JP6512805B2 - Blood purification system - Google Patents

Description

  The present invention provides a blood purification system comprising a plurality of blood purification means to which a blood purifier for treating blood purification treatment is attached, and a dialysate supply means capable of supplying dialysate to each of the blood purification means. It is about

  Generally, in a blood purification system, a dialysate supply means is installed in a machine room at a medical site such as a hospital, and a blood purification means (dialysis monitoring apparatus) is installed in a dialysis room (treatment room). The means and the blood purification means are connected by piping. The dialysate supply means produces a dialysate having a predetermined concentration, and the blood purification means is installed in a plurality with a blood purifier (dialyser) for performing dialysis treatment on the patient, and is produced by the dialysate supply means. The blood purification treatment (dialysis treatment) is performed by introducing the dialysate through the piping and supplying it to the blood purifier.

  That is, the dialysate supply means installed in the machine room distributes to a plurality of blood purification means installed in the dialysis room to send the dialysate, and the respective blood purification means supplies the dialysate to the dialyzer for treatment Is configured to be performed. The blood purification system for supplying the dialysate thus prepared by the dialysate supply means to the monitoring devices for dialysis is generally referred to as "central system for dialysis treatment" and disclosed, for example, in Patent Document 1 Are listed. According to such a conventional blood purification system, since the dialysate prepared at once by the dialysate supply means is distributed to the patients in each blood purification means to carry out the blood purification treatment, it is effective for a large number of people. Blood purification treatment can be performed.

JP 2012-249750 A

  However, in the above-mentioned conventional blood purification system, since the dialysate prepared collectively by the dialysate supply means is distributed to each blood purification means to perform the blood purification treatment, the supplied dialysate has the same composition. It is difficult to supply dialysate corresponding to different conditions (patient condition, treatment method, etc.) for each patient. In addition, although various personal blood purification means for supplying dialysate to one patient has been proposed variously, such personal blood purification means efficiently supplies dialysate to a large number of patients. It will be difficult.

  The present invention has been made in view of such circumstances, and an object thereof is to provide a blood purification system capable of efficiently supplying a large number of patients with dialysate corresponding to different conditions for each patient. .

The invention according to claim 1 comprises a plurality of blood purification means attached with a blood purifier for giving blood purification treatment to a patient, a dialysate supply means capable of supplying a dialysate to each of the blood purification means, and In a blood purification system provided with a supply flow path for circulating and supplying dialysate from each of the blood purification means from the dialysate supply means, the dialysate flowing through the supply flow path in the middle of the supply flow path Provided with an injection means capable of injecting a specific component into the blood vessel, and provided with a concentration measurement means capable of measuring the concentration of the individual components contained in the dialysate flowing through the supply flow passage over time during blood purification treatment. The concentration measuring means is connected to the upstream side and the downstream side of the injection means in the supply flow channel, and can compare the concentrations of the individual components measured by the concentration measuring means. Do

  The invention according to claim 2 is the blood purification system according to claim 1, wherein the supply flow channel is branched into a plurality, and the blood purification unit is disposed in each of the branched supply flow channels and is branched. The injection means is connected to an arbitrary supply flow path.

  The invention according to claim 3 is the blood purification system according to claim 1 or 2, wherein the blood purification means is disposed at a predetermined site of the supply flow channel on the upstream side and the downstream side, respectively. The injection means is connected.

The invention according to a fourth aspect is the blood purification system according to any one of the first to third aspects, wherein the injection means comprises a containing means for containing a drug containing the specific component, the containing means, and the containing means. It has a connection flow path for connecting to a supply flow path, and an injection pump disposed in the connection flow path for feeding a drug containing a specific component of the storage means to the supply flow path. .

According to the invention of claim 1, since the injection means capable of injecting a specific component into the dialysate flowing through the supply flow path is connected in the middle of the supply flow path, the dialysate can not be injected with the specific component. And the dialysate in which the specific component was inject | poured can be distribute | circulated in a supply flow path, respectively, and a large number of patients can be efficiently supplied with the dialysate made to respond | correspond to a different condition for every patient.
In addition, since the concentration measurement means capable of measuring the concentration of the individual components contained in the dialysate flowing through the supply flow path during the blood purification treatment is provided, the blood purification from the dialysate supply means is performed during the blood purification treatment. The concentration of the dialysate supplied to the means can be measured accurately and automatically, and the propriety of the concentration of the dialysate can be determined more accurately.
Furthermore, since the concentration measuring means is connected to the upstream and downstream sides of the injection means in the supply channel, respectively, and the concentrations of the individual components measured by the concentration measuring means can be compared, it is possible to specify The determination as to whether or not the component has been properly injected can be made accurately.

  According to the second aspect of the present invention, the supply flow channel is branched into a plurality of branches, and the blood purification unit is disposed in each of the branched supply flow channels, and the injection unit is connected to any branched supply channel. Since the dialysate into which the specific component has been injected flows through the supply flow channel to which the injection means is connected, and the dialysate through which the specific component is not injected is flowed through the supply flow channel to which the injection means is not connected. Can.

  According to the invention of claim 3, since the injection means is connected to the predetermined portion of the supply flow path and to the portion where the blood purification means is disposed on the upstream side and the downstream side respectively, the portion to which the injection means is connected The dialysate into which the specific component has been injected can be distributed further downstream, and the dialysate into which the specific component can not be injected can be distributed upstream of the site to which the injection means is connected.

According to the invention of claim 4 , the injection means is provided in the storage means for storing the medicine containing the specific component, the connection flow path connecting the storage means and the supply flow path, and the connection flow path. And the infusion pump for feeding the medicine containing the specific component of the storage means into the supply channel, so that the specific component can be injected more reliably and smoothly to the dialysate flowing through the supply channel. .

Overall schematic diagram showing a blood purification system according to an embodiment of the present invention The schematic diagram which shows the structure of the blood purification means in the same blood purification system A schematic diagram showing concentration measurement means in the same blood purification system The schematic diagram which shows the concentration measurement means of the other aspect in the same blood purification system Flow chart showing the control contents of the same blood purification system

Hereinafter, embodiments of the present invention will be specifically described with reference to the drawings.
The blood purification system according to the present embodiment is for producing a dialysate having a predetermined concentration from a dialysate stock solution and supplying the dialysate to a plurality of blood purification means, and as shown in FIG. And the like. A plurality of blood purification means 1 installed in a dialysis room (treatment room) at a medical site, a dialysate supply device 2 installed in a machine room at the medical site, each blood purification means 1 and a dialysate supply means 2 Are mainly composed of supply flow paths H, H1 and H2 connecting the two, injection means B1 and B2, and concentration measurement means (M1 to M3).

  The blood purification means 1 is referred to as a monitoring device, and is provided with a dialyzer 3 (blood purifier) for performing blood purification treatment (hemodialysis treatment) on the patient, and the dialysis supplied from the dialysate supply device 2 A plurality of liquids are supplied to the dialyzer 3, and a plurality of liquids are provided along the supply flow paths H1 and H2. The blood purification means 1 is provided with a touch panel capable of performing instructions for hemodialysis treatment and other control contents (washing or disinfection) and predetermined display.

  More specifically, as shown in FIG. 2, each of the plurality of blood purification means 1 installed in the dialysis chamber is connected to piping from the supply channel H 1 or the supply channel H 2 extended from the dialysate supply device 2. A pipe L2 is connected to a drainage means (not shown) while L1 is drawn in, and a duplex pump 8 is disposed across the pipes L1 and L2. Among them, the pipe L1 in the blood purification means 1 is provided with a conductivity sensor 5 for measuring the conductivity of the dialysate flowing through the pipe L1, a fluid pressure detection sensor 6 for detecting the fluid supply pressure of the fluid, etc. It is done. In addition, the code | symbol 7 in the same figure has shown the control means, and various control for performing the blood purification treatment by this control means 7 is performed.

  Further, a dialysate introduction line L4 in communication with the pipe L1 and a dialysate discharge line L5 in communication with the pipe L2 are extended from the double pump 8, and the tip of the dialysate introduction line L4 via the coupler C is extended. Can be connected to the dialysate inlet 3a of the dialyzer 3, and the tip of the dialysate outlet line L5 can be connected to the dialysate outlet 3b of the dialyzer 3 via the coupler C. Thus, each blood purification means 1 is provided with a dialyzer 3 adapted to each patient, and a blood circuit 4 for circulating the patient's blood outside the blood vessel is connected to the dialyzer 3. Become.

  The pump chamber of the duplex pump 8 is separated by a single plunger (not shown) into a liquid feed side pump chamber connected to the pipe L1 and a discharge side pump chamber connected to the pipe L2, and the plunger is By reciprocating, the dialysate or the washing solution sent to the fluid feed side pump chamber is supplied to the dialyzer 3, and the dialysate in the dialyzer 3 is sucked into the discharge side pump chamber. Furthermore, in the blood purification means 1, there is formed a pipe L3 connecting the pipe L2 and the dialysate discharge line L5 while bypassing the double pump 8, and the water removal pump 9 is disposed in the middle of this pipe L3. It is done. By driving the water removal pump 9, it is possible to remove water from the patient's blood flowing in the dialyzer 3.

  In addition, instead of the dual pump 8, a so-called chamber type may be used, and sensors such as the conductivity sensor 5 and the hydraulic pressure detection sensor 6 may be provided arbitrarily or other general purpose You may add something. Furthermore, in the present embodiment, the sensors are disposed in the pipe L1, but may be disposed in another pipe (for example, the pipe L4). For example, sensors such as the conductivity sensor 5 and the fluid pressure detection sensor 6 may be disposed in either one or both of the pipe L1 and the pipe L4.

  The dialysate supply means 2 can produce a dialysate having a predetermined concentration using, for example, clean water obtained by a water treatment apparatus (not shown) and a dialysate stock solution produced by a dissolution apparatus (not shown), and The prepared dialysate can be supplied to each of the purification means 1. That is, the dialysate supply means 2 is connected to each of the plurality of blood purification means 1 through the supply flow paths H, H1, H2, and dialysis is performed to each of the blood purification means 1 through the supply flow path H. It is configured to be able to supply a desired liquid such as liquid, wash water and disinfectant liquid. In addition, the undiluted solution for dialysis applied in the present embodiment is a drug comprising an undiluted solution A by dissolving undiluted solution of powdered sodium bicarbonate (agent A) with clean water, powdered aqueous sodium bicarbonate ( Although the B solution is obtained by dissolving the B agent) in clean water, the A solution or B solution provided as a liquid may be stored in a tank or the like and used as it is. That is, the dialysate supply means 2 can mix and dilute the undiluted solution A and undiluted solution B with clean water obtained as described above to obtain a dialysate. It is possible to supply to each.

  Furthermore, the dialysate supply means 2 according to the present embodiment is electrically connected to concentration measurement means (M1 to M3) described later in detail, and based on the measurement values of these concentration measurement means (M1 to M3). When the concentration of the individual component of the dialysate exceeds the appropriate range as a result of the determination by the determination unit 10 that determines whether the concentration of the individual component of the dialysate flowing through the supply flow path H is appropriate and the determination unit 10 It has the alerting | reporting means 11 which performs the alerting | reporting etc. by the alerting | reporting by a display, and the output of a sound.

  The supply flow paths H, H1 and H2 are pipes for circulating and supplying the dialysate (including the washing solution and the disinfectant solution) from the dialysate supply means 2 to the respective blood purification means 1. In this embodiment, the supply flow path H extends from the dialysate supply means 2, and is branched into a plurality of (two) supply flow paths H1 and H2 at a branch point G, and the branch is made A plurality of blood purification means 1 are disposed in each of the supply flow paths H1 and H2, and injection means (B1 and B2) are connected to any of the branched supply flow paths.

  The supply flow path H1 is formed endlessly via the circulation heating unit Y, and is configured to supply the blood purification means 1 with circulating the dialysate. The circulation heating unit Y is for heating and circulating the circulating dialysate, and in the present embodiment, a discharge pipe Hd for discharging the circulating dialysate to the outside is extended. . Moreover, between the branch point G in the supply flow passage H1 and the circulation heating unit Y, a single non-circulation flow passage is extended, and the downstream side from the circulation heating unit Y is a circulation flow passage. A plurality of blood purification means 1 are provided.

  The supply flow path H2 is composed of one non-circulating flow path extended from the branch point G, and the drainage valve V is connected to the end, and the drainage valve V is opened. Then, the water remaining in the supply channel H2 is pushed out and drained at the start of dialysis fluid supply, and the inside of the supply channel H2 is quickly replaced with dialysate, or when washing and disinfecting after the end of dialysis, the supply channel The dialysate and disinfectant remaining in H2 are quickly pushed out and discharged. The blood purification means 1 may be disposed such that the supply flow path H2 is further branched in the middle of the supply flow path H2 or the supply flow path H2 is a circulation flow path, and each branched supply flow path or the circulated supply flow path. It is also good. Further, three or more supply flow channels may be branched from the branch point G, and the blood purification unit 1 may be disposed in each branched supply flow channel.

  Here, in the middle of the supply flow passage H1 and the supply flow passage H2 according to the present embodiment, injection means B1 and B2 capable of injecting a specific component to the dialysate flowing in the supply flow passages H1 and H2 are connected. ing. The injection means B1 is connected to a portion between the branch point G in the supply flow path H1 and the circulation heating unit Y, and the injection means B2 is a predetermined portion of the supply flow path H2 and is located upstream and downstream Are connected to the site where the blood purification means 1 is disposed.

  These injection means B1 and B2 include storage means D1 and D2 for storing a medicine containing a specific component, connection flow paths a and b connecting the storage means D1 and D2 and the supply flow paths H1 and H2, and connection flow Infusion pumps P1 and P2 disposed in the passages a and b for feeding medicines containing specific components of the storage means D1 and D2 into the supply passages H1 and H2, and dialysate flowing in the supply passages H1 and H2 , And a mixing chamber m1, m2 for stirring and mixing an agent containing a specific component.

The medicine contained in the housing means D1, D2 includes, for example, sodium chloride (NaCl), potassium chloride (KCl), calcium chloride (CaCl ₂ ), sodium hydrogen carbonate (NaHCO ₃ ), glucose (C ₆ H) as specific components. _It contains ₁₂ O ₆ ) and the like, and may contain a plurality of components in addition to those containing a single component. The specific component injected by the injection means B1 and the specific component injected by the injection means B2 may be the same or different in type and concentration. The injection means B1 and B2 may inject the medicine in the storage means D1 and D2 under their own weight. In that case, it is preferable to connect a shutoff valve instead of the injection pumps P1 and P2.

  Thus, during blood purification treatment, a dialysate is caused to flow in the supply flow paths H, H1, H2, and the infusion pumps P1, P2 are driven, whereby a medicine containing specific components in the containing means D1, D2 After being injected into the supply flow paths H1 and H2 and the dialysate and the drug are stirred and mixed in the mixing chambers m1 and m2, they are supplied to the blood purification means 1 further downstream. In this way, if a drug containing any specific component is contained and infused into the containing means D1, D2, for example, patients with hypokalemia infused with potassium chloride (KCl) as the specific component For patients who need to use dialysate and prevent a drop in blood pressure, dialysate infused with sodium chloride (NaCl) as a specific ingredient can be used.

  Furthermore, the concentration (composition concentration) of the individual components contained in the dialysate flowing through the supply flow paths H, H1, H2 in the supply flow paths H, H1, H2 according to the present embodiment during the blood purification treatment The concentration measuring means (M1 to M3) which can be measured in a random manner are connected. The concentration measurement means M1 is the supply flow path H and is connected to the upstream side of the branch point G (between the dialysate supply means 2 and the branch point G), and the concentration measurement means M2 is in the supply flow path H1. The circulation flow path and the concentration measurement means M3 are connected to the downstream side of the injection means B2 in the supply flow path H2, respectively.

  More specifically, as shown in FIG. 3, the concentration measuring means M1 (as well as the concentration measuring means M2 and M3) have a drawing flow path h1 which can draw the dialysate flowing through the supply flow path H, and the drawing flow A concentration measurement unit N capable of measuring the concentration of the individual components while accommodating the dialysate drawn in the flow passage h1, and an injection pump Pa disposed in the draw passage h1 for feeding the dialysate to the concentration measurement unit N And a discharge flow passage h2 for discharging the dialysate after the concentration of the individual component has been measured by the concentration measurement unit N to the outside.

The concentration of the individual component measured by the concentration measurement unit N is the concentration of the individual component contained in the dialysate, and, for example, sodium (Na), potassium (K), calcium (Ca), carbon dioxide (CO ₂ ), etc. Concentration of In addition to the concentrations of the individual components contained in the dialysate flowing through the supply flow path H, the concentration measurement means M1 may be capable of measuring the osmotic pressure, pH and conductivity of the dialysate, in that case In addition to the propriety of the concentration of the dialysate flowing through the supply channel H, the propriety of the osmotic pressure, the pH and the conductivity can also be determined.

  Furthermore, the concentration measuring means (M1 to M3) may be configured to measure the concentrations of all the same individual components, or may be configured to measure the concentrations of different individual components. Furthermore, in the present embodiment, the injection pump Pa disposed in the drawing flow passage h1 for feeding the dialysate to the concentration measurement unit N is disposed, but in place of the injection pump Pa, FIG. The shutoff valve Va may be disposed as shown in FIG. Further, in the present embodiment, the discharge flow path h2 for discharging the dialysate after the concentration of the individual components has been measured by the concentration measurement unit N is extended, but instead of the discharge flow path h2 Alternatively, the dialysate after the concentration of the individual component has been measured by the concentration measurement unit N may be returned to the supply passage H again.

  Therefore, during blood purification treatment (during dialysis treatment), when the injection pump Pa is driven (the shutoff valve Va may be opened), part of the dialysate flowing through the supply flow passage H is drawn into the suction flow passage h1. The concentration measurement unit N is drawn in and reaches the concentration measurement unit N, the concentration of the individual components is measured while being stored in a state where the flow is stopped, and the measured dialysate flows through the discharge flow path h2 and is discharged It will be done. The concentration of the individual components contained in the dialysate flowing through the supply flow passage H can be measured over time by repeating the operation continuously or intermittently during the blood purification treatment. The information of the concentration of the individual component measured here is transmitted to the determination unit 10 of the dialysate supply unit 2, and it is determined whether the concentration of the individual component is appropriate. The determination means 10 need not necessarily be provided in the dialysate supply means 2. For example, the determination means 10 may be provided in each of the concentration measurement means (M1 to M3) or is provided independently. It is also good.

  Furthermore, in the present embodiment, before or after blood purification treatment, the dialysate supply unit 2 can supply a cleaning solution or a disinfectant solution to each blood purification unit 1, and concentration measurement unit (M1 to M3) Preferably, the concentration of individual components (for example, chlorine (Cl) etc.) contained in the cleaning solution or the disinfecting solution can be measured. In this case, it is possible to accurately determine whether the concentration of the cleaning solution or the disinfecting solution supplied from the dialysate supply unit 2 to the blood purification unit 1 is being cleaned or disinfected.

  The concentration measuring means M1 and M2 and the concentration measuring means M1 and M3 according to the present embodiment are connected to the upstream and downstream sides of the injection means B1 and B2 in the supply flow paths H, H1 and H2, respectively, The concentrations of the individual components measured by means (M1 to M3) can be compared. As a result, it is possible to accurately determine whether or not the specific component has been properly injected by the injection means B1 and B2.

Next, an example of control contents in the blood purification system according to the present embodiment will be described based on the flowchart of FIG.
When the blood purification treatment (dialysis treatment) is started, the dialysate is circulated from the dialysate supply means 2 through the supply flow path H and supplied to the respective blood purification means 1 while the specific component is supplied by the injection means B1 and B2. The medicine contained is injected (S1), and the concentration measuring means (M1 to M3) measure the concentrations of the individual components of the dialysate flowing through the supply flow paths H, H1 and H2 (S2). Thereafter, the measurement values of the concentration measurement means (M1 to M3) are transmitted to the determination means 10, and it is determined whether the concentration of the individual component of the dialysate is appropriate (S3).

  Then, if it is determined in S3 that the concentration of the individual components of the dialysate is appropriate (within the appropriate range), the supply of dialysate by the dialysate supply means 2 is continued (S4) and the dialysis in S3 If it is determined that the concentration of the individual components of the solution is not appropriate (outside the appropriate range), the dialysate stock solution injection pump provided in the dialysate supply means 2 at S5, or each of the injection pumps P1 and P2, or It controls everything, drives so that the density | concentration of the separate component of the supply flow path H, H1, H2 dialysate becomes appropriate, returns to S2, and performs subsequent control again. In addition, in order to discover the failure of the concentration measuring means (M1 to M3), the measurement values of the concentration measuring means (M1 to M3) are compared in a state where the injection of the drug by the injecting means B1 and B2 is not performed. Alternatively, plural concentration sensors (not shown) may be provided in the respective concentration measuring means (M1 to M3) to compare the two.

  According to the above embodiment, since the injection means B1 and B2 capable of injecting a specific component into the dialysate flowing in the supply flow paths H1 and H2 are connected in the middle of the supply flow paths H1 and H2 The dialysate from which no component is infused and the dialysate into which a specific component is infused can be circulated through the supply channels H1 and H2, respectively, and can be efficiently handled by a large number of patients and different among the patients. It can supply dialysate.

  Further, the supply flow path H is branched into a plurality, and the blood purification means 1 is disposed in each of the branched supply flow paths H1 and H2, and the injection means B1 is connected to any branched supply flow path H1 and H2. Since B2 is connected, the dialysate into which the specific component is injected is made to flow through the supply flow paths H, H1 and H2 to which the injection means B1 and B2 are connected, and the supply flow paths not connected with the injection means B1 and B2 H, H1, H2 can be passed through a dialysate in which specific components are not injected.

  Furthermore, since the injection means B2 is connected to the predetermined part of the supply flow path H2 and to the part where the blood purification means 1 is disposed on the upstream side and the downstream side, respectively, downstream from the part to which the injection means B2 is connected Can flow the dialysate in which the specific component is injected, and can flow the dialysate in which the specific component is not injected upstream of the site where the injection means B2 is connected.

  Furthermore, since blood was provided with concentration measuring means (M1 to M3) capable of measuring the concentrations of the individual components contained in the dialysate flowing through the supply flow paths H, H1 and H2 over time during blood purification treatment, During purification treatment, the concentration of the dialysate supplied from the dialysate supply means 2 to the blood purification means 1 can be measured accurately and automatically, and the propriety of the concentration of the dialysate can be determined more accurately.

  Further, the injection means B1 and B2 according to the present embodiment are connection means for connecting the means for containing D1 and D2 for containing the medicine containing the specific component, and the means for containing D1 and D2 and the supply flow path H1 and H2. a and b, and infusion pumps P1 and P2 disposed in the connection channels a and b for feeding medicines containing specific components of the storage means D1 and D2 into the supply channels H1 and H2, Specific components can be more reliably and smoothly injected into the dialysate flowing through the supply flow paths H1 and H2.

  As mentioned above, although the blood purification system concerning this embodiment was explained, the present invention is not limited to this, for example, a concentration measurement means is a supply flow path in blood purification means 1 (pipe L1 in FIG. It may be connected to the introductory line L4 etc.) and the specific component different from the above is injected by the injection means B1 and B2, or the concentration of the individual component different from the above is temporally during blood purification treatment. It may be measurable. Further, the arrangement positions and the number of arrangement of the injection means B1 and B2 and the concentration measurement means (M1 to M3) may be other forms. Furthermore, the pipes H, H1 and H2 do not necessarily have to be this combination, and either the pipe H1 or the pipe H2 or another combination may be present. In addition, in this embodiment, although it is set as the system which performs a hemodialysis treatment, you may make it apply it to the blood purification system which performs other blood purification treatment.

An injection means capable of injecting a specific component into the dialysate flowing through the supply flow path is connected midway in the supply flow path , and individual components contained in the dialysate flowing through the supply flow path during blood purification treatment The concentration measurement means is connected to the upstream side and the downstream side of the injection means in the supply flow channel, and the concentration measurement means can measure the concentration of the individual components measured by each concentration measurement means. The blood purification system whose concentration can be compared can also be applied to those to which other functions are added.

1 blood purification means 2 dialysate supply device 3 dialyzer (blood purifier)
4 blood circuit 5 conductivity sensor 6 fluid pressure detection sensor 7 control means 10 determination means 11 notification means B1, B2 injection means H supply flow paths M1 to M3 concentration measurement means

Claims (4)

A plurality of blood purification means fitted with a blood purifier for providing blood purification treatment to the patient;
A dialysate supply means capable of supplying dialysate to each of the blood purification means;
A supply flow path for circulating and supplying dialysate from the dialysate supply means to each blood purification means;
In a blood purification system equipped with
In the middle of the supply flow path, an injection means capable of injecting a specific component into the dialysate flowing through the supply flow path is connected , and during blood purification treatment, it is contained in the dialysate flowing through the supply flow path. Measurement means capable of measuring the concentration of the individual components to be measured over time, and the concentration measurement means is connected to the upstream and downstream sides of the injection means in the supply flow channel, and each concentration measurement means A blood purification system characterized in that it is possible to compare the concentrations of the individual components measured in the above .   The supply flow channel is branched into a plurality of parts, and the blood purification means is disposed in each of the branched supply flow channels, and the injection means is connected to any of the branched supply flow channels. The blood purification system according to claim 1.   The blood according to claim 1 or 2, wherein the injection means is connected to a predetermined portion of the supply flow path, at a portion where the blood purification means is disposed on the upstream side and the downstream side, respectively. Purification system. The injection means includes a storage means for storing a drug containing the specific component, a connection flow path connecting the storage means and the supply flow path, and a connection flow path disposed to specify the storage means The blood purification system according to any one of claims 1 to 3 , further comprising: an infusion pump for feeding a drug containing the following ingredients into the supply channel.

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