JP2007126364A - Emulsion composition containing slightly volatile substance - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To obtain an emulsion composition that is produced by stably emulsifying a slightly volatile substance and exhibits high volatility. <P>SOLUTION: The oil-in-water type emulsion composition comprises (A) a polysaccharide derivative in which a part or the whole of the hydroxy group of a polysaccharide may be substituted with the following substituent group (a) represented by general formula (1) -E<SP>1</SP>-(OA<SP>1</SP>)<SB>n</SB>-E<SP>2</SP>-R (1) [E<SP>1</SP>is a 1-6C bifunctional saturated hydrocarbon group which may be substituted with a hydroxy group or an oxo group; n is a number of 8-300; n A<SP>1</SP>s are each the same or different and a 1-6C straight-chain or branched-chain bifunctional saturated hydrocarbon group; E<SP>2</SP>is an ether bond or an oxy carbonyl group (-OCO- or -COO-); R is a 4-30C alkyl group], (B) a polyol, (C) a nonionic surfactant, (D) a slightly volatile substance, (E) an oil agent (F) water (the hydrogen atom of the hydroxy group of the substituent group (a) may be further substituted with the substituent group (a)). <P>COPYRIGHT: (C)2007,JPO&INPIT

Description

  The present invention relates to an emulsion composition containing a hardly volatile substance and a method for volatilizing a hardly volatile substance using the same.

  Technology that enhances volatility is indispensable in order to exert the effects of fragrance components, insecticides and the like that are difficult to volatilize. Conventionally, as a technique for controlling volatility, a method using a special material or means such as heating is known (Patent Documents 1 to 7).

  On the other hand, in preparations such as lotion, milky lotion, cream, cosmetic liquid, liquid foundation, etc., if the substance to be volatilized is difficult to volatilize, it is desirable to increase the amount of the compound, but the feeling of use at the time of skin application and the stability of the formulation are impaired. There is a problem that the amount of blending is limited due to the problem. Furthermore, if the substance to be volatilized is difficult to dissolve, adding an amount that provides sufficient volatilization will cause crystals to precipitate, not only the stability of the formulation, but also a feeling of roughness and pain when applied to the skin. Therefore, there is a problem that it is difficult to develop a product that satisfies the user.

In order to solve this problem, a technology is known in which a hardly soluble, non-volatile substance is dispersed as a fine crystal from the beginning to prevent crystal growth, thereby achieving both stabilization of the preparation and improvement of volatility. (Patent Document 8). However, in order to maintain uniform dispersion of fine crystals, a viscosity of 2000 mPa · s or more is required, and it cannot be applied to low-viscosity emulsions, microemulsion preparations that can be sprayed in a mist form, and the like.
JP 2001-158843 A Japanese Patent Laid-Open No. 10-17846 JP 2001-172153 A JP 2001-279232 A Japanese Patent Laid-Open No. 11-286429 Japanese Patent Laid-Open No. 11-286430 JP-A-11-286431 JP 2005-187371 A

  Accordingly, an object of the present invention is to stably emulsify a hardly soluble non-volatile substance that is solid at room temperature, and to exhibit a high volatility without impairing the stability of the preparation and the feeling during use on the skin. It is an object to provide an emulsion having a viscosity and a microemulsion preparation that can be sprayed in a mist form.

  As a result of investigating a preparation that stably emulsifies a hardly soluble non-volatile substance that is solid at room temperature without crystal precipitation and exhibits high volatility, a polysaccharide derivative known as a water-soluble thickener (WO00 / 73351, JP 2003-226612 A) and non-ionic surfactants of HLB 4 to 9 are used to finely emulsify an oil agent in which a hardly soluble non-volatile substance is dissolved together with a polyol, thereby making it difficult to dissolve. It was found that the non-volatile substances of the above can be dispersed in the preparation as fine emulsified particles, and low-viscosity emulsions and microemulsions having high volatility can be obtained.

That is, the present invention includes the following components (A) to (F):
(A) Some or all of the hydrogen atoms of the hydroxy group of the polysaccharide or derivative thereof are the following substituents (a)
(A) A group represented by the following general formula (1) (the hydrogen atom of the hydroxy group of the substituent (a) may be further substituted with the substituent (a)).

[Wherein E ¹ represents a linear or branched divalent saturated hydrocarbon group having 1 to 6 carbon atoms which may be substituted by a hydroxy group or an oxo group, and n represents a number of 8 to 300. , N A ¹ are the same or different and each represents a linear or branched divalent saturated hydrocarbon group having 1 to 6 carbon atoms, and E ² represents an ether bond or an oxycarbonyl group (—OCO— or —COO). -), R represents a linear or branched alkyl group having 4 to 30 carbon atoms which may be substituted by a hydroxy group. ]
Polysaccharide derivatives substituted with
(B) polyols,
(C) a nonionic surfactant of HLB 4-9,
(D) a non-volatile material having a melting point of 30 ° C. or higher,
(E) an oil for dissolving component (D),
(F) An oil-in-water emulsion composition containing water is provided.

In the present invention, a non-volatile material (component (D)) having a melting point of 30 ° C. or higher is converted into the following components (A), (B), (C), (E) and (F):
(A) Some or all of the hydrogen atoms of the hydroxy group of the polysaccharide or derivative thereof are the following substituents (a)
(A) A group represented by the following general formula (1) (the hydrogen atom of the hydroxy group of the substituent (a) may be further substituted with the substituent (a)).

[Wherein E ¹ represents a linear or branched divalent saturated hydrocarbon group having 1 to 6 carbon atoms which may be substituted by a hydroxy group or an oxo group, and n represents a number of 8 to 300. , N A ¹ are the same or different and each represents a linear or branched divalent saturated hydrocarbon group having 1 to 6 carbon atoms, and E ² represents an ether bond or an oxycarbonyl group (—OCO— or —COO). -), R represents a linear or branched alkyl group having 4 to 30 carbon atoms which may be substituted by a hydroxy group. ]
Polysaccharide derivatives substituted with
(B) polyols,
(C) a nonionic surfactant of HLB 4-9,
(E) an oil for dissolving component (D),
(F) The volatilization method of the component (D) mixed and emulsified with water is provided.

Difficult to dissolve and hardly volatile substances, especially those having a vapor pressure at 25 ° C. of 1.33 × 10 ⁻⁶ kPa or more and a solubility at 25 ° C. of 10% by mass or less when isopropyl palmitate is used as a solvent. Non-volatile substances can be stably emulsified without precipitating their crystals, and the volatility of the non-volatile substances is improved, making it useful as a low-viscosity emulsion or a microemulsion formulation that can be sprayed into a mist. .

E ¹ in the substituent (a) represented by the general formula (1) of the polysaccharide derivative of the component (A) is preferably one having 2 or 3 carbon atoms, specifically, ethylene, propylene, trimethylene, 2- Hydroxytrimethylene, 1-hydroxymethylethylene, 1-oxoethylene, 1-oxotrimethylene, 1-methyl-2-oxoethylene and the like are preferable.

As A ¹ in the general formula (1), those having 2 or 3 carbon atoms are preferable, and specifically, ethylene, propylene and trimethylene are preferable. The degree of polymerization of (—OA ¹ —) represented by n is preferably 8 to 120, particularly 10 to 60 from the viewpoint of thickening effect and emulsion stability, and the n A ¹ may be the same or different. . Here, n means the average number of moles added. E ² is an ether bond or an oxycarbonyl group, and an ether bond is preferred.

  R in the general formula (1) preferably has 5 to 25 carbon atoms, particularly preferably a linear or branched alkyl group having 6 to 20 carbon atoms, and is preferably a linear alkyl group from the viewpoint of stability. Specifically, octyl group, decyl group, dodecyl group, tetradecyl group, hexadecyl group, octadecyl group, isostearyl group and the like are preferable.

  The degree of substitution by the substituent (a) in the polysaccharide derivative of the component (A) is in the range of 0.0001 to 1, more preferably 0.0005 to 0.5, particularly 0.001 to 0.1 per constituent monosaccharide residue. preferable.

  The polysaccharide derivative of component (A) may be further substituted with one or more groups selected from the following substituents (b), (c) and (d) in addition to the above substituent (a). Moreover, the hydrogen atom of the hydroxy group of substituent (a)-(d) may be further substituted by substituent (a)-(d).

(B) a C1-C5 sulfoalkyl group which may be substituted by a hydroxy group or a salt thereof As the substituent (b), a 2-sulfoethyl group, a 3-sulfopropyl group, a 3-sulfo-2-hydroxy Examples thereof include a propyl group and a 2-sulfo-1- (hydroxymethyl) ethyl group. Among them, a 3-sulfo-2-hydroxypropyl group is preferable from the viewpoint of stability and production. All or part of these substituents (b) may be salts with group 1 or group 2 elements such as sodium, potassium, calcium and magnesium, amines, organic cations such as ammonium and the like. The degree of substitution with these substituents (b) is preferably in the range of 0 to 1, more preferably 0 to 0.8, especially 0 to 0.5 per constituent monosaccharide residue.

(C) a C2-C6 carboxyalkyl group which may be substituted by a hydroxy group or a salt thereof As the substituent (c), a carboxymethyl group, a carboxyethyl group, a carboxypropyl group, a carboxybutyl group, a carboxypentyl group A carboxymethyl group is preferred from the standpoint of stability and production. All or part of these substituents (c) may be salts with group 1 or group 2 elements such as sodium, potassium, calcium and magnesium, organic cations such as amine and ammonium. The degree of substitution by these substituents (c) is preferably in the range of 0 to 1, more preferably 0 to 0.8, especially 0 to 0.5 per constituent monosaccharide residue.

(D) Cationic substituent represented by the following general formula (2)

[Wherein D ¹ represents a linear or branched divalent saturated hydrocarbon group having 1 to 6 carbon atoms which may be substituted by a hydroxy group, and R ¹ , R ² and R ³ are the same or different. And a hydroxy group, a linear or branched alkyl group having 1 to 3 carbon atoms which may be substituted with a hydroxy group, and X- represents a hydroxy ion, a halogen ion or an organic acid ion. ]

As D ¹ in the cationic substituent (d), ^one having 2 or 3 carbon atoms is preferable, and specifically, ethylene, propylene, trimethylene, 2-hydroxytrimethylene, 1-hydroxymethylethylene and the like are preferable.

Examples of R ¹ , R ² and R ³ in the cationic substituent (d) include a methyl group, an ethyl group, a propyl group, and a 2-hydroxyethyl group, and among them, a methyl group and an ethyl group are preferable.

As the halogen ion represented by X- in the cationic substituent (d), chlorine ion, bromine ion, iodine ion and the like are exemplified, and as the organic acid ion, CH ₃ COO-, CH ₃ CH ₂ COO-, CH ₃ ( CH ₂ ) ₂ COO— and the like. X- is preferably a hydroxy ion, a chlorine ion or a bromine ion.

  The degree of substitution with these cationic substituents (d) is preferably in the range of 0 to 0.5, particularly 0 to 0.3 per constituent monosaccharide residue.

  The polysaccharide derivative of component (A) is preferably a polymer compound having a molecular weight of 10,000 to 10,000,000, more preferably 10,000 to 2,000,000, particularly 30,000 to 1,500,000. Specific examples of the polysaccharide derivative include a hydrophobic polysaccharide having a group represented by the formula (1), and a group represented by the formula (1) of 0.0001 to 0.1, preferably 0.001 with respect to the main chain monomer. Examples thereof include water-soluble polysaccharide derivatives having a molecular weight of 10,000 to 2,000,000, preferably 30,000 to 1,500,000 added at a ratio of ˜0.05.

  Examples of the polysaccharide to which the group of formula (1) is bonded include polysaccharides such as cellulose, guar gum, starch, pullulan, dextran, fructan, mannan, agar, carrageenan, chitin, chitosan, pectin, alginic acid, and hyaluronic acid. These include derivatives substituted with a methyl group, an ethyl group, a hydroxyethyl group, a hydroxypropyl group, or the like. These substituents can be substituted singly or in combinations of constituent monosaccharide residues. Examples of polysaccharide derivatives include hydroxyethyl cellulose, hydroxyethyl ethyl cellulose, hydroxyethyl guar gum, hydroxyethyl starch, methyl cellulose, methyl guar gum, methyl starch, ethyl cellulose, ethyl guar gum, ethyl starch, hydroxypropyl cellulose, hydroxypropyl guar gum, hydroxypropyl Starch, hydroxyethyl methylcellulose, hydroxyethyl methyl guar gum, hydroxyethyl methyl starch, hydroxypropyl methyl cellulose, hydroxypropyl methyl guar gum, hydroxypropyl methyl starch and the like can be mentioned. Of these polysaccharides or derivatives thereof, cellulose, starch, hydroxyethyl cellulose, methyl cellulose, ethyl cellulose, and hydroxypropyl cellulose are preferable, and hydroxyethyl cellulose is particularly preferable. The weight average molecular weight of these polysaccharides or derivatives thereof is preferably 10,000 to 10,000,000, more preferably 10 to 5,000,000, and particularly preferably 200,000 to 2,000,000.

  The polysaccharide derivative of component (A) is exemplified by the following general formula when the case where cellulose is used as the polysaccharide or its derivative is taken as an example.

[Wherein, R ⁴ , R ⁵ and R ⁶ are the same or different, and (1): a hydrogen atom, a methyl group, an ethyl group, a hydroxyethyl group, a hydroxypropyl group, etc. (2): a polyoxyalkylene group A substituent, (3): a sulfoalkyl group, (4): a carboxyalkyl group, (5): a group selected from cationic substituents, Q being the same or different, an alkylene group having 2 to 4 carbon atoms P, q and r are the same or different and represent a number of 0 to 10. QO group, R ⁴ group, R ⁵ group, R ⁶ group, p, q and r may be the same or different within a repeating unit or between repeating units. ]

  Component (A) is added in the oil-in-water emulsion composition of the present invention in an amount of 0.001 to 10% by mass, and more preferably 0.01 to 5% from the viewpoint of emulsification stability, viscosity and usability when applied to the skin. It is preferable to contain 0.1 mass%, especially 0.1-2 mass%.

  The polyols of component (B) are polyhydric alcohols having two or more hydroxyl groups in the molecule, and specifically include ethylene glycol, propylene glycol, 1,3-butylene glycol, 1,4-butylene glycol, and the like. Alkylene glycol; Polyalkylene glycols such as dipropylene glycol; Sugar alcohols such as glucose, maltose, maltose, sucrose, fructose, xylitol, sorbitol, erythritol, maltotriose, and threitol; glycerin, polyglycerin and amylolytic reduced alcohol These 1 type (s) or 2 or more types are used.

  In the oil-in-water emulsion composition of the present invention, the component (B) is 0.01 to 30% by mass, and further 0.5 to 20% from the viewpoint of emulsion stability, viscosity, and feeling when used on the skin. It is preferable to contain 1 mass%, especially 1-10 mass%.

  The component (C) HLB 4 to 9 nonionic surfactant is important for stably emulsifying the oil in the oil-in-water emulsion composition of the present invention. When a nonionic surfactant having an HLB of less than 4 is used, the lipophilicity of the nonionic surfactant is too high, so that the polysaccharide derivative of component (A) and the interface between the aqueous phase and the oil phase Due to the poor orientation, the oil droplets coalesce to increase the particle size. Also, when the HLB exceeds 9, the nonionic surfactant is too hydrophilic to be compatible with the oil phase to be emulsified, and therefore cannot function as a surfactant, resulting in separation. To. Therefore, it is important in this invention oil-in-water-type emulsion composition that HLB is 4-9.

  Here, the HLB value is calculated by the following formula:

(Formula)
HLB = 7 + (logMw / logMo)
Mw: molecular weight of hydrophilic group, Mo: molecular weight of lipophilic group

The value calculated by. A preferable HLB is 4 to 8, and 4 to 7 is more preferable.

  As the nonionic surfactant having an HLB of 4 to 9 as the component (C), polyoxyethylene sorbitan fatty acid ester, sorbitan fatty acid ester, polyoxyethylene alkyl ether, polyoxyethylene hydrogenated castor oil, polyoxyethylene glycerin fatty acid ester Glycerin fatty acid ester, alkyl glyceryl ether, alkyl polyglucoside and the like. Among these, sorbitan fatty acid ester, polyoxyethylene sorbitan fatty acid ester, polyoxyethylene hydrogenated castor oil, and alkyl glyceryl ether are more preferable.

  Component (C) is 0.001 to 10% by mass, more preferably 0.01 to 5% by mass, and particularly preferably 0.1 to 1% by mass in the oil-in-water emulsion composition from the viewpoint of emulsion stability and oil phase stability. It is preferable to contain by mass.

As the non-volatile substance having a melting point of component (D) of 30 ° C. or higher, the vapor pressure at 25 ° C. is preferably 1.33 × 10 ⁻⁶ kPa or higher, and more preferably 6.66 × 10 ⁻⁶ kPa or higher. In particular, it is preferably 1.33 × 10 ⁻⁵ or more.

  Moreover, as a non-volatile substance having a melting point of 30 ° C. or higher, the solubility at 25 ° C. when using isopropylpyrmitate as a solvent is 10% by mass or less of the composition comprising component (D) and isopropyl palmitate. Is preferred. The solubility is preferably 0.00001 to 10% by mass, more preferably 0.0001 to 10% by mass, and the melting point is preferably 40 to 200 ° C.

  Examples of the non-volatile material having a melting point of component (D) of 30 ° C. or higher include aroma components and insect repellents. Examples of the aroma component include monoterpenes, sesquiterpenes, diterpenes, aromatic compounds, and fatty acid esters thereof. Specific examples include monoterpene alcohols such as camphene, α-terpineol, and menthol, and sesquiterpene alcohols such as cedrol and β-caryophyllene alcohol. As the aroma component, α-terpineol, cedrol, β-caryophyllene alcohol and the like are preferable. Examples of insect repellents include camphor and naphthalene.

    Component (D) is 0.0001 to 10% by mass, more preferably 0.001 to 5% by mass, especially 0.01 to 1% in the oil-in-water emulsion composition from the viewpoint of emulsion stability and oil phase stability. It is preferable to contain by mass.

  The oil agent for dissolving the component (D) of the component (E) has a solubility of 10% by mass or more of the composition comprising the components (D) and (E) at 50 ° C., and is used in the fields of cosmetics and pharmaceuticals. Although it will not restrict | limit especially if used, Higher alcohols, sterols, silicones, a fluorine-type oil agent, another oil-based component, etc. are mentioned.

  Examples of higher alcohols include benzyl alcohol, isocetyl alcohol, isostearyl alcohol, behenyl alcohol, hexadecyl alcohol, phenylethyl alcohol, cetanol, stearyl alcohol, oleyl alcohol, 2-octyldodecanol, batyl alcohol, and 2-hexyldecanol. Especially, cetanol and stearyl alcohol are preferable.

Examples of the sterols include cholesterol, cholesteryl isostearate, provitamin D ₃ , campesterol, stegmasteranol, stigmasterol, 5-dihydrocholesterol, α-spinasterol, parissterol, cryonasterol, γ-sitosterol, stigmastenol, Salgasterol, apenasterol, ergostanol, sitosterol, corvisterol, chondirasterol, polyferasterol, halicuronasterol, neosbongosterol, fucosterol, aptostanol, ergostadienol, ergosterol, 22-dihydroergosterol, Brassicasterol, 24-methylenecholesterol, 5-dihydroergosterol, dehydroergosterol, Nguisterol, Cholestanol, Coprostanol, Dimostosterol, 7-Hetcholesterol, Latosterol, 22-Dehydrocholesterol, β-Sitosterol, Cholestatrien-3β-ol, Coprostanol, Cholestanol, Ergosterol, 7-Dehydrocholesterol , 24-dehydrocholestetanin-3β-ol, echilenin, echrin, estrone, 17β-estradiol, androst-4-ene-3β, 17β-diol, dehydroshrimp androsterone, alkenyl succinate cholesterol (Japanese Patent Laid-open No. Hei 5-294899) No. gazette). Of these, cholesterol, cholesteryl isostearate, and cholesteryl alkenyl succinate are particularly preferable.

  Examples of silicones are those usually used in toiletry products, such as octamethylpolysiloxane, tetradecamethylpolysiloxane, methylpolysiloxane, highly polymerized methylpolysiloxane, methylphenylpolysiloxane, octamethylcyclotetrasiloxane, Methyl polycyclosiloxane such as methylcyclopentasiloxane, trimethylsiloxysilicic acid, further alkyl-modified silicone, polyether-alkyl-modified silicone, amino-modified silicone, fluorine-modified silicone, alkyl glyceryl ether-modified silicone, JP-A-6-72851 Examples include modified silicones such as modified organopolysiloxanes described in the publication.

  As the fluorinated oil, perfluoropolyether and fluorine-modified silicone, which are perfluoro organic compounds that are liquid at room temperature, are preferable. For example, perfluorodecalin, perfluoroadamantane, perfluorobutyltetrahydrofuran, perfluorooctane, perfluorononane. , Perfluoropentane, perfluorodecane, perfluorododecane, perfluoropolyether, fluorine-containing ether compound represented by the following general formula (4)

(In the formula, Rf represents a linear or branched perfluoro group having 1 to 20 carbon atoms, R ⁷ represents a linear or branched cycloalkyl group having 3 to 9 carbon atoms, and m represents a number of 1 to 8. And the like. Specific examples include 1,3-dimethylbutyl {2- (perfluorooctyl) ethyl} represented by the following formula (5).

  The other oily components may be volatile or non-volatile, for example, hydrocarbons such as solid or liquid paraffin, petrolatum, crystal oil, ceresin, ozokerite, montan wax, squalane, squalene; eucalyptus oil Mint oil, camellia oil, macadamia nut oil, avocado oil, beef tallow, lard, horse fat, egg yolk oil, olive oil, carnauba wax, lanolin, jojoba oil; glycerin monostearate, glycerine distearate, glycerin monooleate, Isopropyl palmitate, isopropyl stearate, butyl stearate, isopropyl myristate, neopentyl glycol dicaprate, diethyl phthalate, myristyl lactate, diisopropyl adipate, cetyl myristate, lactic acid Listyl, diisopropyl adipate, cetyl myristate, cetyl lactate, 1-isostearoyl-3-myristoylglycerol, cetyl 2-ethylhexanoate, 2-ethylhexyl palmitate, myristate-2-octyldodecyl, di-2-ethyl Ester oil such as neopentyl glycol hexanoate, oleic acid-2-octyldodecyl, glycerol triisostearate, di-paramethoxycinnamic acid-glyceryl mono-2-ethylhexanoate; higher grades such as stearic acid, palmitic acid, oleic acid Fatty acids; and natural essential oils such as rosemary, rooibos, royal jelly, and hamamelis, lignans, vitamin E, oil-soluble vitamin C, vitamin A derivatives, and the like.

  Component (E) is preferably contained in the oil-in-water emulsion composition of the present invention in an amount of 0.01 to 30% by mass, more preferably 0.05 to 20% by mass, and particularly preferably 0.5 to 10% by mass.

  The non-volatile substance having a melting point of component (D) of 30 ° C. or higher is 0.01 to 30% by mass, more preferably 0.05 to 20% by mass, particularly 0.1 to 15% by mass in the oil agent of component (E). Even when it is contained, the non-volatile material can be stably held in a dissolved state in oil droplets.

  In the oil-in-water emulsion composition of the present invention, the component (F) water is preferably 50 to 90 mass%, more preferably 70 to 90 mass%.

  The oil-in-water emulsion composition of the present invention has a viscosity at 25 ° C. of 2000 mPa · s or less, preferably 1000 mPa · s or less, more preferably 1 to 500 mPa · s, particularly 1 to 50 mPa · s, as measured by a B-type viscometer. It is preferable to be in the range of from the viewpoints of emulsion stability, volatility of component (D), good spreadability and no stickiness.

  In the method for producing the oil-in-water emulsion composition of the present invention, the component (C) is added to and mixed with a solution or dispersion of some of the components (F), components (A) and (B), It is preferable to manufacture by diluting with the component (F). Furthermore, after (1) component (C), (D), and (E) are added and mixed in the solution or dispersion liquid of a part of component (F), component (A) and (B), the remaining components A method of diluting with (F); and (2) adding component (C) to a solution in which a part of component (F), components (A), (B), (D) and (E) are dissolved or dispersed, It is more preferable to manufacture by the method of diluting with the remaining component (F) after mixing.

The weight ratio of the composition obtained by adding and mixing the component (C) to the solution or dispersion containing the component (F), the components (A) and (B) and the remaining component (F) is 1/99. ~ 99/1, 1/99 ~
It is preferably in the range of 65/35, particularly 1/99 to 50/50.

  The particle size of the oil droplets in the obtained emulsion composition of the present invention is preferably 10 μm or less, more preferably 0.1 to 10 μm, and particularly preferably 0.1 to 5 μm. When such fine particle oil droplets are formed, the stability is particularly good. Here, the particle diameter of the oil droplets can be measured by a laser diffraction / scattering particle size distribution analyzer (for example, HORIBA LA-910).

  The emulsion composition of the present invention is stable even if it contains a hardly soluble hardly volatile substance in the oil droplets, and can improve the volatility of the hardly soluble hardly volatile substance. Moreover, the form of a composition can also be made into mist form, emulsion, a lotion form, etc. Moreover, it can be used as a microemulsion preparation (for example, for aroma mist, body odor prevention mist, room mist, insect mist), lotion, milky lotion, cream, bathing agent, scent imparting agent, etc.

Examples 1-3
Components (A), (B) and a part of water described in Table 1 are dispersed at 30 to 60 ° C., and components (C), (D) and (E) dissolved at 30 to 80 ° C. are added thereto. Then, after mixing at 30 to 60 ° C. for 30 to 60 minutes, it was diluted with the remainder of the water to produce an oil-in-water emulsion composition.

The particle diameter of the emulsion immediately after production was measured with a dynamic light scattering particle size distribution measuring apparatus.
The volatilization amount is 20 mg / cm ² on the filter paper, dried for 10 minutes, put in a glass bottle, aerated for 0.5 minutes at 0.5 L / min, captured the volatilized material with dichloromethane, and used gas chromatography. Measured by internal standard method. The viscosity was measured at 25 ° C. using a BL type viscometer (Toki Sangyo).

Each of Examples 1 to 3 was a low-viscosity oil-in-water emulsion composition.
Comparative Example 1 uses a nonionic active agent of HLB2.1 instead of the nonionic active agent used in Examples 1 to 3, and the emulsion particle diameter immediately after production is as large as 25 μm. Completely separated. Comparative Example 2 and Comparative Example 3 are respectively an aqueous preparation and an oil preparation in which a hardly volatile substance is uniformly dispersed as fine crystals, and the viscosity does not have to be higher than that of the oil-in-water emulsion compositions of Examples 1 to 3. There was a rough feeling due to crystals and a sticky feeling due to high viscosity.

  The volatilization amount of Examples 1 to 3 was comparable to or greater than the volatilization amount of Comparative Examples 2 and 3, and was a microemulsion having a very low viscosity, and could be applied to a mist type preparation. Since there was no precipitation of non-volatile substances, it was confirmed that the preparation was stable and not rough, and had a superior feeling of use with no stickiness because of its low viscosity.

Claims (5)

The following components (A) to (F):
(A) Some or all of the hydrogen atoms of the hydroxy group of the polysaccharide or derivative thereof are the following substituents (a)
(A) A group represented by the following general formula (1) (the hydrogen atom of the hydroxy group of the substituent (a) may be further substituted with the substituent (a)).

[Wherein E ¹ represents a linear or branched divalent saturated hydrocarbon group having 1 to 6 carbon atoms which may be substituted by a hydroxy group or an oxo group, and n represents a number of 8 to 300. , N A ¹ are the same or different and each represents a linear or branched divalent saturated hydrocarbon group having 1 to 6 carbon atoms, and E ² represents an ether bond or an oxycarbonyl group (—OCO— or —COO). -), R represents a linear or branched alkyl group having 4 to 30 carbon atoms which may be substituted by a hydroxy group. ]
Polysaccharide derivatives substituted with
(B) polyols,
(C) a nonionic surfactant of HLB 4-9,
(D) a non-volatile material having a melting point of 30 ° C. or higher,
(E) an oil for dissolving component (D),
(F) An oil-in-water emulsion composition containing water. The oil-in-water emulsion composition according to claim 1, wherein the vapor pressure of component (D) at 25 ° C is 1.33 × 10 ^-6 kPa or more.   The oil-in-water emulsion composition according to claim 1 or 2, wherein the component (D) has a solubility (25 ° C) in isopropyl palmitate of 10% by mass or less.   The oil-in-water emulsion composition according to any one of claims 1 to 3, wherein the viscosity of the oil-in-water emulsion composition is 2000 mPa · s or less. A non-volatile material (component (D)) having a melting point of 30 ° C. or higher is converted into the following components (A), (B), (C), (E) and (F):
(A) Some or all of the hydrogen atoms of the hydroxy group of the polysaccharide or derivative thereof are the following substituents (a)
(A) A group represented by the following general formula (1) (the hydrogen atom of the hydroxy group of the substituent (a) may be further substituted with the substituent (a)).

[Wherein E ¹ represents a linear or branched divalent saturated hydrocarbon group having 1 to 6 carbon atoms which may be substituted by a hydroxy group or an oxo group, and n represents a number of 8 to 300. , N A ¹ are the same or different and each represents a linear or branched divalent saturated hydrocarbon group having 1 to 6 carbon atoms, and E ² represents an ether bond or an oxycarbonyl group (—OCO— or —COO). -), R represents a linear or branched alkyl group having 4 to 30 carbon atoms which may be substituted by a hydroxy group. ]
Polysaccharide derivatives substituted with
(B) polyols,
(C) a nonionic surfactant of HLB 4-9,
(E) an oil for dissolving component (D),
(F) The volatilization method of the component (D) mixed and emulsified with water.