KR100904859B1 - The healthy and funtional foods for the gastritis, stomach and duodenal ulcer patients using solanum tuberosum l., cv. bora valley - Google Patents

Abstract

A health food for gastritis, gastric ulcer and duodenal ulcer patients by using Bora valley potato juice and starch is provided to inhibit the activities of gastritis, gastric ulcer and duodenal ulcer, which results from the Bora valley potato juice and starch. A health food contains Bora valley potato starch as an active ingredient. The Bora valley potato starch is obtained by separating a filtrate from Bora valley potato juice. The health food has a formulation selected among tablet, granule, pill, hard gelatin capsule, soft gelatin capsule and liquid. The health food represents a pouch, drink and the like. A method for preparing the health food comprises the following steps of: washing 55g of the Bora valley potato and squeezing the Bora valley potato in a juicer; leaving the Bora valley potato juice to stand at room temperature through 10 minutes; decompression-filtering to separate the juice into a starch portion and a filtrate; and drying the starch portion at 65°C to obtain the dried potato starch.

Description

Health and funtional foods for the gastritis, stomach and duodenal ulcer patients using Solanum tuberosum L., cv. Bora valley}

The present invention relates to a dietary supplement containing fresh juice or starch of a new kind of potato, Solanum tuberosum L., cv.Bora valley, and having a function of preventing or improving gastritis, gastric ulcer and duodenal ulcer.

Potatoes are native to the Andes of South America and are useful crops for coarse grain crops. Potatoes are one of the four largest food crops next to rice, wheat and corn, which are grown in more than 130 countries because of their short growing period, relatively high yields per unit area, and relatively high environmental adaptability. Potatoes are low-calorie compared to other crops such as rice and barley, and have almost the same nutrients as vitamins C, B ₁ , B ₂ , and niacin. Therefore, there have been many studies on the general nutritional analysis of potatoes and the biological activities such as antioxidant activity. The global potato production area is increasing every year, especially in less developed countries.

Recent changes in the international agricultural environment are putting increasing pressure on food wars and seed wars, and countries are focusing their efforts on protecting crop rights in relation to food crops because food will become the weapon of the future. Korea also joined UPOV, a new plant protection international federation in 2002, and the protection period for varieties varies slightly from country to country, but at least 18 to 35 years have been enacted. In this situation, the inventors developed various functional potato varieties and registered as national varieties (National Seed Service, 15 new varieties and 4 varieties of application), and foreign potato varieties (Sumi and American varieties Superior, Motherland and Japanese varieties 大地, Atlantic / USA In addition to replacing the cultivar Atlantic, they are also undergoing trial cultivation in the United States, Canada, France, Russia, Mongolia, China, Kazakhstan and India.

Potatoes are not only important as stocks in some countries, they are also used to make a variety of processed products, and the consumption of potatoes is on the rise as the food culture becomes westernized. This increase in consumption necessitates the development of healthier potato varieties.

Potatoes are reported to be useful in many types of diseases in the private sector. Korean Laid-Open Patent Publication No. 2001-29185 discloses that potato has antibacterial and anticancer effects by inhibiting hypertension, heart disease, constipation, hepatitis and other microorganisms, but its efficacy is not known at all.

The present inventors have developed new varieties of potatoes by improving potatoes, and the new varieties of potatoes developed by the present inventors have different efficacy for each new varieties. In other words, Korea Patent Publication No. 628417 is known that the new varieties Valley Potato (Bora Valley, Juice Valley, Dasom Valley, Gogu Valley) is effective in strengthening the human long-term function, Republic of Korea Patent Publication No. 654231 Peptides isolated from potato varieties ( Solanum tuberosum L cv. Gogu Valley) are known to have excellent antimicrobial activity, and Korean Patent Publication No. 654232 discloses potato from Solanum tuberosum L cv. Golden Valley. It is known that the peptide is excellent in antibacterial action. In addition, Korean Patent Publication No. 583192 discloses an antioxidant of Borlan valley varieties Potato ( Solanum tuberosum L., cv Bora valley) extract, Republic of Korea Patent No. 709238, Solanum tuberosum L., cv It is known that ethanol extract of Bora valley has an anti-obesity effect by blocking mast cells from differentiating and reducing leptin protein that differentiates into mast cells.

Boran valley potato ( Solanum tuberosum L., cv Bora valley) according to the present invention is purple until the flesh developed by the present inventors, a new potato for processing for purple potato chips, varieties protection application (application number: 2002-11) was registered as a national breed in 2004 (registration number: 1-5-2004-5). The cultivars used A87spx14-4 as a model and gurmeys purple as a copy, and obtained real seed by artificial breeding method in 1996, not genetically modified. This test was conducted in 1998 and the productivity test and the adaptability test (Chuncheon Seomyeon, Gimje Gwangsaengmyeon, Daegwallyeong Transverse, etc.) in 1999-2001. The adaptability test was conducted in spring, summer, autumn and winter house growing areas. In 2002, a new varieties of rights protection application was filed, and the National Seed Management Service was commissioned by three national research institutes for two years and verified. The varieties have a glossy purple cuticle and dark purple flesh, which have been shown to be applicable to various dishes and food development. Bora Valley Potatoes are a globally recognized potato variety that won the Gold Prize in the Innovation Awards at the 2007 International Potato Fair in Moscow.

The present inventors have been taught that the long-term folk remedies in Korea have been said to have an excellent effect on gastritis and enteritis when eaten raw potatoes as a health functional food of the new varieties potato, Solanum tuberosum L., cv Bora valley. Unlike the efficacy that has been orally used during research, the general potato does not show any activity on gastritis, gastric ulcer and duodenal ulcer. It confirmed and completed this invention.

An object of the present invention to provide a health functional food that can prevent and improve gastritis, gastric ulcer and duodenal ulcer by using a new varieties of potatoes, Solanum tuberosum L., cv Bora valley.

In order to achieve the above object, the present invention provides a health functional food that can prevent and improve gastritis, gastric ulcer and duodenal ulcer by containing the juice or starch of Boran valley potato ( Solanum tuberosum L., cv Bora valley).

The present invention can be prepared using a juicer after removing the shoot portion of the Bora valley potato ( Solanum tuberosum L., cv. Bora valley).

In addition, the Bora Valley potato starch according to the present invention is left in the Bora Valley potato juice at room temperature for 10 minutes and then filtered under reduced pressure to separate the Bora Valley potato starch layer and the filtrate and dried under reduced pressure drying the Bora Valley potato starch layer and dried starch Or dried at 65 ° C. to obtain dried potato starch.

And the present invention is added to the juice or starch of Bora Valley potato in the usual palatable foods, such as ramen noodles, raw noodles, noodles, tofu, cereals, breads, chewing gum, candy, confectionery to produce a variety of food by a commonly known method Can also be used in powders, tablets, granules, It may be formulated into a general formulation such as pills, hard capsules, soft capsules, or liquid formulations, and may be prepared in juice, pouches, beverages, or polysaccharides. You can mix.

Health functional foods that can prevent and improve gastritis, gastric ulcer and duodenal ulcer of the present invention is prepared by using the Bora valley potato ( Solanum tuberosum L., cv. It can be prepared by adding to. At this time, food supplements that can be used food acceptable.

Solanum tuberosum L., cv. Bora valley of the present invention, the test in ethanol-induced rat gastric ulcer model of the juice or starch has a superior preventive effect than the omeprazole formulation commercially available for the prevention and treatment of gastric ulcer Showed.

In addition, the present invention shows a significant inhibition rate in the PGE 2 measurement test of gastritis model of the juice or starch of Bora Valley potato, so the health functional food containing it can be usefully used to prevent and improve gastritis, gastric ulcer and duodenal ulcer have.

Therefore, the raw juice or starch of Solanum tuberosum L., cv.Bora valley of the present invention is a novel dietary supplement for patients with gastritis, gastric ulcer and duodenal ulcer and for preventing and improving gastritis, gastric ulcer and duodenal ulcer. Can be developed as a dietary supplement.

Solanum tuberosum L. (cv. Bora valley) juice or starch of the present invention is suitable for use in foods as a result of acute toxicity test.

The present invention suppresses the occurrence of gastric ulcer that is equal to or higher than the omeprazole preparation marketed as a prophylactic and therapeutic agent for the prevention and treatment of gastritis, gastric ulcer and duodenal ulcer in the juice or starch of Boran valley ( Solanum tuberosum L., cv Bora valley). It can be seen that there is a significant inhibitory action.

Therefore, the present invention can be usefully used as a dietary supplement for the prevention and improvement of gastritis, gastric ulcer and duodenal ulcer.

Hereinafter, the present invention will be described in more detail with reference to the following examples. The following examples are intended to illustrate the invention and are not intended to limit the scope of the invention.

<Example 1> Preparation of Bora Valley Potato Juice

Solanum tuberosum L., cv. Bora valley (55 g) was washed well, the shoots were removed, and juice juicers were used to obtain approximately 50 ml of Bora Valley potato juice.

<Example 2> Preparation of Bora Valley Potato Starch

40 ml of the Bora Valley potato juice prepared in Example 1 was left at room temperature for 10 minutes, filtered under reduced pressure, separated into a Bora Valley potato starch layer and a filtrate, and the Bora Valley potato starch layer was dried at 65 ° C. to dry 6.4 g of potato chips. Got minutes.

<Example 3> Preparation of Bora Valley Potato Starch

40 ml of the Bora Valley potato juice prepared in Example 1 was left at room temperature for 10 minutes and filtered under reduced pressure to separate the Bora Valley potato starch layer and the filtrate. The Bora Valley potato starch layer was dried under reduced pressure and freeze dried potato starch 7.4 g. Got it.

Comparative Example 1 Preparation of Plain Potato Juice

55 g of ordinary potatoes were prepared in the same manner as in Example 1, to obtain about 31 ml of raw potato juice.

Comparative Example 2 Preparation of Plain Potato Starch

30 ml of normal potato juice prepared in Comparative Example 1 was prepared in the same manner as in Example 2 to obtain 8.8 g of dried potato starch.

Experimental Example 1 Inhibition of Potatoes in Ethanol-induced Rat Gastric Ulcer Model

0.5 ml of potato juice prepared in Examples 1 and 2 and Comparative Examples 1 and 2, and 10 mg of potato starch, respectively, were dissolved in 0.1% CMC in SD rats (male, SPF, 150-200 g, purchased from Orient Bio Company). Oral administration. Then, in order to induce gastric ulcers, according to the method of Rao et al. (J. Ethnopharmacol. 91, 243, 2004), ethanol was orally administered after 1 hour, sacrificed rats after 4 hours, and excised stomach was fixed in formalin. The area of ulcer was measured and the results are shown in Table 1. 5 mg of omeprazole was used as a control.

As can be seen from Table 1, it can be seen that Example 1 and Example 2 according to the present invention showed more than equivalent gastric ulcer inhibitory effect in the comparison test with omeprazole commercially available for the prevention and treatment of gastric ulcer.

However, it can be seen that Comparative Examples 1 and 2 (Sumi, Superior, USA), which are ordinary potatoes, show little effect unlike the effects of gastritis, which have been orally transmitted.

Therefore, the fresh juice or starch of the new varieties Boran valley ( Solanum tuberosum L., cv. Bora valley) is very effective in gastritis, gastric ulcer and duodenal ulcer, unlike ordinary potatoes.

Experimental Example 2 Inhibitory Activity in Gastritis Model

0.5 ml of potato juice and 10 mg of potato starch prepared in Examples 1 and 3 and Comparative Examples 1 and 2, respectively, were dissolved in 0.1% CMC and orally in SD rats (male, SPF, 150-200 g, purchased from Orient Bio Company). Administered. After 1 hour, indomethacin was orally administered to SD rats at a dose of 10 mg / rat. After 5 hours, the stomach was excised, ground with a polytron homogenizer, and centrifuged to obtain a supernatant. Then extracted with ethyl acetate and dried. After dissolving in methanol, Park (Eur. J. Pharmacol. 425, 153-157, 2001), put into Sep-Pak C18 column, and drained, dried with N2, and then PGE which is a parameter of gastric inflammation by ELISA method. The amount of 2 was quantified and the results are shown in Table 2.

As can be seen from Table 2, Example 1 and Example 3 according to the present invention is very excellent in inhibiting the PGE2, but Comparative Example 1 and Comparative Example 2, which is a regular potato, is different from the effect of gastritis, etc. In contrast, it can be seen that almost no PGE2 inhibitory effect.

Therefore, the fresh juice or starch of the new varieties Boran valley ( Solanum tuberosum L., cv. Bora valley) is very effective in gastritis, gastric ulcer and duodenal ulcer, unlike ordinary potatoes.

Experimental Example 3 Acute Toxicity Experiment

Acute toxicity was tested for ICR mice (males) according to KFDA guidelines. As a result, the juice of Bora Valley potato did not find any toxicity up to 5.0 ml / kg, and the starch of Bora Valley potato starch was not found up to 750 mg / kg.

As such, the fresh juice and starch of Bora valley potatoes were practically non-toxic, and the effective dose for this purpose was 0.1-5 ml / kg for fresh juice and 1 mg-500 mg / kg for starch. One to three doses are appropriate.

Raw juice and starch of Bora valley potato according to the present invention through this safety test Is not expected to adversely affect the human body.

Solanum tuberosum L., cv Bora valley extract according to the present invention is added to various solid foods, such as chewing gum, ramen noodles, candy, confectionery, cereals, breads, etc. to prevent gastritis, gastric ulcer or duodenal ulcer And health functional foods having an improvement function, and may also be produced as tea and beverages.

Preparation Example 1 Preparation of Biscuits

Force Grade 1 19.59 wt%, Gravity Grade 1 22.22 wt%, White sugar 4.80 wt%, Salt 0.73 wt%, Glucose 0.78 wt%, Palm shortening 11.15 wt%, Ammo 1.54 wt%, Neutral 0.17 wt%, Sodium bisulfite 0.16 wt% , Rice flour 1.45%, Vitamin B1 0.0001%, Vitamin B2 0.0001%, Milk flavor 0.04%, Water 21.3298%, Whole milk powder 1.16%, Substitute powder 0.29%, calcium phosphate 0.03%, Spray salt Biscuits were prepared in a conventional manner by combining 0.29 wt% and 7.27 wt% of spray oil with 7 wt% of the dry powder of Bora Valley potatoes prepared in Example 2.

Preparation Example 2 Preparation of Chewing Gum

Chewing gum was prepared in a conventional manner by combining 20% by weight of gum base, 70% by weight of sugar, 1% by weight of perfume, and 2% by weight of water, and 7% by weight of Bora Valley potato dry powder prepared in Sealing Example 2.

Preparation Example 3 Preparation of Candy

Candy was prepared by the conventional method by combining 50% by weight of sugar, 39.8% by weight of starch syrup, 0.2% by weight of fragrance, and 10% by weight of Bora Valley potato dry powder prepared in Example 2.

Preparation Example 4 Preparation of Beverage

0.26% by weight of honey, 0.0002% by weight of thioctoamide, 0.0004% by weight of nicotinic acid, 0.0001% by weight of sodium riboflavinate, 0.0001% by weight of pyridoxine hydrochloride, 0.001% by weight of inositol, 0.002% by weight of orthoic acid and 89.7362% by weight of water Drinks were prepared in a conventional manner by combining 10% by weight of the Bora Valley potato juice prepared in Example 1.

Preparation Example 5 Preparation of Tablet

Example 2 See the valley potato dry powder 200mg, vitamin production in B ₁ 15mg, vitamin B _2, 15mg, Vitamin C 25mg, vitamin B ₆ 25mg, mixture of nicotinamide 15mg and lock churro agarose powder for formulation of the tablet 200mg Sodium silicoaluminate 25mg, sucrose fatty acid ester 25mg, hydroxypropylmethylcellulose 25mg, glycerin fatty acid ester 15mg, zinc oxide 15mg, beta-cyclodextrin 15mg was added and mixed to prepare a tablet with a tablet press.

Preparation Example 6 Preparation of Hard Capsule

100 mg of Bora Valley potato dry powder prepared in Example 2, vitamin B ₁ 15 mg, vitamin B ₂ 15 mg, vitamin C 25 mg, vitamin B ₆ 25 mg, nicotinic acid amide 15 mg, citric acid 25 mg, lactose 400 mg 500 mg purified water. Thereafter, the mixture was put into a granulator to form granules, and the molded granules were dried in a hot air dryer at 40 to 50 ° C., and then passed through a sieve of 12 to 14 mesh to prepare uniform granules. Charged to.

1 is a Bora Valley potato ( Solanum) according to the present invention tuberosum L. cv. A real photograph of the Bora valley is shown.

Claims (6)

A dietary supplement for the prevention and improvement of gastritis, gastric ulcer or duodenal ulcer containing an active starch layer of Bora valley potato starch obtained after separating filtrate from the juice of Solanum tuberosum L. cv.Bora valley. According to claim 1, wherein the health functional food powder, tablets, granules, Health functional food, characterized in that selected from pills, hard capsules, soft capsules or liquid formulations. According to claim 1, wherein the health functional food is a pouch, Health functional food characterized in that the drink or tea. delete delete delete

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