JP2007145724A - Endurance improver - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a highly safe and easily available endurance improver and anti-fatigue agent having rich history of use in foods and even excellent processability. <P>SOLUTION: The endurance improver and anti-fatigue agent comprise nootkatone as an active ingredient. A food and drink, etc., having endurance improving effects and anti-fatigue effects on sports and broadly-defined exercises including activities of daily life and labors are provided by using a highly safe natural product material having the rich history of use in foods. <P>COPYRIGHT: (C)2007,JPO&INPIT

Description

  The present invention relates to an endurance improver and an anti-fatigue agent for exercise in a broad sense including exercise and daily activities and labor.

  Endurance is indispensable not only for competitive exercises but also for daily activities such as labor, walking, standing and so on. In other words, endurance is extremely important for a meaningful and healthy life. However, in recent years, with the progress of an aging society, the development of transportation means and the development of information / communication technology, a decrease in endurance due to lack of exercise has become a problem. In addition, with the arrival of an aging society in the future, the decline in motor function will be a bigger problem. It can be said that exercise is appropriate to improve endurance, but people who cannot do enough exercise due to their busyness or who cannot exercise due to physical circumstances There are many current situations.

  As one means for solving these problems, it is conceivable to ingest food components having endurance improvement and anti-fatigue action on a daily basis. For example, the present inventors have found an endurance improvement effect by ingesting catechin (Patent Document 1). Examples of other reported components having endurance enhancing effects include hawthorn extract (Patent Document 2), ganoderma component (Patent Document 3), proanthocyanidins and lycopene (Patent Document 4). Examples of the component having anti-fatigue action include coenzyme Q10, a carnitine compound (Patent Document 5), a glutamine peptide (Patent Document 6), and the like.

  Nootkaton is a sesquiterpene ketone, 4,4a, 5,6,7,8-hexahydro-6-isopropenyl-4,4a-dimethyl-2 (3H) -naphthalenone, present in grapefruit peels, Although it has a characteristic flavor, it is a substance that has attracted a great deal of attention as a fragrance (Non-patent Document 1), but its physiological action has hardly been reported so far. As for grapefruit, a perfume composition containing grapefruit oil (essential oil) exhibits an anti-obesity action by activating the sympathetic nervous system (Patent Document 7), and a skin external preparation containing grapefruit oil (Patent Document 7) Patent Document 8) has been reported. However, the effects of Noot Katon on endurance, athletic performance, and fatigue have never been known.

JP 2005-89384 A JP-A-8-47381 JP-A-5-123135 Japanese Patent Laying-Open No. 2005-334022 JP-A-2005-97161 JP-A-2005-97162 JP 2002-193824 A JP-A-2005-47935 Arai Junichi, “Latest Perfume Encyclopedia”, 1st edition, Asakura Shoten, May 10, 2000, p.112, p.254

  The present invention relates to providing endurance improvers, anti-fatigue agents, and foods and drinks containing them, which have abundant food experience, are highly safe, are easily available, and are excellent in processability.

  As a result of searching for an effective component in improving endurance, the present inventors have found that it is present in grapefruit peels, etc. from among natural products with abundant food experience and high safety, and a characteristic aroma component of grapefruit It was found that Nootkaton, which has the effect of improving endurance, is useful as an endurance improver and anti-fatigue agent.

  That is, the present invention provides an endurance improver and an anti-fatigue agent containing nootkatone as an active ingredient.

  Further, the present invention is characterized in that it contains nootkaton and has an effect of improving endurance, and contains beverages or foods labeled as being used for improving endurance, and nootkaton, and has an anti-fatigue effect. It is characterized by having a drink, or a food with an indication that it is used for anti-fatigue.

  ADVANTAGE OF THE INVENTION According to this invention, the foodstuffs etc. which have the endurance improvement with respect to the exercise in a broad sense including exercise and daily operation | movement and labor using the natural product material with rich food experience and high safety, an anti-fatigue effect, etc. are provided. The

  In the present invention, nootkatone refers to a sesquiterpene ketone of 4,4a, 5,6,7,8-hexahydro-6-isopropenyl-4,4a-dimethyl-2 (3H) -naphthalenone. There are eight types of optical isomers in the Nootkaton. In the present invention, these isomers can be used alone or confused, but (+)-Nootkatone represented by the following structural formula (I) is preferably used.

  Nootkatone used in the present invention can be produced by known organic chemical synthesis, synthesis using microorganisms, and the like. For example, JP 2004-123561 A, JP 2003-250591, JP 11-501052 A. It can obtain by the method of description.

  Moreover, the nootkaton used by this invention can also be obtained by extracting by a well-known method from the natural product containing a nootkaton. Here, the extraction is performed by a method in which, for example, an extraction operation performed using water, hot water, alcohol water, an organic solvent, or the like is combined with a purification operation or a distillation operation using a high performance liquid chromatograph or a column chromatograph as appropriate. Can do. Examples of natural products containing nootkaton include grapefruit. When extracting from grapefruit, the raw material can be, for example, grapefruit fruit, grapefruit peel, grapefruit oil, grapefruit concentrated fruit juice, residues after squeezing grapefruit juice, and the like.

  The nootkatone obtained by the above synthesis or extraction is preferably a high purity product from which impurities are removed by single or multiple step purification, but may be a crude product as long as the effects of the present invention are exhibited. . Grapefruit essential oil, which is known to contain a relatively large amount of nootkaton, can also be used.

  The endurance improver of the present invention can be administered to humans and animals, and can be ingested by being mixed with various foods, medicines, pet foods and the like. The food is based on the concept of physiological functions such as improving endurance and preventing or improving fatigue, and can be applied to functional foods, foods for the sick, and foods for specified health use. Although the form of a drink is not specifically limited, For example, it can mix | blend with all drinks, such as a fruit juice drink, a carbonated drink, a tea-type drink, a milk drink, an alcoholic drink, a soft drink. Moreover, it can mix | blend with all food forms, such as jelly-like foodstuffs, various snacks, baked confectionery, cakes, chocolate, gum, candy, and soups, and it can be used as an endurance food and anti-fatigue food. When used as a pharmaceutical, for example, oral solid preparations such as tablets and granules, and oral liquid preparations such as oral liquids and syrups can be used.

  When preparing an oral solid preparation, after adding an excipient, if necessary, a binder, a disintegrant, a lubricant, a colorant, a corrigent, a corrigent, etc. to the nootkaton of the present invention, Tablets, coated tablets, granules, powders, capsules and the like can be produced by conventional methods. Moreover, when preparing a liquid preparation for oral use, a liquid preparation, a syrup, an elixir, etc. can be manufactured by a conventional method by adding a corrigent, a buffer, a stabilizer, a corrigent and the like.

  Although the compounding quantity of Nootkaton with respect to these things changes with the usage forms, in forms, such as food-drinks and pet food, it is 0.0002-5 mass% normally, Furthermore, 0.001-3 mass%, Especially 0.02- It is preferable to set it as 2 mass%. When used as pharmaceutical preparations such as oral solid preparations such as tablets, granules and capsules, oral liquid preparations such as oral liquids and syrups, etc., usually 0.01 to 95% by mass, and further 0.1 to 95%. It is preferable to set it as the mass%, especially 2-80 mass%.

  The dosage (effective intake) of the endurance improving agent of the present invention is preferably 1 to 1000 mg / 60 kg body weight per day, particularly 2 to 700 mg / 60 kg body weight, more preferably 5 to 500 mg / 60 kg body weight. Is preferred.

The following are representative examples of the present invention.
Example 1 Evaluation of Nootkaton for Endurance Improvement / Anti-fatigue Effect Evaluation of nootkaton for endurance improvement / anti-fatigue effect was performed as follows. In addition, the thing made from Avocado company was used for Nootkaton.

  Endurance improvement and anti-fatigue effects were evaluated by a method for measuring the limit swimming time of mice in a running water pool (reference: Am J Physiol Regul Integr Comp Physiol, Vol. 288, R708-R715, 2005). The experimental pool was used with a transparent acrylic pool (length 90 × width 45 × depth 45 cm) filled with water to a depth of 38 cm and maintained at 34 ° C. with a heater. The water flow was created using a pump (C-P60H, manufactured by Hitachi), and the flow rate was adjusted by connecting a water flow meter (Tokyo Flow Meter Laboratory) to the pump and opening and closing the valve. Moreover, the flow velocity was confirmed with a velocimeter (SV-101-25S, Sanko Precision Industry).

  As experimental animals, 5-week-old Balb / c male mice (Charles River) were used and pre-bred for 1 week in a constant breeding environment (23 ± 2 ° C, light period: 7am to 7pm). Acclimated. After that, for one week, training was performed three times a week to get used to swimming exercise (30 minutes of swimming exercise was performed on the first day for 30 minutes at a flow rate of 5 L / min, 3 days on the third day, and 6 L / min for 30 minutes on the third day). ). In the next week, with each individual fasted for 2 hours, limit swimming time at a flow rate of 7 L / min (the limit swimming time was defined as the time when rescued in a state where the face could not be exposed due to breathing). Measured once. The group was divided into two groups, the test food group and the control food group, with 8 animals per group so that there was no difference between the groups in the limit swimming time. Using the diet prepared with the composition shown in Table 1, the animals were reared for 10 weeks. During this time, limit swimming time measurement (7 L / min) and training (6 L / min, 30 minutes) were performed once a week. Table 2 shows the limit swimming time of mice at the 10th week of breeding.

  From Table 2, the mice that took the test meal containing nootkaton had significantly increased marginal swimming time after 10 weeks of breeding compared to the control diet group, and nootkaton has the effect of improving endurance and anti-fatigue. You can see that

Example 2 Formulation Example (1) Better Endurance / Anti-fatigue Beverage The following composition was mixed to produce a fruit juice drink.

(2) Endurance improvement / anti-fatigue capsule The following composition (300 mg) was encapsulated in an encapsulating agent.

(3) Endurance improvement / anti-fatigue tablet The following composition (1 tablet = 250 mg) was tableted to produce a tablet.

(4) Endurance improvement / anti-fatigue granule The following composition (1 bag = 500 mg) was mixed to produce a granule.

(5) Food for improving endurance and anti-fatigue The following composition (1 tablet = 1000 mg) was tableted to produce a chewable tablet food.

(6) Endurance improvement / anti-fatigue drink The following composition was mixed to produce an endurance improvement / anti-fatigue drink.

(7) Capsule for improving endurance and anti-fatigue The following composition (300 mg) was encapsulated in a capsule agent.

Claims (4)

  An endurance improver containing nootkaton as an active ingredient.   Anti-fatigue agent containing nootkaton as an active ingredient.   A beverage or food containing nout katon, characterized by having an effect of improving endurance, and having an indication that it is used for improving endurance.   Beverages or foods that contain nootkaton and have an anti-fatigue effect, and are labeled as being used for anti-fatigue.