JP2002068976A - Composition for human body, formulated with alkaline guanidine - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain a new alkaline agent for applying to human body, such as in cosmetics, excellent in cleaning effect, penetrability and swelling property for the skin and hair and, on the other hand, hardly exhibiting irritating tendency and retainability. SOLUTION: This composition for human body, which contains the new alkaline agent, is such one as to be formulated with guanidine hydroxide and guanidine carbonate and, concretely, is used as a pimple treating agent, a body shampoo, a soap, a depilating agent, a bleaching agent, a hair decolorant, a hair dye, a permanent wave lotion, or the like. Guanidine is a water-soluble and oil-soluble alkali, so, highly compatible with the composition and capable of increasing its alkalinity to >=pH 13 and has swelling action on the tissue, is not retainable and also has no problem of toxicity and environmental pollution.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

The compositions produced according to the invention are:
It is used for the mucous membranes, skin, and hair of the human body, and falls under the category of drugs, quasi-drugs, and cosmetics according to the Ministry of Health and Welfare standards. Cold cream, moisturizing cream, nourishing cream,
Cleansing cream, face wash, soap, shampoo,
Rinse, foundation, whitening, makeup cosmetics, pack cosmetics, shaving cream, foaming cosmetics,
It is applied to so-called human body compositions such as skin whitening cosmetics, ultraviolet protection cosmetics, hair styling cosmetics, hair restorer for hair, hair bleaching agent, hair dye, permanent wave agent (hereinafter referred to as perm agent), hair remover.

[0002]

2. Description of the Related Art Alkali agents are almost completely incorporated in the preparation of the above-mentioned composition for human body.
The alkali agent is necessary for adjusting the liquid properties of the composition, and also affects the feel of cosmetics such as viscosity, spreading, and smoothness of texture. In the case of hair dyes and depilatory agents, the alkalinity is one factor that affects the efficacy. Alkali content on the skin
It acts on mucous membranes and hair, swells and softens them, makes the penetration of the target drug more effective, and has the action of removing waste products. However, if the alkali is made too strong, it will attack the skin, mucous membranes and hair. Therefore, in the composition for the human body, at the time of its blending, a substance that binds to the alkali agent and relaxes the action is added, but at this time, the amount of the alkali is also appropriate, and the type of the alkali affects the feel of the composition. The impact is great.

Conventionally used alkaline agents include hydroxides of alkali metals and earth metals of caustic potash, caustic soda and slaked lime, alkali metal carbonates of sodium carbonate, potassium carbonate and sodium sesquicarbonate, sodium polyphosphate and triphosphate. Sodium phosphate of sodium, ammonia water, monoethanolamine, triethanolamine,
Alkanolamines such as isopropanolamine / aminomethylpropanediol / aminohydroxymethylpropanol / aminoethylethanolamine and acetylethanolamine; and aliphatic amines such as morpholine, dioctylamine and isopropylamine.

Conventionally, guanidine soap produced by neutralizing fatty acids has been reported in human products using guanidine. However, the details are unknown, except that it is used for infants with weak skin because it is mild. Guanidine carbonate is listed in the Permissible Criteria for Cosmetic Varieties, but does not describe under what conditions it is used or how it is effective. The presence of guanidine hydroxide is known to the extent that it has no known use.

[0005]

Problems to be Solved by the Invention The above-mentioned alkalis have different characteristics, and are naturally selected depending on the purpose of use of the composition, but they cannot always be said to be completely satisfactory. The pH of the aqueous solution
Reached 13.5 or more, the highest alkalinity combined with higher fatty acids to form soap,
Since the OH group is also weakly bonded, the composition becomes fine and contributes to homogeneity, and the separation phenomenon can be prevented. Even with inorganic alkalis, the composition appears to be more firmly finished with Na ⁺ than K ⁺ . Ca (OH) ₂ has low solubility and is not used much except for use as a depilatory. The disadvantage of these caustic alkalis is that they are easily adsorbed by the human body. For example, if they are used in hair, the alkalis remaining in the hair will cause the hair to turn reddish or torn at a later time. Therefore, in a permanent or hair dye, ammonia is preferred as an alkaline source. Alkali carbonate has a pH of 10.
At about 5, there is a disadvantage that the neutralization becomes insufficient as R increases with the fatty acid, and the texture of the prepared composition is coarse, and in the case of cosmetics, the feel when applied is poor.
In the case of alkali phosphate, the pH is about 12.0, and the alkalinity is not so high, but depending on the preparation, a fine texture may be obtained. There are some places that cannot be explained theoretically, such as beeswax and sodium borate, which have excellent smoothness. In the case of alkali phosphate, it becomes a social problem of eutrophication of wastewater and is difficult to use in the cosmetics industry. Ammonia water has a pH of about 9.8 and naturally does not make soap and does not contribute to the feel of the composition. After applying to the hair, it can be easily removed by washing,
Also, when heat blown to finish, it will volatilize, so that it does not remain. However, low alkalinity,
The unusual odor is a disadvantage. Alkanolamines such as triethanolamine and monoethanolamine have a maximum pH of 9.6 and a low alkalinity. If the composition containing ammonia does not like odors, it is often replaced with this product. Viscosity is high and there is a slimy feeling, which may be opposite to good. Morpholine is an organic liquid and can bind fatty acids. However, since it is irritating to the skin and has a strong off-flavor, it is not often used in personal care products. Aliphatic amines such as dioctylamine and isopropylamine exhibit alkalinity in liquid properties but have an odor, and have a surface activity, but are rarely used. Further, even though aromatic amines show alkali, they are toxic and therefore cannot be used for human body compositions. Guanidine carbonate has a low alkalinity at around pH 10. Although there are few reports of its use results, according to the study of the present inventors, there is little adsorption to skin and hair and no odor. It is a remarkable compound because it has very mild sensitization to human skin and has no toxicity.

[0006] In the preparation of a composition for the human body, an alkaline agent is one of important agents, but does not remain on the skin or hair after use, has a high degree of alkalinity, has no odor, and has hair loss. Among the agents, hair dyes and perm agents, those having a swelling action on the hair are preferred. Of course, there should be no toxicity or sensitization, and it should be considered that it has no adverse effect on the environment. In this sense, alkali agents other than those listed above are desired.

[0007]

The inventor of the present invention has searched for an alkaline agent satisfying the above-mentioned object, and has come to assume quanidine. Guanidine exhibiting alkalinity includes (1) guanidine hydroxide and (2) guanidine carbonate.

[0008] Guanidine hydroxide is formed when guanidine (NH ₂ ) ₂ C = NH obtained by heating ammonium thiocyanate or by reacting ammonia with ethyl orthocarbonate is dissolved in water. NH ₄ SCN + NH ₃ → (NH ₂ ) ₂ C = NH + H ₂ S (I) (NH ₂ ) ₂ C = NH + H ₂₀ (NH ₂ ) ₂ C = NH ₂ OH (II) Guanidine hydrochloride obtained by melting and reacting dicyandiamide and ammonium chloride at around 180 ° C. is dissolved in alcohol, and an equivalent amount of sodium hydroxide is dissolved.
An alcohol solution is added, and the salt generated by the substitution reaction is removed by filtration, whereby an alcohol solution of guanidine hydroxide is obtained. The aqueous solution of guanidine hydrochloride can also be obtained by an ion transfer method using an ion exchange membrane. HN = C (NH ₂ ) NHCN + 2NH ₄ Cl → 2 [(NH ₂ ) ₂ C = NH—HCl] ＜<III> (NH ₂ ) ₂ C = NH · HCl + NaOHＯＨ (NH ₂ ) ₂ C = NH ₂ OH + NaCl <IV> Calcium carbonate produced by adding calcium hydroxide to an aqueous solution of guanidine carbonate can be obtained by filtration. When the guanidine inorganic acid salt and the inorganic alkali hydroxide are in an aqueous solution, guanidine hydroxide is present due to an equilibrium reaction. Guanidine carbonate is obtained by reacting guanidine hydroxide with carbon dioxide gas.

Guanidine hydroxide (NH ₂ ) ₂ C = NH ₂
OH <MW: 77.07> About 30 in water or alcohol
% Is the limit, and at room temperature, no higher concentration decomposes. Due to the high degree of dissociation, it shows strong alkali and one basicity. Guanidine carbonate [(NH ₂ )
₂ C = NH] ₂ H ₂ CO ₃ <MW = 180.17> White crystalline powder. There is another bicarbonate, but the present invention refers to the ortho salt.

The advantages of utilizing the alkaline guanidine compound in the composition for human body are as follows. (1) The aqueous solution of guanidine hydroxide has a pH of 13 or more, and is comparable to sodium hydroxide. Guanidine carbonate, which is used when less is desired, is around pH 9.9,
The action is mild. This drug is well compatible with the other drugs incorporated in the composition and improves the finish of the composition. (2) It has the ability to swell into tissues, so that it can be applied to various nutrients and beautifying agents for the skin, and to the hair as a perm agent and a dye, so that the penetration of the active ingredient is improved. (3) Less residue on hair and skin after use. In observing the structure of both hair and skin, it is known that there are fine folds and holes in which alkali components adhere or penetrate. Some of this adsorption phenomenon is not completely removed even by several washings with alkali, causing tissue damage. It was confirmed that guanidine was easily washed away by washing with water and was decomposed by heating and air-drying. (4) No odor. Ammonia has a bad smell, but it is unavoidably used, but has little residue in tissues and has no particular chronic damage. Morpholine is not only smelling but also sensitizing and should not be used continuously. Guanidine has no smell at this point. (5) Toxicity and environmental pollution. Guanidine is a substance that exists even in the living body, and its oral toxicity is about the same as ammonium chloride. In nature, there are organic matter decomposition circles, and biological proteins become guanidine in the process of decomposing guanine and guanosine acid and decompose to ammonia, so there is no environmental pollution.

Table 1 shows that for some alkalis, p
H shows the results obtained by examining the amount adsorbed on hair and sensitization. The concentration of the aqueous solution of the reagent is 0.5 equivalent / liter

[Table-1] Description of Table-1. pH: Measured at a temperature of 2 ° C. Adhesion rate to hair: 20 g of human hair per 200 ml of aqueous solution
Soak for 0 minutes. This is taken out, drained on a net, then immersed in 200 ml of water, and shaken for 1 minute to take out. Drain and repeat the same four times. 100 ml of a 0.01N sulfuric acid standard solution was added to the hair treated in this manner, and the mixture was shaken for 10 minutes.
Back titrate with 01N sodium hydroxide standard solution. Degree of attached alkali = sulfuric acid standard solution (ml) -sodium hydroxide solution (ml) Sensitization (irritation degree T): phytochamber [Epites
t Ltd. 1% of a 2% aqueous solution of each drug on a piece of filter paper
The sample impregnated with the drop (1/20 g) is attached to the upper arm of the subject, observed 24 hours later, and scored according to the following six-step criteria. Irritation grade Observation at test site 1-No response 0 point 2 ± Mild erythema or uncertain change 1 point 3+ Obvious erythema, minor 2 points 4 ++ Erythema with edema or papule 3 points 5 +++ Erythema with small blisters or rash 4 points 6 +++++ Erythema with large blisters or abnormalities that spread out of the test position 5 points Judgment Performed for x (30 or more), and the number of personnel affected by each grade Is M, T = Σ [M ₁ × 0 +
_{M 2 × 1 + M 3 ×} 2 + M 4 × 3 + M 5 × 4 + M 6 × 6]
From the data in Table 1, it can be demonstrated that guanidine hydroxide is an excellent alkaline agent.

[Description of Components in the Specification] The [A] fat component in the present invention means "oil" in a broad sense. In other words, it is a general term for substances that are not compatible with water (somewhat compatible) and float on water regardless of whether they are liquid or solid.
a) Petroleum and its refined products: for example, gasoline, kerosene, machine oil, liquid paraffin, vaseline, paraffin, isoparaffin, ceresin, microcristan,
Mixed wax, etc. b) Animal and plant derived hydrocarbons: for example squalane, lanolin and lanolin derivatives, lanolin acetate, lecithin, cholesterol, hydrocholesterol, phytosterols and the like. c) Waxes derived from animals and plants:
For example, beeswax, whale wax, gelac wax, wax wax,
Rice wax, carbana wax, jojoba wax, cocoa butter,
etc. d) Fats and oils derived from animals and plants: for example, pork oil, horse oil, tallow and hardened tallow, whale oil, fish oil and hydrogenated fish oil, lard, butter, pupa oil, egg oil, rapeseed oil, coconut oil, olive oil, safflower oil, cottonseed oil , Soybean oil, camellia oil, rice bran oil,
Castor oil, shea butter, etc. e) Plant-derived terpene oils: pine resin, cedar oil, camphor oil, tangerine oil, terpene oil, etc. f) Mono-di-triglycerides: For example, glycerin monocetyl alcohol, neopentyl glycol dioctanoate, glyceryl distearate, glycerin tri (caprylic / capric acid), glyceryl trilaurate, glyceryl oxystearate and the like. g) Glycolides: for example, ethylene glycol distearate, propylene glycol oleate, polyglycol distearate, and the like. h) Polybasic acid esters: for example, diisopropyl adipate, tricetyl citrate, myristyl lactate, pentaerythrit tetramyristate and the like. i) higher alcohol ethers:
Isostearyl octyl ether, diglycerin oleyl ether, j) Fatty acid esters: for example, cetyl octoate, hexyl isostearate, oleyl oleate, isodecyl vivalate, castor oil hardened with isostearic acid and the like. k) higher fatty acids: for example, lauric acid, linoleic acid, myristic acid, stearic acid, erucic acid,
etc. 1) Higher alcohols; for example, lauryl alcohol, stearyl alcohol, cetanol, oleyl alcohol, cetostearyl alcohol, behenyl alcohol, octyldodecanol, jojoba alcohol and the like.
m) Other hydrocarbons: for example, blister, α-olefin oligomer, polyisostyrene, etc. The fat component is present in the composition for the human body, acts itself on the skin, hair, nails and the like to impart color and luster, and also serves as a base constituting the composition. For example, the base of an ointment, the oil component of a cream, and the selection of this combination greatly affects the physical properties of the composition.

Next, the resin component (B) referred to in the present invention is:
It is a natural or synthetic chemical that is polymerized and has a certain degree of high molecular structure. From the viewpoint of its use, it functions as a gelling agent, a thickening agent, a sizing agent, a stabilizer, and a bulking agent for the composition. In addition, it improves the physical action of holding the composition in contact with the human body, and has the effect of directly coating the skin and setting the hair. Although they will be described separately, the main resins made of synthetic compounds are, for example, as follows. a) Acrylic resin and a copolymer thereof with acrylamide, alkyl acrylate, acrylate, alkanolamine, styrene and methacrylic acid. b) Acrylonitrile and butadiene copolymer. c) Copolymers of alkyd resin such as succinic acid type, cyclohexane type and tar acid type. d) Epoxy resins and copolymers with isostearic acid esters, fatty acid esters, fatty acid bisphenols and the like. e) Polyvinyl chloride and copolymers of polyvinyl acetate with crotonic acid and the like. f) Copolymer of carboxyvinyl resin with styrene, methylstyrene, indene, etc.
g) Copolymers of maleic acid with ethylene, isoprene, vinyl methyl ether, and the like. h) Copolymers of vinylpyrrolidone with vinyl acetate, methacrylic acid, styrene, phthalic acid and the like. i) Copolymer of alkyd resin and polyamide epichlorohydrin. j) Co-condensates of polyethylene glycol, epichlorohydrin and fatty alkylamines. k) Resin of polyvinyl alcohol and toluenesulfonamide. 1) Polybutene, polypropylene, m) Collagen keratin and resin condensate.

[0014] The silicones of [C] refer to Si in the molecule.
Organic compounds having the following formulas, which can be used in human body products, such as methylpolysiloxane, methylphenolsiloxane, high-polymerization degree silicone, cyclic silicone, modified silicone, stearoxymethylpolysiloxane, trimethylsiloxysilicic acid, decamethyltesilasiloxane, octa And methylcyclotetrasiloxane. These series of corns are also sold in emulsion form so that they can be easily incorporated into the composition.

Since the solvent [D] includes a very large number, the following are typical examples. Isopentane, hexane,
Isooctene, cyclopentane, cyclohexanol,
Xylene, ethylbenzene, petroleum ether, petroleum benzine, ethanol, propanol, butanol, ethylene glycol, propylene glycol, isobutylene glycol, diethylene glycol, cyclohexanol, cyclohexanone, furfural, benzyl alcohol,
Glycerin, acetone, methyl ethyl ketone, diacetone alcohol, brotin, butyl ether, methyl phenyl ether, ethylene glycol monoethyl ether, ethylene glycol diethyl ether, diethylene glycol diethyl ether, [a group of solvents commonly referred to as cellosolve, carbitol, dowanol], formic acid Methyl, butyl acetate, butyl carbitol acetate, ethylene carbonate, propylene carbonate, acetic anhydride, ethylhexanoic acid, N-methylpyrrolidone, and the like.

Since the powder of [E] includes the majority of the powders, representative examples are given below. Clay, kaolin, bentonite, montmorillonite, talc, mica, acid clay, chalk powder, limestone powder, tuff powder, mica powder, sedimentary mud powder, apatite powder, coral powder, diatomaceous earth, gypsum, precipitated calcium carbonate, basic Magnesium carbonate, zirconium oxide, titanium oxide, barium sulfate, alumina, silica, calcium silicate, zinc white, ceramic powder, charcoal powder, oil soot, powdered activated carbon, walnut shell powder, coconut shell powder, wood powder, cane core powder, Seaweed powder, pulp powder, processed cellulose powder, crystalline cellulose, rice bran, milk powder, bone powder, shell powder, eggshell powder, crab husk powder, cotton dust powder, silkworm cocoon powder, spun silk thread, magnesium stearate, aluminum stearate, lysine , Nylon powder, corn starch, potato starch, flour, cyclodextrin, lactose, amihope LL, Ishimatsuko Various synthetic resin powder, foamed resin powder, various dried plant powders, etc.

[F] Surfactant: The purpose of using a surfactant in a composition for human body is to wash away dirt on the skin or hair, applied makeup medicine, and finished cosmetics by a washing action. The foaming action creates a mousse that is easy to apply to skin and hair and also prevents dripping. The penetrating action softens and swells the skin and hair tissue when applied, helping the penetration of the formulated chemicals. The moisturizing action keeps applied skin and hair moist and gives moisture.
The antistatic effect prevents the hairs from getting loose when the air dries. By the dispersing action, the compounded chemicals can be uniformly dispersed and compounded, and the compounding time can be shortened. By selecting a surfactant by defoaming action,
Bubbles that occur during preparation of the composition can be eliminated. Due to the solubilizing action, substances that are completely insoluble in water can also be made somewhat soluble. By the emulsifying action, the oily substance and water are mutually dispersed, and can be adjusted to a uniform phase of cream or milk. For these purposes, an appropriate surfactant should be selected depending on the case, and reference is made to the nature of the components and the amount of hydrophilic groups / oily components attached thereto = HLB. Surfactants are roughly classified as follows according to the action of the surfactant. However, since the chemical name and the trade name are explained in general technical manuals and manufacturer catalogs, individual specific names are omitted. Since the chemical name and the product name are explained in the technical book and the manufacturer's catalog, individual specific names are omitted. a) cationic surfactants, b) anionic surfactants, c) nonionic surfactants, d) vinylic surfactants, e) polar surfactants.

[G] Thickener: a compounding agent that increases the viscosity of an aqueous base or an oily base, and is added to improve the physical properties of the composition. Some of them can be selected from the above [B] and [C]. Others
Bentonite gel, starch, seaweed powder, saponin, arabinose, xantham gum, guar gum, polysaccharide, vegetable gum, sodium alginate, collagen, albumin,
Gluten, methylcellulose, carboxymethylcellulose, polyethylene oxide, trade names such as poval, leopard, and katinal.

[H] Gluing agent: The bean paste, which is also used in packs and eye makeup, is mainly used for setting the hair, and can be selected from [G]. Extract, polyvinylpyrrolidone, trade names such as Gantrez, Gaffcut, Dalmacril, Yuka Former, Diamond Hold, Self-Quart, Resin 28, Unformer, Carbopol, etc.

[I] Gelling agent: applied to aqueous-based high-viscosity cosmetics, increasing the concentration of [G] and [H], and mixing amino acids with amino acids in the mixing of certain surfactants. In the combination of activators, the protein and Ca ⁺⁺ , M
It is known to gel at the g ⁺⁺ bond. Agar, casein, pectin, oligosaccharide, water absorbing resin,
Mannan may be used.

[J] Acid-alkali agents: inorganic and organic acids such as sulfuric acid, hydrochloric acid, phosphoric acid, acetic acid, citric acid, lactic acid, sodium hydroxide, potassium hydroxide, sodium carbonate, sodium bicarbonate, aqueous ammonia, TEA , MAP, etc. [K] pH adjuster: sodium bicarbonate, sodium acetate, ammonium chloride, ammonium phosphate, sodium lactate, potassium citrate, amino acids and the like.

[L] ion sequestering agent: ethylenediamineacetic acid 2Na, ethylenediaminehydroxyethyltriacetic acid 3
Na, hydromexiethyldiamine triacetic acid 3Na, diethylenehydroxyamine pentaacetic acid. Hydroxyethanediphosphonic acid, phytic acid, acetylene alcohol, etc.

[M] Stabilizer: A stabilizer for maintaining the form of the composition, for example, sodium stearoyl lactate which is added to stabilize the sol when an emulsion is prepared, for preventing the decomposition of the compounded drug. Stabilizers, such as magnesium metaphosphate to prevent oxidation of ascorbic acid, and stabilizers to prevent corrosion of the containers, such as PVC containers filled with shampoo, make the dissolution weaker by the activator. Such as gallic acid ester added to prevent.

[N] preservative: paraben, dehydroacetic acid,
Potassium sorbate, cresol, resorcinol, isopropylmethylphenol, dibutylhydroxytoluene, trichlorocarbanide, methylbenzethonium chloride, alkylisoquilinium bromide, carbenoxolone,
Chlorohexidine gluconate, zinc chloride, caisson G
C, etc. are listed as typical examples.

[O] Colorant: [P] Fragrance: Quality and quantity within the range of common sense as a composition for human body. However, coloring is important in foundations and makeup cosmetics, and various pigments and dyes are used.

[R] Nourishing beautifying agents: those that make the skin, mucous membranes, and hair beautiful by applying topically, and those that are believed to be beautiful. There are countless examples of these. Ascorbic acid partimate,
Riboflavin, pantothenyl alcohol, d-α tocopherol, biotin, vitamins, albumin, whey, egg white, polyglutamic acid, amino acids, rice nucleic acid,
Silk degrading protein, pancreatin, olive oil, milk oil, egg oil, mink wax, purified lanolin, allantoin, ozogenite, acid clay, bentonite, choral powder, seaweed extract, mulberry bark extract, chamomile extract, aloe extract, oyster extract, shiitake mushroom Extracts, comfrey leaves, tea mushrooms, loofah water, rose water, rice bran, casein,
Birch sap, wood acetic acid, brown sugar, honey propolis, chlorella, bird droppings, mango pulp, black beans, azuki starch, hyaluronic acid, kojic acid, chitotinic acid, gluconic acid, taurine, hydrolyzed elastin, chlorophyll, alkaline ionized water, Such.

"S" UV screening agent: titanium white, pigment composed of zirconium oxide / zinc oxide / silicon oxide, oxybenzone, glycol salicylate, alkyl cinnamate, dihydroxybenzophenone, p-aminobenzoate, 4-t-butyl 4'-methoxybenzoylmethane, sucrose benzoate, sinoxate, and the like.

[T] Humectants: propylene glycol, glycerin, polyglycerin, dextran, tosaka extract, placenta extract, maltitol, mannitol, sorbitan, linoleic acid, glyceryl linoleate, betaine, deoxylipo nucleic acid, various plant extracts ,Such.

[U] astringents: alum, aluminum chloride,
Butyl gallate, resorcinol, salicylic acid, phenol, tannic acid, rutin, quercetin, flavanols, rosin, icutamol.

[V] Anti-inflammatory drugs: Allantoin, undecylenic acid, adenosine phosphate, glucosamine hydrochloride, guaiazulene, hinokitiol, pyridoxine, glycyrrhizinate K, calcium pantothenate, squalane, and the like.

[W] Filler: a drug added to make the whole 100%, for example, water, alcohol, kerosene, petrolatum, cocoa butter, palm oil, lactose, talc, clay powder, polyoxyethylene polyoxy Propylene glycol, polyoxyethylene polyoxypropylene cetyl ether, isopentane, and the like.

[X] Foaming agent and propellant: An aerosol product is filled with a high-pressure gas or a liquefied gas as described below, but a product that forms a foam by adjusting the amount can also be produced. Liquefied petroleum gas, isopentane, isoheptane (foamed after heating), dimethyl ether, chlorofluorocarbon 135
a, carbon dioxide gas, nitrogen gas, compressed air, etc.

[Reason for setting claims] The present invention relates to a composition for the human body containing guanidine hydroxide, and it has been recognized that guanidine binds to fatty acids to form soaps. The details of the sled were unknown fields. As described above, despite its high alkalinity, guanidine hydroxide has a low degree of adsorption to hair and skin and can be easily washed away,
It has low persistence and decomposes when dried with warm air to evaporate like ammonia. That is, since it does not remain, it has no adverse effect on the human body: in the case of skin, it becomes bulky and rough, and in the case of head hair, there are many redheads and split ends. However, the disadvantage is that the concentration in the aqueous solution is 30-31.
% Is the limit (4 mol / l, more than this will decompose)
Therefore, when the upper limit for stability when the composition is obtained by adding other components is determined, the limit is 25 w%, while the property as guanidine hydroxide appears at 0.25 w%. Is the reason for setting.

One of the effects of adding guanidine is that the guanidine can improve the detergency. However, this effect is remarkable in alkalinity. As an experiment, a certain amount of artificial dirt colored with carbon black was rubbed against bleached pig leather, immersed in a detergent at the pH of each stage prepared according to the following formula for a certain period of time, and the chromaticity of the carbon black eluted in the detergent Was measured to determine an artificial scale removal rate. The sum of the three items marked with * was the same, and the pH was changed by changing the combination of the contents. The results were as shown in FIG. That is, p
When H is equal to or less than 7.0, the detergency is inferior, but there is a remarkable improvement at around 9.0 and 10.5. Guanidine alkali is considered to be the reason for high detergency because it has two aspects of water solubility and oil solubility.

[Fig. 1]

As a disadvantage, as in the case of aqueous ammonia, the concentration of guanidine hydroxide cannot be increased. Therefore, when a soap with fatty acid is made, it is not solid and is at most about ooze, and there is a difficulty in commercializing the soap. Then, the present inventor has devised to harden this to some extent, and as a result, has produced a formulation in which a higher aliphatic alcohol having 8 to 24 carbon atoms is added to the composition in an amount of 0.05 to 5 w%. Although the theoretical elucidation is scandal, it can certainly increase the hardness. The alkyl group of the alcohol is most preferably a straight-chain type having 16 carbon atoms, but may be other or may be combined.

Now, experimental values will be reported for an example in which a stock solution in which a fatty acid is neutralized with guanidine hydroxide is charged with a liquefied gas under pressure. It forms a foamy mass when spouted and is called mousse. It should be noted that a small amount of menthol and allantoin can be added to the formulation of the present example to make it practical for shaving foam and the like. Formulation Coconut fatty acid 4w% 25% guanidine hydroxide solution (90% ethanol) 20 Stearyl alcohol QS Concentrated glycerin 3 50% silicone emulsion 1 Purified water 72

[Table-2] In the experiment, a stock solution prepared by adding a higher alcohol based on this formulation was used. 90 parts by weight of the stock solution was placed in a pressure-resistant can for aerosol, and 10 parts by weight of 3 kg / cm ² liquefied petroleum gas was pressure-filled to prepare a sample. The physical properties of the foam were measured by measuring the foam viscosity cp and the foam breaking rate 10% value%. The results are shown in Table
As shown in FIG. 2, it can be seen that the addition of the higher alcohol in an amount of 0.05% by weight or more makes the foam hard and hard to break even after a certain time. However, when the amount exceeds the limit, the powder becomes soft again, so the upper limit is set to 5% by weight.

Guanidine hydroxide has a high alkalinity and therefore swells the hair. However, there is little residue on the skin and the effect is less than that of inorganic alkali. Therefore, in combination with thioglycolic acid, it can be applied to hair removal of hair. In terms of the hair removal effect, thioglycerin, thioglycol, thiosucrose, or alkali sulfide can be used instead. The depilatory is used to weaken and rub off these hairs by breaking their S--S bonds.
At this time, the hair has a swelling agent so that the cutting agent can easily penetrate. To swell the hair, it is better to use an alkaline solution. On the other hand, when the pH of the drug is too high, the drug attached to the skin invades the skin, so that thioglycolic acid is 5%. A theoretical amount of various alkalis for neutralization was added, and Na was added until pH = 12.7.
Add OH. When the degree of swelling of the hair was tested for this adjusted liquid, the results shown in Table 3 were obtained. Note * <EC
-Direct criteria: thioglycolic acid = 5%, p
H = 12.7. >

[Table-3] The results show that guanidine is by far the most effective. Since the pH is kept constant, it can be said that the guanidine group itself has a high swelling effect.

From the viewpoint of the swelling effect on hair, application to various hair products is suggested. One is a bleaching agent. Recently, due to the influence of television talent, fashion that intentionally removes the color of old Japanese black hair has become popular, and sales of bleaching agents are growing rapidly. However, since the hydrogen peroxide solution by Poisonous and Deleterious Substance Control Law is specified as a deleterious substance for more than 60% strength, H ₂ 0 ₂ in the bleaching agent-hair dye both its second agent corresponding to quasi-drugs The concentration is set at 6% or less. However, since it is not possible to achieve a sufficient bleaching, professionals currently use a mixture of oxidol sold by pharmacies. *: If the mixing ratio of the first agent and the second agent is 1: 1, the H ₂ O ₂ concentration of the mixed agent becomes 3%. However, this concept is limited to a quasi-drug frame, and it is possible to sell as a drug, which is why the upper limit of 15 w% is set as the upper limit that does not cause irritation to the scalp.

The present inventor applied a cream having the following formulation to a human hair black hair bundle and determined the color change after 10 minutes of treatment. The results are shown in Table-4. Here, each cream A
[Guanidine hydroxide], B [ammonia], and C [Na hydroxide] have the same composition except that the alkali agent is 0.1 mol in 100 g. << A >><< B >><< C >> Myristic acid 4% 4% 4% Liquid paraffin 2 22 POE (10) cetyl ether 2 2 2 Glyceryl monostearate 11 1 11 Guanidine hydroxide solution (25%) 31--Ammonia water (NH328%) - 6 - sodium hydroxide - - 4 hydrogen peroxide _{(H 2 O 2 30%)} 10 10 10 purified water 50 75 77

[Table-4]

To determine the color difference, a color difference meter is used. The indication is C. I. E, -L ^* , a ^* , b ^* , color system chromaticity diagram (J
ISZ8729). The standard is evaporated magnesia.
From this result, it can be seen that guanidine alkali has a special bleaching effect.

Even when the hair is bleached, the hair that grows on the arms and shin is thinner than the head hair, and the conditions for bleaching may be relaxed. Also, for cosmetics that declare skin whitening, apply to the skin and
Because it is to reduce skin melanin as well as bleaching of downy hair>, hydrogen peroxide concentration should be reduced,
For this purpose, the content is set to 0.2 to 6 w%. At this concentration, the skin will not hurt even after repeated use. It should be noted that, in place of hydrogen peroxide, a mixture of potassium persulfate, acetic peroxide, bromate and the like is also conceivable, and can be similarly quantified by iodometry.

The following is an application to a hair dye. As is well known, the hair dye mainly comprises a basic oxidation dye. [A] Some are based on polyphenols. [A] The basic oxidation dyes are, for example, dyes such as paraphenylenediamine, metaphenylenediamine, nitroparaphenylenediamine, and phenoldiamine. ing. Since this dye often encounters the problem of <rash>, it is desirable that the dyeing time be as short as possible. This formulation contains a first agent containing a basic oxidation dye and a second agent containing an oxidizing agent such as H ₂ O ₂ for condensing the first agent. Mix and use. Thus, the first agent is ammonia-alkaline (alkanolamine / aminoalcohol in a direction that dislikes odor) and has a pH of about 9.5 and the second agent has a pH of about 3.3 for stabilizing H ₂ O _2. The pH is about 9.0 when mixed. To speed up the penetration of the dye into the hair, it is necessary to raise the pH a little more, but as described above, there was no suitable alkaline agent.

Now, a comparison was made of the hair dyeing effect of an agent using ammonia water and an agent using guanidine carbonate as an alkaline agent. The second formulation was added to the first formulation of the following formulation:
The mixture was added in 1 and several goat hair bundles were immediately immersed, taken out and washed with water, and the color difference was measured. The result is shown in FIG. It is clear that the color difference reaches the peak at the immersion time of 30 minutes, but that the one added with guanidine carbonate reaches the peak earlier. It should be noted that the processing time should be further reduced due to the large amount of dye in the actual formulation. In recent years, instead of dyeing the shiraga black, it is used as a fashion system, so the range of both dyes and the amount of the dye has expanded. From this point of view, the range of the basic oxidation dye is set to 0.5 to 50% by weight because some powdery compositions are available. Note since the second agent is appropriated containing composition H ₂ O _2, may also be used other products. Composition of the composition used in FIG. (W%) First agent <A><B> Paramine 1.5 1.5 Metaphenylenediamine 1.5 1.5 POE Alkyl ether sodium sulfate 4.0 4.0 28% ammonia water 5.0 Guanidine carbonate 7 .8 Make up to 100 by adding purified water. Second agent 10% oxidol 40.0 40.0 Phosphate 0.5 0.5 Phenacetin 0.1 0.1 Add purified water to make 100.

[Fig. 2]

[A] A polyphenol is a compound having a plurality of OH groups in an aromatic ring.
Compounds where the two OHs are in the ortho position are Fe, C
Chelates metal ions such as o, and causes a coloring reaction.
When this compound penetrates or adheres to the hair tissue, the hair is dyed. The first agent is specifically catechol /
Pyrogallol, gallic acid, tannic acid, hematin, and plant pigments. For plant pigments, coumarin, charcon,
It is found in flavanone, antochlor, flavanol and anthocyanidin pigments. When dyeing hair, first, hair is treated with a first agent containing polyphenol, and then colored with a second agent. This hair dye has a low degree of coloring and is dyed only after several treatments, and since the second agent is not necessarily used, the invention is limited to the first agent. ~ 25w%.

[0045] This type of hair dye is also used when the alkali is ammonia and guanidine carbonate.
A comparison was made. First agent <A><B> Catechol tannin 2.0 2.0 chamomile dye 1.0 1.0 POE cetyl ether 2.0 2.0 Xanthan cam 0.5 0.5 28% ammonia water 8.0 Carbonic acid Guanidine 12.8 Second agent Ferrous sulfate 0.5 0.5 Both agents are adjusted to 100 by adding purified water. Phosphoric acid 0.2 0.2 Hydroquinone 0.2 0.2 Purified water is added to make 100.

[Fig. 3]

Next is the application to a permanent wave preparation, and the present invention is applied to this first preparation. The effects of guanidine alkali have the effect of swelling the hair, softening the hair tissue, and facilitating the penetration of the drug from the surface of the cuticle into matnox. That is, the advantages of shortening the processing time, applying a certain wave, not damaging the hair, and not causing a bad smell were confirmed. In the current quasi-drugs, only thioglycolic acid and cysteine are approved by the Ministry of Health and Welfare as main agents, but this has been negotiated by humans, and in the long term, Since a change is also expected, in the present invention, in addition to thioglycolic acid, which has a curly hair effect, thioacetic acid, thioglycol, thioglycerin, thiochol, thiophenol, and thiolactic acid are also included in the component range, and the molecular weight range is defined as the molecular weight. The ratio was set at 2 to 10 w% in consideration of the ratio. In the case of a perm, the height of the alkali is not so necessary.
May be about 9, and in this case, quanidine carbonate may be used.

The composition of the present invention has been described above. However, the composition may be in the form of a liquid, emulsion, emulsion, gel, cream, powder, kneading agent, solid agent, etc. It is not particularly limited over various types.

Here, the aerosol product will be additionally described. This product is a combination of a liquefied gas and a compressed gas, and is filled in a pressure-resistant container equipped with an ejection mechanism (valve). . The composition to be filled is commonly called <stock solution>, and the gas is called a propellant. Filled composition is simply extruded when button is pressed
There are three types: foamy and misty. For this, the volume ratio of stock solution: propellant is important and depends on aerosol technology.

The “pH of the composition” as defined in the present invention is:
Unless otherwise specified, the term refers to a value measured at 20 ° C. for a solution obtained by diluting the composition to a four-fold amount (weight) with water.

[0050]

[Example 1] [Claim 1] This example is a paste for acne treatment. Although there are various causes of "acne", the skin tissue of the face becomes oily due to metabolic hormones until the adolescent age, and the sweat sac becomes clogged with oil, causing purulent or red rash. Occasionally, acne infections require caution when it comes to infection. The following formulas are recommended because creams with fats and oils are used to cleanse the face as they become increasingly fat. . Bentonite 2.5 w%. Phenol 0.5. 25% guanidine hydroxide solution (solvent is 90% ethanol) 3.0. Hydroxyethanediphosphonic acid 4Na 0.5. Adjust to 100 w% with purified water. Betonite is mixed with water in advance to form a gel, which is aged for one week before use. Apply this product to the rash, and after a few minutes, rinse with cold or hot water. The pH of this product was 12.8.

[Embodiment 2] [Claim 1] This embodiment is an example of a body shampoo. . POE (3) sodium lauryl sulfate (29% solution) 32.0w%. Carboxymethylcellulose Na 1.0. Guanidine hydroxide solution (25%) 12.0. Perfume 0.1. Paraben Mix 0.4 Add purified water to make 100. The pH of the product was 9.8.

[Embodiment 3] [Claim 2] This embodiment is an example of soap. Alkali salts of higher fatty acids are commonly referred to as soaps. Guanidine soap is used for infants with weak skin, but it does not have the same hardness as sodium soap and the conventional product is paste-like. In the method of the present invention, a higher fatty acid is neutralized with a guanidine hydroxide alcohol solution, a higher alcohol component is added at that time, and a solid moldable soap is obtained when the alcohol content evaporates. Formulation Amount (parts by weight). Coconut oil fatty acid 45.0. Cetanol 1.2. 25% guanidine hydroxide (90% ethanol solvent) 53.2. Diethylene glycol 0.6 Total 100.0 Put the above amount in a reaction kettle, heat and melt at 65 ° C,
Add. Take out the reaction product, cool it, and leave it indoors.The alcohol content will evaporate, so add a small amount of fragrance and colorant, knead it, mold it in a mold, leave it indoors again, and completely solidify it as a product. I do. The yield was 61 parts based on the above 100 parts. The analysis value of the product was fatty acid 7
3.2%, 2.0% cetanol, (NH ₂ ) ₂ C = N
H was 16.7%.

Example 4 [Claims 3 and 9] This example is an example of a hair remover for useless hair. The foam emitted by the aerosol product sticks to the skin and has a moderate firmness. Formulation of stock solution Lauric acid 4.8w% Cetostearyl alcohol 0.6 Thioglycolic acid (90%) 6.5 Sodium hydroxide 2.0 Guanidine hydroxide solution (28%) 20.0 Sodium alginate 0.8 Dipotassium glycyrrhizinate 0.1 Add purified water to make 100% w / w. Formulation of aerosol 10 parts by weight of liquefied petroleum gas is blended with 100 parts by weight of the stock solution. An AE120 tin can for aerosol was filled with 80 ml of the above stock solution and 18.5 ml of 3.5 kg pressure LPG, and a valve was set to produce a hair remover according to the present invention.

[Example 5] [Claim 4] This example relates to a hair bleaching agent. Both the first agent and the second agent are creamy and filled in a tube. When used, equal amounts of both agents are mixed and applied to the hair. Formulation First agent Second agent Cetanol 3.0 w% 4.0 w% White petrolatum 10.0 16.0 Liquid paraffin 6.0 7.0 Beeswax 4.0 4.0 Polyoxyethylene cetyl ether (20E0 7.0 8 3.0 Nikkor MGS-TG 3.0 3.0 Sodium lauryl sulfate 4.0-25% guanidine hydroxide solution (90% ethanol) 15.0-Guanidine carbonate 12.5-(10) Anhydrous sodium sulfite 0.5- (11) Phenacetin-0.2 (12) Monoammonium phosphate-0.4 (13) Phosphoric acid-0.4 (14) Propylene glycol 5.0 7.0 (15) Hydrogen peroxide (30%) −20.0 (16) Purified water 30.0 30.0 Total 100.0 100.0 After application, the hair was placed for 20 minutes, washed, and the hair was decolorized.
Compared to the formulation without guanidine, the hair quality was less damaged and the hair was clearly lighter in color.

[Example-6] [Claim 5] This example is a lotion for maintaining skin whitening and moisturizing,
Both the first agent and the second agent are aqueous and are contained in a spray container. In use, both are sprayed alternately. First agent Second agent Ethanol 5.0 w% 5.0 w% Glycerin 4.0 4.0 Rose water 10.0-Guanidine carbonate 1.2-Phenacetin-0.2 Hydrogen peroxide (30%)-3. 3 Phosphoric acid-0.2 Paraben 0.3 0.2 Purified water 78.5 81.9 (10) Colorant trace trace total 100.0 100.0

Example 7 "Claim 6" This example is a hair colorant for hair and is of a powder type. At the time of use, add 10 g of this product to 40 g of water, paste it, add 1.5 g of H ₂ O ₂ as a second agent, apply it to the hair, wash it well after about 20 minutes, and dye it . Formulation of the first agent Paraphenylenediamine 24.0 w% Paraaminophenol 6.0 Orthoaminophenol 6.0 2 Amino-5-nitrophenol 6.0 Sodium lauryl sulfate 25.0 Ramepon LPO (Henkel white water) 25.0 Guanidine carbonate 12. 0 Sodium sulfite 2.0 Total 100.0 In addition, when the powder of the second agent is applied, 10 g of ammonium peroxylate is included separately.

[Embodiment 8] [Claim 7] This is an example of a polyphenol-based hair dye, which is coated with a first agent, placed on a steamed towel, set for about ten minutes, washed lightly, and then washed with a second agent. Sprinkle and comb through. The present hair dye is gradually colored by several treatments, and sometimes the treatment of only the first agent is sufficient. Therefore, the scope of the claims is the first agent. First agent Second agent Hematin 0.5w%-w% Catechol 2.0-Henna leaf extract (solid content 12%) 5.0-Paramine 2.0-Hydroquinone 1.5 0.5 Guanidine carbonate 5.0- propylene glycol 50.0 - water 34.0 94.0 ferrous sulfate _{(7H 2 0) - 5.0 ▲} 10 ▼ phosphate - 0.5 total 100.0 100.0

[Example-9] [Claim 8] This example is an example of a perming agent. The agent for perm is a first agent that contains a thio compound and cleaves cystine bonds in hair,
It is a combination with an oxidizing agent for binding and reducing it again and a second agent containing hydrogen peroxide / potassium bromate, but the present invention refers to the first agent. Formulation Thioglycolic acid (92%) 6.30 w% Guanidine hydroxide solution (28%) 29.00 Guanidine carbonate 6.00 Fragrance 0.05 Add purified water to make 100.00. Conventional product, TEA with strong alkaline smell
The alkalinity is slimy and the curling workability is poor,
The MAP alkalinity has a problem that the alkali remains on the hair, but this product is free from the disadvantages.

[Embodiment 10] [Claim 10] This embodiment is an example of re-hairing of a hair. When I woke up in the morning,
We often experience that the pillows are out of place and the hair is disturbed, but at the left, it is a product that solves the problem immediately by spraying this product and applying a comb. Composition of stock solution Ethylene glycol 2.0 w% Catinal HC200 (Toho Chemical) 1.0 Guanidine carbonate 1.0 Silicone NUC FZ-4153 (Nihon Unica) 0.5 Perfume 0.2 Purified water is added to make 100.00. In a full-filled 150ml A1 aerosol pressure can, stock solution 7
5 ml was filled, a mountain cap fitted with a valve was crimped, and nitrogen was filled to 5 atm to produce the product of the present invention.

[0060]

The guanidine compound has not been applied to human body products so far. However, looking at the culprit, guanidine is referred to as guano, which is made from the accumulation and fermentation of countless bird feces that fly to the offshore islands, and is partially used as fertilizer. It was named after twisting the alkaline substance. There is a cosmetic product called "Wagu's droppings", but I don't think it uses raw duckweed droppings as a raw material, but there is a private opinion in ancient Japan that washing face with bird droppings would make it beautiful. There is a legend that bird feces in the eyes of priests who looked up in heaven abroad and lost their sight after intense stimulation. Considering this way, it is thought that guanidine has some special action as a component. In the present invention, it has been confirmed as alkaline guanidine, which acts on human skin and hair, enhances the swelling effect, the penetrating effect, and the washing effect, and thus has a very low effect on the human body. Also, guanidine hydroxide shows high alkalinity,
It has been found that when blended into the composition, a fine and soft texture can be obtained. With the above, a new invention has been made by applying it to various medicines, quasi-drugs, and cosmetics to be applied to skin and hair.

[Brief description of the drawings]

The drawings are for describing the operation and effect of the present invention.

[Fig. 1]: Detergency, presence of guanidine and pH
The result of an experiment on the relationship is shown.

FIG. 2 is a drawing (graph) for describing the effect of the addition of guanidine alkali on hair dyeing on hair.

[Fig. 3]: Same as Fig. 1.

[Procedure amendment]

[Submission date] November 20, 2000 (200.11.
20)

[Procedure amendment 2]

[Document name to be amended] Drawing

[Correction target item name] All figures

[Correction method] Change

[Correction contents]

FIG.

FIG. 2

FIG. 3

──────────────────────────────────────────────────続 き Continued on the front page (51) Int.Cl. ⁷ Identification symbol FI theme coat ゛ (Reference) A61K 7/00 A61K 7/00 N 7/06 7/06 7/09 7/09 7/13 7/13 7/135 7/135 7/48 7/48 A61P 17/00 A61P 17/00 F-term (reference) 4C083 AA082 AA112 AB032 AB082 AB282 AB352 AB412 AB442 AC012 AC022 AC072 AC112 AC122 AC182 AC242 AC302 AC422 AC442 AC472 AC482 AC492 AC552 AC642 AC741 AC742 AC772 AC782 AC892 AD042 AD152 AD272 AD302 AD352 AD532 CC34 CC35 CC36 DD08 EE16 4C206 AA01 AA02 HA31 MA01 MA04 MA05 MA33 MA83 NA14 ZA89 ZA92

Claims (10)

[Claims] The present invention relates to a drug which is applied to the skin, mucous membrane or hair of a human body, and wherein the guanidine compound is (NH ₂ )
_A composition for human body, wherein the composition contains 0.25 to 25 w% as 2C = NH and has a pH of 9.0 or more. 2. A method for converting guanidine hydroxide into (NH ₂ ) ₂ C ＝ NH
0.25 to 25 W%, a fatty acid having 8 to 24 carbon atoms, 1.0 to 75 w%, an aliphatic alcohol having 8 to 24 carbon atoms, 0.05 to 5 w%, and if necessary, a fat component. Resin components, silicones, solvents, powders, surfactants, thickeners, sizing agents, gelling agents, acid alkali agents, pH adjusters, ion sequestering agents, stabilizers, preservatives, coloring agents, flavors, nutrition Formulate with one or more kinds of beautifying agent, ultraviolet shielding agent, anti-inflammatory agent, moisturizer, astringent, bulking agent, water, and total amount is 100w%
A composition for the human body for use on mucous membranes, skin, and hair of the human body, characterized in that: 3. A method for converting guanidine hydroxide to (NH ₂ ) ₂ C = NH
0.25 to 25% by weight of thioglycolic acid, cysteine, thioglycolamide, thioglycol hydratide, thioacetic acid, thioglycol, thioglycerin,
One or more selected from thiolactic acid / thiophere and alkali sulfide is 0.5 to 20% by weight in total
And, if necessary, fats and oils components, resin components, silicones, solvents, powders, surfactants, thickeners, sizing agents, gelling agents, acid alkali agents, ion sequestering agents, stabilizers, coloring agents, A composition for removing unwanted hair, which is prepared by mixing one or more of a fragrance, a nutrition beautifying agent, an anti-inflammatory agent, a moisturizing agent, an astringent, a bulking agent, and water, to give a total amount of 100% by weight. 4. The first dispersant contains guanidine hydroxide (N
0.25 to 25 w% as H ₂ ) ₂ C = NH, 0.5 to 15 w% as H ₂ O ₂ for the _second dispensing agent,
Oil and fat components, resin components, silicones, solvents, powders, surfactants, thickeners, sizing agents, gelling agents, acid-alkali agents, pH adjusters, ion-sequestering agents, stable if necessary for both the second and third components Formulation of preservatives, preservatives, coloring agents, fragrances, nourishing beautifiers, ultraviolet shielding agents, anti-inflammatory agents, moisturizers, astringents, bulking agents, water or one or more types of water. A composition for the human body for bleaching hair, characterized in that the first and second components are mixed at the time of use. 5. A first agent comprising a guanidine compound exhibiting alkalinity in the range of 0.25 to 25 w as (NH ₂ ) ₂ C = NH.
% And 0.2 to 6% by weight as H ₂ O ₂ for the _second dispensing agent.
Oil and fat components, resin components, silicones, solvents, powders, surfactants, thickeners, sizing agents, gelling agents, acid alkali agents, pH adjusters, if necessary for both the first and second components Ion sequestering agents, stabilizers, preservatives, coloring agents, fragrances, nutrition beautifying agents,
Formulate with one or more kinds of UV screening agents, anti-inflammatory agents, moisturizers, astringents, bulking agents, water, and a total of 100 each.
A composition for the human body for whitening skin, characterized in that it is used by mixing the first and second ingredients at the time of use. 6. A guanidine compound exhibiting alkalinity of (NH ₂ ) ₂ C = NH in the range of 0.25 to 25 w%, a basic oxidation dye of 0.5 to 50 w%, and, if necessary, an oil / fat component / resin component / silicone. Classes, solvents, powders, surfactants, thickeners, sizing agents, gelling agents, acid-alkali agents, pH adjusters, ion-sequestering agents, stabilizers, preservatives, coloring agents, fragrances, nutritional beautifying agents, ultraviolet rays Combine with one or more kinds of shielding agents, anti-inflammatory agents, moisturizers, astringents, bulking agents, water, and a total amount of 100
The composition for human body of the first agent for hair dyeing, characterized in that the composition is w%. 7. A guanidine compound having an alkalinity of (NH ₂ ) ₂ C = NH of 0.25 to 25% by weight, and pyrogallol / catechol / gallic acid / tannic acid / hematin / vegetable polyphenol-flavonol plant pigment 0.2 or more of one or more selected from
25w%, if necessary, fats and oils components, resin components, silicones, solvents, powders, surfactants, thickeners, sizing agents, gelling agents, acid-alkali agents, pH adjusters, ion-sequestering agents, stabilizers・ Preservatives ・ colorants ・ flavors ・ nutrition beautifying agents ・ ultraviolet shielding agents ・ anti-inflammatory agents ・ moisturizers ・ astringents ・ bulking agents ・ mixing with water or water or two or more types to make the total amount 100 w% A human body composition whose purpose is to dye hair. 8. A guanidine compound exhibiting alkalinity of (NH ₂ ) ₂ C = NH in the range of 0.25 to 25% by weight, thioglycolic acid, cysteine, thioacetic acid, thioglycolol, thioglycerin, thioglycolamide and thiolactic acid Total amount of one or more selected from 2
10 to 10% by weight, if necessary, fats and oils components, resin components, silicones, solvents, powders, surfactants, thickeners, sizing agents, acid alkali agents, pH adjusters, ion sequestering agents, stabilizers, preservatives・ Characteristics, fragrances, nutritive beautifying agents, ultraviolet shielding agents, anti-inflammatory agents, moisturizing agents, astringents, bulking agents, one or more types of water, and the total amount is 100 w%.
A composition for the human body in which the first component of the agent for permanent waves is intended. 9. The composition according to claim 1, 2, 3, 4, 5, 6, 7 or 8 is used as a stock solution, and 5 to 100 parts by weight of a liquefied gas is mixed with 100 parts by weight of the stock solution. , Composition for human body. 10. The composition according to claim 1, 2, 3, 4, 5, 6, 7 or 8 is used as a stock solution, and 50 to 500 parts by volume of a compressed gas is mixed with 100 parts by volume of the stock solution. ,
Composition for human body.