JP2007017242A - Liquid container for dispenser, and dispenser - Google Patents

Liquid container for dispenser, and dispenser Download PDF

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JP2007017242A
JP2007017242A JP2005198115A JP2005198115A JP2007017242A JP 2007017242 A JP2007017242 A JP 2007017242A JP 2005198115 A JP2005198115 A JP 2005198115A JP 2005198115 A JP2005198115 A JP 2005198115A JP 2007017242 A JP2007017242 A JP 2007017242A
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reagent
dispensing
reagent bottle
nozzle
liquid container
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Osamu Nakamu
修 中務
Mitsuhiro Yoshihira
光宏 吉平
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Juki Corp
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Juki Corp
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Abstract

<P>PROBLEM TO BE SOLVED: To prevent a reagent from spilling from a reagent bottle when a worker conveys or arranges the reagent bottle to a predetermined position in an analysis device. <P>SOLUTION: In this liquid container for a dispenser (reagent bottle 20) where liquid (reagent 18) is sucked by a dispensing nozzle 12 inserted from an upward opening 22, both longitudinal ends of the opening 22 are provided with a lid-like member 26 of which inside tip is bent in the inserting direction of the dispensing nozzle 12 and that can be turned only downward. <P>COPYRIGHT: (C)2007,JPO&INPIT

Description

本発明は、上方の開口部から挿入される分注ノズルにより液体の吸引が行なわれる分注装置用液体容器及び分注装置に係り、特に、創薬スクリーニング分野、バイオテクノロジー、ライフサイエンス分野等で血液等の検体を試薬に反応させ、又は複数種類の試薬同士を反応させて分析を行なう際の液体の分注に用いられる分注装置に試薬ボトルとして用いるに好適な、試薬を貯留した試薬ボトルを分注装置の所定の位置に運搬・配置する際に、試薬ボトルから試薬がこぼれるのを防止することが可能な、分注装置用液体容器、及び、これを用いた分注装置に関する。   The present invention relates to a liquid container for a dispensing apparatus and a dispensing apparatus in which liquid is sucked by a dispensing nozzle inserted from an upper opening, and particularly in the field of drug discovery screening, biotechnology, life science, etc. A reagent bottle storing a reagent, which is suitable for use as a reagent bottle in a dispensing apparatus used for dispensing a liquid when reacting a specimen such as blood with a reagent or reacting a plurality of types of reagents with each other The present invention relates to a liquid container for a dispensing device and a dispensing device using the same, which can prevent a reagent from spilling out from a reagent bottle when transporting and arranging the liquid at a predetermined position of the dispensing device.

血液等の検体を試薬に反応させ、又は複数種類の試薬同士を反応させて分析を行なう分析装置には、図1に例示する如く、試薬ボトル20に貯蔵された試薬の分注を行なうための複数の分注ノズル12が1列に並んだ分注ヘッド10が設けられている。また、分注ノズル12の先端には着脱可能なノズルチップ14が装着されている。該分注ヘッド10は、試薬ボトル収容部に対して設定された吸引対象位置と、検体等を収容する容器が載置された分注ステージに対して設定された吐出対象位置との間を移動し、且つ、これら吸引対象位置及び吐出対象位置のそれぞれにおいて、それぞれの分注ノズル12は上下方向に移動できるように設けられている。   In an analyzer that performs analysis by reacting a specimen such as blood with a reagent or reacting a plurality of types of reagents with each other, as illustrated in FIG. 1, the reagent stored in the reagent bottle 20 is dispensed. A dispensing head 10 in which a plurality of dispensing nozzles 12 are arranged in a line is provided. A detachable nozzle tip 14 is attached to the tip of the dispensing nozzle 12. The dispensing head 10 moves between a suction target position set for the reagent bottle storage unit and a discharge target position set for a dispensing stage on which a container for storing a sample or the like is placed. In addition, in each of the suction target position and the discharge target position, each dispensing nozzle 12 is provided so as to be movable in the vertical direction.

試薬ボトル収容部は、1列に並んだ分注ノズル12と直交する方向に沿って配置されており、それぞれの試薬ボトル20は、ノズルチップ14が装着された複数の分注ノズル12が同時に試薬を吸引することができるように、1列に並んだ分注ノズル12と並行する方向が長手方向となるように開口部22が設けられている。又、各試薬ボトル20には、分析に必要となる液状の試薬が個別に貯留されている。   The reagent bottle storage unit is arranged along a direction orthogonal to the dispensing nozzles 12 arranged in a row, and each of the reagent bottles 20 includes a plurality of dispensing nozzles 12 each having a nozzle chip 14 attached thereto. The opening 22 is provided so that the direction parallel to the dispensing nozzles 12 arranged in a row is the longitudinal direction. Each reagent bottle 20 individually stores a liquid reagent necessary for analysis.

試薬が貯留される試薬ボトル20は、分析装置外でそれぞれ試薬が所定量注がれ、試薬ボトル20を1本ずつ作業者が分析装置内の所定の位置に運搬・配置するか、若しくは、トレイ等に試薬ボトル20を配置し、トレイ毎一括で作業者が分析装置内の所定の位置に運搬・配置するのが一般的である。   The reagent bottles 20 in which the reagents are stored are poured into a predetermined amount of each reagent outside the analyzer, and an operator transports and arranges the reagent bottles 20 one by one at a predetermined position in the analyzer, or a tray. In general, the reagent bottles 20 are arranged in a tray, and the operator carries and arranges the trays at a predetermined position in the analyzer in a lump.

しかしながら、試薬が貯留された試薬ボトル20を作業者が装置の所定位置に運搬・配置する際に、試薬ボトル20の内部において、試薬の慣性力による流動によって、試薬が試薬ボトル20からこぼれ易いという問題があった。   However, when the operator transports and arranges the reagent bottle 20 in which the reagent is stored at a predetermined position of the apparatus, the reagent easily spills from the reagent bottle 20 due to the flow of the reagent due to the inertial force inside the reagent bottle 20. There was a problem.

このような問題点を解決するべく、(1)試薬ボトル20に入れる試薬の量を減らすこと、(2)試薬ボトル20を大きくすること、(3)市販製品のように、試薬ボトル20毎に運搬時用の密閉蓋を設けること、(4)特許文献1に記載されているように、試薬ボトル20の開口部22を小さくすると共に、試薬ボトル20の内部に試薬の慣性力による流動を妨げる仕切板(バッファプレート)24を設けることが考えられる。   In order to solve such problems, (1) reducing the amount of reagent put into the reagent bottle 20, (2) enlarging the reagent bottle 20, and (3) each reagent bottle 20 like a commercial product. (4) As described in Patent Document 1, the opening portion 22 of the reagent bottle 20 is made smaller and the flow of the reagent due to the inertial force of the reagent is prevented inside the reagent bottle 20. It is conceivable to provide a partition plate (buffer plate) 24.

特開2005−17176号公報JP-A-2005-17176

しかしながら、(1)のように試薬ボトルに入れる試薬の量を減らすと、試薬ボトルを交換する頻度が増えてしまい、作業者の負担が増えてしまう。又、(2)のように試薬ボトルの容量を大きくすると、装置サイズが大きくなってしまう。又、(3)のように試薬ボトル毎に密閉蓋を設けると、試薬ボトルを装置内の所定の位置に配置した後、全ての試薬ボトルの蓋を取り除かなくてはならず、やはり作業者の負担が増えてしまう。又、(4)特許文献1のように開口部22を小さくすると、入口が狭くなるため、特許文献1の例ではノズルが1本しか入れられず、更に、仕切板24を設けると、ノズル位置が仕切板24により制約を受けるという問題点を有する。   However, if the amount of the reagent put into the reagent bottle is reduced as in (1), the frequency of replacing the reagent bottle increases and the burden on the operator increases. Further, when the capacity of the reagent bottle is increased as in (2), the apparatus size is increased. In addition, when a sealing lid is provided for each reagent bottle as shown in (3), all reagent bottle lids must be removed after the reagent bottles are arranged at predetermined positions in the apparatus. The burden will increase. (4) Since the entrance becomes narrow when the opening 22 is made small as in Patent Document 1, only one nozzle can be inserted in the example of Patent Document 1, and further, if the partition plate 24 is provided, the nozzle position Has a problem that it is restricted by the partition plate 24.

本発明は、前記従来の問題点を解消するべくなされたもので、運搬・配置の際に液体容器から液体がこぼれないようにすることを課題とする。   The present invention has been made to solve the above-described conventional problems, and an object of the present invention is to prevent liquid from spilling from a liquid container during transportation and arrangement.

本発明は、上方の開口部から挿入される分注ノズルにより液体の吸引が行なわれる分注装置用液体容器において、前記開口部の長手方向両端に、前記分注ノズルの挿入を妨害しない蓋状部材を設けることにより、前記課題を解決したものである。   The present invention relates to a liquid container for a dispensing device in which liquid is sucked by a dispensing nozzle inserted from an upper opening, and a lid shape that does not obstruct the insertion of the dispensing nozzle at both ends in the longitudinal direction of the opening. By providing a member, the above-mentioned problem is solved.

又、前記蓋状部材の内側先端を、前記分注ノズルの挿入方向に曲げることにより、波立った液体を容器内側にはね返すと共に、分注ノズルの動きを円滑にして、分注ノズルからノズルチップが外れないようにしたものである。   Also, the inner tip of the lid-like member is bent in the direction in which the dispensing nozzle is inserted, so that the undulating liquid is rebounded to the inside of the container and the movement of the dispensing nozzle is smoothed, so that the nozzle tip from the dispensing nozzle Is to prevent it from coming off.

又、前記蓋状部材を、下方にのみ回動自在として、液体容器をぎりぎりまで小さくできるようにしたものである。   In addition, the lid-like member can be rotated only downward so that the liquid container can be made as small as possible.

本発明は、又、前記の液体容器を備えたことを特徴とする分注装置を提供するものである。   The present invention also provides a dispensing apparatus comprising the liquid container.

本発明によれば、分析装置外で液体が所定量注がれた液体容器を1本ずつ作業者が分析装置内の所定の位置に運搬・配置するか、若しくは、トレイ等に液体容器を配置し、トレイ毎一括で作業者が分析装置内の所定の位置に運搬・配置する際に、液体容器から液体がこぼれるのを防止することができる。   According to the present invention, an operator transports and arranges a liquid container in which a predetermined amount of liquid is poured outside the analyzer to a predetermined position in the analyzer, or arranges a liquid container on a tray or the like. In addition, it is possible to prevent liquid from spilling from the liquid container when the operator transports and arranges the trays at a predetermined position in the analyzer.

以下図面を参照して、本発明の実施形態を詳細に説明する。   Hereinafter, embodiments of the present invention will be described in detail with reference to the drawings.

本実施形態は、図3に示す如く、上方から挿入されるノズルチップを装着した複数の分注ノズル(図示省略)が同時に吸引できるように、上面に長方形の開口部22を持つ分注装置用の試薬ボトル20において、前記開口部22の長手方向両端部に、前記ノズルチップ14を装着した分注ノズル12の挿入を妨害しない、先端がR形状に曲げられた蓋状部材26を、図4に示す如く、下方にのみ回動自在に設けたものである。又、蓋状部材26は、復元ばね28の作用により、常に元の位置に戻るように構成されている。   As shown in FIG. 3, the present embodiment is for a dispensing apparatus having a rectangular opening 22 on the upper surface so that a plurality of dispensing nozzles (not shown) equipped with nozzle tips inserted from above can be sucked simultaneously. In the reagent bottle 20 of FIG. 4, a lid-like member 26 whose tip is bent in an R shape that does not obstruct the insertion of the dispensing nozzle 12 fitted with the nozzle tip 14 at both longitudinal ends of the opening 22 is shown in FIG. As shown in FIG. 4, the lower part is provided so as to be rotatable only downward. The lid-like member 26 is configured to always return to the original position by the action of the restoring spring 28.

以上の構成において、試薬18が貯留された試薬ボトル20を分析装置の所定位置に運搬・配置する際に、試薬ボトル本体の内部において試薬の慣性力による流動によって、試薬18が試薬ボトル20の長手方向に波立つが、試薬ボトル20の開口部22の長手方向両端部に設けられた、先端がR形状の蓋状部材26により、波立った試薬は試薬ボトル20の内側に戻される。なお、開口部22の短辺方向の波立ちは小さく、問題となることはない。   In the above configuration, when the reagent bottle 20 in which the reagent 18 is stored is transported / placed to a predetermined position of the analyzer, the reagent 18 becomes longer than the length of the reagent bottle 20 due to the flow of the inertia force of the reagent inside the reagent bottle body. The undulating reagent is returned to the inside of the reagent bottle 20 by the lid-shaped members 26 having R-shaped tips provided at both ends in the longitudinal direction of the opening 22 of the reagent bottle 20. In addition, the wave of the short side direction of the opening part 22 is small, and does not become a problem.

又、先端がR形状の蓋状部材26は、下方に回動自在に支持されているために、図4に示す如く、ノズルチップ14を装着した複数の分注ノズル12が同時に試薬を吸引するために下降した際は、蓋状部材26がノズルチップ14に押されて下側の容器内側に回動する。又、分注ノズル12が上昇する際には、蓋状部材26の先端がR形状となっているため、分注ノズル12に装着されたノズルチップ14が上昇するのを妨げることがなく、復元ばね28の作用により元の位置に戻る。   Further, since the lid-shaped member 26 having an R-shaped tip is rotatably supported downward, as shown in FIG. 4, a plurality of dispensing nozzles 12 fitted with the nozzle tips 14 simultaneously aspirate the reagent. Therefore, when it is lowered, the lid-like member 26 is pushed by the nozzle tip 14 and rotates to the inside of the lower container. Further, when the dispensing nozzle 12 is raised, the end of the lid-like member 26 has an R shape, so that the nozzle tip 14 attached to the dispensing nozzle 12 is not hindered from being raised and restored. The spring 28 returns to the original position by the action.

本実施形態においては、蓋状部材26の内側先端を、分注ノズル12の挿入方向に曲げているので、試薬ボトル20内で波立った試薬18を再び下方に戻すことができると共に、分注ノズルの動作を円滑にして、分注ノズル12からノズルチップ14が外れないようにすることができる。   In the present embodiment, the inner tip of the lid-like member 26 is bent in the direction in which the dispensing nozzle 12 is inserted, so that the undulating reagent 18 in the reagent bottle 20 can be returned downward again and dispensed. The nozzle operation can be made smooth so that the nozzle tip 14 is not detached from the dispensing nozzle 12.

又、蓋状部材26を、下方に回動自在に支持しているので、ノズルチップ14を装着した複数の分注ノズル12が同時に試薬を吸引する際に、試薬ボトル20で分注ノズル12の上下動作を妨げることはない。従って、分注ノズル12を試薬ボトル20の側壁にぎりぎりまで近付けて配置することができ、分注ノズル12との干渉を避けるために、必要以上に試薬ボトル20を大きくする必要が無い。   In addition, since the lid-like member 26 is supported so as to be pivotable downward, when the plurality of dispensing nozzles 12 to which the nozzle chips 14 are attached simultaneously sucks the reagent, the reagent bottle 20 can be used to dispose the dispensing nozzle 12. It does not interfere with the vertical movement. Therefore, the dispensing nozzle 12 can be arranged as close as possible to the side wall of the reagent bottle 20, and it is not necessary to enlarge the reagent bottle 20 more than necessary in order to avoid interference with the dispensing nozzle 12.

なお、蓋状部材26の形状や動きは、本実施形態に限定されない。   The shape and movement of the lid-like member 26 are not limited to this embodiment.

前記説明においては、本発明が、分注装置の試薬ボトルに適用されていたが、本発明の適用対象は、これに限定されず、分注装置用の液体容器一般に同様に適用できることは明らかである。   In the above description, the present invention has been applied to the reagent bottle of the dispensing apparatus. However, the application target of the present invention is not limited to this, and it is obvious that the present invention can be applied to liquid containers for dispensing apparatuses in general. is there.

従来の分注装置の一例の要部構成を示す斜視図The perspective view which shows the principal part structure of an example of the conventional dispensing apparatus. 特開2005−17176号に記載された試薬ボトルを示す斜視図The perspective view which shows the reagent bottle described in Unexamined-Japanese-Patent No. 2005-17176 本発明の実施形態の構成を示す斜視図The perspective view which shows the structure of embodiment of this invention 同じく作用を説明するための、正面から見た断面図Similarly, a sectional view seen from the front to explain the action

符号の説明Explanation of symbols

10…分注ヘッド
12…分注ノズル
14…ノズルチップ
18…試薬
20…試薬ボトル
22…開口部
26…蓋状部材
28…復元ばね
DESCRIPTION OF SYMBOLS 10 ... Dispensing head 12 ... Dispensing nozzle 14 ... Nozzle tip 18 ... Reagent 20 ... Reagent bottle 22 ... Opening part 26 ... Lid-like member 28 ... Restoration spring

Claims (4)

上方の開口部から挿入される分注ノズルにより液体の吸引が行なわれる分注装置用液体容器において、
前記開口部の長手方向両端に、前記分注ノズルの挿入を妨害しない蓋状部材を設けたことを特徴とする分注装置用液体容器。
In a liquid container for a dispensing device in which liquid is sucked by a dispensing nozzle inserted from an upper opening,
A liquid container for a dispensing apparatus, wherein lid-like members that do not obstruct the insertion of the dispensing nozzle are provided at both ends in the longitudinal direction of the opening.
前記蓋状部材の内側先端が、前記分注ノズルの挿入方向に曲げられていることを特徴とする請求項1に記載の分注装置用液体容器。   The liquid container for a dispensing device according to claim 1, wherein an inner front end of the lid-like member is bent in the insertion direction of the dispensing nozzle. 前記蓋状部材が、下方にのみ回動自在とされていることを特徴とする請求項1又は2に記載の分注装置用液体容器。   The liquid container for a dispensing device according to claim 1 or 2, wherein the lid-like member is rotatable only downward. 請求項1乃至3のいずれかに記載された分注装置用液体容器を備えたことを特徴とする分注装置。   A dispensing apparatus comprising the liquid container for a dispensing apparatus according to any one of claims 1 to 3.
JP2005198115A 2005-07-06 2005-07-06 Liquid container for dispenser, and dispenser Pending JP2007017242A (en)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104769439A (en) * 2012-10-30 2015-07-08 株式会社日立高新技术 Reagent container and automated analyzer

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104769439A (en) * 2012-10-30 2015-07-08 株式会社日立高新技术 Reagent container and automated analyzer

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