiber ribbons with integrated fixation sutures and methods of making the same |
| US9694106B2 (en) | 2011-07-11 | 2017-07-04 | Mimedx Group, Inc. | Synthetic collagen threads for cosmetic uses including skin wrinkle treatments and associated methods |
| US8986378B2 (en) | 2011-11-02 | 2015-03-24 | Mimedx Group, Inc. | Implantable collagen devices and related methods and systems of making same |
| US9433489B2 (en) | 2013-03-12 | 2016-09-06 | Soft Tissue Regeneration, Inc. | Absorbable synthetic braided matrix for breast reconstruction and hernia repair |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4792336A (en) * | 1986-03-03 | 1988-12-20 | American Cyanamid Company | Flat braided ligament or tendon implant device having texturized yarns |
| US5263984A (en) * | 1987-07-20 | 1993-11-23 | Regen Biologics, Inc. | Prosthetic ligaments |
| EP0306018A1 (en) * | 1987-09-04 | 1989-03-08 | Bio-Products, Inc. | Tendon/ligament substitutes composed of long, parallel, non-antigenic tendon/ligament fibers |
| US5078744A (en) * | 1987-09-04 | 1992-01-07 | Bio-Products, Inc. | Method of using tendon/ligament substitutes composed of long, parallel, non-antigenic tendon/ligament fibers |
| US5376118A (en) * | 1989-05-10 | 1994-12-27 | United States Surgical Corporation | Support material for cell impregnation |
| JP3493199B2 (ja) * | 1993-07-07 | 2004-02-03 | スミス アンド ネフュー ピーエルシー | 埋込型プロステーシス、キットおよびそれを製造するための装置 |
| EP0677297B1 (en) * | 1993-09-24 | 2000-12-13 | Takiron Co. Ltd. | Implantation material |
| GB2282328B (en) * | 1993-09-29 | 1997-10-08 | Johnson & Johnson Medical | Absorbable structures for ligament and tendon repair |
| JPH10505250A (ja) * | 1994-06-06 | 1998-05-26 | ケース ウエスターン リザーブ ユニバーシティ | 組織再生のためのバイオマトリックス |
| US5718012A (en) * | 1996-05-28 | 1998-02-17 | Organogenesis, Inc. | Method of strength enhancement of collagen constructs |
| CA2252860C (en) * | 1996-05-28 | 2011-03-22 | 1218122 Ontario Inc. | Resorbable implant biomaterial made of condensed calcium phosphate particles |
-
2001
- 2001-03-22 EP EP01922531A patent/EP1272127B1/en not_active Expired - Lifetime
- 2001-03-22 WO PCT/US2001/009079 patent/WO2001072241A1/en not_active Ceased
- 2001-03-22 DK DK01922531T patent/DK1272127T3/da active
- 2001-03-22 AT AT01922531T patent/ATE381912T1/de active
- 2001-03-22 AU AU2001249322A patent/AU2001249322B2/en not_active Ceased
- 2001-03-22 CA CA002403983A patent/CA2403983C/en not_active Expired - Lifetime
- 2001-03-22 DE DE60132079T patent/DE60132079T2/de not_active Expired - Lifetime
- 2001-03-22 ES ES01922531T patent/ES2299481T3/es not_active Expired - Lifetime
- 2001-03-22 AU AU4932201A patent/AU4932201A/xx active Pending
- 2001-03-22 JP JP2001570204A patent/JP4452426B2/ja not_active Expired - Fee Related
-
2007
- 2007-06-20 JP JP2007161999A patent/JP4897583B2/ja not_active Expired - Fee Related
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