JP2007210935A - Anti-inflammatory composition and health cosmetic composition having anti-inflammatory action - Google Patents
Anti-inflammatory composition and health cosmetic composition having anti-inflammatory action Download PDFInfo
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Abstract
Description
本発明は、ナタマメの生の莢から抽出したエキスを主成分とする抗炎症組成物及び抗炎症作用を有する健康美容用組成物に関する。 The present invention relates to an anti-inflammatory composition mainly composed of an extract extracted from raw pods of field beans, and a health and beauty composition having an anti-inflammatory action.
ナタマメの豆に関しては、のどの腫れ、痛み、声がれ、口内炎に効くこと、又便秘、下痢、腹痛の解消に効果があること、排膿消炎作用があること、ウミのたまる病気に用いられること、痔瘻等で煎じ液をふろの中に入れ、浴剤として用いること、等に効果があることが知られている（例えば、特許文献１及び特許文献２参照）。 As for beans of beans, it is effective for swelling of throat, pain, vocalization, stomatitis, constipation, diarrhea, abdominal pain, anti-pus drainage, and it is used for urine diseases. In addition, it is known that the decoction liquid is put in a bath with a candy etc. and used as a bath agent, etc. (see, for example, Patent Document 1 and Patent Document 2).
さらにナタマメのつるや茎を採取して乾燥させたものが湿疹等の皮膚病の改善に有効であること等も知られている（例えば、特許文献１参照）。 Furthermore, it is also known that a product obtained by collecting and drying peas and stems of peas is effective in improving skin diseases such as eczema (for example, see Patent Document 1).
しかし、前記文献にはナタマメの莢に関しては何も記載されていない。ナタマメの莢に関しては残渣として捨てられ産業廃棄物となっているのが現状である。 However, the above document does not describe anything about peas. The present condition is that it is thrown away as residue and becomes industrial waste.
そこで、本発明者らは残渣として捨てられていたナタマメの莢に着目し、ナタマメの莢に関して何か効果があれば残渣として捨てられることもなく産業廃棄物になることもないと考え、鋭意研究した結果ナタマメの莢に抗炎症作用があることを発見した。 Therefore, the present inventors focused on the peas that were thrown away as a residue, and thought that if there was any effect on the pods of peas, they would not be thrown away as a residue and would not become industrial waste. As a result, it was discovered that the pods of jujube have anti-inflammatory effects.
通常、植物等を利用する場合、保存等を考慮し、乾燥させてからエキス等を抽出して利用するものであり、このため、ナタマメを利用する場合も乾燥させてから利用するのが通常である。その結果ナタマメの莢に抗炎症作用があることを発見したが、乾燥させると活性作用が落ちてしまうことが分かった。 Normally, when using plants, etc., in consideration of preservation, etc., the extract is extracted and used after drying. For this reason, it is usually used after drying the beans. is there. As a result, it was discovered that the pods of jujube have an anti-inflammatory effect, but it was found that the active action declines when dried.
そこで、さらに鋭意研究の結果生の莢で実験したところ、生の莢は乾燥させた莢よりもより強い抗炎症作用があることを発見した。生の莢は２０％以上（w/w）水分を含んでいることが必要である。２０％未満（w/w）だと乾燥状態になってしまうからである。したがって水分含有量が多ければ多いほど生の状態に近いので多いほど良い。 As a result of further diligent research, we discovered that raw cocoons have a stronger anti-inflammatory effect than dried cocoons. Raw straw must contain 20% or more (w / w) moisture. This is because if it is less than 20% (w / w), it becomes dry. Therefore, the higher the moisture content, the closer to the raw state, the better.
したがって、本発明の目的は、ナタマメの莢のエキスを主成分とする抗炎症組成物及び抗炎症作用を有する健康美容用組成物を提供することを目的とする。 Accordingly, an object of the present invention is to provide an anti-inflammatory composition mainly composed of an extract of jujube pod and a health beauty composition having an anti-inflammatory action.
前記目的を達成するため、本発明の抗炎症組成物及び抗炎症作用を有する健康美容用組成物は、ナタマメの生の莢から抽出したエキスを主成分とすることからなる。
又、ナタマメの生の莢は２０％以上（w/w）水分を含んでいるものでなければならないが、水分含有量が多ければ多いほど生の状態に近いので多いほど良い。
抗炎症組成物の例としては、抗炎症作用を有する医薬部外品、抗炎症作用を有する健康美容用組成物としては、化粧品、健康食品等がある。
In order to achieve the above object, the anti-inflammatory composition and the health cosmetic composition having anti-inflammatory action of the present invention are mainly composed of an extract extracted from raw soybeans of peanut.
In addition, raw pods of jujube must contain 20% or more (w / w) moisture, but the higher the moisture content, the closer to the raw state, the better.
Examples of the anti-inflammatory composition include quasi-drugs having an anti-inflammatory effect, and health cosmetic compositions having an anti-inflammatory effect include cosmetics and health foods.
ナタマメの生の莢から抽出したエキスにより抗炎症組成物、抗炎症作用を有する健康美容用組成物等を提供することが出来る。 An extract extracted from raw peas of peanut can provide an anti-inflammatory composition, a health beauty composition having an anti-inflammatory effect, and the like.
下記に本発明の実験例を示す。
［実験例１］
マウス皮膚における強力な発癌プロモーターである12-O-tetradecanoylphorbol-13-acetate (TPA)が誘発する炎症に対する効果を検討し、抑制効果についてマウス皮膚二段階発癌実験を行った。今回，本発癌系に対して、ナタマメの莢についてその有効性を検討した。
Experimental examples of the present invention are shown below.
[Experimental Example 1]
We investigated the effects of 12-O-tetradecanoylphorbol-13-acetate (TPA), a strong tumor promoter in mouse skin, on inflammation induced by mouse skin, and conducted two-stage mouse skin carcinogenicity experiments. In this study, we investigated the effectiveness of peanut spear against this carcinogenic system.
実験方法はT. Kaminagaらの方法を用いた（T. Kaminaga, K. Yasukawa, M. Takido, T. Tai, Y. Nunoura,Phytother. Res. 10, 581-584(1996)）。実験動物各7週齢のICR雌性マウスをJapan SLCから購入し、室温23±5 °C、湿度50±5%のSPF飼育室で8時より20時まで照明を付けて飼育した。
マウスの右内・外耳殻にTPA 1μgを20μ1のacetone溶液として塗布し，最高腫脹時である塗布6時間後の耳殻腫脹を測定し、対照群との比より算出した。検体は、CHCl3-MeOH-H2O (1:2:1〕混液20μ1に溶解しTPA塗布の30分前に同一部位に塗布した。各群4匹を用いて行った。
The experimental method used was the method of T. Kaminaga et al. (T. Kaminaga, K. Yasukawa, M. Takido, T. Tai, Y. Nunoura, Phytother. Res. 10, 581-584 (1996)). Experimental animals 7-week-old ICR female mice were purchased from Japan SLC and reared from 8 o'clock to 20 o'clock in an SPF breeding room at room temperature 23 ± 5 ° C and humidity 50 ± 5%.
TPA 1μg was applied as a 20μ1 acetone solution to the right inner and outer ear shells of mice, and the swelling of the ear shell 6 hours after the application, which was the maximum swelling, was measured and calculated from the ratio with the control group. The specimen was dissolved in 20 μ1 of a CHCl 3 -MeOH-H 2 O (1: 2: 1) mixed solution and applied to the same site 30 minutes before TPA application, using 4 mice in each group.
薬物及びTPAの塗布には、エッペソドルフピペット4710クリスタルを用いた。
ナタマメの乾燥させた莢，生の莢の50%EtOH抽出エキスは、TPAが誘発する炎症に対して1 mg/earの用量で 29％， 40%の抑制率を示した。又、50%EtOHエキスのEtOAc可溶部について同様の実験を行ったところ、0.5 mg/earの用量で、それぞれ同様に 31％， 72%の抑制率を示した。生の莢は乾燥させた莢よりもかなり強い抑制効果が見られた。抗炎症薬であるインドメタシン及びヒドロコーチゾンのID50は、それぞれ325，25.2 μgであり、これらはインドメタシンと同程度の効果を有すると考えられる。
For application of the drug and TPA, an Eppesordorf pipette 4710 crystal was used.
Extracts of dried peas and raw cocoons with 50% EtOH extract showed 29% and 40% inhibition of TPA-induced inflammation at a dose of 1 mg / ear. When the same experiment was conducted on the EtOAc soluble part of 50% EtOH extract, the inhibition rate was 31% and 72% respectively at the dose of 0.5 mg / ear. The raw cocoons showed a much stronger inhibitory effect than the dried cocoons. The anti-inflammatory drugs indomethacin and hydrocortisone have ID 50 of 325 and 25.2 μg, respectively, which are considered to have the same effect as indomethacin.
下記に本発明の生の莢の抽出エキスの抽出例を示す。 The extraction example of the raw cocoon extract of the present invention is shown below.
［抽出例１］
ナタマメの生の莢を適当な大きさに刻み、８０％エタノールにつけ、８０℃で２０分間加熱する。加熱後、ろ過し抽出エキスを減圧で乾燥した。抽出エキスはスプレードライ末、凍結乾燥末、エキスそのもの等を使用する。
[Extraction Example 1]
Sliced raw peas are chopped to an appropriate size, soaked in 80% ethanol, and heated at 80 ° C. for 20 minutes. After heating, the mixture was filtered and the extract was dried under reduced pressure. As the extract, spray-dried powder, freeze-dried powder, or the extract itself is used.
下記にローション、乳液、健康食品（通常行われているように、カプセル状、パウダー状、錠剤、顆粒、液状等の形態があるが、ここでは代表例として、カプセル状、パウダー状を例に示す。）の混合例、配合例を示す。 Lotions, emulsions, health foods (as usual, there are capsules, powders, tablets, granules, liquids, etc., but here representative examples are capsules and powders) .)) Examples of mixing and formulation.
［例３］
ソフトカプセルの健康食品の混合例
小麦胚芽油 ５０％（w/w）
ミツロウ ７％
抽出例１のエキス１０％
豚由来ジェラチン ２２％
グリセリン ７％
小麦末 ４％
[Example 3]
Soft capsule health food mixed example Wheat germ oil 50% (w / w)
Beeswax 7%
Extract 10% of Extraction Example 1
Gelatin from pork 22%
Glycerin 7%
4% wheat flour
［例４］
パウダー状の健康食品の配合例
明日葉パウダー ５０％（w/w）
大麦若葉バウダー４０％
抽出例１のパウダー１０％
[Example 4]
Formulation of powdered health food tomorrow leaf powder 50% (w / w)
Barley Wakaba Bower 40%
Extraction example 1 powder 10%
Claims (4)
The health cosmetic composition having an anti-inflammatory effect according to claim 2, wherein the raw pods of jujube contain 20% or more (w / w) moisture.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2011055712A (en) * | 2009-09-07 | 2011-03-24 | Toyo Shinyaku Co Ltd | Composition including barley young leaf and glucosamine |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2000154119A (en) * | 1998-11-19 | 2000-06-06 | Kureha Chem Ind Co Ltd | Hair-restoring and growing composition |
| JP2005350419A (en) * | 2004-06-14 | 2005-12-22 | Sceti Co Ltd | Antiallergic composition |
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2000154119A (en) * | 1998-11-19 | 2000-06-06 | Kureha Chem Ind Co Ltd | Hair-restoring and growing composition |
| JP2005350419A (en) * | 2004-06-14 | 2005-12-22 | Sceti Co Ltd | Antiallergic composition |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2011055712A (en) * | 2009-09-07 | 2011-03-24 | Toyo Shinyaku Co Ltd | Composition including barley young leaf and glucosamine |
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