JP2007262004A - Hair tonic - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a hair tonic free from tackiness and stiffness and having excellent hair-nursing effect. <P>SOLUTION: The hair tonic is obtained by formulating (a) 0.001-10 mass% collagen derived from fishes with (b) 0.0001-5 mass% antiinflammatory agent. In the hair tonic, a uniform film is formed and the antiinflammatory agent which is an active ingredient for hair growth is retained to enhance hair-nursing effect. <P>COPYRIGHT: (C)2008,JPO&INPIT

Description

  The present invention relates to a hair nourishing agent, and more specifically, by adding fish-derived collagen and an anti-inflammatory agent to form a uniform film that is not sticky and non-sticky, and retains an anti-inflammatory agent that is an active ingredient for hair growth. The present invention relates to a hair nourishing agent that suppresses inflammation that causes hair loss caused by lipid peroxide and exhibits an excellent hair nourishing effect.

  Conventionally, various active ingredients such as a vasodilator, a blood flow promoter, a scalp stimulant, a sebum secretion inhibitor, and an anti-inflammatory agent are blended in the hair growth / hair restoration according to its mechanism and purpose. However, there are cases where a sufficient hair nourishing effect cannot be obtained simply by blending these active ingredients.

  In hair nourishing, a method of blending xanthan gum, hyaluronic acid salts, sclerotium gum, clay mineral, collagen-derived material, etc. for the purpose of improving the stability of the active ingredient and the feeling of use (see, for example, Patent Document 1) ), And a method of combining a water-soluble mixture containing α, α-trehalose and a water-soluble polymer, which has been reported for the hair growth effect, with a substance commonly used as a component of a hair restorer (for example, Patent Documents 2 to 4). Etc.) have been proposed. However, hair restorations containing water-soluble polymers that have been used in the past feel the stickiness and stiffness unique to the polymers, and the film formation effect cannot be expected so much that sufficient retention of the active ingredients cannot be expected. There was a problem that the hair effect was not sufficiently exhibited.

On the other hand, it has been known that collagen, which has been widely used as a cosmetic raw material, has a moisture retention ability and a film-forming ability, so that it improves skin moisture retention and is effective for tissue regeneration. Recently, marine collagen derived from fish and the like has attracted attention as an alternative to collagen derived from animals such as cattle and pigs, which has been mainly used so far, and its amino acid composition is similar. Protein denaturation temperature is related to the living environment of the organism from which it is derived, and in general, knowledge has been obtained that marine collagen derived from fish and the like is lower than animal-derived collagen (for example, non-patent literature) 2).
Cosmetics Handbook Published by Nikko Chemicals Co., Ltd. Published November 1, 1996, pages 471-488 Fragrance Journal Fragrance Journal, Inc. 1997-7 81-85 JP-A-2005-53784 Japanese Patent Laid-Open No. 10-7529 JP-A-10-279438 JP-A-10-279439

  Accordingly, an object of the present invention is to develop a hair nourishing agent that takes advantage of the characteristics of fish-derived collagen, has no stickiness or wrinkle, retains an active ingredient for hair growth, and exhibits an excellent hair nourishing effect.

In view of such circumstances, as a result of intensive studies to solve the above problems, the present inventor forms a uniform film without stickiness and stickiness by blending a specific amount of collagen derived from fish and an anti-inflammatory agent. And it became possible to retain the anti-inflammatory agent which is one of the active ingredients of hair growth, and discovered that the outstanding hair nourishing agent was obtained, and came to complete this invention.
That is, the present invention includes the following components (a) and (b):
(A) 0.001 to 10% by mass of fish-derived collagen,
(B) Anti-inflammatory agent 0.0001-5 mass%
A hair nourishing agent is provided.
Further, the present invention provides a hair nourishing product having a protein denaturation temperature peak of 40 ° C. or lower.

  The hair nourishing agent of the present invention has a non-sticky and uniform film, can retain an anti-inflammatory agent that is an active ingredient for hair growth, and can suppress inflammation that causes hair loss caused by lipid peroxide. Exhibits excellent hair nourishing effect.

The fish-derived collagen of component (a) used in the present invention is collagen originating from fish, and the type of fish, the site of use, the preparation method, etc. are not particularly limited as long as it is collagen obtained from fish. Native collagen that is extracted from the skin, bones, and floats of teleost fish such as sardines and tuna according to a conventional method and is not subjected to enzyme treatment such as protease is preferred.
By blending the fish-derived collagen of component (a), it is possible to form a uniform film that is not sticky and non-sticky, and to retain component (b), which is an active ingredient for hair growth, and has an excellent hair restoration effect Is obtained.
In addition, the fish-derived collagen of component (a) of the present invention preferably has a protein denaturation temperature peak of 40 ° C. or less by differential thermal analysis, more preferably around human body temperature (36 ° C.). When this is blended into a hair nourishing agent, it is denatured at body temperature by application, and forms a uniform and non-sticky film with excellent sealing power, so that the retention of component (b) can be further improved, and excellent nourishing Hair effect is obtained.
As a commercial item of a component (a), PANCOGEN MARINE (The modification | denaturation temperature peak of a protein: 38 degreeC by GATTEFOSSE company) etc. are mentioned.

  The compounding amount of the fish-derived collagen of the component (a) used in the present invention is 0.001 to 10% by mass (hereinafter simply referred to as “%”), and more preferably 0.01 to 5%. Within this range, the scalp and hair after application do not become sticky, form a uniform, non-stiff film with excellent sealing power, and without causing problems such as coloring, odor and precipitation due to collagen. The anti-inflammatory agent (b) can be retained, and an excellent hair nourishing effect can be obtained together with the tissue regeneration effect of the component (a).

On the other hand, the anti-inflammatory agent of component (b) used in the present invention is known to be one of the causes of hair loss due to inflammation by lipid peroxide in the scalp. It is something that works. The component (b) is not particularly limited as long as it exhibits an anti-inflammatory action. Specifically, glycyrrhizic acid, glycyrrhetinic acid, mefenamic acid, phenylbutazone, indomethacin, ibuprofen, ketoprofen , Allantoin, guaiazulene and their derivatives and their salts, ε-aminocaproic acid, zinc oxide, diclofenac sodium, aloe extract, sicon extract, salvia extract, arnica extract, chamomile extract, birch extract, hypericum extract , Eucalyptus extract and mukuroji extract, etc., such as glycyrrhizic acid, glycyrrhetinic acid, allantoin, guaiazulene and derivatives thereof, and salts thereof, ε-aminocaproic acid, sicon extract, arnica extract, chamomile extract, eucalypt Re-extraction is more preferred.
Among these, in the case of a plant extract, the extraction method is not particularly limited, and any one such as pressing or solvent extraction can be used. In the case of solvent extraction, the above plant is extracted by a conventional method using one or more extraction solvents such as water, lower monohydric alcohol, polyhydric alcohol, lower alkyl ester, hydrocarbon, ether and the like. be able to.
The anti-inflammatory agent of a component (b) can be used 1 type, or 2 or more types as needed.

  The compounding quantity of the anti-inflammatory agent of the component (b) used for this invention is 0.0001 to 5% in conversion to dry solid content, More preferably, it is 0.001 to 3%. If it is this range, the anti-inflammatory agent which is a component (b) can be retained by combined use with a component (a), the inflammation which causes the hair loss produced by a lipid peroxide can be suppressed, and the hair growth effect is fully exhibited. Is done.

In addition to the above essential components, the hair nourishing agent of the present invention has purified water, lower alcohols, polyhydric alcohols, fats and oils, surface activity, in a qualitative and quantitative range that does not impair the effects of the present invention. Agents, cosmetic ingredients, ultraviolet absorbers, thickeners, pigments, preservatives, fragrances, and the like that are usually used in cosmetics can be appropriately blended.
In addition, vasodilators, female hormone agents, skin function enhancers, topical stimulants, keratolytic agents, vitamins, amino acids, plant extracts other than the above, moisturizers, etc., which are generally known as medicinal agents for hair restoration You may mix according to.

Examples of the form of the hair nourishing agent of the present invention include various types of hair nourishing agents such as emulsions, creams, lotions, gels, aerosols, etc., which are generally known as hair nourishing agents, and hair tonics, hair liquids, hair lotions, hairs. It can be appropriately prepared and used for cream, hair mist, hair spray and the like.
Furthermore, there is no restriction | limiting in particular as a usage method of the hair nourishing agent of this invention, According to a dosage form, an appropriate amount may be picked up and applied to a scalp, hair, or it may be made to spray, but the fish of component (a) Store the hair nourishing agent of the present invention at room temperature or lower and rub it on the hair root or scalp so that the protein is denatured when applying the characteristics of the collagen derived to form a film and the retention of the component (b) is increased. Then it is more effective.

  EXAMPLES Next, although an Example is given and this invention is demonstrated further, this invention is not limited at all by these.

Example 1 (Invention Products 1 to 4 and Comparative Products 1 to 3): Hair Lotion A hair lotion having the composition shown in Table 1 below was prepared by the following production method, (1) No stickiness, (2) No stiffness (3) The hair restoration effect was evaluated by the following method, and the evaluation results are shown in Table 1.

(Manufacturing method)
A: Components (1) to (3) and component (5) are mixed uniformly.
B: Component (4) was added to A and mixed uniformly to obtain a hair lotion.

[Evaluation methods: (1) No stickiness, (2) No stickiness]
Twenty cosmetic panels specially used the hair lotions of the present invention products 1 to 4 and comparative products 1 to 3 to evaluate the feeling of use and uniform film formation, respectively (1) No stickiness (2) The non-stiffness was sensory-evaluated according to the following (b) 5-step evaluation criteria, and the average score of all panels was determined using (b) 4-step evaluation criteria.
(B) Five-level evaluation criteria (Evaluation): (Grade)
Very good: 5 points Good: 4 points Normal: 3 points Defect: 2 points Very bad: 1 point (b) Four-step criteria (average of all panel scores): (Judgment)
Average score of 4.5 or more: ◎
Average score of 3.5 or more and less than 4.5: ○
Average score of 2.5 or more and less than 3.5: △
Average score of 2.5 or less: ×

[Evaluation method: (3) Hair restoration effect]
As the hair nourishing effect, non-patent document 1 and references cited therein were referred to, and the hair nourishing effect was evaluated by confirming the effect of preventing hair loss by the following method.
That is, a panel test was conducted with 10 panelists as one group, and the hair lotions of the present invention products 1 to 4 and comparative products 1 to 3 were applied to the scalp.
The period of use was 8 weeks, during which time the panel was washed daily, and then each of the hair lotions of the products 1 to 4 of the present invention and the comparative examples 1 to 3 was applied to the scalp. Wash hair every day from 10 days before starting use, count the number of hair loss at the time of washing every other day, and use the average of the total of 5 measurements as the number of hair loss before application, and also after 8 weeks use The hair was washed every day in the same manner as before the start, and the number of hair loss at the time of shampooing was counted every other day, and the average value of a total of 5 measurements was taken as the number of hair loss after application.
The number of hair loss before application and the number of hair loss after application are compared, and the effect of preventing this loss is evaluated according to the following (c) 5-step evaluation criteria, and the average score of all panels is (d) Judgment was made using a 4-step criterion.
(C) Five-level evaluation criteria (Evaluation): (Grade)
Hair loss decreased by 20 or more: 5 points Hair loss decreased by 15 or more and less than 20: 4 points Hair loss decreased by 5 or more and less than 15: 3 points Hair loss decreased by less than 5: 2 points Hair loss increased by 5 or more: 1 Points (d) Four-step criteria (average score of all panels): (Judgment)
Average score of 4.5 or more: ◎
Average score of 3.5 or more and less than 4.5: ○
Average score of 2.5 or more and less than 3.5: △
Average score of 2.5 or less: ×

  As is clear from the results in Table 1, the hair lotions of the present invention products 1 to 4 which are the present invention products have no stickiness or wrinkle and are excellent in hair restoration effect compared to the hair lotions of the comparative products 1 to 3. It was a hair lotion. On the other hand, the comparative product 1 in which the fish-derived collagen of the component (a) is not blended cannot retain the component (b), which is an active ingredient for hair growth, and contains a large amount of the component (b). Regardless, the hair restoration effect was inferior. Comparative product 2 containing bovine-derived collagen instead of component (a) was stiff and lacked uniformity of the film, and was inferior in stickiness and hair-restoring effect. In addition, Comparative Product 3 which does not contain the anti-inflammatory agent of component (b) has good tackiness and non-stickiness, and although the hair restoration effect by component (a) is slightly seen, it is not satisfactory. There wasn't.

Example 2: Hair liquid (component) (%)
1. Polyoxypropylene butyl ether phosphate (35 PO) 9
2. Polyoxypropylene monobutyl ether (60 PO) 10
3. Triethanolamine 1
4). Fish-derived collagen (Note 1) 2
5). Silicon extract (Note 5) 2
6). Stearyl glycyrrhetinate (Note 6) 0.2
7). Ethyl alcohol 30
8). Perfume appropriate amount 9. Purified water Remaining Note 5: Shikon Extract Ichimaru Falcos Note 6: Sea Augretinol Maruzen Pharmaceutical Co., Ltd.

(Manufacturing method)
A: Components (3) to (6) and component (9) are mixed uniformly.
B: Components (1) and (2) and components (7) and (8) are mixed uniformly.
C: B was added to A and mixed uniformly to obtain a hair liquid.

  The hair liquid of Example 2 was a hair liquid that had no stickiness, formed a uniform film without stiffness, and had an excellent hair nourishing effect.

Example 3: Hair cream
(Ingredient) (%)
1. Beeswax 1
2. Liquid paraffin 50
3. Stearic acid 3
4). Sorbitan sesquioleate 2
5). Monolauric acid polyoxyethylene sorbitan (20E.O.) 1.5
6). Fish-derived collagen (Note 1) 2
7). Chamomile extract (Note 7) 1
8). Perfume appropriate amount 9. Methyl paraoxybenzoate Appropriate amount10. Purified water remaining amount Note 7: Chamomile extract (manufactured by Koei Kogyo Co., Ltd.)

(Manufacturing method)
A: Components (1) to (5) are uniformly mixed at 70 ° C.
B: A part of component (9) and component (10) is heated to 70 degreeC.
C: A is added to B, emulsified and cooled.
D: The components (6), (7) and the remainder of the component (10) are mixed uniformly.
E: D and (8) were added to C and mixed uniformly to obtain a hair cream.

  The hair cream of Example 3 was a hair cream that had no stickiness, formed a uniform film without stiffness, and had an excellent hair nourishing effect.

Claims (2)

The following components (a), (b);
(A) Collagen derived from fish 0.001-10% by mass
(B) Anti-inflammatory agent 0.0001-5 mass%
A hair nourishing agent characterized by blending.   2. The hair nourishing product according to claim 1, wherein the protein (a) has a denaturation temperature peak of 40 ° C. or lower.