JP2007262003A - Hair tonic - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a hair tonic having excellent hair-nursing effect, good use feeling and high stability of an active ingredient. <P>SOLUTION: The hair tonic forms a uniform film free from stickiness of collagen and free from stiffness by formulating (a) 0.001-10 mass% collagen derived from fishes with (b) 0.0001-5 mass% cell activator. As a result, the cell activator being active ingredient for hair growth and activating a hair-matrix cell is retained in the scalp and the hair, to provide the hair tonic excellent in effects. <P>COPYRIGHT: (C)2008,JPO&INPIT

Description

  The present invention relates to a hair nourishing agent, and more specifically, by incorporating fish-derived collagen and a cell activator, it forms a uniform film without stickiness and non-stickiness, and is an active ingredient for hair growth that activates hair matrix cells. The present invention relates to a hair nourishing agent that retains a cell activator and exhibits an excellent hair nourishing effect.

  Conventionally, various active ingredients such as a vasodilator, a blood flow promoter, a scalp stimulant, a sebum secretion inhibitor, and an anti-inflammatory agent are blended in the hair growth / hair restoration according to its mechanism and purpose. However, there are cases where a sufficient hair nourishing effect cannot be obtained simply by blending these active ingredients.

  In hair nourishing, a method of blending xanthan gum, hyaluronic acid salts, sclerotium gum, clay mineral, collagen-derived material, etc. for the purpose of improving the stability of the active ingredient and the feeling of use (see, for example, Patent Document 1) ), And a method of combining a water-soluble mixture containing α, α-trehalose and a water-soluble polymer, which has been reported for the hair growth effect, with a substance commonly used as a component of a hair restorer (for example, Patent Documents 2 to 4). Etc.) have been proposed. However, hair restorations containing water-soluble polymers that have been used in the past feel the stickiness and stiffness unique to the polymers, and the film formation effect cannot be expected so much that sufficient retention of the active ingredients cannot be expected. There was a problem that the hair effect was not sufficiently exhibited.

On the other hand, it has been known that collagen, which has been widely used as a cosmetic raw material, has a moisture retention ability and a film-forming ability, so that it improves skin moisture retention and is effective for tissue regeneration. Recently, marine collagen derived from fish and the like has attracted attention as an alternative to collagen derived from animals such as cattle and pigs, which has been mainly used so far, and its amino acid composition is similar. Protein denaturation temperature is related to the living environment of the organism from which it is derived, and in general, knowledge has been obtained that marine collagen derived from fish and the like is lower than animal-derived collagen (for example, non-patent literature) 2).
Cosmetics Handbook Published by Nikko Chemicals Co., Ltd. Published November 1, 1996, pages 471-488 Fragrance Journal Fragrance Journal, Inc. 1997-7 81-85 JP-A-2005-53784 Japanese Patent Laid-Open No. 10-7529 JP-A-10-279438 JP-A-10-279439

  Accordingly, an object of the present invention is to develop a hair nourishing agent that takes advantage of the characteristics of fish-derived collagen, has no stickiness or wrinkle, retains an active ingredient for hair growth, and exhibits an excellent hair nourishing effect.

In view of such circumstances, as a result of intensive studies to solve the above problems, the present inventor forms a uniform film without stickiness and stickiness by blending a specific amount of fish-derived collagen and a cell activator. Thus, the cell activator, which is one of the active ingredients for hair growth, can be retained, the hair matrix cells are activated and an excellent hair nourishing agent is obtained, and the present invention has been completed.
That is, the present invention includes the following components (a) and (b):
(A) 0.001 to 10% by mass of fish-derived collagen,
(B) Cell activator 0.0001-5 mass%
A hair nourishing agent is provided.
Further, the present invention provides a hair nourishing product having a protein denaturation temperature peak of 40 ° C. or lower.

  The hair nourishing agent of the present invention has a non-sticky, non-sticky uniform film, retains a cell activator that is an active ingredient for hair growth that activates hair matrix cells, and exhibits an excellent hair nourishing effect.

The fish-derived collagen of component (a) used in the present invention is collagen originating from fish, and the type of fish, the site of use, the preparation method, etc. are not particularly limited as long as it is collagen obtained from fish. Native collagen that is extracted from the skin, bones, and floats of teleost fish such as sardines and tuna according to a conventional method and is not subjected to enzyme treatment such as protease is preferred.
By blending the fish-derived collagen of component (a), it is possible to form a uniform film that is not sticky and non-sticky, and to retain component (b), which is an active ingredient for hair growth, and has an excellent hair restoration effect Is obtained.
In addition, the fish-derived collagen of component (a) of the present invention preferably has a protein denaturation temperature peak of 40 ° C. or less by differential thermal analysis, more preferably around human body temperature (36 ° C.). When this is blended into a hair nourishing agent, it is denatured at body temperature by application, and forms a uniform and non-sticky film with excellent sealing power, so that the retention of component (b) can be further improved, and excellent nourishing Hair effect is obtained.
As a commercial item of a component (a), PANCOGEN MARINE (The modification | denaturation temperature peak of a protein: 38 degreeC by GATTEFOSSE company) etc. are mentioned.

  The compounding amount of the fish-derived collagen of the component (a) used in the present invention is 0.001 to 10% by mass (hereinafter simply referred to as “%”), and more preferably 0.01 to 5%. Within this range, the scalp and hair after application will not be sticky, will form a uniform, non-stiff film with excellent sealing power, and will not cause problems such as coloring, odor, or precipitation due to collagen. The cell activator of (b) can be retained, and an excellent hair nourishing effect is obtained in combination with the tissue regeneration effect of component (a).

On the other hand, the cell activator of the component (b) used for this invention works effectively with respect to the hair growth effect by activating the hair matrix cell in a scalp. The component (b) is not particularly limited as long as it exhibits an action to activate hair matrix cells. Specific components include deoxyribonucleic acid and salts thereof, adenosine triphosphate, adenosine. Adenylate derivatives such as monophosphate and salts thereof, ribonucleic acid and salts thereof, nucleic acid-related substances such as guanine, xanthine and derivatives thereof, and salts thereof, animal-derived extracts such as royal jelly; yeast extract, lactic acid bacteria Extracts derived from microorganisms such as extracts, bifidobacteria extracts, ganoderma extract, etc .; plant-derived extracts such as carrot extract, assembly extract, rosemary extract, buckwheat extract, garlic extract, hinokitiol, cephalanthin Α- or γ-linolenic acid, eicosapentaenoic acid and derivatives thereof, succinic acid and derivatives thereof And their salts, α-hydroxy acids such as glycolic acid, lactic acid, salicylic acid and their derivatives and salts thereof, deoxyribonucleic acid and its salts, adenosine triphosphate, royal jelly, yeast extract, lactic acid bacteria extract Bifidobacteria extract, Ganoderma extract, carrot extract, hinokitiol are more preferable.
Among these, in the case of a plant extract, the extraction method is not particularly limited, and any one such as pressing or solvent extraction can be used. In the case of solvent extraction, the above plant is extracted by a conventional method using one or more extraction solvents such as water, lower monohydric alcohol, polyhydric alcohol, lower alkyl ester, hydrocarbon, ether and the like. be able to.
One or two or more cell activators of component (b) can be used as necessary.

  The compounding quantity of the cell activator of the component (b) used for this invention is 0.0001 to 5% in conversion to dry solid content, More preferably, it is 0.001 to 3%. If it is this range, by using together with a component (a), the cell nourishing agent which is a component (b) will be made to stay and a hair matrix cell will be activated, and a hair growth effect is fully exhibited.

In addition to the above essential components, the hair nourishing agent of the present invention has purified water, lower alcohols, polyhydric alcohols, fats and oils, surface activity, in a qualitative and quantitative range that does not impair the effects of the present invention. Agents, cosmetic ingredients, ultraviolet absorbers, thickeners, pigments, preservatives, fragrances, and the like that are usually used in cosmetics can be appropriately blended.
In addition, vasodilators, female hormone agents, skin function enhancers, anti-inflammatory agents, local irritants, keratolytic agents, vitamins, amino acids, plant extracts other than the above, moisturizing agents, which are generally known as medicinal agents for hair nourishing You may mix | blend an agent etc. as needed.

Examples of the form of the hair nourishing agent of the present invention include various types of hair nourishing agents such as emulsions, creams, lotions, gels, aerosols, etc., which are generally known as hair nourishing agents, and hair tonics, hair liquids, hair lotions, hairs. It can be appropriately prepared and used for cream, hair mist, hair spray and the like.
Furthermore, there is no restriction | limiting in particular as a usage method of the hair nourishing agent of this invention, According to a dosage form, an appropriate amount may be picked up and applied to a scalp, hair, or it may be made to spray, but the fish of component (a) Store the hair nourishing agent of the present invention at room temperature or lower so that the collagen derived from the protein is denatured during application to form a film and increase the retention of component (b), and rub it on the hair root and scalp. Then it is more effective.

  EXAMPLES Next, although an Example is given and this invention is demonstrated further, this invention is not limited at all by these.

Example 1 (Invention Products 1 to 4 and Comparative Products 1 to 3): Hair Lotion A hair lotion having the composition shown in Table 1 below was prepared by the following production method, (1) No stickiness, (2) No stiffness (3) The hair restoration effect was evaluated by the following method, and the evaluation results are shown in Table 1.

(Manufacturing method)
A: Components (1) to (3) and component (5) are mixed uniformly.
B: Component (4) was added to A and mixed uniformly to obtain a hair lotion.

[Evaluation methods: (1) No stickiness, (2) No stickiness]
Twenty cosmetic panels specially used the hair lotions of the present invention products 1 to 4 and comparative products 1 to 3 to evaluate the feeling of use and uniform film formation, respectively (1) No stickiness (2) The non-stiffness was sensory-evaluated according to the following (b) 5-step evaluation criteria, and the average score of all panels was determined using (b) 4-step evaluation criteria.
(B) Five-level evaluation criteria (Evaluation): (Grade)
Very good: 5 points Good: 4 points Normal: 3 points Defect: 2 points Very bad: 1 point (b) Four-step criteria (average of all panel scores): (Judgment)
Average score of 4.5 or more: ◎
Average score of 3.5 or more and less than 4.5: ○
Average score of 2.5 or more and less than 3.5: △
Average score of 2.5 or less: ×

[Evaluation method: (3) Hair restoration effect]
As the hair nourishing effect, non-patent document 1 and references cited therein were referred to, and the hair nourishing effect was evaluated by confirming the effect of preventing hair loss by the following method.
That is, a panel test was conducted with 10 panelists as one group, and the hair lotions of the present invention products 1 to 4 and comparative products 1 to 3 were applied to the scalp.
The period of use was 8 weeks, during which time the panel was washed daily, and then each of the hair lotions of the products 1 to 4 of the present invention and the comparative examples 1 to 3 was applied to the scalp. Wash hair every day from 10 days before starting use, count the number of hair loss at the time of washing every other day, and use the average of the total of 5 measurements as the number of hair loss before application, and also after 8 weeks use The hair was washed every day in the same manner as before the start, and the number of hair loss at the time of shampooing was counted every other day, and the average value of a total of 5 measurements was taken as the number of hair loss after application.
The number of hair loss before application and the number of hair loss after application are compared, and the effect of preventing this loss is evaluated according to the following (c) 5-step evaluation criteria, and the average score of all panels is (d) Judgment was made using a 4-step criterion.
(C) Five-level evaluation criteria (Evaluation): (Grade)
Hair loss decreased by 20 or more: 5 points Hair loss decreased by 15 or more and less than 20: 4 points Hair loss decreased by 5 or more and less than 15: 3 points Hair loss decreased by less than 5: 2 points Hair loss increased by 5 or more: 1 Points (d) Four-step criteria (average score of all panels): (Judgment)
Average score of 4.5 or more: ◎
Average score of 3.5 or more and less than 4.5: ○
Average score of 2.5 or more and less than 3.5: △
Average score of 2.5 or less: ×

  As is clear from the results in Table 1, the hair lotions of the present invention products 1 to 4 which are the present invention products have no stickiness or wrinkle and are excellent in hair restoration effect compared to the hair lotions of the comparative products 1 to 3. It was a hair lotion. On the other hand, the comparative product 1 in which the fish-derived collagen of the component (a) is not blended cannot retain the component (b), which is an active ingredient for hair growth, and contains a large amount of the component (b). Regardless, the hair restoration effect was inferior. Comparative product 2 containing bovine-derived collagen instead of component (a) was stiff and lacked uniformity in the film, and was inferior in stickiness and hair-restoring effect. Moreover, although the comparative product 3 which does not mix | blend the cell activator of a component (b) does not have stickiness and wrinkle, although the hair-restoration effect by a component (a) was slightly seen regarding the hair-restoration effect, it is an active ingredient Since the effect of component (b) is not obtained, a satisfactory hair-growth effect was not obtained.

Example 2: Hair liquid (component) (%)
1. Polyoxypropylene butyl ether phosphate (35 PO) 9
2. Polyoxypropylene monobutyl ether (60 PO) 10
3. Triethanolamine 1
4). Fish-derived collagen (Note 1) 2
5). Reishi Extract (Note 5) 2
6. Ethyl alcohol 30
7. Perfume appropriate amount 8. Purified water remaining amount Note 5: Ganoderma Extract (manufactured by Maruzen Pharmaceutical Co., Ltd.)

(Manufacturing method)
A: Components (3) to (5) and component (8) are mixed uniformly.
B: Components (1) and (2) and components (6) and (7) are mixed uniformly.
C: B was added to A and mixed uniformly to obtain a hair liquid.

  The hair liquid of Example 2 was a hair liquid that had no stickiness, formed a uniform film without stiffness, and had an excellent hair nourishing effect.

Example 3: Hair cream
(Ingredient) (%)
1. Beeswax 1
2. Liquid paraffin 50
3. Stearic acid 3
4). Sorbitan sesquioleate 2
5). Monolauric acid polyoxyethylene sorbitan (20E.O.) 1.5
6). Fish-derived collagen (Note 1) 2
7). Adenosine triphosphate disodium (Note 6) 1
8). Perfume appropriate amount 9. Methyl paraoxybenzoate Appropriate amount10. Purified water remaining amount Note 6: ADENOSINE-5'-TP, DISODIUM
(Manufactured by PHAWA WALDHOF)

(Manufacturing method)
A: Components (1) to (5) are uniformly mixed at 70 ° C.
B: A part of component (9) and component (10) is heated to 70 degreeC.
C: A is added to B, emulsified and cooled.
D: The components (6), (7) and the remainder of the component (10) are mixed uniformly.
E: D and (8) were added to C and mixed uniformly to obtain a hair cream.

  The hair cream of Example 3 was a hair cream that had no stickiness, formed a uniform film without stiffness, and had an excellent hair nourishing effect.

Claims (2)

The following components (a), (b);
(A) Collagen derived from fish 0.001-10% by mass
(B) Cell activator 0.0001-5 mass%
A hair nourishing agent characterized by blending.   2. The hair nourishing product according to claim 1, wherein the protein (a) has a denaturation temperature peak of 40 ° C. or lower.