JP2007075276A - Multichamber container - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide multichamber container formed of a thermoplastic resin film which facilitates the formation of an easily removable seal portion and which is excellent in balance between the sealability and removability of the easily removable seal portion. <P>SOLUTION: A plurality of accommodating chambers 13a, 13b are partitioned by the easily removable seal portion 11 constituted by welding one side surfaces of the thermoplastic resin film each other. Further, a polyolefin resin in which the difference (Tem-Tim) between an extrapolation melting starting temperature Tim and an extrapolation melting finishing temperature Tem obtained by a DSC is 35°C or higher is used as the one side surfaces of the films and a strong welded portion 16 and a weak welded portion 17 with different heatseal strength each other are formed in the easily removable seal portion 11. <P>COPYRIGHT: (C)2007,JPO&INPIT

Description

  The present invention relates to a multi-chamber container.

  A combination of an amino acid infusion solution and a glucose infusion solution, or a combination of an antibiotic and a solution thereof may be altered over time in a mixed state. Therefore, these combinations are accommodated in a multi-chamber container having two or more accommodating chambers partitioned by an easily peelable seal portion in a state where they are not mixed with each other. The multi-chamber container can aseptically mix the contents of different storage chambers in the multi-chamber container by peeling off the easy-peeling seal portion with the hydraulic pressure when the storage chamber is pressurized. By performing such a mixing process immediately before use, it is possible to suppress deterioration of the contents over time.

The easy peel seal part of the multi-chamber container is easily peeled off by the hydraulic pressure when the storage chamber is pressurized, but has an adhesive strength that does not cause accidental peeling during normal storage. In other words, there is a demand for a balance between heat sealability and peelability.
Conventionally, an easily peelable seal portion is, for example, a film in which resins that are not highly compatible with each other and that have different melting temperatures are mixed, specifically, for example, a mixed resin film of polyethylene and polypropylene. And are thermally bonded at a temperature intermediate between the melting temperatures of the two.

However, for example, when a mixed resin of polyethylene and polypropylene is used for forming the easy peel seal portion, there is a problem that the material cost becomes high. It is desired to form an easily peelable seal portion with a film using a single resin.
On the other hand, in Patent Document 1, a pair of heat and pressure plates subjected to a specific shape knurling is used, and a synthetic resin film is thermally bonded while holding the pair of heat and pressure plates in a specific positional relationship. Thus, an infusion bag formed by forming a partition seal portion (easy peel seal portion) is described.

Further, Patent Document 2 discloses a multi-chamber infusion container formed of a thermoplastic resin film and having a plurality of drug chambers for storing drugs, and a detachable weak seal portion (easy peel seal) separating each drug chamber. Part) is formed of a plurality of fusion parts having different fusion strengths, and among these fusion parts, the strong fusion part, which is the fusion part having the largest fusion strength, is dispersed in the weak seal part. There is described a multi-chamber infusion container in which the total area occupied by the strongly fused portion is set to be less than 25% of the area of the weakly sealed portion.
JP-A-8-24314 Japanese Patent Laid-Open No. 2004-476

However, in the case of the infusion bag described in Patent Document 1, it is difficult to hold the pair of heating and pressurizing plates in a specific positional relationship, and the positional relationship is shifted, so that the heat sealability and the peelability are balanced. There is a problem that it becomes difficult.
Further, in the case of the multi-chamber infusion container described in Patent Document 2, an appropriate easy peelability can be imparted to the weak seal portion in a relatively wide temperature range without multilayering the resin film. Thus, when the total occupied area of the strongly fused portion is 25% or more with respect to the area of the weakly sealed portion, the heat seal strength of the weakly sealed portion is increased and the easy peelability is impaired. Occurs. That is, in the multi-chamber infusion container described in Patent Document 2, the heat seal strength of the weak seal portion depends on the occupied area ratio of the strong fusion portion with respect to the area of the weak seal portion. There is annoyance that the distribution state of the strongly fused portion must be set strictly.
In addition, when the multi-chamber infusion container described in Patent Document 2 is made of a general-purpose polyethylene film and the obtained multi-chamber container is filled with a chemical solution and subjected to heat sterilization, the weak seal described above is used. Among the portions, peeling occurs in the strong fusion portion, which causes a problem that the heat seal strength of the entire weak seal portion is reduced.

  Accordingly, an object of the present invention is a multi-chamber container formed of a thermoplastic resin film, which is easy to form an easily peelable seal portion, and has a balance between the sealability and peelability of the easily peelable seal portion. It is to provide a good multi-chamber container.

In order to achieve the above object, the present invention provides:
(1) It is formed of a thermoplastic resin film, and includes a plurality of storage chambers defined by an easily peelable seal portion formed by fusing one surface of the thermoplastic resin film, and the thermoplastic resin film On the one side surface, the difference (Tem−Tim) between the extrapolation melting start temperature Tim and the extrapolation melting end temperature Tem obtained by differential scanning calorimetry (DSC) or differential thermal analysis (DTA) is 35 ° C. or more. A multi-chamber container comprising a polyolefin-based resin, wherein the easily peelable seal portion has a strong fusion portion and a weak fusion portion having different heat seal strengths,
(2) It is formed of a thermoplastic resin film, and includes a plurality of storage chambers defined by an easily peelable seal portion formed by fusing one surface of the thermoplastic resin film, and the thermoplastic resin film The surface on one side is made of a polyolefin-based resin whose amount of components extracted with boiling hexane is 2.0% by weight or less, and the easily peelable seal portion has a strongly fused portion and a weakly fused portion having different heat seal strengths. A multi-chamber container, characterized in that
(3) The multi-chamber container according to (1) or (2), wherein the thermoplastic resin film is a multilayer film,
(4) The multi-chamber container according to any one of (1) to (3), wherein the polyolefin-based resin forming the one side surface of the thermoplastic resin film is polyethylene.
(5) The multi-chamber container according to any one of (1) to (4), wherein the heat-sealing strength of the entire easy-peel seal part is 1 to 7 N / 15 mm,
(6) In any one of (1) to (5), the total area of the strongly fused portions is 1 to 70% with respect to the entire area of the easily peelable seal portion. Double-chamber container as described,
Is to provide.

In the present invention, “extrapolation melting start temperature Tim” and “extrapolation melting end temperature Tem” are the differential scanning calorimetry (DSC) or differential for the polyolefin resin forming the one side surface of the thermoplastic resin film. It is a value determined based on an endothermic peak measured by thermal analysis (DTA), and is specifically determined according to the method described in JIS K 7121-1987 “Method for Measuring Transition Temperature of Plastic”. That is, the melting peak temperature Tpm is obtained by DSC or DTA, the straight line obtained by extending the low-temperature base line to the high-temperature side, and the melting peak (when two or more overlaps appear, the melting peak having the lower melting peak temperature) The temperature at the intersection of the tangent drawn at the point where the gradient is maximum on the low temperature side curve of the curve is the extrapolation melting start temperature Tim, and the high temperature base line is extended to the low temperature side, and the melting peak ( When two or more overlaps appear, the temperature at the intersection of the tangent drawn at the point where the gradient is maximized on the curve on the high temperature side of the melting peak with the higher melting peak temperature) and the extrapolated melting end temperature Tem .
In the present invention, the “component amount extracted with boiling hexane” means the component amount extracted with boiling hexane by Soxhlet extraction, and is obtained by the following equation.

(Extracted component amount / total amount of sample) × 100
In the present invention, “heat seal strength” is the method described in “Test method of heat seal soft packaging bag and semi-rigid container 7. Heat seal strength test of bag” defined in JIS-Z0238: 1998. It is the strength (N / 15 mm) of the fused part (easy peel seal part and the peripheral part of the multi-chamber container) obtained according to the above.

  According to the multi-chamber container of the present invention, the easy-peeling seal portion can be easily peeled by pressurizing any of the plurality of housing chambers. For example, during easy storage, the sealing property of the easily peelable seal portion can be maintained. Further, the multi-chamber container of the present invention can maintain the heat seal strength of the easily peelable seal portion even when, for example, the chemical solution is filled in the storage chamber and subjected to heat sterilization. Therefore, before and after the heat sterilization treatment, the balance between the sealability and the peelability of the easily peelable seal portion can be maintained in a good state.

The multi-chamber container of the present invention is formed of a thermoplastic resin film, and includes a plurality of storage chambers that are partitioned by an easily peelable seal portion formed by fusing one surface of the thermoplastic resin film. And one surface of the thermoplastic resin film is
(I) a polyolefin resin having a difference (Tem−Tim) between the extrapolation melting start temperature Tim and the extrapolation melting end temperature Tem of 35 ° C. or higher, or
(Ii) The easily peelable seal portion is made of a polyolefin-based resin whose component amount extracted with boiling hexane is 2.0% by weight or less, and the easily peelable seal portion has a weak heat seal strength and a weakly fused portion. And a fused part.
FIG. 1 is a plan view showing an embodiment of a multi-chamber container, and FIG. 2 is a schematic plan view showing an enlarged view of the strong fusion part 16 and the weak fusion part 17 of the easy peel seal part 11. is there.

This multi-chamber container 10 has an easily peelable seal portion 11 and a peripheral edge portion 12 formed by fusing (thermobonding) one side surfaces of a thermoplastic resin film. In addition, the multi-chamber container 10 has a plurality of storage chambers 13 (13a, 13b) for storing a chemical solution, which are partitioned by an easily peelable seal portion 11 therein.
The easily peelable seal portion 11 is opened by pressurizing the storage chamber (13a or 13b) and applying pressure with the liquid stored in the storage chamber 13, thereby being stored in each of the storage chambers 13a and 13b. The mixed liquid is mixed. The easy peel seal portion 11 has a strong fusion portion 16 and a weak fusion portion 17 having different heat seal strengths.

The said thermoplastic resin film is the one side surface, Comprising: The surface of the side which makes the welding surface (thermal-bonding surface) for forming the easily peelable seal part 11 and the peripheral part 12 is said (i) or said ( It consists of polyolefin resin shown in ii).
Examples of the polyolefin resin of the polyolefin resin in which the difference (Tem-Tim) between the extrapolation melting start temperature Tim and the extrapolation melting end temperature Tem shown in (i) above is 35 ° C. or more include, for example, polyethylene, ethylene Examples thereof include polyolefins composed of olefins having 2 to 20 carbon atoms, such as α-olefin copolymers, polypropylene, propylene / α-olefin random copolymers, propylene / α-olefin block copolymers, polybutene, and poly-4-methylpentene.

  Examples of the α-olefin of the ethylene / α-olefin copolymer include α-olefins having 3 to 6 carbon atoms such as propylene, 1-butene, 1-pentene, 1-hexene and 4-methyl-1-pentene. As the α-olefin of the propylene / α-olefin random copolymer and the propylene / α-olefin block copolymer, for example, ethylene or, for example, 1-butene, 1-pentene, 1-hexene, 4-methyl Examples include α-olefins having 4 to 6 carbon atoms such as -1-pentene.

The polyolefin contained in the polyolefin-based resin is not particularly limited in terms of its molecular structure (linear, branched) and density. For example, for polyethylene, high-density polyethylene, linear low-density polyethylene, Various polyethylenes such as high pressure low density polyethylene can be used.
Particularly preferred examples of the polyolefin resin include polyethylene, polypropylene, polybutene and poly-4-methylpentene, and more preferred is polyethylene. Moreover, when polyethylene and other polyolefin resin are mixed, it is preferable that the ratio of the polyethylene in the obtained mixture is 50 weight% or more.

It is also possible to add thermoplastic elastomer (TPE), talc, silica or the like to the polyolefin-based resin shown in (i) above.
In the polyolefin resin shown in (i) above, the difference (Tem−Tim) between the extrapolation melting start temperature Tim and the extrapolation melting end temperature Tem is 35 ° C. or more.
In the polyolefin resin shown in (i) above, the difference (Tem−Tim) between the extrapolation melting start temperature Tim and the extrapolation melting end temperature Tem satisfies the above range, and the melting ends with the temperature at which the polyolefin resin starts to melt. Since the interval with the temperature is wide, the seal temperature capable of imparting an appropriate heat seal strength to the entire easy peel seal portion 11 can be appropriately set from a wide temperature range. Further, when the difference Tem-Tim satisfies the above range, the strong fusion portion in the easy peel seal portion 11 for adjusting the heat seal strength of the easy peel seal portion 11 to an appropriate range. The area ratio between 16 and the weakly fused portion 17 can be set within a relatively wide range.

  On the other hand, when the difference Tem-Tim is less than the above range, the seal temperature when forming the easily peelable seal portion 11 and the range of the area ratio of the strong fusion portion 16 in the easily peelable seal portion 11 are respectively It will be limited to a narrow range. Therefore, it becomes difficult to adjust the heat seal strength of the easily peelable seal portion 11 to an appropriate range. For example, when the difference Tem-Tim is below the above range, the heat-sealing strength of the easy-peeling seal portion 11 as a whole can be adjusted to an appropriate range. The area ratio of 16 is limited to less than 25%.

  Regarding the polyolefin resin shown in (i) above, the number of melting peaks measured by DSC or DTA is not particularly limited, and may be one or may be two or more. . When the number of melting peaks is one, the above difference (Tem−Tim) is 35 ° C. or more, and therefore the melting peak is necessarily broad. On the other hand, when the number of melting peaks is 2 or more, the width of each melting peak can be narrowed, and the temperature at which only the low-temperature melting component dissolves in the polyolefin resin, and the polyolefin resin Since the interval with the temperature at which the whole melts becomes wider, the range of selection for the temperature at which the easily peelable seal portion is formed becomes wider, and the processing for forming the easily peelable seal portion becomes easier.

  In addition, when there are a plurality of melting peaks, the melting peaks of each other overlap (that is, a set of extrapolation melting start temperature Tim and extrapolation melting end temperature Tem are determined for a plurality of melting peaks). Is preferred. When a plurality of melting peaks are independent from each other (when they do not overlap), the difference Tem-Tim in this case is the lowest from a plurality of sets of extrapolation melting start temperature Tim and extrapolation melting end temperature Tem. The difference T′em−T′im between the extrapolation melting start temperature T′im and the highest extrapolation melting end temperature T′em is a standard.

  Although melting peak temperature Tpm is not specifically limited, Preferably, it is 100-135 degreeC, More preferably, it is 110-130 degreeC. Further, when there are a plurality of melting peaks, the melting peak temperature Tpm of each peak is not particularly limited. For example, when there are two melting peaks, the melting peak temperature Tpm on the low temperature side is preferably 90 to 120 ° C., more preferably 100 to 115 ° C., and the melting peak temperature Tpm on the high temperature side is preferably 120 to 140 ° C., more preferably 125 to 135 ° C.

The polyolefin resin having a difference (Tem−Tim) between the extrapolation melting start temperature Tim and the extrapolation melting end temperature Tem shown in (i) above is 35 ° C. or more, for example, the following (a) to (c): It can be produced by the method shown in FIG.
(A) Two or more materials having different densities are polymerized using a polymerization facility having a plurality of reaction vessels.
(B) A catalyst capable of polymerizing materials having different densities under the same polymerization conditions is introduced into a plurality of reaction vessels for polymerization.
(C) Two or more materials having different densities are blended.

As a specific method for obtaining a polyolefin resin having a difference (Tem−Tim) of 35 ° C. or more, for example, a method of blending two kinds of materials having a density difference of 0.02 g / cm ³ or more can be mentioned. It is done.
Further, more specifically, but not limited to, for example, a linear low density polyethylene having a density of 0.920g / cm ³ (LLDPE), a LLDPE of density of 0.940 g / cm ³ (e.g., 50 And a method of blending polyethylene having a density of 0.960 g / cm ³ and polypropylene having a density of 0.900 g / cm ³ . In addition, from the viewpoint of improving the visibility inside the multi-chamber container, it is required that the thermoplastic resin film has high transparency. Therefore, in blending, the same kind of materials (for example, polyethylene, polypropylene, etc.) It is preferable to employ a combination of.

The catalyst shown in (b) is not particularly limited, and examples thereof include various Ziegler-Natta catalysts and metallocene catalysts.
In the cases shown in the above (a) and (b), the polymerization process is not particularly limited. For example, various methods such as slurry polymerization, solution polymerization, bulk polymerization, and gas phase polymerization are appropriately employed. can do.

The melt flow rate (MFR) of the polyolefin resin shown in the above (i) is not particularly limited, but as a measured value at 190 ° C. and a load of 2.16 kg, preferably 0.1 to 20 g / 10 min, more preferably 0.5 to 10 g / 10 min.
The polyolefin resin of the polyolefin resin having a component amount extracted with boiling hexane of 2.0% by weight or less shown in (ii) is the same as the polyolefin resin shown in (i), for example, Polyolefins composed of olefins having 2 to 20 carbon atoms, such as polyethylene, ethylene / α-olefin copolymer, polypropylene, propylene / α-olefin random copolymer, propylene / α-olefin block copolymer, polybutene and poly-4-methylpentene. Can be mentioned.

The α-olefin of the ethylene / α-olefin copolymer, the propylene / α-olefin random copolymer, and the α-olefin of the propylene / α-olefin block copolymer are the same as those of the polyolefin resin shown in (i) above. Can be mentioned.
The polyolefin contained in the polyolefin-based resin is not particularly limited in terms of its molecular structure (linear, branched) and density. For example, for polyethylene, high-density polyethylene, linear low-density polyethylene, Various polyethylenes such as high pressure low density polyethylene can be used.

Particularly preferred examples of the polyolefin resin include polyethylene, polypropylene, polybutene and poly-4-methylpentene, and more preferred is polyethylene. Moreover, when polyethylene and other polyolefin resin are mixed, it is preferable that the ratio of the polyethylene in the obtained mixture is 50 weight% or more.
It is also possible to add thermoplastic elastomer (TPE), talc, silica and the like to the polyolefin resin shown in (ii) above.

About the polyolefin-type resin shown to said (ii), the component amount extracted with boiling hexane is 2.0 weight% or less.
When the amount of components extracted with boiling hexane exceeds the above range, the range of the sealing temperature when forming the easily peelable seal portion 11 and the area ratio of the strong fusion portion 16 in the easily peelable seal portion 11 is as follows. , Each is limited to a narrow range. Therefore, it becomes difficult to adjust the heat seal strength of the easily peelable seal portion 11 to an appropriate range. In addition, for example, when the amount of components extracted with boiling hexane exceeds the above range, the heat seal strength of the easy peel seal portion 11 as a whole can be adjusted to an appropriate range, and within the easy peel seal portion 11. The area ratio of the strongly fused portion 16 is limited to less than 25%.

A polyolefin resin in which the amount of components extracted with boiling hexane is 2.0% by weight or less can be obtained, for example, by reducing the content of low molecular weight components in the polyolefin resin.
Further, the density of the polyolefin resin shown in the above (ii) is not particularly limited, but is preferably 0.920 to 0.940 g / cm ³ .

  When the density of the polyolefin resin shown in the above (ii) is below the above range, the flexibility and transparency of the multi-chamber container are improved, but there is a risk of blocking, and the polyolefin resin shown in the above (ii) There is a possibility that the adhesiveness of the resin becomes excessive, and the processability is lowered. On the other hand, if the density of the polyolefin-based resin shown in (ii) exceeds the above range, the flexibility of the multi-chamber container may be impaired, and the touch of the multi-chamber container may be reduced. And the multi-chamber container may be damaged when it is accidentally dropped on the floor.

The film obtained from the polyolefin-based resin shown in the above (i) or (ii) may be a single-layer film composed of one kind of film or a multilayer film in which a plurality of kinds of films are laminated. .
When the film obtained from the polyolefin resin shown in the above (i) or (ii) is a single layer film, as the material of the polyolefin resin shown in the above (i), among the resins exemplified above, Linear low density polyethylene, polypropylene, propylene-ethylene random copolymer, propylene-ethylene block copolymer, mixture of propylene resin and ethylene elastomer, mixture of propylene resin and propylene elastomer, propylene resin It is preferable to use a mixture of styrene elastomer and the like. When these resins are used, the transparency and flexibility of the multi-chamber container can be further improved.

  On the other hand, when the film obtained from the polyolefin-based resin shown in (i) or (ii) is a multilayer film, the layer structure of the multilayer film is not particularly limited. For example, the one-side surface of the thermoplastic resin film (High-density polyethylene / linear low-density polyethylene (two-layer structure), medium-density polyethylene / low-density polyethylene / high-density polyethylene (three-layer structure), high-density polyethylene / low-density) Examples include polyethylene / high density polyethylene (three-layer structure).

  In addition, when the film obtained from the polyolefin resin shown in (i) or (ii) is a multilayer film, the one side surface (the inner surface side of the multi-chamber container) of the thermoplastic resin film is easily peeled off. You may form with resin which is easy to form a seal part. Examples of the resin that can easily form the easily peelable seal portion include a mixed resin of polyethylene and polypropylene.

  Moreover, when the film obtained from the polyolefin-type resin shown in said (i) or (ii) is a multilayer film, as a layer other than the said one side surface (inner surface side of a multi-chamber container) of a thermoplastic resin film. For example, an oxygen barrier resin layer can also be used. The oxygen barrier resin layer is not particularly limited. For example, when a multilayer film is formed by coextrusion molding, for example, ethylene vinyl alcohol, polyamide, polyester, or the like can be used as the oxygen barrier resin. Further, when a multilayer film is formed by dry lamination, as the oxygen barrier resin layer, in addition to the above-exemplified resin layer, or together with the above-exemplified resin layer, for example, polyester (preferably A film in which a vapor-deposited film of inorganic oxide is formed on the surface of a base film made of a stretched polyester), a stretched polyamide film, a stretched polypropylene film, and the like can be used.

  The method for forming a film obtained from the polyolefin-based resin shown in (i) or (ii) is not particularly limited. For example, various methods such as T-die molding, inflation molding, water-cooled inflation molding, blow molding, lamination molding, etc. The molding method is mentioned. From the viewpoint of transparency of the film, T-die molding, inflation molding, and water-cooled inflation molding are particularly preferable among the above molding methods.

  Moreover, the thickness of the film obtained from the polyolefin-type resin shown to said (i) or (ii) is although it does not specifically limit, Usually, it is 5-1000 micrometers, Preferably, it is about 50-500 micrometers. When the thickness of the film is within the above range, the multi-chamber container can be provided with sufficient strength for holding the contents, and the one side surface (the inner surface side of the multi-chamber container) An easily peelable seal portion can be formed by heat sealing between each other.

  In the multi-chamber container of the present invention, the heat seal strength of the easy peel seal portion 11 as a whole is maintained when the multi-chamber container is stored under normal conditions, and for example, the multi-chamber container is flattened. It is placed on a table and peeled when one of the storage chambers is pressed so as to be crushed by hand, and is adjusted so as to open between the adjacent storage chambers via an easily peelable seal portion. Specifically, the heat seal strength (JIS-Z0238: 1998) of the easy peel seal part 11 as a whole is preferably 1 to 7 N / 15 mm, and more preferably 3 to 5 N / 15 mm. If the heat seal strength of the easy peel seal portion 11 as a whole is below the above range, the easy peel seal portion 11 may be unintentionally peeled. Conversely, if it exceeds the above range, the easy peel seal portion 11 is peeled off. There is a risk that it may be difficult.

  The strong fusion part 16 and the weak fusion part 17 of the easily peelable seal part 11 usually sandwich the thermoplastic resin film at a predetermined pressure and time after heating the pair of upper and lower seal bars to an appropriate temperature. What is necessary is just to heat seal. For adjusting the heat seal strength, the temperature of the heat seal bar (heating temperature of the thermoplastic resin film), pressure and time are appropriately set. Usually, the pressure of the heat seal bar is fixed and the heating temperature is adjusted. adjust. Although there is no restriction | limiting in particular in the pressure and time for heat-sealing, About 1-10 Mpa in a pressure and about 1 to 20 seconds are common in 1 hour.

In addition, for example, by sandwiching a multilayer film with a heat seal bar having a partially different thickness or temperature, a portion where the thickness of the heat seal bar is large (that is, a portion where the pressure sandwiching the multilayer film increases), or a heat seal bar The heat seal strength of the part where the temperature is high can be set larger than the heat seal strength of the other part.
Although the shape and arrangement of the strong fusion part 16 and the weak fusion part 17 of the easy peel seal part 11 are not particularly limited, the balance between the heat sealability and the peelability of the easy peel seal part 11 is maintained in a good state. From this point of view, for example, (a) the strongly fused portion 16 is disposed in a wave shape within the easily peelable seal portion 11, and (b) the easily fused seal portion is formed in a spot-like shape. 11 and the like.

In the case where the strongly fused portion 16 is formed in a spot shape, in order to prevent variation in the heat seal strength within the easily peelable seal portion 11, the strongly fused portion 16 is placed inside the easily peelable seal portion 11. In this case, it is preferable to arrange them at regular intervals.
The total area of the strong fusion bonding portions 16 is preferably 1 to 70%, more preferably 1 to 60%, and still more preferably 1 to 50% with respect to the entire area of the easily peelable seal portion 11. It is. If the total area of the strong fusion bonding portions 16 is less than the above range with respect to the total area of the easy peel seal portion 11, the heat sealability of the easy peel seal portion 11 may be reduced. On the other hand, when the total area of the strong fusion bonding portions 16 exceeds the above range with respect to the total area of the easy peel seal portion 11, the temperature for controlling the heat seal strength of the easy peel seal portion 11 to an appropriate range. There exists a possibility that a width | variety may become narrow and the easy peeling seal | sticker part 11 may become difficult to peel.

The peripheral edge portion 12 may be formed according to a conventional method. For example, after the inner surface layers of the multilayer film are overlapped with each other, the inner surface layer is sandwiched between a pair of heat seal bars, and uniformly heated and pressurized. It can be formed by thermally bonding the layers together.
The heating conditions when the peripheral edge portion 12 is formed by thermal bonding are set according to the material for forming the inner surface layer of the multilayer film, and are not particularly limited. For example, preferably, 140 to 155 ° C, More preferably, it is 140-145 degreeC and is about 4 to 5 second.

In the multi-chamber container 10 shown in FIG. 1, the peripheral edge 12 is formed over the entire circumference of the container. For example, when a cylindrical thermoplastic resin film is used as a material, the length of the film is long. The peripheral edge portion 12 may be formed only at both ends in the vertical direction, and the heat sealing does not necessarily have to be performed over the entire peripheral edge of the container.
The easily peelable seal portion 11 is formed, for example, by sandwiching two stacked thermoplastic resin films from two sides of the two heat seal bars each having a specific seal edge formed on the seal surface. be able to.

  As an example of the said heat seal bar, as shown in FIG. 3, the heat seal bar which has an unevenness | corrugation on the surface is mentioned, for example. In such a heat seal bar, the portion 21 where the surface forms a convex portion is in close contact with the resin with a stronger pressure, so that the strongly fused portion 16 of the easily peelable seal portion 11 is formed and the surface is a concave portion. In the portion 22 forming the film, the weakly fused portion 17 is formed because it is in close contact with the resin with a weaker pressure.

The uneven shape on the surface of the heat seal bar is not particularly limited, and may be, for example, a shape in which convex portions (or concave portions) such as circles, squares, triangles, and rhombuses are dispersed and arranged to some extent. Irregularities may be formed by lines having a width of.
The uneven shape on the surface of the heat seal bar may be formed on each of the pair of upper and lower heat seal bars, or may be formed on only one of them. In addition, the pair of heat seal bars can have different shapes and arrangements of uneven shapes. Furthermore, it is possible to provide a gentle inclination between the convex portion and the concave portion.

Next, the present invention will be described based on production examples, examples, comparative production examples, and comparative examples, but the present invention is not limited to the following examples.
<Preparation of easy peel seal>
Production Example 1
Linear low density polyethylene A (MFR = 2 g / 10 min (190 ° C.), density 0.920 g / cm ³ ) and high density polyethylene B (MFR = 18 g / 10 min (190 ° C.), density 0.960 g / cm ³ ) was melted and mixed at a ratio of 80:20 (weight ratio), and a film having a thickness of 300 μm was produced by a water-cooled inflation method. The difference (Tem−Tim) between the extrapolation melting start temperature Tim and the extrapolation melting end temperature Tem of the obtained film was measured by DSC, and was found to be 44 ° C.

  The DSC measurement was performed using Pyris-1 manufactured by PerkinElmer. Specific measurement conditions are as follows. First, under a nitrogen gas flow of 20 ml / min, heating is performed from room temperature to 200 ° C. at a heating rate of 500 ° C./min, and then maintained at 200 ° C. for 10 minutes. Then, it cools to 30 degreeC with the temperature-fall rate of 10 degree-C / min, and keeps at 30 degreeC for 10 minutes. After giving a heat history in this manner, the sample is again heated to 200 ° C. at a rate of temperature increase of 10 ° C./min to obtain a melting peak curve.

Two of the above films are stacked, and this is sandwiched by a heat seal bar (see FIG. 3) in which the area ratio of the embossed (diamond-shaped) strongly fused portion 16 is 38%, and the temperature of the upper and lower seal bars is changed, Under the conditions of a sealing pressure of 0.3 MPa and a sealing time of 3.4 seconds, the easily peelable sealing portion 11 having a width of 10 mm between both the storage chambers 13a and 13b was formed.
The seal strength was measured according to ASTM F88. Specifically, a film including a part fused with a heat seal bar is cut out to a width of 15 mm, and a part not sealed is sandwiched between jigs of a tensile tester. The force when the tensile fused part peeled upward at a speed of 200 mm / min was defined as the seal strength.

The optimum strength as the peel strength was set to 3 to 5 N / 15 mm width, and the molding temperature width within this strength was measured. As a result, the molding temperature range of the film was 3 ° C.
Comparative production example 1
Using a linear low density polyethylene A (MFR = 2 g / 10 min (190 ° C.), density 0.920 g / cm ³ only, a film having a thickness of 300 μm was produced by a water-cooled inflation method. It was 30 degreeC as a result of measuring the difference (Tem-Tim) of the extrapolation melting start temperature Tim and the extrapolation melting end temperature Tem by DSC.

  Heat sealing was performed in the same manner as in Production Example 1 except that the above two films were used. As a result, the molding temperature range when the area ratio of the embossed (diamond-shaped) strongly fused portion 16 was 38% was 1 ° C. or less. That is, the molding temperature range within which the peel strength falls within the optimum value of 3 to 5 N / 15 mm width is extremely narrow as compared with Production Example 1, and it is necessary to strictly control the molding process conditions.

<Manufacture of multi-chamber containers>
A multi-chamber container 10 shown in FIG. 1 was manufactured using a multilayer film of thermoplastics.
Each component constituting the multilayer film is as follows.
Resin A: Linear high-density polyethylene (trade name “Ultzex (registered trademark) Uz2010B”, density 0.920 g / cm ³ , component amount 0.6% by weight extracted with boiling hexane, Mitsui Chemicals, Inc. 80% by weight, medium density polyethylene (trade name “Neozex (registered trademark) Nz510”, density 0.965 g / cm ³ , 1.6% by weight of components extracted with boiling hexane, manufactured by Mitsui Chemicals, Inc. ) 20% by weight of mixed resin (Tem-Tim = 44 ° C.)
Resin B: Linear high-density polyethylene (trade name “Ultzex (registered trademark) Uz2010BM”, density 0.920 g / cm ³ , component amount 2.6% by weight extracted with boiling hexane, Tem-Tim = 30 ℃, Mitsui Chemicals, Inc.)
Resin C: Polyethylene Resin D: Ethylene α-olefin elastomer Example 1
By coextrusion molding, a three-layer multilayer film was obtained in which the outer surface layer was made of resin C, the intermediate layer was made of resin D, and the inner surface layer was made of resin A.

  Next, after the two multilayer films are overlapped with each other, the mouth member 14 is arranged as shown in FIG. 1 and sandwiched between a pair of heat seal bars with flat surfaces, 12 was formed. Further, the multilayer film is sandwiched between a heat seal bar having a flat surface and a heat seal bar 15 having irregularities shown in FIGS. 2 and 3, and heated and heated at 0.4 MPa for 3.5 seconds. By pressing, the easily peelable seal portion 11 was formed. The two storage chambers 13a and 13b were each filled with physiological saline before the easily peelable seal portion 11 was formed. Thus, a multi-chamber container 10 having two storage chambers 13a and 13b was obtained.

  When forming the easily peelable seal portion 11, the surface temperature of the heat seal bar 15 is set under four conditions of 118 ° C., 119 ° C., 120 ° C. or 122 ° C., and the surface temperature of the heat seal bar having a flat surface is: The temperature was fixed at 115 ° C. Moreover, the area ratio of the convex part 16 in the said heat seal bar 15 was set to 25%. This area ratio was the same as the ratio of the area (total) of the strongly fused portion to the entire area of the easily peelable seal portion 11.

Next, steam sterilization was performed on the multi-chamber container 10 at 108 ° C. for 40 minutes.
In addition, the heat seal strength of the easily peelable seal portion 11 of the infusion bag 10 is determined according to the provisions of JIS-Z0238: 1998 (Test method for heat seal soft packaging bags and semi-rigid containers 7. Heat seal strength test for bags). Measurements were made before and after steam sterilization. The measurement results are shown in Table 1.

Example 2
The area ratio of the protrusions 16 in the heat seal bar 15 (the ratio of the area of the strong fusion part to the total area of the easily peelable seal part 11 (total)) was 38%, and the surface temperature of the heat seal bar 15 was 126 ° C. Except for this, a multi-chamber container 10 was produced in the same manner as in Example 1.
Further, as in Example 1, steam sterilization was performed on the multi-chamber container, and the heat seal strength of the easily peelable seal part before and after steam sterilization was measured. The measurement results are shown in Table 2.

Comparative Example 1
A multi-chamber container 10 was produced in the same manner as in Example 2 except that the resin B was used instead of the resin A for the inner surface layer of the multilayer film. In addition, the area ratio of the convex part 16 in the heat seal bar 15 was 38%, and the surface temperature of the heat seal bar 15 was 126 ° C.
Moreover, when steam sterilization was performed on the multi-chamber container in the same manner as in Example 1, the easily peelable seal portion 11 was cleaved after sterilization.

  The present invention is not limited to the above description, and various design changes can be made within the scope of the matters described in the claims.

It is a top view which shows one Embodiment of this invention. FIG. 3 is a schematic plan view showing an enlarged view of a strongly fused portion 16 and a weakly fused portion 17 of the easy peel seal portion 11. It is a top view which shows an example of the metal mold | die for forming an easily peelable seal part. It is AA sectional drawing of FIG.

Explanation of symbols

DESCRIPTION OF SYMBOLS 10 Multi-chamber container 11 Easy peeling seal part 12 Peripheral part 13 Storage chamber 16 Strong melt | fusion part 17 Weak melt part

Claims (6)

Formed of thermoplastic resin film,
A plurality of storage chambers defined by an easily peelable seal portion formed by fusing one surface of the thermoplastic resin film;
The one surface of the thermoplastic resin film has a difference between the extrapolated melting start temperature Tim and the extrapolated melting end temperature Tem obtained by differential scanning calorimetry (DSC) or differential thermal analysis (DTA) (Tem−Tim). ) Is a polyolefin resin having a temperature of 35 ° C. or higher,
The multi-chamber container, wherein the easily peelable seal portion has a strongly fused portion and a weakly fused portion having different heat seal strengths. Formed of thermoplastic resin film,
A plurality of storage chambers defined by an easily peelable seal portion formed by fusing one surface of the thermoplastic resin film;
The one side surface of the thermoplastic resin film is composed of a polyolefin resin in which the amount of components extracted with boiling hexane is 2.0% by weight or less,
The multi-chamber container, wherein the easily peelable seal portion has a strongly fused portion and a weakly fused portion having different heat seal strengths.   The multi-chamber container according to claim 1 or 2, wherein the thermoplastic resin film is a multilayer film.   The multi-chamber container according to any one of claims 1 to 3, wherein the polyolefin resin forming the one surface of the thermoplastic resin film is polyethylene.   The multi-chamber container according to any one of claims 1 to 4, wherein the heat-sealing strength of the entire easily peelable seal portion is 1 to 7 N / 15 mm.   The multi-chamber container according to any one of claims 1 to 5, wherein a total area of the strongly fused portions is 1 to 70% with respect to an entire area of the easily peelable seal portion.

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