JP2007236533A - Dissolution apparatus and its filter judgement method - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a dissolution apparatus capable of accurately judging the clogging degree of a filter for filtering stock solution for dialysis and removing impurities and evading the formation of a contamination source by eliminating the connection part of a separate body such as a manometer, and its filter judgement method. <P>SOLUTION: The dissolution apparatus comprising a dissolver 5 for obtaining the stock solution for the dialysis, a reservoir 6 for tentatively housing the stock solution for the dialysis, a stock solution supply line L1 for supplying the stock solution for the dialysis housed inside the reservoir to the side of a dialyzer 4 and the filter 8 for filtering the stock solution for the dialysis flowing through the stock solution supply line L1 and removing the impurities is provided with a flow rate measurement means 10 for measuring the flow rate of liquid when discharging washing water or disinfecting liquid housed inside the dissolver 5 through the filter 8 and a filter judgement means 11 for judging the clogging of the filter 8 on the basis of the measured flow rate. <P>COPYRIGHT: (C)2007,JPO&INPIT

Description

  The present invention relates to a dissolution apparatus for dissolving a dialysis powder drug at a predetermined concentration to obtain a dialysis stock solution and a filter determination method thereof.

  Dialysis fluids used for the treatment of patients with renal failure in hospitals are generally divided into bicarbonate and acetic acid. Of these, bicarbonate-based dialysate does not contain sodium bicarbonate (hereinafter referred to as “bicarbonate”). It is prepared by mixing water with two types of drugs, called A agent and sodium bicarbonate (hereinafter referred to as B agent). In recent years, from the viewpoint of improving transportability, attempts have been made to dissolve these A agent and B agent powdered powder (hereinafter referred to as dialysis powder drug) before dialysis. With regard to B agent), the concentration tends to decrease over time, and it was difficult to prepare the next day after dialysis.

  For this reason, a dissolving operation is required for each dialysis, and recently, various dissolving devices for dissolving have been proposed. For example, a dissolution tank that dissolves the powder drug for dialysis and a storage tank that temporarily stores the dialysis stock solution generated in the dissolution tank, and the dialysis stock solution stored in the storage tank is dialyzed from the stock solution supply line. There has been proposed a dissolution apparatus capable of sequentially sending liquids to a liquid supply apparatus to produce a dialysate.

  By the way, since impurities or the like may be mixed in the dialysis powder drug, the dialysis stock solution is usually filtered through a flow path (stock solution supply line) through which the dialysis stock solution flows from the storage tank to the dialysate supply device. A filtration filter is provided to supplement the impurities. As a result, only a clean dialysis stock solution reaches the dialysis fluid supply device while removing impurities with a filtration filter, and after a dialysis fluid having a predetermined concentration is prepared from the clean dialysis stock solution, it is supplied to each dialysis device. The Rukoto.

  However, conventionally, in order to detect the degree of clogging of the filtration filter due to the use of a dissolving device, the differential pressure before and after the filtration filter has been measured. Specifically, pressure gauges that detect the hydraulic pressure are connected to the front and rear (upstream side and downstream side) of the filtration filter in the stock solution supply line, respectively, and the detected differential pressure is normal when there is no clogging. It was configured to be able to detect how much the difference was and to determine the degree of clogging of the filtration filter. In addition, since this prior art does not relate to the literature known invention, there is no prior art document information to be described.

  However, in the above conventional dissolution apparatus, it was necessary to connect a pressure gauge separately to determine the degree of clogging of the filtration filter, so that the dialysis stock solution flowing in the stock solution supply line stays at the connection portion. Could be a source of contamination. For this reason, some medical institutions do not have a pressure gauge for determining the degree of clogging, and the filter is periodically replaced, but the replacement time of the filter is the processing capacity of the dissolving device. There is a problem that it is often wasted because it varies significantly depending on the factors such as.

  The present invention has been made in view of such circumstances, and can accurately determine the degree of clogging of a filtration filter for removing impurities by filtering the dialysis stock solution, and a separate pressure gauge or the like. It is an object of the present invention to provide a dissolution apparatus and a filter determination method thereof that can avoid the formation of a contamination source by eliminating a connection site.

  The invention according to claim 1 is a dissolution tank in which a predetermined amount of powder drug for dialysis and water are charged, and the powder drug for dialysis is dissolved and stirred to obtain a stock solution for dialysis, and for dialysis obtained in the dissolution tank A storage tank for temporarily storing the stock solution, a stock solution supply line for supplying the stock solution for dialysis stored in the storage tank to a plurality of dialysis apparatuses for performing dialysis treatment on a patient, and connected to the stock solution supply line And a filtration filter for removing impurities by filtering the dialysis stock solution flowing through the stock solution supply line, wherein a predetermined liquid contained in the dissolution tank or storage tank is fed into the stock solution via the filtration filter. A flow rate measuring unit for measuring the flow rate of the liquid when discharged from the supply line; and a filter determining unit for determining clogging of the filtration filter based on the flow rate measured by the flow rate measuring unit. It is characterized in.

  The invention according to claim 2 is the dissolution apparatus according to claim 1, wherein the flow rate measuring means measures the flow rate of the liquid from a change in the liquid level of the predetermined liquid in the dissolution tank or storage tank. Features.

  According to a third aspect of the present invention, in the dissolution apparatus according to the first or second aspect, when the dialysis stock solution is discharged from the dissolution tank or the storage tank, aeration is performed to suck or exhaust the inside of the dissolution tank or the storage tank. A vent line and an air filter disposed in the vent line, and discharging the predetermined liquid stored in the dissolution tank or the storage tank without passing through the filtration filter while venting the vent line. The flow rate of the liquid at the time is measured by the flow rate measuring unit, and clogging of the air filter is determined based on the flow rate measured by the flow rate measuring unit.

  According to a fourth aspect of the present invention, in the dissolution apparatus according to any one of the first to third aspects, the predetermined liquid is the flow path of the dialysis stock solution generated in the dissolution tank and the dissolution tank. It is the washing water or disinfection liquid for washing or disinfecting.

  The invention according to claim 5 is a dissolution tank in which a predetermined amount of powder drug for dialysis and water are charged, and the powder drug for dialysis is dissolved and stirred to obtain a stock solution for dialysis, and for dialysis obtained in the dissolution tank A storage tank for temporarily storing the stock solution, a stock solution supply line for supplying the stock solution for dialysis stored in the storage tank to a plurality of dialysis apparatuses for performing dialysis treatment on a patient, and connected to the stock solution supply line And a filter determination method for a dissolution apparatus comprising a filtration filter for removing impurities by filtering the dialysis undiluted solution flowing through the undiluted solution supply line, wherein a predetermined liquid contained in the dissolution tank or storage tank is filtered through the filtration filter A flow rate measuring step for measuring the flow rate of the liquid when discharged from the stock solution supply line, and a filter for determining clogging of the filtration filter based on the flow rate measured by the flow rate measuring means Characterized by comprising a constant step.

  A sixth aspect of the present invention is the dissolution apparatus filter determination method according to the fifth aspect, wherein the flow velocity measuring step measures the flow velocity of the liquid from a change in the liquid level of the predetermined liquid in the dissolution tank or storage tank. It is characterized by being.

  The invention according to claim 7 is the filter determination method of the dissolution apparatus according to claim 5 or claim 6, wherein the dissolution apparatus discharges the dialysis stock solution from the dissolution tank or storage tank. A predetermined liquid stored in the dissolution tank or the storage tank while being ventilated by the ventilation line. And measuring the flow rate of the liquid when it is discharged without passing through the filtration filter, and determining clogging of the air filter based on the measured flow rate.

  The invention according to claim 8 is the filter determination method of the dissolution apparatus according to any one of claims 5 to 7, wherein the predetermined liquid is for the dialysis generated in the dissolution tank and the dissolution tank. It is a cleaning water or a disinfecting solution for cleaning or disinfecting the flow path of the stock solution.

  According to the invention of claim 1 or claim 5, when the predetermined liquid accommodated in the dissolution tank or the storage tank is discharged from the stock solution supply line through the filtration filter, the flow rate of the liquid is measured and the measurement is performed. Since clogging of the filtration filter is determined based on the flow rate, the degree of clogging of the filtration filter for removing impurities by filtering the dialysis stock solution can be accurately determined, and a separate pressure gauge or the like can be used. It is possible to avoid the formation of a contamination source by eliminating the connection site.

  According to the invention of claim 2 or claim 6, the flow velocity measuring means or flow velocity measuring step measures the flow velocity of the liquid from the change in the liquid level of the predetermined liquid in the dissolution tank or storage tank. The flow rate of a predetermined liquid can be measured using an existing liquid level sensor or the like in a tank or a storage tank.

  According to invention of Claim 3 or Claim 7, while measuring the flow velocity of the said liquid at the time of discharging | emitting the predetermined | prescribed liquid accommodated in the dissolution tank or the storage tank without passing through the filtration filter, performing ventilation | gas_flowing by a ventilation line. Since the clogging of the air filter is determined based on the measured flow velocity, it is possible to easily identify which of the air filter and the filtration filter is clogged in addition to the determination of the clogging of the air filter itself.

  According to the invention of claim 4 or claim 8, because the predetermined liquid is a washing water or a disinfecting solution for washing or disinfecting the flow path of the dissolution tank and the dialysis stock solution produced in the dissolution tank, It is possible to determine clogging of the filtration filter or the air filter in a cleaning or disinfection process such as a dissolution tank that is usually performed regularly.

Hereinafter, embodiments of the present invention will be specifically described with reference to the drawings.
The dissolution apparatus according to the first embodiment is for obtaining a dialysis stock solution by dissolving a powder drug for dialysis at a predetermined concentration. As shown in FIG. It is a thing. A plurality of dialysis devices 4 (dialysis monitoring devices) and a central monitoring device 3 are installed in a dialysis chamber isolated from the machine room.

  Further, the dialysis stock solution (concentrated solutions of agent A and agent B) produced by the dissolving device 1 reaches the dialysate supply device 2 via the stock solution supply line L1 (L1a and L1b in FIG. 3), and is predetermined there. A dialysate having a concentration is prepared, and the dialysate is supplied to each dialyzer 4 (dialysis monitoring device) via dialysate supply lines L2 to L4. In addition, each dialysis apparatus 4 and the central monitoring apparatus 3, and the central monitoring apparatus 3 and the dissolution apparatus 1 are electrically connected by wiring D1-D3, D4, respectively.

  As shown in FIG. 2, the dissolution apparatus 1 includes a dissolution tank 5, a storage tank 6, a level sensor 7, a filtration filter 8, an air filter 9, a flow velocity measuring means 10, a filter determination means 11, and a notification means. 12 mainly. Although not shown, a dissolution apparatus having the same configuration as that shown in the figure is separately provided, and each of the A and B agents as a dialysis powder drug is dissolved and stirred to produce each dialysis stock solution. It has come to be able to do.

  The dissolution tank 5 has float switches S1 (for upper limit detection) and S2 (for lower limit detection) in a part of the internal storage space, and is connected via a water supply source A and a water supply line L5. By opening the electromagnetic valve V1 disposed in the water supply line L5, the dissolution water is supplied into the dissolution tank 5. Thereby, if water for dissolution is supplied into the dissolution tank 5 and the supply of the water is stopped when the water level reaches the float switch S1, a certain amount of water can be accommodated in the dissolution tank 5. It is like that.

  The storage tank 6 is for temporarily storing the dialysis stock solution obtained in the dissolution tank 5, and from here the dialysis stock solution is supplied to the dialysate supply device 2 (a plurality of dialysis devices 4 side) described later. It is configured to be supplied sequentially. The storage tank 6 and the dissolution tank 5 are provided side by side, and both are connected by a transfer line L7 to which an electromagnetic valve V4 is connected. That is, if the electromagnetic valve V4 is opened, the dialysis stock solution in the dissolution tank 5 is fed into the storage tank 6 by gravity.

  Further, a level sensor 7 composed of a pressure gauge or the like is disposed on the lower surface of the storage tank 6, and the level sensor 7 is configured to continuously detect the remaining amount of the dialysis stock solution in the storage tank 6. ing. The pressure gauge as the level sensor 7 can detect the fluid pressure of the undiluted dialysis solution in the storage tank 6 over time in terms of the pressure applied to the bottom surface of the storage tank 6, and based on the detected fluid pressure. The amount of dialysis stock solution (the amount of residual solution) can be detected.

  Further, the middle of the transfer line L7 and the upper part of the dissolution tank 5 are connected by a circulation line L8. A circulation pump P1 is connected to the middle of the circulation line L8, and a bottle B containing a powder drug for dialysis. Can be connected. As a result, if the circulation pump P1 is driven with the electromagnetic valve V4 closed, the water in the dissolution tank 5 circulates in the circulation line L8 and the bottle B, so that the dissolution and stirring are performed to obtain a uniform concentration. A dialysis stock solution can be obtained.

  A stock solution supply line L10 and a return line L11 each having a feed pump P2 extend from the bottom of the storage tank 7, and these lines are connected to the stock solution supply line L1 (strictly 2 Are connected to stock solution supply lines L1a, L1b) extending from two storage tanks. The stock solution supply line L1 is connected to the dialysate supply device 2 at its tip. That is, the dialysis stock solution in the storage tank 6 passes through the filtration membrane (not shown) of the filtration filter 8 in the process of being discharged from the stock solution supply lines L10 and L1, and is sent to the dialysate supply device 2 to be dialyzed at a predetermined concentration. After being made into a liquid, it is supplied to each dialysis machine 4.

  The filtration filter 8 is connected to the stock solution supply line L1 (strictly, between the stock solution supply lines L10 and L1), and filters the dialysis stock solution flowing through the stock solution supply line L1 to remove impurities. Thus, the stock solution for dialysis discharged from the storage tank 6 by driving the liquid feed pump P2 is filtered by the filter 8 to remove impurities contained therein, and then supplied to the dialysate supply device 2. The inherent gas and the like are returned to the storage tank 6 through the return line L11.

  When a hydrophobic endotoxin cut filter having a small filter membrane pore size is used as the filter filter 8, air and carbonic acid can be returned from the return line L11, so that gas accumulation on the primary side of the filter can be avoided. Further, if such a filter is not used, the return line L11 may not be provided, and the raw solution supply lines L10 and L1 may be directly connected.

  On the other hand, a ventilation line L12 is extended from the upper part of the dissolution tank 5 and the storage tank 6, and the ventilation line L12 is connected via an air filter 9 to an overflow line L13 opened to the atmosphere. The aeration line L12 is for venting the lysis tank 5 or the storage tank 6 so as to be sucked or exhausted when the dialysis stock solution is discharged from the dissolution tank 5 or the storage tank 6. That is, in the process in which the electromagnetic valve V4 is opened and the dialysis stock solution in the dissolution tank 5 is transferred into the storage tank 6, the air present in the storage tank 6 is discharged and the dialysis stock solution is discharged in the dissolution tank 5. Air can be introduced into the dissolution tank 5 by the reduced amount.

  In particular, when air is introduced into the dissolution tank 5 or the storage tank 6, the air from the overflow line L13 is cleaned by removing foreign substances and the like by the air filter 9 and then sucked through the ventilation line L12. Become. Since the air filter 9 performs both intake and exhaust of the dissolution tank 5 or the storage tank 6 and overflow of the cleaning water or the disinfecting liquid, unlike the filter 8, the filter membrane has a large pore size. Those are preferred.

  The aeration line L12 and the overflow line L13 are also used when washing and disinfecting the dissolution tank 5 and the flow path of the dialysis stock solution generated in the dissolution tank 5. In order to perform cleaning and disinfection, with the electromagnetic valve V4 opened, the storage tank 6 is filled with cleaning water or disinfecting liquid, and the cleaning water or disinfecting liquid is continuously supplied to the dissolving tank 5 to perform overflow operation. Thereafter, the supply of the cleaning water or the disinfecting liquid is stopped, the electromagnetic valves V5 and V6 are opened, and the liquid is allowed to flow through the raw liquid supply lines L1b and L1a. At this time, electromagnetic valves V5 and V6 of the dialysate supply device 2 described later are opened, and the washing water or the disinfectant flowing through the flow path of the dialysate stock solution is discharged from the waste liquid lines L12 and L13.

  When the flow rate measuring means 10 discharges a predetermined liquid (for example, the above-described washing water or disinfecting liquid) stored in the dissolution tank 5 or the storage tank 6 from the stock solution supply lines L10 and L1 through the filter 8, the liquid is measured. Is connected to the float switches S1 and S2. Specifically, at the time of the cleaning or disinfection process, the time until the cleaning water or disinfecting liquid filled in the dissolution tank 5 due to the overflow by the overflow line L13 reaches the liquid level detected by the float switch S1 or S2 is measured. Then, the flow rate is measured from that time.

  Thus, the liquid discharged from the dissolution tank 5 and the storage tank 6 passes through the stock solution supply lines L10 and L1 through the filtration filter 8, and then reaches the dialysate supply apparatus 2 and the waste liquid of the dialysate supply apparatus 2 It will be discharged | emitted from line L12, L13. Therefore, if the filter 8 is clogged, the flow resistance of the liquid (washing water or disinfectant) increases and the flow velocity decreases, and the clogging can be determined by the filter determination means 11 described later. It becomes.

  In this embodiment, the time until the liquid (washing water or disinfecting liquid) filled in the dissolution tank 5 reaches the liquid level detected by the float switch S1 is measured. For example, the float switch S1 The time from the time when the liquid level is detected to the time when the liquid level is detected by the float switch S2 may be measured, and the flow velocity may be measured from that time. Further, the flow rate is measured by measuring the liquid level (or amount) of the liquid in the storage tank 6 with the level sensor 7 in the state where the dissolution tank 5 is empty or the electromagnetic valve V4 is closed. Also good.

  The filter determination unit 11 determines clogging of the filter 8 based on the flow rate measured by the flow rate measurement unit 10. That is, the filter determination unit 11 stores in advance a flow rate (hereinafter referred to as a reference flow rate) when the filter 8 in a normal state without clogging is attached, and is measured by the flow rate measurement unit 10. By comparing the measured flow rate with the reference flow rate, it is possible to determine how much clogging has occurred in the filter 8 at that time.

  Further, when determining clogging, the processing capacity of the dissolution apparatus 1 (capacity of the dissolution tank 5 and the storage tank 6, etc.), stock solution supply capacity (length, thickness, flow rate, etc. of the stock solution supply line L1), or attached filtration In consideration of the type of the filter 8 and the like, the degree of clogging is determined by performing correction according to these conditions. Therefore, it is possible to accurately determine the degree of clogging of the filter 8 and to avoid the formation of a contamination source by eliminating a separate connection site such as a pressure gauge.

  The notification means 12 is for notifying the degree of clogging of the filtration filter 8 determined by the filter determination means 11. For example, the notification means 12 displays an indication of the replacement time of the filtration filter 8 on the screen, A display prompting replacement can be displayed. Further, when the filter determination unit 11 determines that the filter 8 is clogged significantly, it is possible to emit a warning sound or turn on or blink a warning light.

  Furthermore, from the bottom of each of the dissolution tank 5 and the storage tank 6, waste liquid lines L6 and L9 to which electromagnetic valves V2 and V3 are connected are extended, and the electromagnetic valves V2 and V3 are opened to dissolve. The liquid in the tank 5 or the storage tank 6 can be discharged outside without passing through the filter 8. For example, when the electromagnetic valve V2 is opened in a state in which the dissolution tank 5 is filled with a predetermined liquid (overflowed state) and the electromagnetic valve V4 is closed, the melting is performed while the ventilation line L12 is vented. The liquid in the tank 5 is discharged from the waste liquid line L6.

  Accordingly, the predetermined liquid stored in the dissolution tank 5 can be discharged without passing through the filtration filter 8 while aeration is performed through the ventilation line L12, and the air flowing through the ventilation line L12 passes through the air filter 9. It will be. Therefore, if the flow rate at the time of discharging the liquid in the dissolution tank 5 is measured by the flow rate measuring means 10, the degree of clogging of the air filter 9 can be determined by the filter determining means 11.

  That is, the flow rate (hereinafter referred to as a reference flow rate) when the air filter 9 in a normal state without clogging is attached is stored in advance in the filter determination unit 11 and is measured by the flow rate measurement unit 10. By comparing the measured flow rate with the reference flow rate, it is possible to determine how much clogging has occurred in the air filter 9 at that time.

  In addition, since the reference flow velocity is different between the clogging determination of the filtration filter 8 and the clogging determination of the air filter 9, each reference flow velocity is stored in the filter determination means 11. Further, by closing the electromagnetic valve V2 and opening the electromagnetic valve V3, a predetermined liquid in the storage tank 6 is discharged from the waste liquid line L9, and the flow rate is measured by the level sensor 7 and the flow rate measuring means 10. Thus, the degree of clogging of the air filter 9 may be determined.

  By the way, as shown in FIG. 3, the dialysate supply device 2 is connected to a water supply line Lw in which water metering means 13 for measuring the amount of water flowing and the metering pump P3 (piston pump) flows. At the same time, a stock solution line L1a for flowing a stock solution for dialysis obtained by dissolving agent A and a metering pump P4 (piston pump) are connected, and a stock solution for dialysis obtained by dissolving agent B is flowed. It has mainly a stock solution line L1b. The stock solution lines L1a and L1b communicate with the stock solution supply line L1 in FIG. Further, a concentration measurement unit for measuring the concentration of the dialysate prepared in FIG. 3 and a heating unit for heating the dialysate are omitted.

  After the water in the water supply line Lw passes through the water metering means 13, the stock solution for dialysis from the stock solution lines L1a and L1b sent by driving the metering pumps P3 and P4 is mixed to prepare a dialysate having a predetermined concentration. Then, it will be discharged | emitted from the dialysate supply line L14. The dialysate supply line L14 is connected to the dialysate supply lines L2 to L4 (see FIG. 1), and the prepared dialysate is supplied to each dialyzer 4.

  In addition, the codes L12 and L13 in the figure are the waste liquid lines branched from the upstream side of the metering pumps P3 and P4 in the stock liquid lines L1a and L1b, as described above, and there are electromagnetics in the middle of the waste liquid lines L12 and L13. Valves V5 and V6 are connected. Accordingly, when the electromagnetic valve V5 or V6 is opened, a predetermined liquid (washing water or disinfecting liquid) flowing through the stock solution lines L1a and L1b is discharged to the outside through the waste solution line L12 or L13.

  However, the dialysis treatment is performed on the patient by the dialysate supplied to each dialysis apparatus 4. In addition, data related to dialysis treatment (treatment conditions, treatment time, and the like) is transmitted and received between each dialysis device 4 and the central monitoring device 3, so that optimal and safe treatment is performed.

Next, the effect | action for the filter determination in the said dissolving apparatus 1 is demonstrated.
First, in the cleaning process or the disinfection process, the overflow operation is performed by filling the storage tank 6 with the cleaning water or the disinfecting liquid while the electromagnetic valve V4 is opened, and continuing to supply the cleaning water or the disinfecting liquid to the dissolving tank 5 as it is. Thereafter, the supply of cleaning water or disinfectant is stopped, the electromagnetic valves V5 and V6 are opened, the liquid is supplied to the stock solution supply lines L1b and L1a, and the flow rate measuring means based on the time when the liquid level drops from the overflow state to the float switch S1. The flow rate is measured at 10 (flow rate measurement step).

  Then, the filter determination unit 11 compares the flow rate measured in the flow rate measurement step with the reference flow rate, thereby determining whether one of the air filter 9 and the filtration filter 8 is clogged (filter determination step). . Subsequently, the electromagnetic valve V2 is opened while the electromagnetic valve V4 is closed, and the time until the liquid level in the dissolution tank 5 falls from the float switch S1 to the float switch S2 is measured (flow velocity measuring step), and the air filter 9 Can be determined (filter determination step).

  In the above operation, the clogging of the air filter 9 and the filtration filter 8 is first determined, but the air filter 9 is measured alone by measuring the liquid level drop time from the overflow state to the float switch S1, Thereafter, the clogging of the air filter 9 and the filtration filter 8 may be determined by measuring the liquid level lowering time from the float switches S1 to S2. Of course, the determination result is notified by the notification means 12.

  According to the above embodiment, the flow rate when the washing water or the disinfectant stored in the dissolution tank 5 is discharged without passing through the filtration filter 8 while being vented by the vent line L12 is measured, and the measured flow rate is set. Based on this, since the clogging of the air filter 9 is determined, in addition to the clogging determination of the air filter 9 itself, it is possible to easily identify which of the air filter 9 and the filtration filter 8 is clogged.

  Further, the flow rate measuring means 10 or the flow rate measuring step measures the flow rate from the change in the level of the washing water or the disinfecting solution in the dissolution tank 5, so that the existing liquid level sensor (that is, the float) in the dissolution tank 5 is measured. The flow rate of a given liquid can be measured using the switches S1, S2). Further, the washing water or the disinfecting liquid for washing or disinfecting the dissolution tank 5 and the flow path of the dialysis stock solution generated in the dissolution tank 5 is discharged, and the filtration filter 8 or the air filter 9 is clogged from the flow rate. Therefore, the determination can be performed in a cleaning or disinfection process that is normally performed regularly.

Next, a second embodiment according to the present invention will be described.
As in the first embodiment, the dissolution apparatus according to this embodiment is installed in a machine room in order to obtain a dialysis stock solution by dissolving a powder drug for dialysis to a predetermined concentration (see FIG. 1). As shown, the dissolution tank 14 for generating the dialysis stock solution, the storage tank 15 for temporarily storing the generated dialysis stock solution, and the dialysis stock solution flowing in the stock solution supply line L16 are filtered to produce impurities. The filter is mainly composed of a filter 16 for removing water, a flow rate measuring means 10, a filter determining means 11, and a notifying means 12.

  The same components as those in the first embodiment are denoted by the same reference numerals, and detailed description thereof is omitted. Further, as in the first embodiment, dissolution devices having the same configuration as in FIG. 4 are separately disposed, and each of the A agent and the B agent as a dialysis powder drug is dissolved and stirred to be used for each dialysis. A stock solution can be generated, and as shown in FIG. 1, a stock solution for dialysis is supplied from each dissolving device to the dialysate supply device 2.

  The dissolution tank 14 is provided with float switches S3 to S5 in a part of the internal storage space, and is configured so that the level of a predetermined liquid in the dissolution tank 14 can be detected by these switches. A transfer line L15 to which a liquid feed pump P5 is connected extends from the bottom of the dissolution tank 14, and the tip of the transfer line L15 is connected to the storage tank 15. The storage tank 15 is provided with float switches S6 (for upper limit) and S7 (for lower limit) in a part of the internal storage space, and the liquid level of a predetermined liquid in the storage tank 15 can be detected by these switches. It is configured as follows.

  A filtration filter 16 is connected to the stock solution supply line L16 extending from the bottom of the storage tank 15. As a result, the stock solution for dialysis from the storage tank 15 is purified by removing impurities by the filter 16 and then supplied to the dialysate supply device 2 (see FIG. 3), where the dialysate has a predetermined concentration. Are supplied to each dialysis machine 4. In the present embodiment, the upper part of the dissolution tank 14 (the same applies to the storage tank 15) is opened, and a predetermined amount of the powder drug for dialysis is manually supplied.

  The flow rate measuring means 10 is electrically connected to the float switches S6 and S7 in the storage tank 15. Similar to the previous embodiment, the flow velocity measuring means 10 can measure the flow velocity of a predetermined liquid (washing water or disinfecting liquid) in the storage tank 15 from the time of the liquid level change detected by the float switches S6 and S7. Is. That is, in the cleaning process or the disinfection process, after the storage tank 15 is filled with the cleaning water or the disinfecting liquid, the electromagnetic valves V5 and V6 (see FIG. 3) are opened so that the cleaning water or the disinfecting water is removed from the storage tank 15. The flow rate is made to flow to the waste liquid lines L12 and L13 through the filtration filter 16, and the flow velocity measuring means 10 obtains the flow velocity from the time of the liquid level change in the storage tank 15 in the process.

  As a result, when the cleaning water or the disinfecting liquid stored in the storage tank 15 is discharged from the stock solution supply line L16 via the filter 16, the flow rate of the cleaning water or the disinfecting liquid is measured and the measured flow rate is set. Based on this, since the degree of clogging of the filter 16 can be determined by the filter determination means 11, the degree of clogging of the filter 16 can be determined with high accuracy, and a separate connection site such as a pressure gauge can be eliminated to eliminate the contamination source. It can be avoided that it is formed.

  Further, as in the previous embodiment, the flow velocity measuring means 10 measures the flow velocity from the change in the liquid level of the cleaning water or the disinfecting liquid in the storage tank 15, so that the existing liquid level sensor in the storage tank 15 (i.e., The flow rate of a given liquid can be measured using the float switches S6, S7). Furthermore, since the washing water or the disinfectant for washing or disinfecting the flow path of the dialysis stock solution generated in the dissolution tank 14 is discharged and the degree of clogging of the filter 16 is determined from the flow rate, it is usually regularly The determination can be performed in the cleaning or disinfection step to be performed. Of course, the determination can be performed in the cleaning or disinfection process of the storage tank 15 and the stock solution supply line L1 which are periodically performed. As in the previous embodiment, the notification unit 12 reports the degree of clogging of the filtration filter 16 determined by the filter determination unit 11.

  Although the present embodiment has been described above, the present invention is not limited to these embodiments. For example, while using an existing dissolution tank and storage tank (without a flow rate measuring means), the dialysis shown in FIG. Instead of the liquid supply means 2, a dialysate supply apparatus 2 as shown in FIG. The dialysate supply device 2 is mainly composed of a mixing tank 17 having a predetermined capacity, and stock solution measuring tanks 18 and 19 connected to the mixing tank 17.

  The raw material measuring tanks 18 and 19 are provided with float switches S8 and S9 at predetermined positions inside the raw material measuring tanks 18 and 19, respectively, and are connected to the tips of raw liquid lines L1a and L1b having liquid feed pumps P7 and P6. Further, transfer lines L17 and L18 to which electromagnetic valves V7 and V8 are respectively connected are extended from the lower bottoms of the raw material measuring tanks 18 and 19, and their tips are connected to the upper part of the mixing tank 17.

  When the dialysis stock solutions for agent A and agent B are fed from the dissolving device 1 side, they are respectively stored in the raw material measuring tanks 18 and 19. When the flow switches S8 and S9 detect that a predetermined dialysis stock solution has been stored in the raw material measuring tanks 18 and 19, the electromagnetic valves V7 and V8 are opened, dropped into the mixing tank 17, and mixed there. A dialysis solution having a predetermined concentration is prepared. The mixing tank 17 is supplied with water via the water supply line L19 by opening the electromagnetic valve V9, and has a stirring means (not shown) for stirring the mixed dialysis stock solution. It is arranged.

  The flow rate measuring means 10 is electrically connected to the float switches S8 and S9, and thereby includes a predetermined liquid in the stock solution metering tank 18 (in addition to the stock solution for dialysis, the washing water or the disinfecting solution in the washing step or the disinfecting step). ) Can be measured until a predetermined amount is reached. As a result, the flow rate of the liquid flowing through the stock solution supply line L1 (L1a, L1b) can be obtained from the measured time, and the degree of clogging of the filtration filter 8 is determined (the air filter 9 eye) as in the above embodiment. The same applies to the determination of the degree of clogging). In addition, the float sensors in the dissolution tank and the storage tank can be set to an arbitrary number or can continuously measure the liquid level.

  On the other hand, in this embodiment, each of the dialysis machines 4 is a multi-person dialysis machine (that supplies dialysis fluid produced by one dialysis fluid supply device to each dialysis fluid). The present invention may also be applied to a device equipped with a dialysis device for use (equipped with a means for producing a dialysis fluid such as a dialysis fluid supply device for each dialysis device). Even in this case, when the predetermined liquid stored in the dissolution tank or the storage tank is discharged from the stock solution supply line through the filtration filter, the flow rate of the liquid is measured, and based on the measured flow rate, If the clogging of the filtration filter is determined, it is possible to accurately determine the degree of clogging of the filtration filter, and it is possible to avoid the formation of a contamination source by eliminating a separate connection site such as a pressure gauge.

  When the specified liquid stored in the dissolution tank or storage tank is discharged from the stock solution supply line through the filtration filter, the flow rate of the liquid is measured and the clogging of the filtration filter is determined based on the measured flow rate. As long as the melting apparatus and its filter determination method are used, the present invention can be applied to a form in which other functions are added.

The schematic diagram which shows the connection state of the melting | dissolving apparatus and other component in embodiment (common to 1st and 2nd embodiment) of this invention. The schematic diagram which shows the structure of the melt | dissolution apparatus in the 1st Embodiment of this invention. The schematic diagram which shows the structure of the dialysate supply apparatus in embodiment (common to 1st and 2nd embodiment) of this invention. The schematic diagram which shows the structure of the melt | dissolution apparatus in the 2nd Embodiment of this invention. The schematic diagram which shows the structure of the dialysate supply apparatus applied to the dissolving apparatus in other embodiment of this invention.

Explanation of symbols

DESCRIPTION OF SYMBOLS 1 Dissolution apparatus 2 Dialysate supply apparatus 3 Central monitoring apparatus 4 Dialysis apparatus (dialysis monitoring apparatus)
DESCRIPTION OF SYMBOLS 5 Dissolution tank 6 Storage tank 7 Level sensor 8 Filtration filter 9 Air filter 10 Flow rate measurement means 11 Filter determination means 12 Notification means 13 Water measurement means 14 Dissolution tank 15 Storage tank 16 Filtration filter 17 Mixing tank 18, 19 Concentration liquid measurement tank L1 (L1a, L1b), L10 Stock solution supply line L2-L4 Dialysate supply line L5 Water supply line L6, L9 Waste liquid line L7 Transfer line L8 Circulation line L11 Return line L12 Vent line L13 Overflow line

Claims (8)

A dissolution tank in which a predetermined amount of powder drug for dialysis and water are charged, and the powder drug for dialysis is dissolved and stirred to obtain a stock solution for dialysis;
A storage tank for temporarily storing the dialysis stock solution obtained in the dissolution tank;
A stock solution supply line for supplying a stock solution for dialysis stored in the storage tank to a plurality of dialyzers for performing dialysis treatment on a patient;
A filtration filter connected to the stock solution supply line for filtering impurities through the stock solution supply line to remove impurities;
In a melting apparatus comprising:
A flow rate measuring means for measuring a flow rate of the liquid when the predetermined liquid stored in the dissolution tank or the storage tank is discharged from the stock solution supply line through the filtration filter;
Filter determination means for determining clogging of the filtration filter based on the flow velocity measured by the flow velocity measurement means;
A melting apparatus comprising:   2. The dissolution apparatus according to claim 1, wherein the flow rate measuring means measures the flow rate of the liquid from a change in liquid level of the predetermined liquid in the dissolution tank or storage tank. When discharging the dialysis stock solution from the dissolution tank or storage tank, a ventilation line for venting to inhale or exhaust into the dissolution tank or storage tank,
An air filter disposed in the ventilation line;
And measuring the flow rate of the liquid when the predetermined liquid stored in the dissolution tank or the storage tank is discharged without passing through the filtration filter while performing ventilation through the ventilation line by the flow rate measuring means. 3. The dissolution apparatus according to claim 1, wherein the clogging of the air filter is determined based on the flow velocity measured by the flow velocity measuring means.   The predetermined liquid is washing water or disinfecting liquid for washing or disinfecting the flow path of the dissolution tank and the dialysis stock solution produced in the dissolution tank. The melting apparatus according to any one of the above. A dissolution tank in which a predetermined amount of powder drug for dialysis and water are charged, and the powder drug for dialysis is dissolved and stirred to obtain a stock solution for dialysis;
A storage tank for temporarily storing the dialysis stock solution obtained in the dissolution tank;
A stock solution supply line for supplying a stock solution for dialysis stored in the storage tank to a plurality of dialyzers for performing dialysis treatment on a patient;
A filtration filter connected to the stock solution supply line for filtering impurities through the stock solution supply line to remove impurities;
In the method for determining the filter of the dissolution apparatus comprising:
A flow rate measuring step for measuring a flow rate of the liquid when the predetermined liquid stored in the dissolution tank or the storage tank is discharged from the stock solution supply line through the filtration filter;
A filter determination step for determining clogging of the filtration filter based on the flow velocity measured by the flow velocity measuring means;
A method for determining a filter of a melting apparatus, comprising:   6. The filter determination method for a dissolution apparatus according to claim 5, wherein the flow rate measurement step measures a flow rate of the liquid from a change in a liquid level of the predetermined liquid in the dissolution tank or the storage tank. The dissolution apparatus comprises:
When discharging the dialysis stock solution from the dissolution tank or storage tank, a ventilation line for venting to inhale or exhaust into the dissolution tank or storage tank,
An air filter disposed in the ventilation line;
Comprising
The flow rate of the liquid is measured when the predetermined liquid stored in the dissolution tank or the storage tank is discharged without passing through the filtration filter while aeration is performed through the aeration line, and the air is measured based on the measured flow rate. 7. The filter determination method for a melting apparatus according to claim 5, wherein clogging of the filter is determined.   The said predetermined liquid is the wash water or disinfection liquid for washing | cleaning or disinfecting the flow path | route of the said lysis tank and the dialysis undiluted | stock solution produced | generated in this dissolution tank. The filter determination method of the dissolution apparatus as described in any one.

Images