JP2010125207A - Extracorporeal circulation system - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To prevent contamination of an air pressure sensor with liquid of a liquid separator, in an extracorporeal circulation system. <P>SOLUTION: This extracorporeal circulation system 1 for treating liquid extracted from the interior of a body and returning it to the interior of the body includes: a first liquid separator 10 having a primary side A in which blood extracted from the interior of the body flows and which has an inlet 10a and an outlet 10b of the blood, and a secondary side B in which plasma separated from the blood in the primary side A flows via a hollow fiber membrane 50 and which has an outlet 10c of the plasma; a conduit 60 communicated with the first liquid separator 10 at a portion above the outlet 10c of the secondary side B of the first liquid separator 10; the air pressure sensor 62 connected to the conduit 60; and a pump 63 connected to the conduit 60. A liquid sump section 70 is formed between the air pressure sensor 62 of the conduit 60 and the first liquid separator 10. <P>COPYRIGHT: (C)2010,JPO&INPIT

Description

  The present invention relates to an extracorporeal circulation system that processes a liquid taken from a body of a patient or the like and returns the liquid to the body.

  For example, blood purification therapies such as plasma purification therapy and leukocyte removal therapy that take out blood from a patient's body and treat it outside the body and return it to the body are performed using an extracorporeal circulation system. The extracorporeal circulation system has an extracorporeal circulation circuit through which a liquid containing blood flows, and the extracorporeal circulation circuit is connected to, for example, a liquid separator that separates plasma and white blood cells from blood.

  For example, the liquid separator has a separation material such as a hollow fiber membrane inside, and a blood inlet and an outlet are formed on the primary side (region before separation) of the separation material, and the secondary side (after separation). In the region (2), an outlet for the separated blood component is formed (see FIG. 2 of Patent Document 1).

  A pipe line is connected to the upper part of the secondary side of the liquid separator. An atmospheric pressure sensor that detects the pressure on the secondary side of the liquid separator via the atmospheric pressure in the pipeline, a pump that can pump and suck gas on the secondary side, and the like are connected to the pipeline. The pressure sensor monitors the pressure on the secondary side during blood purification treatment, for example, and the pressure difference between the primary side and the secondary side becomes too large and blood cells etc. are forced into the hole of the hollow fiber membrane and damaged. Can be prevented.

  By the way, when the blood purification treatment described above is performed, a priming process of the extracorporeal circulation system is performed prior to the treatment. In this priming process, the extracorporeal circuit including the liquid separator is replaced with a clean liquid such as physiological saline and washed.

  For example, during the priming process or subsequent blood purification treatment, a gas space is formed in the upper part of the secondary side of the liquid separator, and the liquid level on the secondary side is lowered to a predetermined position. By doing so, for example, during the priming process, the secondary liquid efficiently flows to the outlet side or the primary side, so that the liquid replacement is performed efficiently. Further, during blood purification treatment, the total amount of blood to be circulated can be reduced by the amount of gas space formed on the upper side of the secondary side, thereby reducing the burden on the patient.

  On the other hand, for example, when the liquid level on the secondary side falls below the outlet, bubbles are mixed in the extracorporeal circuit. In order to prevent such air bubbles from being mixed, for example, in the priming process, liquid level adjustment is performed to adjust the liquid level on the secondary side to an appropriate position. This liquid level adjustment can be performed by, for example, feeding or sucking gas to the secondary side by a pump while detecting the pressure on the secondary side by an atmospheric pressure sensor.

JP 2005-253555 A

  However, when performing the above-described liquid level adjustment, a liquid such as physiological saline may remain on the wall surface of the gas space on the secondary side. When the liquid is sucked by the pump, the liquid enters the pipe line and adheres to, for example, the atmospheric pressure sensor to contaminate the atmospheric pressure sensor. If the atmospheric pressure sensor is contaminated with liquid, the pressure detection accuracy may be reduced, or the atmospheric pressure sensor may be broken. In such a case, it is necessary to replace the atmospheric pressure sensor.

  This invention is made | formed in view of this point, and it aims at preventing the contamination of the atmospheric | air pressure sensor by the liquid of a liquid separator.

  In order to achieve the above object, the present invention provides an extracorporeal circulation system that processes a liquid taken out of the body and returns it to the body, wherein the liquid taken out from the body flows in, and has a primary and an inlet for the liquid. A liquid separator having a side and a secondary side into which a predetermined liquid component separated from the primary side liquid flows through the separating material and has an outlet for the liquid component; and the secondary of the liquid separator A conduit communicating with the upper part of the outlet on the side, an atmospheric pressure sensor connected to the conduit and detecting the pressure in the secondary side of the liquid separator via the atmospheric pressure in the conduit, and A pump connected to a pipe and capable of pumping and sucking gas to and from the secondary side of the liquid separator, and the liquid between the barometric pressure sensor and the liquid separator in the pipe A liquid reservoir is formed where the liquid flowing in from the separator is stored. And wherein the are. The “pipe” includes not only those directly connected to the upper part of the secondary side of the liquid separator but also those indirectly connected.

  According to the present invention, since the liquid in the pipeline is captured by the liquid reservoir, it is possible to suppress the liquid in the liquid separator from reaching the atmospheric pressure sensor through the pipeline. Therefore, contamination of the atmospheric pressure sensor with the liquid of the liquid separator can be prevented.

  A filter is provided at a position closer to the liquid separator than the pump and the atmospheric pressure sensor in the pipeline, and a filter that prevents passage of unnecessary substances in the gas in the pipeline is provided. The liquid reservoir may be formed between the liquid separators. In such a case, it is possible to prevent the filter from getting wet by the liquid in the liquid separator and preventing the gas from passing therethrough, so that the pressure detection by the atmospheric pressure sensor is performed appropriately.

  A connector part capable of cutting and connecting the pipe line may be formed at a position closer to the atmospheric pressure sensor than the liquid reservoir part of the pipe line. In such a case, for example, since the liquid reservoir is formed in a portion closer to the liquid separator than the connector portion that is removed and replaced for each patient, it is possible to prevent liquid from entering a portion on the pressure sensor side that is not replaced. Thereby, it can prevent that non-exchange parts, such as a pressure sensor, are contaminated with the infectious substance etc. which are contained in the liquid.

  The liquid pool portion may be formed by making the inner diameter of the pipe line larger than other portions. In such a case, the liquid reservoir can be formed with a simple structure.

  The liquid pool portion may have an inner diameter of 8 mm or more. In such a case, the liquid in the pipe is surely separated from the inner surface of the liquid reservoir due to the relationship between the surface tension of the liquid in the pipe and gravity, so that the liquid can be more reliably collected in the liquid reservoir.

  The inner diameter of the conduit may be 4 mm or less. When the pipe line is thin in this way, the liquid level on the secondary side can be easily adjusted by the pump, and the operability such as connection of the pipe line is good, but the liquid tends to remain in the pipe line. For this reason, once the liquid enters the pipe line, the liquid is likely to remain and move to the atmospheric pressure sensor side. Therefore, the effect of forming the liquid reservoir in the pipe line as in the present invention is very large.

  Another outlet communicating with the pipe line may be formed above the outlet on the secondary side of the liquid separator, and the atmospheric pressure sensor may be installed at a position higher than the other outlet. . In such a case, the liquid on the secondary side of the liquid separator is unlikely to reach the atmospheric pressure sensor due to gravity, so that contamination of the atmospheric pressure sensor can be prevented more reliably.

  The separation material may be a hollow fiber membrane.

  The liquid treatment may be blood plasma purification, and the liquid separator may separate plasma from blood. In such a case, it is preferable to use the present invention in a configuration in which plasma is separated and filtered on the secondary side of the liquid separator, so that inflow of plasma to the pressure sensor side can be efficiently prevented.

  According to the present invention, it is possible to prevent the atmospheric pressure sensor from being contaminated by the liquid in the liquid separator. For example, the number of replacements of the atmospheric pressure sensor can be reduced.

  Hereinafter, preferred embodiments of the present invention will be described with reference to the drawings. FIG. 1 is an explanatory diagram showing an outline of the configuration of the extracorporeal circulation system 1 according to the present embodiment.

  In the present embodiment, for example, an extracorporeal circulation system 1 that performs double filtration plasmapheresis (DFPP) of plasma purification therapy will be described.

  As shown in FIG. 1, an extracorporeal circulation system 1 includes an extracorporeal circulation circuit 2 through which a liquid such as blood and the extracorporeal circulation circuit 2 are fixed, and the extracorporeal circulation circuit 2 circulates the liquid or the extracorporeal circulation circuit 2. It has an extracorporeal circulation device 3 for adjusting the internal pressure.

  The extracorporeal circuit 2 includes, for example, a blood circuit 11 that sends blood taken from a patient to the first liquid separator 10 and returns the blood to the patient, and plasma separated by the first liquid separator 10 is a second liquid separator. The plasma circuit 13 is sent to 12 and returned to the blood circuit 11.

  The blood circuit 11 has one end connected to the blood collection unit of the patient and the other end connected to the inlet 10a of the first liquid separator 10, and one end connected to the outlet 10b of the first liquid separator 10. And the other end of the blood vessel 21 is connected to the blood return portion of the patient. A drip chamber 30 for deaerating blood is connected to the blood collection tube 20. The drip chamber 30 is connected to, for example, a branch pipe 31 whose end portion can be opened to the atmosphere. A pressure sensor 32 provided in the extracorporeal circulation device 3 is connected to the branch conduit 31. A drip chamber 40 is provided in the return blood vessel path 21. The drip chamber 40 is connected to, for example, a branch pipe 41 whose end portion can be opened to the atmosphere. A pressure sensor 42 of the extracorporeal circulation device 3 is connected to the branch conduit 41.

  The first liquid separator 10 has, for example, a substantially cylindrical shape, and is installed in the extracorporeal circulation device 3 so that the axis is directed in the vertical direction. The first liquid separator 10 has a hollow fiber membrane 50 as a separating material for separating plasma from blood inside, and the inside is separated into a primary side A and a secondary side B. The hollow fiber membrane 50 is disposed, for example, in the center inside the first liquid separator 10, the primary side A is formed in a columnar shape in the center, and the secondary side B is formed in a cylindrical shape surrounding the primary side A. Has been. The upper part of the first liquid separator 10 is formed with an inlet 10a to which a blood collection tube 20 is connected, and the lower part is formed with an outlet 10b to which a return blood vessel 21 is connected. The inlet 10a and the outlet 10b communicate with the internal primary side A, whereby the blood in the blood collection tube 20 passes through the primary side A of the first liquid separator 10 and flows to the return blood vessel 21. be able to.

  A plasma outlet 10c is formed in the lower part of the side surface of the first liquid separator 10, and another outlet 10d is formed in the upper part. The outlets 10c and 10d communicate with the internal secondary side B.

  The outlet 60d at the top of the first liquid separator 10 is connected to a pipe line 60 whose end can be opened to the atmosphere. In the pipe line 60, a pressure in the secondary side B of the first liquid separator 10 via a filter 61 that blocks passage of unnecessary substances in the gas in the pipe line 60 and the atmospheric pressure in the pipe line 60 is provided. Is connected in this order from the first liquid separator 10 side to the atmospheric pressure sensor 62 for detecting the pressure and the tube pump 63 capable of pumping and sucking gas to the secondary side B of the first liquid separator 10. . The atmospheric pressure sensor 62 and the tube pump 63 are installed in the extracorporeal circulation device 3. Further, the atmospheric pressure sensor 62 is installed at a position higher than the outlet 10d of the first liquid separator 10.

  The pipe 60 has a connector portion 60a immediately after the filter 61, and can cut and connect the pipe 60 in the middle. A liquid reservoir 70 is formed on the side of the first liquid separator 10 from the filter 61 of the pipe line 60. The liquid reservoir portion 70 is formed in a cylindrical shape as shown in FIG. 2, for example, and is formed by making the inner diameter of the pipe line 60 larger than other portions. The inner diameter D1 of the liquid reservoir 70 is formed to be 8 mm or more, for example. In addition, the internal diameter of the other part of the pipe line 60 is 4 mm or less, for example. Further, the liquid reservoir 70 is formed, for example, in a tapered shape with an end on the filter 61 side. The liquid reservoir portion 70 is installed such that the axis is directed in the vertical direction and the taper side is directed upward.

  For example, the plasma circuit 13 has one end connected to the outlet 10 c of the first liquid separator 10 and the other end connected to the inlet 12 a of the second liquid separator 12, and one end connected to the second fluid separator 12. A return pipe 81 is connected to the outlet 12 b of the liquid separator 12 and the other end is connected between the first liquid separator 10 of the return blood vessel 21 and the drip chamber 40. A drip chamber 90 is connected to the outgoing line 80. The drip chamber 90 is connected to, for example, a branch pipe 91 whose end is open to the atmosphere. A pressure sensor 92 of the extracorporeal circulation device 3 is connected to the branch conduit 91. For example, a branch pipeline 100 is connected to the return pipeline 81.

  The second liquid separator 12 has the same configuration as the first liquid separator 10 and is provided with a hollow fiber membrane 110 that separates pathogenic substances from plasma. The hollow fiber membrane 110 is disposed in the center of the second liquid separator 12. As a result, a cylindrical primary side E is formed at the center of the second liquid separator 12, and a cylindrical secondary side F is formed therearound. In the lower part of the second liquid separator 12, an inlet 12 a that communicates with the primary side E and is connected to the outgoing line 80 is formed. At the lower part of the side surface portion of the second liquid separator 12, an outlet 12b that communicates with the secondary side F and to which the return pipe 81 is connected is formed. An outlet 12c leading to the primary side E is formed in the upper part of the second liquid separator 12, and a waste liquid conduit 120 for discharging a pathogenic substance is connected to the outlet 12c. An outlet 12d leading to the secondary side F is formed at the upper part of the side surface of the second liquid separator 12, and a branch pipe 130 whose end is opened to the atmosphere through a filter, for example, is connected to the outlet 12d. Has been.

  The extracorporeal circulation device 3 includes the above-described atmospheric pressure sensor 62, tube pump 63, pressure sensors 32, 42, 92, tube pumps 140, 141, 142, 143, and clamps 150, 152 that open and close across the pipeline. I have.

  For example, the tube pump 140 is connected to the patient side from the drip chamber 30 of the blood collection channel 20. The tube pump 141 is connected to the first liquid separator 10 side from the drip chamber 90 of the outgoing line 80. The tube pump 142 is connected to the waste liquid conduit 120, and the tube pump 143 is connected to the branch conduit 100. In addition, let the arrow direction in FIG. 1 be the normal rotation direction of each tube pump 63,140-143.

  For example, the clamp 150 is attached to the patient side from the drip chamber 40 of the return blood vessel 21, and the clamp 151 is attached to the branch conduit 130.

  The extracorporeal circulation device 3 is a latch that latches the suspension portion of the physiological saline bag 160 used during the priming process, the liquid separators 10 and 20 of the extracorporeal circulation circuit 20, the drip chambers 30, 40, 90, and the like. A control unit that controls pressure detection by the pressure sensors 32, 42, 62, and 92 and operation of the tube pumps 63 and 140 to 143, an operation unit that can operate the entire system on a screen, and the like.

  Next, operations during the priming process and the plasma purification treatment of the extracorporeal circulation system 1 configured as described above will be described.

  At the time of the priming process, first, for example, as shown in FIG. 3, the physiological saline bag 160 is suspended from the suspension portion above the extracorporeal circulation device 3, and the end of the return blood vessel path 21 is connected to the physiological saline bag 160. The Further, the first liquid separator 10 and the second liquid separator 12 which are filled with water at the time of shipment are connected to the blood circuit 11 and the plasma circuit 13, respectively, and the whole extracorporeal circulation circuit 2 is the extracorporeal circulation apparatus. 3 is attached.

  Then, for example, the tube pump 143 of the branch pipe 100 of the return pipe 81 is rotated forward, the outlet 10b side of the first liquid separator 10 is set to a negative pressure, and in this state, the tube pump 63 of the pipe 60 is positive. The gas is rotated and pumped to the secondary side B of the first liquid separator 10. Thereby, the inside of the secondary side B of the first liquid separator 10 is pressurized, and the liquid of the first liquid separator 10 flows out from the outlet 10b and moves toward the return pipe 81 side. As a result, at least a section from the outlet 10 b of the first liquid separator 10 to the branch point G between the return blood vessel path 21 and the return pipeline path 81 is filled with the liquid. At this time, the liquid level on the secondary side B of the first liquid separator 10 is lowered.

  Thereafter, for example, the clamp 150 of the return blood vessel path 21 is released, and the physiological saline in the physiological saline bag 160 is sent to at least the branch point G. Thereafter, the tube pump 140 of the blood collection tube 20 is rotated counterclockwise, and physiological saline is sent to the end of the blood collection tube 20 through the first liquid separator 10. Thereby, the whole blood circuit 11 is filled with the liquid.

  Thereafter, for example, the clamp 151 of the branch line 130 is opened, and in this state, the tube pump 141 of the forward line 80 is counter-rotated, and the liquid in the return blood line 21, the return line 81, and the second liquid separator 12 is recovered. Is sent to the first liquid separator 10 side through the outgoing line 80. Thereafter, the tube pump 141 is once rotated forward, the tube pump 142 of the branch line 120 is rotated forward, and the second liquid separator 12 and the branch line 120 are filled with liquid. Thereafter, the tube pump 141 is rotated in the opposite direction again, and the flow of the physiological saline bag 160 → the return blood vessel path 21 → the first liquid separator 10 → the blood collection tube path 20 and the physiological saline bag 160 → the return blood vessel path 21 → reverted. A flow of the pipe 81 → the second liquid separator 12 → the outgoing pipe 80 → the first liquid separator 10 → the blood collection tube 20 is formed, whereby the whole extracorporeal circuit 2 is replaced with physiological saline, Washed.

  During this priming process, the liquid level of the secondary side B of the first liquid separator 10 is adjusted. For example, the pressure is detected by the atmospheric pressure sensor 62, and the tube pump 63 is rotated forward and backward based on the pressure to adjust the liquid level to a desired position. At this time, the liquid level is adjusted to be higher than the outlet 10c. When the tube pump 63 is rotated in the reverse direction, the pressure in the pipe line 60 becomes negative. However, even if the liquid on the secondary side B enters the pipe line 60, it is collected and stored in the liquid reservoir 70.

  At the time of plasma purification treatment, as shown in FIG. 1, the tube pumps 140 and 141 are rotated forward, and blood taken from the patient is sent to the primary side A of the first liquid separator 10. The plasma separated by the hollow fiber membrane 50 in the first liquid separator 10 flows into the secondary side B. The remaining blood is sent from the primary side A of the first liquid separator 10 to the return blood vessel 21. On the other hand, the plasma on the secondary side B flows out from the outlet 10 c and is sent to the primary side E of the second liquid separator 12 through the forward line 80. The plasma from which the pathogenic substance is separated by the hollow fiber membrane 110 in the second liquid separator 12 flows out to the secondary side F, and flows out from the secondary side F to the return pipe 81. The pathogenic substance is discharged through the branch line 120. The plasma that has flowed out to the return conduit 81 is returned to the return blood vessel 21, joined with the blood from the first liquid separator 10, and returned to the patient.

  At the time of this plasma purification treatment, the liquid level of the secondary side B of the first liquid separator 10 is adjusted as in the priming process. For example, the pressure is detected by the atmospheric pressure sensor 62, and the tube pump 63 is rotated forward and backward based on the pressure to adjust the liquid level to a desired position. At this time, the liquid level is adjusted to be higher than the outlet 10c. When the tube pump 63 is rotated in the reverse direction, the pressure in the pipe line 60 becomes negative. However, even if the liquid on the secondary side B enters the pipe line 60, it is collected and stored in the liquid reservoir 70.

  According to the above embodiment, the liquid reservoir 70 is formed in the pipe line 60 that leads from the secondary side B of the first liquid separator 10 to the atmospheric pressure sensor 62. Therefore, when adjusting the liquid level on the secondary side B using the tube pump 63 during the priming process and the plasma purification treatment, the pressure on the side of the pipe 60 becomes negative, and the liquid in the secondary side B enters the pipe 60. Even if it enters, it is stored in the liquid reservoir 70. As a result, since the liquid can be prevented from reaching the atmospheric pressure sensor 62, contamination of the atmospheric pressure sensor 62 can be prevented, and for example, the number of replacements of the atmospheric pressure sensor 62 can be reduced.

  Further, since the liquid reservoir 70 is formed between the filter 61 of the pipe line 60 and the first liquid separator 10, it is possible to suppress the liquid from adhering to the filter 61. As a result, it is possible to prevent the filter 61 from getting wet with the liquid and preventing the gas from passing therethrough, so that the pressure detection by the atmospheric pressure sensor 62 can be performed appropriately.

  Since the connector 60a capable of cutting and connecting the pipe 60 is formed at a position closer to the pressure sensor 62 than the liquid reservoir 70 of the pipe 60, liquid is applied to the part of the extracorporeal circulation device 3 on the pressure sensor 62 side. Can be prevented from entering. Thereby, it is possible to prevent a portion not exchanged for each patient, such as the atmospheric pressure sensor 62, from being contaminated by an infectious substance contained in the liquid.

  Moreover, since the liquid pool part 70 is formed by making the internal diameter of the pipe line 60 larger than another part, the liquid pool part 70 can be formed with a simple structure.

  Since the inner diameter of the liquid reservoir 70 is formed to be 8 mm or more, the liquid in the pipe 60 is reliably transferred from the inner surface of the liquid reservoir 70 from the relationship between the surface tension of the liquid in the pipe 60 and gravity. Leave. As a result, the liquid can be collected more reliably in the liquid reservoir 70.

  In this embodiment, since the inner diameter of the pipe line 60 is 4 mm or less and is thin, in this case, the liquid level of the secondary side B can be easily adjusted by the tube pump 63, and operations such as connection of the pipe line 60 are possible. While the property is good, the liquid tends to remain in the pipe line 60. For this reason, since the possibility that the liquid once enters the pipe line 60 will remain and move toward the atmospheric pressure sensor 62 increases, the effect of forming the liquid reservoir 70 in the pipe line 60 as in the present invention is very large.

  Since the atmospheric pressure sensor 62 is installed higher than the position of the outlet 10d of the first liquid separator 10, the liquid on the secondary side B of the first liquid separator 10 does not easily reach the atmospheric pressure sensor 62 due to gravity. Further, contamination of the atmospheric pressure sensor 62 can be prevented more reliably.

  The preferred embodiments of the present invention have been described above with reference to the accompanying drawings, but the present invention is not limited to such examples. It will be apparent to those skilled in the art that various changes or modifications can be made within the scope of the ideas described in the claims, and these are naturally within the technical scope of the present invention. It is understood that it belongs.

  For example, in the above embodiment, the liquid reservoir portion 70 is formed by increasing the diameter of the pipe line 60. However, other configurations, for example, on the first liquid separator 10 side in the upper part of the container in which the liquid is stored. Further, the pipes 60 leading to the pressure sensor 62 side may be connected to each other. In the above embodiment, the liquid reservoir is formed in the pipe 60 of the so-called primary separation liquid separator 10 into which blood flows directly. However, the liquid separator performs separation after the so-called secondary separation. A liquid reservoir may be formed in the pipe line. The above embodiment is the extracorporeal circulation system 1 for the double filtration plasma purification method. It may be applied to an extracorporeal circulation system for blood purification therapy. Moreover, you may apply to the extracorporeal circulation system of liquids other than blood.

It is the schematic which shows the structure of the extracorporeal circulation system in this Embodiment. It is explanatory drawing which shows the outline of a structure of a liquid reservoir part. It is the schematic which shows the structure of the extracorporeal circulation system at the time of a priming process.

Explanation of symbols

DESCRIPTION OF SYMBOLS 1 Extracorporeal circulation system 2 Extracorporeal circulation circuit 3 Extracorporeal circulation apparatus 10 1st liquid separator 50 Hollow fiber membrane 60 Pipe line 61 Filter 62 Pressure sensor 63 Tube pump 70 Liquid reservoir A Primary side B Secondary side

Claims (9)

An extracorporeal circulation system that processes the liquid removed from the body and returns it to the body,
The liquid extracted from the body flows in, the primary side having the inlet and outlet of the liquid, and the secondary side having the liquid component separated from the primary liquid through the separating material and having the liquid component outlet. A liquid separator comprising:
A conduit communicating above the outlet on the secondary side of the liquid separator;
An atmospheric pressure sensor connected to the pipeline and detecting the pressure in the secondary side of the liquid separator via the atmospheric pressure in the pipeline;
A pump connected to the conduit and capable of pumping and sucking gas to and from the secondary side of the liquid separator;
An extracorporeal circulation system, wherein a liquid reservoir for storing liquid flowing in from the liquid separator is formed between the atmospheric pressure sensor and the liquid separator in the pipe line. A filter is provided at a position closer to the liquid separator than the pump and the atmospheric pressure sensor in the pipeline, and prevents passage of unnecessary substances in the gas in the pipeline,
The extracorporeal circulation system according to claim 1, wherein the liquid reservoir is formed between the filter and the liquid separator in the pipe line.   The extracorporeal body according to claim 1, wherein a connector part capable of cutting and connecting the pipe line is formed at a position closer to the atmospheric pressure sensor than the liquid reservoir part of the pipe line. Circulation system.   The extracorporeal circulation system according to any one of claims 1 to 3, wherein the liquid reservoir is formed by making the inner diameter of the pipe line larger than the other part.   The extracorporeal circulation system according to claim 4, wherein an inner diameter of the liquid reservoir is 8 mm or more.   The extracorporeal circulation system according to any one of claims 1 to 5, wherein an inner diameter of the conduit is 4 mm or less. Above the outlet on the secondary side of the liquid separator, another outlet communicating with the pipe line is formed,
The extracorporeal circulation system according to claim 1, wherein the atmospheric pressure sensor is installed at a position higher than the other outlets.   The extracorporeal circulation system according to claim 1, wherein the separation material is a hollow fiber membrane. The treatment of the liquid is blood plasma purification,
The extracorporeal circulation system according to claim 1, wherein the liquid separator is for separating plasma from blood.

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