JP2005137204A - Liquid drink - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide liquid drink made from citrus fruit peel, and containing predetermined ingredients. <P>SOLUTION: This liquid drink is made from citrus fruit peel, and contains nootkatone as an antibacterial substance so as to exhibit antibacterial actions in a wide range. <P>COPYRIGHT: (C)2005,JPO&NCIPI

Description

  The present invention relates to a liquid drink that can exhibit antibacterial action using citrus peel as a raw material.

  It has already been publicly known that an extract liquid made from citrus peel or the like is used as a cosmetic product having a hair-growth effect, and the applicant has filed a patent application related to this point (described later). Patent Documents 1 and 2).

  Citrus fruits contain vitamin C, which not only suppresses the synthesis of nitrosamine, a powerful carcinogen, in the body, but its essential oil component has been confirmed to have antibacterial activity, especially citrus fruits. The fruit skin contains useful materials.

  However, the structure of the invention based on focusing on a predetermined effect when an extracted liquid drink is obtained by using citrus peel as a raw material has not been proposed so far.

JP-A-3-227911

JP-A-9-202716 50 pages of abstract for the 51st Annual Conference of the Japanese Society for Food Hygiene Magazine "Fragrance Journal" February 1989 (85-90 pages)

  This invention makes it a subject to provide the structure of the liquid drink which paid its attention to containing a useful component from citrus peel as a raw material.

  In order to solve the above-mentioned problems, the composition of the present invention comprises a liquid drink based on the fact that citrus peel is used as a raw material and contains nootkatone, which is an antibacterial substance.

  The liquid drink according to the present invention is an antibacterial substance contained in the pericarp, although it is a relatively simple production method using a relatively easily available material such as citrus peel and extracting liquid from the raw material. By the action of Nootkaton, it is possible to realize an effect of having a certain recovery action against health infringement based on the activity of bacteria.

  The chemical structural formula of nootkaton is as shown in FIG. 1. However, it was confirmed that nootkaton has a wide range of antibacterial activity and that the extraction of citrus peel with chloroform and high performance chromatography (HPLC) revealed the presence of nootkatone. What can be confirmed is publicly known as shown in Non-Patent Document 1, for example.

  Thus, despite the fact that citrus peel contains useful substances such as Nootkaton, it has not been proposed to use it as a liquid drink after extracting liquid from the peel. Absent.

  The present invention pays attention to this point and, without extracting the nootkaton in a pure state, the liquid is extracted from the citrus peel and is drunk, thereby enjoying the special effects as described later in the examples. There is a basic technical philosophy that makes this possible.

  The extraction method is not particularly limited, for example, a method of extracting the contained liquid while filtering the citrus peel and filtering the solid components exposed together with the liquid, citrus peel and ethanol Coexisting, extracting the liquid in the pericarp into ethanol and filtering the solid component, etc., but in the filtration, filtering through a mesh of units of μm or less to exclude the polymer Is essential.

  As a specific embodiment, 2 kg, 2 kg, and 1 kg of sweet summer citrus peel, Iyokan peel, and Yawata peel are stored in separate containers, respectively, and first grade sake is placed in each container. When 3600 cc was added, the liquid extract was extracted and filtered 5 times with a filter paper in μm units. As a result, 2600 cc, 1600 cc, and 1400 cc of Akanatsu extract, Iyokan extract and Yawata extract were obtained (however, the basics) The volume excluding alcohol.

  The typical liquid drink of this invention can be obtained by mixing these sweet summer citrus extract, Iyokan extract, and Yawata extract.

As shown in Non-patent Document 1, grapefruit and sweet summer peels contain 280 μg / g and 65 μg / g of nootkatone, respectively. Although it has been found that it contains 120 μg / g, nootkatone is inevitably contained in the liquid which is necessarily an extract of citrus peel by the extraction method as described above.
This is because, in the process of extracting the liquid in the skin in the production method, nootkatone is also extracted, and nootkaton does not correspond to a polymer. is there.

  Since the liquid drink, which is a liquid extract produced in this way, contains nootkatone having a wide range of antibacterial effects, it can escape spoilage and alteration due to bacterial growth, In the embodiment, spoilage and alteration do not occur despite long-term storage.

  When the liquid extract is extracted by coexistence with ethanol contained in sake as in the above-described production embodiment, the liquid extract is contained in a state containing limonene and flavonoid as essential oil components. Can be generated.

  Limonene and flavonoids are also known to have a certain antibacterial action, as shown in Non-Patent Document 2.

  Therefore, in the embodiment in the case of extraction with ethanol, it is possible to exert the antibacterial action by limonene in addition to the Nootkaton.

  The chemical structural formula of limonene is as shown in FIG. 2, and the flavonoids have different chemical structural formulas depending on the type of flagone, isoflavone, etc., but both have chemical structural formulas based on phenyl groups, In any case, as long as no chemical reaction is carried out with nootkaton, the antibacterial action of both is not canceled by the coexistence of nootkatone, limonene and flavonoid.

  When the liquid drink of the present invention is drunk, it is possible to expect recovery from a wide range of bacterial symptoms such as viral allergies and viral asthma. In patients suffering from herpes zoster), reports have been made that herpes can be cured in about one month by drinking the liquid drink according to the above embodiment.

  Hereinafter, the Example regarding the effect at the time of drinking the liquid drink of this invention is described.

  Although hepatitis C is caused by infection with hepatitis C virus, coping therapy with an inherent vaccine and coping therapy with a prescribed medication have been studied, but there is still no coping therapy that cures quickly.

  Use the persimmon skins of hassaku and yokan as raw materials, store 2 kg of these pericarps in separate containers, add 3.6 liters of 1st grade sake to the containers, soak and stand at room temperature for 7 days, and extract liquid extract After extraction, the liquid drink by the extract was obtained by repeating filtration about 5 times with filter paper.

When about 8 cc of the liquid drink is taken per day, the following symptoms are improved for GOT (normal reference value 40 to 4) and GPT value (normal reference value 40 to 4), which are indicators of liver function. Was recognized.

  In addition, since the liquid drink of Example 1 is extracted by using the sake containing ethanol, it is understood that it also contains limonene.

  As described above, it was confirmed that the liquid drink of the present invention exhibits the utility of improving abnormal liver function due to hepatitis C and the like.

  At present, what is known as an antibacterial substance contained in citrus fruits and their peels is that the antibacterial action of both is not canceled by the coexistence with nootkatone, limonene, and flavonoids.

  However, limonene has been found to have anticancer effects by animal experiments using mice and the like, but whether it has a wide range of antibacterial activity is not always clear in previous clinical experiments. .

  Similarly, it is not always clear whether flavonoids have a broader antibacterial effect than nootkaton.

  Therefore, it can be understood that at least the antibacterial activity of Nootkaton contributes to the improvement of the symptoms of hepatitis C.

  In a 4-year-old infant diagnosed as suffering from an atopic infection, only 6 cc of the same liquid drink as in Example 1 was drunk for 4 months per day. And abnormal conditions such as swelling of the skin could be lost.

  From these results, it was found that the liquid drink of the present invention has an effect on the recovery of viral skin eczema.

  For the same reason as in Example 1, it is understood that at least the antibacterial activity of Nootkaton contributes to the improvement of the symptoms of atopy.

  The liquid drink of the present invention can be used in the field of health foods that exhibit antibacterial activity.

The chemical structural formula of Nootkaton is shown. The chemical structural formula of limonene is shown.

Claims (2)

  Liquid drink based on citrus peel and containing nootkaton, an antibacterial substance.   The liquid drink according to claim 1, which also contains limonene and flavonoids which are antibacterial substances.

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