JP2007008823A - Therapeutic agent for athlete's foot - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a safe therapeutic agent for athlete's foot (tricophytia pompholyciformis) completely curing the athlete's foot without adverse effects. <P>SOLUTION: The therapeutic agent for the athlete's foot (tricophytia pompholyciformis) is prepared by dipping bark of Aralia elata in ethanol for sterilization and eluting a crude drug active ingredient contained in the bark of the Aralia elata into the ethanol. The crude drug active ingredient contained in the bark of the Aralia elata and the ethanol having disinfecting sterilization actions are utilized. <P>COPYRIGHT: (C)2007,JPO&INPIT

Description

  The present invention relates to a therapeutic agent for athlete's foot (sweaty ringworm) which is a kind of skin disease.

Conventionally, imidazole antifungal agents such as clotrimazole, bifonazole, miconazole nitrate, econazole nitrate, neticonazole hydrochloride, ranoconazole, ketoconazole, sulconazole nitrate, and croconazole hydrochloride have been widely used as topical drugs for treating athlete's foot. In addition, many types of athlete's foot treatments that contain amorolfine hydrochloride, terbinafine hydrochloride, butenafine hydrochloride, tolnaphthalate, pyrrolnitrin, etc. as the main components are commercially available. For internal use, there are oral antifungal agents such as griseofulvin, itrisol, and lamiseal. In addition, there are other traditional drugs that are transmitted to the private sector.
When treating athlete's foot, always keep your hands and feet clean and avoid high temperatures and humidity. At the same time, it has been said that the above-mentioned topical athlete's foot medicine should be applied to the affected area. However, even though it seems that the symptoms of athlete's foot have improved in 2 to 3 weeks depending on the drug, the ringworm that lurks in the back of the skin (the stratum corneum) is not completely dead but is often alive. There was. In winter, athlete's foot ceases to be active, and during this time the athlete's foot symptom subsides, so it is not uncommon for people to think that it may have been fixed and stop treatment. And when it was hot and humid in summer, it recurred. In addition, it is said that the thick part of the stratum corneum such as the sole of the foot will not be cured unless it is treated for half a year to more than one year, and in some cases for several years. It would be humanity to lose shape and make the nails thicker and more brittle, and the nail color would turn from white to yellow and look bad and fast. However, nail athlete's foot is stubborn and difficult to repair, and external medicine alone cannot be expected to be as effective as treatment, and treatment methods that use internal medicine are also being used.

As described above, athlete's foot is considered to be a kind of skin disease that is difficult to completely cure, and although various drugs have been developed one after another as being effective to date, it takes a long time to cure athlete's foot. However, even when treating athlete's foot with a combination of external and internal medicines, side effects include rash caused by external medicines and gastrointestinal symptoms such as stomach discomfort, diarrhea, nausea and abdominal pain. However, adverse effects such as anemia on liver function or anemia have been reported. Moreover, even if the treatment is completed based on its own judgment because it has been completely cured, it often happens again in a hot and humid environment at a later date. At present, there are an overwhelming number of people who give up.
In Japan, according to a nationwide epidemiological survey of 22,000 people from 1999 to 2000, 1 out of 5 people had athlete's foot, and 45% of them found nail athlete's foot. It is estimated that there are over 11 million cases of nail fungus. How many people are suffering from athlete's foot.
“Inventing athlete's foot medicine deserves the Nobel Prize,” he said for a while. As the word suggests, to date there are no effective treatments for athlete's foot, but no safe drugs with no side effects to cure athlete's foot.

On the other hand, ethanol is the name of the international chemical nomenclature, and it is called alcohol, ethyl alcohol, and spirit, but they are the same although they are called differently. Because it is the same as the ingredients of sake, it is safe to enter the mouth, is colorless and transparent, has a fragrance, is a volatile liquid, and has the same drunkness as alcohol. Although it burns well, it is a flame that does not look pale. Does not give off foul odors It has a sterilizing and disinfecting effect and is also effective for mold prevention. Dissolve oil well and mix well with water to extract color and aroma. In addition, it does not freeze unless it becomes minus 114 degrees or less.
There are two types of alcohol: fermented alcohol made from sugar and starch, and synthetic alcohol made from ethylene obtained from petroleum. Alcohol has the above-mentioned characteristics, but it is said that the alcohol concentration around 70v / v% is most suitable for disinfection and sterilization. Japan's 9th edition "Alcohol Handbook", supervised by the Ministry of International Trade and Industry, Basic Industry Bureau, Alcohol Division (currently reorganized into the Ministry of Economy, Trade and Industry), edited by the Japan Alcohol Association and the Bioindustry Association, Details on pages 10 and 11}. The ratio of alcohol to water is good, the speed of soaking and the time to evaporate are moderate, so the bactericidal effect is the highest.
Pharmacopoeia alcohol is alcohol that has passed the standards established by the government, and is divided into the following three types according to the concentration of alcohol. Absolute ethanol (99v / v%), ethanol (95v / v%), disinfectant ethanol (about 80v / v%). These are mainly used in hospitals as medicines for the prevention and treatment of diseases. Pharmacopoeia alcohol is made from fermented alcohol and is safe.

  The problem to be solved is that athlete's foot drugs are difficult to cure even though they are effective despite the fact that there are many other athlete's foot drugs, including external and internal medicines. One out of every five people in Japan is athlete's foot, and the number of athlete ’s athletes continues to increase in the world without decreasing. Next, side effects such as rashes should occur with topical drugs and folklore drugs. Next, for internal medicines, various symptoms such as neurological symptoms such as sleepiness and head pain after taking, photosensitivity, acute heart failure, mucocutaneous syndrome, gastrointestinal disorders and liver dysfunction, The occurrence of various side effects such as disability when taking drugs that are not well matched requires blood tests from time to time to check for side effects, and the cost of the drugs is high, which increases treatment costs. There were the above problems. Therefore, the present invention as a therapeutic agent (external preparation) that safely cures athlete's foot without any side effects was made to solve these problems.

  It is an athlete's foot remedy created by soaking the bark of the cod in ethanol for disinfection and eluting the herbal active ingredient contained in the bark of the cod into the ethanol. It is a therapeutic agent for athlete's foot (sweaty ringworm), characterized by using ethanol having a disinfectant and bactericidal action.

  The present invention has heretofore been used as a folklore medicine because the bark of a cod tree (mainly the root bark) is effective for diabetes, kidney disease, and gastrointestinal disease, but is included in the bark of the cod tree. It was invented as a complete remedy for athlete's foot by combining a crude drug active ingredient and alcohol. Both the bark of the cod and the alcohol are harmless to the human body, and there is no fear of side effects. It is a safe treatment for athlete's foot.

First I will explain the bark. As the stems of trees grow thicker, the original epidermal cells cannot keep up with their growth and eventually die. However, a stiffer structure will be formed outside the stem to protect the stem. There is a hard layer called “cork layer” on the outermost surface of the tree, and this layer is formed by the action of a cell layer called “cork-forming layer” differentiated from the cell layer inside the epidermis and the epidermal cells themselves. The cork-forming layer divides cells to create a cork layer on the outside and a “cork skin layer” on the inside. These tissues are collectively called the pericardium. In other words, what is commonly called bark is that it can be subdivided into three parts as described above. Next, I will explain how to make the athlete's foot treatment. First, the cork layer of the surface layer of the bark of the cod tree is removed with a knife or the like, and then the cork forming layer and the cork skin layer are simultaneously scraped off from the stem of the cod with a knife or the like. When the cork layer is first scraped off, some cork-forming layers and cork skin layers may be scraped off depending on the shape of the cod tree. Here, this portion is temporarily called a cork layer portion. The bark of the cod tree mainly used in the present invention uses the cork forming layer and the bark portion of the cork skin layer that have been scraped off the second time as described above. For ethanol, use ethanol for disinfection of pharmacopoeia alcohol.
Prepare a container that is less likely to chemically react with ethanol, such as plastic bottles, and other containers that are less likely to chemically react with ethanol, such as plastic bottles, put ethanol for disinfection in it, and then follow the procedure described in 2 above. Put the bark part of the cork-forming layer and cork skin layer of the cod that was shaved off in the second round, and immerse in ethanol. The ratio of the cork-forming layer of the bark of the cod and the bark portion of the cork layer is soaked in 1 liter of disinfecting ethanol and stored in a cool and dark place for about 3 months. The athlete's foot treatment is completed.
In addition, if the bark is a part of the bark that is temporarily called the cork layer, the amount used is about three times. In other words, an athlete's foot remedy having the same effect can be obtained by soaking about 60 grams in 1 liter of disinfecting ethanol.
If it carries out as mentioned above, the crude drug active ingredient contained in the bark of a cod tree will elute, it will fuse | melt with ethanol and the athlete's foot therapeutic agent which is this invention will be completed. The main feature of the present invention is that it uses a crude drug active ingredient of bark of cod and uses it together with ethanol for disinfection.

Claims (1)

An athlete's foot remedy created by soaking the bark of the cod in ethanol and eluting the active ingredient in the bark of the cod into the ethanol. Utilizes the herbal active ingredient and ethanol contained in the bark of the cod. A therapeutic agent for athlete's foot (sweaty tinea).