JP5010125B2 - Film preparation for athlete's foot treatment - Google Patents

Description

  The present invention relates to a film preparation for the purpose of prevention and treatment of athlete's foot.

Athlete's foot is a skin disease caused by a kind of mold called ringworm fungus (dermatophyte).
The ringworm bacteria grow in a parasitic manner on the outermost stratum corneum of the skin. There are two conditions for the growth of ringworms: rich food and high temperature and humidity.
The first thing that feeds the ringworm is the keratin that falls in the form of dirt, and the stratum corneum is thickest in the hands and feet. Hands are often washed and dry, so it is unlikely to cause ringworm bacteria, but feet are likely to have ringworm bacteria.
The second high temperature and high humidity activates ringworm, a kind of mold. In general, it is said that activation occurs when the temperature is 15 ° C. or higher and the humidity is 70% or higher. Therefore, ringworms grow from spring to summer when sweating and the inside of shoes is hot. On the other hand, in winter when it is dry at low temperature, ringworm bacteria are hard to increase and become dormant.

Slippers and bath mats can be considered as infection routes of ringworms in the home. If a piece of skin falls on the slippers or bath mat used by athlete's foot patients, the ringworm that survives in the piece will stick to other people's feet and immediately wear socks or wear shoes. As a result, ringworm bacteria adhere to wet skin for a long time, and ringworm bacteria enter the skin and become infected.
Types of athlete's foot include ringworm on the foot and body ringworm, hip ringworm, head ringworm, hand ringworm, and onychomycosis depending on the infected site.
There are three types of tinea pedis: (1) In the intercostal type, the skin between fingers becomes white, it is reddish, the skin is exposed, and it is often wrinkled, and other bacteria are also easily attached. (2) Small water bubbles form small water bubbles on the soles of the feet and the base of the fingers that tear and turn red and become itchy. (3) The stratum corneum growth type is a state in which ringworm bacteria grow on the entire sole, the stratum corneum becomes thick, and the skin is peeled off like powder. In addition to foot ringworm, ringworm bacteria have entered the toenail (4) nail ringworm.

Although athlete's foot is treated with drugs, topical drugs and internal medicines are used properly depending on the symptoms.
In the case of intercostal type and small water bubble type, it is important to apply an external medicine that suppresses the growth of ringworm bacteria, but to keep applying the medicine for at least one month or more in order to prevent recurrence (for example, Patent Document 1) .
For keratoproliferative type and onychomycosis, an internal medicine is used because the active ingredient of the external medicine does not reach the inside of the skin or the inside of the nail. Oral medications generally need to be taken for half a year.
Athlete's foot is caused by the fungus Ringworm. It is important for the prevention of athlete's foot not to prepare conditions for mold infection and growth, but by sharing wet bath mats and slippers, etc., from one athlete's foot patient, at home or in the same workplace, a common bath user, etc. There are very many cases that are infected with ringworm. Therefore, to treat a single athlete's foot patient, it is necessary to ask for the cooperation of the whole family, the workplace, and all the bath users. Is very tough.
JP-A-9-124461

For the treatment of athlete's foot, a topical drug that suppresses the growth of ringworm is used, but the penetration of the drug into the skin is poor, and physically a large amount of drug is applied every day for a long time (about 1 month or more) by massage etc. There is a need.
The topical medicine is applied on the skin, and for Japanese people who have the habit of taking a bath, it is necessary to apply the medicine every day after bathing in order to replenish the topical medicine that has been washed away every day. Moreover, hot water in a bathtub or a bath is often contaminated with a chemical applied one day before bathing, and is generally disliked by family members, friends who dislike infection, and friends who use the same public bath.
In addition, by sharing the same bath mat and slippers at home or in the workplace, there is a very high risk of ringworm fungus from a single athlete's foot patient to a family member, a colleague at work, and people using the same public bath. Without their cooperation, it is extremely difficult to treat athlete's foot perfectly.

The athlete's foot can be classified into four types: (1) small blister type, (2) intercostal type, (3) stratum corneum type, and (4) nail ringworm.
For small water bubbles and intercostal types, external medicine is used as a general treatment, but for keratinous growth type and onychomycosis, even if external medicine is used, the medicine does not penetrate to the place where ringworm bacteria are present. Treatment with is required.
Antifungal drugs such as griseofulvin, terbinafine hydrochloride, and itraconazole are used for internal use, but the antifungal drugs are effective by damaging the cell membrane of fungi, but they also cause the same damage to human cells, so there are side effects. Easy to appear. For example, with griseofulvin, liver dysfunction, jaundice, dizziness, headache, fever, sleepiness, tinnitus, mental confusion, numbness and pain in the limbs, taste disorder, visual impairment, pigmentation, rash other than hypersensitivity, hives, men In the case of gynecomastia, terbinafine hydrochloride is anemia, vomiting, fatigue, rash, hives, itching, arthralgia, muscle pain, etc. Concomitant use with terfenadine, cisapride formulation for gastrointestinal digestion, triazolane formulation for sleep sedation, simvastatin formulation for lipid metabolism improver, cyclosporine formulation for immunosuppressant, digoxin formulation for cardiotonic agent, nifedipine formulation for calcium antagonist, pimozide formulation, etc. Then, there is a reality that side effects are likely to occur.

Therefore, the present inventor examined and analyzed in detail the characteristics of athlete's foot and the actual treatment method. As a result of detailed examination, it has become possible to establish a treatment method using a new preparation that is very different from the treatment method using conventional drugs.
In the conventional treatment method with athlete's foot treatment, the drug applied to the affected area is easily removed by contact with the floor or socks every time bathing or walking in daily life. Realized that there was even a risk of helping to infect ringworm bacteria to third parties.
In addition, conventional external preparations have poor drug penetration into the skin and require repeated application times of about one month or more. However, by applying the ODT (sealing) to the affected area, the applied drug can be applied to the skin. We thought that the patient's burden could be reduced by improving the permeability (percutaneous absorbability) of the drug and reducing the amount and the number of times the drug was applied, so that treatment could be performed more efficiently. Furthermore, it has been found that ODT (sealing) of the affected area can prevent infection by third party bacteria in addition to improving the therapeutic effect.
In addition, keratoproliferative type athlete's foot and onychomycosis, which had been required to be treated with oral antifungal agents, depend on oral treatment of drugs with large side effects by combining ODT therapy (sealing therapy) with keratolytic agents. It has been found that treatment with an external preparation with few side effects is possible.
The problem to be solved by the present invention is to provide an athlete's foot treatment preparation that allows the topical medicine to work more efficiently and have no side effects without infecting the third party with athlete's foot treatment. .

The inventor considered and discussed how to treat the athlete's foot without infecting third parties efficiently and without causing side effects.
And the ODT effect (sealing effect) by covering the affected area infected with athlete's foot with the waterproof sheet to block the outside, without infecting athlete's foot with a third party, and without having to rely on oral administration Has been successfully and safely absorbed through the skin. However, it has been very difficult to continuously fix the waterproof sheet to the affected part in daily life.
Therefore, the inventor thinks that this problem can be solved if a film can be formed to replace the waterproof sheet in the affected area, and nitrocellulose is selected for the purpose of film formation, and 3-methylbutyl acetate and ethyl alcohol are used. When dissolved in a mixed solution and applied to the skin, it can be confirmed that a transparent film is formed after the dissolution agent volatilizes at the body temperature as expected, and the inventor repeated research based on this fact. As a result, the present invention was completed.

The film preparation for athlete's foot treatment according to the present invention solves the above-mentioned problems and is as follows.
That is, in the invention of claim 1, nitrocellulose is dissolved in a dissolving agent of ethyl acetate, 3-methylbutyl acetate, isobutyl acetate, lactic acid ester, acetone, or a mixture of one or more of these, and the nitrocellulose. Dissolve topical medicine in this solubilizer and dissolve the topical medicine in this nitrocellulose solubilizer. Among the solubilizers are natural oils such as perilla oil, sesame oil, sesame oil, olive oil, horse oil, hinoki. oil, castor oil, or phthalic acid ester, is contained one or more aliphatic polybasic acid ester, to increase the sealing effect between strength and flexibility of the film during film formation, further, or ethyl alcohol, Isopuropa Bruno Lumpur, or by adding these mixtures, as the external medicine, a keratolytic agent to facilitate the therapeutic effect of the active drug to dissolve the horny Sari Le acid, urea, among benzoic acid, contain one or more, is for athlete's foot treatment film preparation and is characterized in that the formulation does not contain water.
The invention according to claim 2 is characterized in that the topical drug is an antifungal agent butenafine hydrochloride, terbinafine hydrochloride, neticonazole hydrochloride, amorolfine hydrochloride, econazole nitrate, stico To prevent and treat athlete's foot with one or more of pus extract, tolnaftate, pyrrolnitrin, clotrimazole, waxy plum oil, salicylic acid, benzoic acid, citric acid, acetic acid, wood vinegar, bamboo vinegar The film preparation for athlete's foot treatment according to claim 1.
The invention of claim 3 contains one or more of glycyrrhizic acid, sodium glycyrrhizinate, glycyrrhetinic acid, lidocaine, xylocaine, crotamiton, camphor, l-menthol, and mint oil as the external medicine, The film preparation for athlete's foot treatment according to claim 1, wherein itching is suppressed.
[Effect of the Invention]

In the film preparation for athlete's foot treatment according to the present invention, nitrocellulose is dissolved in a dissolving agent of ethyl acetate, 3-methylbutyl acetate, isobutyl acetate, lactate ester, acetone, or a mixture of one or more of these, A topical drug is dissolved in the nitrocellulose solubilizer, and a topical drug is dissolved in the nitrocellulose solubilizer. Among the solubilizers, there are natural oils such as perilla oil, sesame oil, sesame oil, olive oil, horses. oil, cypress oil, castor oil, or phthalic acid ester, is contained one or more aliphatic polybasic acid ester, further, ethyl alcohol, or isopropyl Roh Lumpur, or a in base with the addition of a mixture thereof Te since the formulation without water, with the sealing effect is enhanced as the strength and flexibility of the film during film formation, in addition to anti-fungal agents, skin Adds stimulants and antipruritics, and after application to the skin, the solvent evaporates, forming a transparent or translucent film on the skin to seal the affected area and prevent the spread of fungus from the affected area It is possible to prevent infection to others. Further, the transdermal absorbability of the antifungal agent is improved by the ODT effect (sealing effect), and the bactericidal effect against ringworm fungi is enhanced by the penetration of the drug into the fungal habitat layer below the skin stratum corneum. In addition, since the solubilizer (3-methylbutyl acetate, isobutyl acetate, acetone, ethyl alcohol) itself has a bactericidal action and an antifungal action, it is sterilized against superficial germs and fungi when applied to the affected skin. And exerts an antifungal action.

According to the present invention, nitrocellulose is dissolved in a solubilizer of ethyl acetate, 3-methylbutyl acetate, isobutyl acetate, lactate ester, acetone, or a mixture of one or more of these, and this nitrocellulose solubilizer Dissolve the topical medicine in the nitrocellulose solubilizer, and the solubilizer contains natural oils such as perilla oil, sesame oil, sesame oil, olive oil, horse oil, hinoki oil, castor oil or, phthalic acid esters, to contain one or more aliphatic polybasic acid ester, further, ethyl alcohol, or Isopuropa Roh Lumpur, or by addition of these mixtures, since the formulation without water , to increase the sealing effect between strength and flexibility of the film during film formation consisting mainly of nitrocellulose, adding antimycotic skin irritants and antipruritic After applying to the skin, the solvent is volatilized and a transparent or translucent film is formed on the skin to seal the affected area and prevent the spread of ringworm fungus from the affected area. To prevent infection to others. Further, the ODT effect (sealing effect) improves the transdermal absorbability of the antifungal agent, and a high bactericidal effect can be expected by sufficiently delivering the antifungal agent to the ringworm fungus layer below the stratum corneum.
In addition, since the dissolving agent itself exerts antifungal and bactericidal effects at the time of drug application, it exerts a bactericidal effect against superficial fungi and bacteria and promotes a therapeutic effect.
Furthermore, by coating the drug applied to the affected area with a film, the drug can be prevented from flowing out by bathing or showering, and the effect can be expected to last. Furthermore, the preparation after film formation flows out with water or warm water. Because there is very little, we do not pollute water of bathtub.

Next, examples of suitable film preparations for treating athlete's foot of the present invention will be described.
Table 1 shows the composition ratio of the film preparation for athlete's foot treatment of the first example [Table 1].
[Composition ratio of Example 1]
Nitrocellulose ... 5.0%
Ethyl alcohol ... 63.0%
3-methylbutyl acetate: 10.0%
Acetone: 5.0%
Salicylic acid: 5.0%
Benzoic acid 10.0%
l-menthol ・ ・ ・ 1.0%
Castor oil ... 1.0%
Total 100.0%

[Preparation Method of Example 1]
The film preparation for athlete's foot treatment of Example 1 is prepared by the following means so as to achieve the above composition ratio. In addition, the sum total of the weight% of the composition of the above-mentioned Example 1 is 100%, and the pharmaceutical formulation does not substantially contain water.
First, after dissolving nitrocellulose in 3-methylbutyl acetate, acetone is further added and stirred well. Next, ethyl alcohol is added to the solution and stirred well. Then, salicylic acid, benzoic acid, l-menthol, and castor oil are added in small portions while sequentially stirring, and the mixture is allowed to stand at room temperature for 24 hours for production.
Here, in order to form a transparent or translucent film on the skin after application to the skin, the nitrocellulose is 3 to 20%, preferably 5 to 12%. If it is too small, film formation with nitrocellulose is difficult, and if it is too much, nitrocellulose, 3-methylbutyl acetate, acetone, etc., which are solvents, will increase, and these solvents may cause, for example, rough skin, itching and eczema. The% of nitrocellulose cannot be too high as it will have an adverse effect on the skin. Further, as a solvent, ethyl alcohol is 50 to 70%, preferably 60 to 65%, 3-methylbutyl acetate is 8 to 12%, preferably 9 to 11%, and acetone is about 3 to 10%, preferably about 4 to 6%. However, if the blending ratio is too small or too large, it becomes difficult to form a film with nitrocellulose, and if it is too large, the skin is adversely affected.

Next, Table 3 shows the composition ratio of the film preparation for athlete's foot treatment of the second example [Table 2].
[Composition ratio of Example 2]
Nitrocellulose ... 10.0%
Isopropyl alcohol ... 73.0%
Isobutyl acetate: 5.0%
Lactic acid ester: 5.0%
Tolnaftate ... 2.0%
Glycyrrhizic acid 1.0%
Salicylic acid 2.0%
Perilla oil ... 2.0%
Total 100.0%

[Preparation Method of Example 2]
The film preparation for athlete's foot treatment of Example 2 is prepared by the following means so that the composition ratio is as described above. In addition, the sum total of the weight% of the composition of the above-mentioned Example 2 is 100%, and the pharmaceutical formulation does not substantially contain water.
First, after dissolving nitrocellulose in isobutyl acetate, a lactic acid ester is further added and stirred well. Next, after adding isopropyl alcohol to this solution and stirring well, tolnaftate, glycyrrhizic acid, salicylic acid, and perilla oil are added in small portions under stirring, and the mixture is allowed to stand at room temperature for 24 hours for production.
Here, the nitrocellulose is 3 to 20%, preferably 5 to 12% to form a transparent or translucent film on the skin after the dissolution agent is volatilized after being applied to the skin. If too little cellulose is formed, it is difficult to form a film with nitrocellulose. If too much cellulose is added, the amount of solvents such as isopropyl alcohol, isobutyl acetate, and lactic acid ester increases, and these solvents adversely affect the skin. % Cannot be too much.
Further, as a solvent, isopropyl alcohol is 50 to 80%, preferably 65 to 75%, isobutyl acetate is 3 to 15%, preferably 3 to 15%, preferably 4 to 10%, and lactic acid ester is 3 to 10%. However, it is preferably about 4 to 8%. However, if the blending ratio is too small, it becomes difficult to form a film with nitrocellulose, and if it is too large, the skin is adversely affected.

In order to verify Example 1 and Example 2 of the present invention, the difference in action and effect from the conventional ones by the [wivesworm affected area wiping culture test] and [athlete's foot treatment test], the following comparative examples 1 to 5 are prepared. did.
(1) Reference Example 1: Film-forming preparation in which the film forming components of Example 1, nitrocellulose, ethyl alcohol, 3-methylbutyl acetate, and acetone were mixed at the same blending ratio as in Example 1, 5.0: 63: 10: 5 (2) Comparative Example 1: No treatment (control)
(3) Comparative Example 2: Commercial athlete ’s athlete's foot ointment containing salicylic acid and benzoic acid-containing athlete's foot preparations manufactured by company E (the medicinal components for athlete ’s foot are the same as in [Example 1]. Prepared to verify the covering action).
(4) Comparative Example 3: A preparation containing only the active ingredient of Example 2, that is, a formulation containing no nitrocellulose as a film-forming component and a solvent, and the same mixing ratio as in [Example 2] tolnaftate, glycyrrhizic acid, salicylic acid (5) Comparative Example 4: Commercially available athlete's foot ointment, manufactured by Y Company, containing active ingredients tolnaftate, glycyrrhizic acid, salicylic acid (medicinal effect against athlete's foot) Ingredients are the same as in [Example 2]).
In addition, the comparative example 3 and the comparative example 4 were prepared in order to verify the athlete's foot therapeutic action of Examples 1 and 2, especially Example 2.

[Wildworm wiping culture test]
Next, the action and effect of the film preparation for treating athlete's foot of Example 1 manufactured by the above-described composition and preparation method and the commercial preparations of Reference Example 1, Comparative Example 1, and Comparative Example 2 are as follows. Comparison was verified by wiping culture test for affected athlete's foot.
(1) Subject As the subject, the above Example 1, Reference Example 1, Comparative Example 1, and Comparative Example 2 were prepared.
(2) Subjects: 5 adult volunteers suffering from athlete's foot (men 35 to 57 years old, No 1 to 5)
(3) Test method: Before the start of the test, the right upper sole of the subject affected with ringworm fungus was wiped into a circular shape with a diameter of about 2 cm using absorbent cotton impregnated with purified water and cultured on a medium placed in a petri dish. This was designated as Comparative Example 1 (no treatment) as a control.
Next, the preparation of Comparative Example 2 was uniformly applied to the lower right foot sole affected by ringworm of the subject, and after 6 hours, wiped into a circular shape having a diameter of about 2 cm using absorbent cotton impregnated with purified water. The medium was cultured on the medium contained in the medium.
Furthermore, the preparation of Reference Example 1 was uniformly applied to the upper part of the left foot sole affected by ringworm of the subject, and similarly, wiped into a circular shape with a diameter of about 2 cm using absorbent cotton impregnated with purified water after 6 hours. The cells were cultured on a medium placed in a petri dish.
At the same time, the preparation of Example 1 was applied to the lower left sole affected by ringworm and treated in the same manner as described above after 6 hours.
In this case, the external state (after 6 hours) applied to the skin could be confirmed to have formed a translucent film by evaporating the dissolving agent at body temperature.

The medium used for the test was a Sabouraud glucose agar medium (SDA medium), and the culture was performed in an incubator at 25 ° C. for 10 days.
Each specimen was observed and judged based on the following judgment conditions after culturing for 10 days.
Judgment conditions: (1) The whole petri dish is covered with colonization of ringworm fungus .... ++++ (4 points)
(2) More than half of the petri dish is covered with colonization of ringworm fungus ... ++ (3 points)
(3) 10-50% of the petri dish covered with colonies of ringworm fungus ... + (2 points)
(4) Less than 10% of the petri dish is covered with colonies of ringworm bacteria ... ± (1 point)
(5) No ringworm colonies can be confirmed in the petri dish ...-(0 points)

(4) Test results The test results are shown in the following [Table 3].
[Table 3]

It can be seen from the above [Table 2] that in Comparative Example 1 as the untreated group (control), colonies of ringworms were confirmed on the entire petri dish in the collected samples of all five subjects, and the average value of the evaluation scores was It shows a very high result of 3.6.
In addition, the preparation of Comparative Example 2 shows a difference in the degree of colony of ± to ++, and about 50% of the inhibition is recognized as compared with Comparative Example 1 (no treatment). The evaluation score was 1.8 points.
On the other hand, in the preparations of Example 1 and Reference Example 1, no colony of ringworms was found on the petri dish, and thus the average score was 0. This is because both the preparations of Example 1 and the reference example have ODT effect (sealing effect) covering the affected area affected by ringworm as compared with Comparative Example 1 and Comparative Example 2 due to film formation. It is presumed to prevent withdrawal and spread of ringworm bacteria from the affected area.

[Squamworm treatment test]
Next, as test specimens, the film preparations for athlete's foot treatment of Examples 1 and 2 manufactured by the above-described composition and preparation method, no treatment of Comparative Example 1, and Comparative Example 3 (film formation of [Example 2]) Ingredients) and Comparative Example 4 (commercially available preparation with no film-forming component equivalent to [Example 2]) were compared and verified under the following conditions.
(1) Example 1, Example 2, Comparative Example 1, Comparative Example 3, and Comparative Example 4 were prepared as specimens.
(2) Subjects: 15 adult male volunteers suffering from athlete's foot (40 to 57 years old)
(3) Test method: 3 people per group, and before the start of the test, the right foot bottom part of each group of test subjects affected by ringworm bacteria was wiped into a 2 cm diameter circle using absorbent cotton impregnated with purified water and placed in a petri dish. Cultivation was carried out on a medium, and this was used as an evaluation judgment of the intensity of ringworm fungus before the start of the test.
Next, each subject was uniformly applied 30 minutes after bathing on the entire right foot site, which was the affected part of athlete's foot. This application action was carried out for 35 days. Using absorbent cotton in which the affected area (right sole) was impregnated with purified water 30 minutes before each drug application 30 minutes after bathing on the 7th, 14th, 21st, 28th and 35th days during this period It was wiped off in a circle with a diameter of 2 cm and cultured in a medium on a petri dish.
The medium used for the test was a Sabouraud glucose agar medium (SDA medium), and the culture was performed in an incubator at 25 ° C. for 10 days.
Each cultured specimen was observed and determined based on the following criteria.
Judgment criteria: (1) The petri dish is entirely covered with colonization of ringworm fungus .... ++ (4 points)
(2) More than half of the petri dish is covered with colonies of ringworm fungus .... ++ (3 points)
(3) 10-50% of petri dish is covered with colonization of ringworm fungus ... + (2 points)
(4) Less than 10% of the petri dish is covered with colonies of ringworm fungus ... ± (1 point)
(5) There is no colonization of ringworm fungus in the petri dish ...-(0 points)

(4) Test results The test results are shown in the following [Table 4].
[Table 4]

It can be seen from the above [Table 4] that Comparative Example 1 as an untreated group (control) shows that the trichophytic fungi are also collected on the 35th day after the start of the test from the collected samples of all three subjects. A colony was observed in a state of covering the entire surface of the petri dish, and the average value of the evaluation score was 4.0, which was a very high value.
In Comparative Example 3 in which the film-forming component was removed from Example 2, an inhibitory effect against ringworm was observed over time, and the evaluation average score was 2.3 on the 28th day after the start of the test and 1. on the 35th day. 7 was recorded, but the bacteria could not be completely suppressed. As in Comparative Example 3, Comparative Example 4 which is a commercially available drug also showed a tendency to suppress ringworms over time, and the evaluation average score was 2.0 on the 35th day of the final test day.
On the other hand, Example 1 and Example 2 suppressed ringworm fungus daily, similar to Comparative Examples 3 and 4, but far exceeded the former two in their suppression strength and speed. On the 28th day from the start of the test, the evaluation average score was 0.3, and on the final 35th day, the ringworm was completely suppressed, and the evaluation average score after 35 days was 0.0.
From the above results, the embodiment of the film preparation for athlete's foot according to the present invention prevents the active ingredient from falling off or disappearing (due to physical irritation due to skin contact with socks, slippers, etc.) by forming it on the affected area to which the film is applied. As a result of the ODT effect (sealing effect) of the affected area, the percutaneous absorbability of the active ingredient was remarkably improved, and as a result, more active ingredient was supplied to the stratum corneum where the ringworm bacteria inhabit faster. It was thought that the highly effective and high bactericidal effect was obtained.

From the results of the above experiments, examples of the preparation for athlete's foot film treatment according to the present invention include nitrocellulose, 3-methylbutyl acetate, ethyl acetate, isobutyl acetate, lactate ester, acetone, and / or a mixture thereof. Since it is dissolved in a solubilizing agent and further added with an external preparation for athlete's foot to a base added with ethyl alcohol, the solvent evaporates after application to the skin, forming a transparent or translucent film on the skin By doing so, it is possible to seal the affected area and prevent the infection from occurring by preventing the spread of the fungus from the affected area. Furthermore, the ODT effect (sealing effect) has improved the percutaneous absorption of antifungal drugs, and it has been demonstrated that the bactericidal effect against ringworm fungi is enhanced by the penetration of the drug into the fungal layer below the stratum corneum. .
In addition, since the dissolving agent (3-methylbutyl acetate, ethyl acetate, isobutyl acetate, lactate ester, acetone, ethyl alcohol) itself has a bactericidal action and an antifungal action, it is a superficial germ at the stage of application to the affected skin. It has also been found to exert bactericidal and antifungal effects against fungi.

  Of course, the present invention is not limited to the above-described examples as long as the characteristics of the present invention are not impaired. For example, in this example, salicylic acid and benzoic acid were used as external preparations for antifungal drugs. In addition, butenafine hydrochloride, terbinafine hydrochloride, neticonazole hydrochloride, amorolfine hydrochloride, econazole nitrate, stipops extract, tolnaftate, pyrrolnitrin, clotrimazole, bran oil, citric acid, acetic acid, wood vinegar, bamboo vinegar One or more of these may be combined as appropriate. Similarly, in this example, salicylic acid and benzoic acid were used as the keratolytic agent that dissolves the keratin and promotes the therapeutic effect of the active drug, but urea may be used in addition to this, and one or more of these may be used. May be combined as appropriate. Similarly, in this example, l-menthol was used as an external medicine for suppressing itching of the affected area, but besides this, glycyrrhizic acid, sodium glycyrrhizinate, glycyrrhetinic acid, lidocaine, xylocaine, crotamiton, camphor, mint oil Or one or more of these may be combined as appropriate. Similarly, in this example, castor oil was used as the solubilizer in order to enhance the strength / flexibility of the film during film formation and the sealing effect, but perilla oil, sesame oil, egoma oil, olive oil, horse Oil, hinoki oil, phthalic acid ester, aliphatic polybasic acid ester, or a combination of these may be used.

Claims (3)

Dissolve nitrocellulose in a solubilizer of ethyl acetate, 3-methylbutyl acetate, isobutyl acetate, lactate ester, acetone, or a mixture of one or more of these, and dissolve the external medicine in this nitrocellulose solubilizer. The solubilizer contains at least one kind of natural oils such as perilla oil, sesame oil, sesame oil, olive oil, horse oil, hinoki oil, castor oil, or phthalic acid ester or aliphatic polybasic acid ester. , to increase the sealing effect between strength and flexibility of the film during film formation, further, ethyl alcohol, or by adding Isopuropa Bruno Lumpur, or mixtures thereof, as the external medicine, the active drug is dissolved horny salicylic acid is a keratolytic agent to facilitate the therapeutic effect, urea, among benzoic acid, this which contain one or more, was and the formulation without water For athlete's foot treatment film preparation according to claim.   Furthermore, as the above-mentioned topical medicine, antifungal drugs butenafine hydrochloride, terbinafine hydrochloride, neticonazole hydrochloride, amorolfine hydrochloride, econazole nitrate, stipops extract, tolnaftate, which have antibacterial or antibacterial activity against ringworm fungus that is the cause of athlete's foot, Claims characterized by containing at least one of pyrrolnitrin, clotrimazole, waxy plum oil, salicylic acid, benzoic acid, citric acid, acetic acid, wood vinegar and bamboo vinegar to prevent and treat athlete's foot. Item 2. The film preparation for athlete's foot treatment according to Item 1.   Furthermore, as said external medicine, it contains one or more of glycyrrhizic acid, sodium glycyrrhizinate, glycyrrhetinic acid, lidocaine, xylocaine, crotamiton, camphor, l-menthol, mint oil, and suppresses itching in the affected area The film preparation for athlete's foot treatment according to claim 1.