1284523 九、發明說明： 【發明所屬之技術領域】 括.一 f兼具麻醉止痛功能的酒精消毒棉球(片)妒置，包 括.基材、赫劍、麻醉劑及促進吸 …衣置包 於皮膚上擦拭後，除有滅_毒魏外，内含魏:進=料以此棉球 痛藥物進人皮膚勒_局魏 啦快速使麻醉止 痛，甚至無疼痛的感覺。&後之打針或抽血等均可減少疼 每個人或多或少都會有打針或被抽血的經驗，如 :打預防針和長大後須作檢驗或健檢時從二= 件不快樂的事，甚至視之為忽多=、孩而言，打針是 子的專利夕士 乂⑶^ 元爾的疋’害怕打針不僅屬於小孩 我們，打針時合產X广部步的事。然而原因為何？打針的經驗告訴 適。對於長期須打針或抽血的病*而+届帶來的不 全身麻醉或施予鐘定劑反辦加直皮杨的患者’常需局部或 針對情形有所改善。θ、危險性。有猎於此，本發明應運而生，盼 $果傳酒精消毒棉球之作用僅為滅菌消毒功能，並無麻醉止痛的 =多卡因⑽。論e HydrcehMe)，是藉降低細胞1284523 IX. Description of the invention: [Technical field to which the invention pertains] An alcohol-sterilized cotton ball (tablet) that has both anesthesia and analgesic functions, including a substrate, a Hercules, an anesthetic, and a promotion After wiping on the skin, in addition to the destruction of _ poison Wei, containing Wei: Jin = feed this cotton ball pain drug into the skin _ _ Wei Wei quickly make anesthesia pain, and even no pain. & after injection or blood draw can reduce the pain of everyone more or less will have an injection or blood draw experience, such as: vaccination and growing up after the test or health check from the two = unhappy The matter, even as it is too much =, child, the injection is the patent of the child Xi Shi (3) ^ Yuan Er's 疋 ' afraid of injections not only belong to the children, we have the X-step step when the injection. But what are the reasons? The experience of injections is appropriate. For patients who have long-term need for injections or blood draws, and those who do not have general anesthesia or who are given a fixative to add scalp, they often need to be improved locally or in response to the situation. θ, danger. In view of this, the present invention came into being, and it is hoped that the effect of the alcohol-suppressing cotton ball is only a sterilization function, and there is no anesthesia and pain relief = docaine (10). On e HydrcehMe), it is to lower the cells
Si^^^低3Μ—)上升_率而抑制感覺神經衝 士 、專¥。麻醉作用的進行與神經纖維的直徑、有無髓鞘及傳導速 ς關神經功能喪失的順序是：痛覺、溫覺、觸覺、自體感覺及骨絡肌 張力·。局部麻醉劑又可分純類和醯麵··前者如古柯驗 (cocaine )和 =〇came ’匕們在肝和血液内很快被水解而失去活性；後者如 1 〇C_e(Xyl〇cain# ，較不純 口处㈤此外局σ卩麻醉劑屬於驗性胺類。Berxzocaine不溶於水，因此 局P使用本务明内含之麻醉劑，如EMLA(Eutectic Mixture of Local 1284523 ^nesttocs) ’它是一種在歐美行之近十年的白色乳狀藥膏。其為兩種常用 胺基型局部麻醉劑利多卡因(Udocaine Μ%)及普羅卡因(pril〇caine 2辦)的 混合物’懸浮在水中組成。由於其為包含兩種藥物的混合物，產生丘溶的 型態，使得魅降低並於室溫下呈錢油狀。進而和水形成乳化並力认氯 虱化納調整水溶液的酸鹼值為弱驗性，之後加入賦型劑使 钱纽穿透皮絲少f _毅下列兩猶件··—絲^含水 —為其以驗基(㈣即不帶電的狀態存在。而此優勢是目前臨床使 用的局補醉所沒有的。此外由目前臨床實驗顯示，隱八安全性很高， t^d〇eaine或MGeaine的濃度皆相#低，塗抹處皮膚若呈現紅斑、泛 點水Μ，這些反應皆是短暫且無害，並不具臨床重要性。 部麻醉藥物使祕皮壯後，通f伽之後需至少—小時以上 棉候時的耗損。本發明之酒精消毒 率及日Hi二Ϊ進吸收之吸收促進劑’可大大地縮短等候時間，增加效 用者於擦拭之後約五分鐘即可有效地產生皮膚的麻醉效 此外本·^二打針或抽血’可有效的止痛且完全避免其所帶來的不適。 皮或淺層的^1_於—般的抽血及打針外，亦可提供不_域的表 手術、植皮:術仃紋為外傷之消毒止痛功用、脊髓液抽取、表皮 耳洞等之消毒止痛帛的去除、皮膚組織切片、疲、或疲的切除及穿 止痛用。故本發明具有產業上之利用性。 【先前技術】 毒功能外並帛球之作用為：將棉球於皮膚上擦拭後，具滅菌消 下進行程中保持無菌無污染的狀態 容器也需每週定_主flf ’或以無菌容器承裝使用。且裝棉球的 酒精消毒棉球^精放置在水中將水煮沸15至20分鐘。 因在其中殺菌作用並_著二有制。其須在酒精濃度6G%，％ ’ 菌細胞，而若”、者別仁右超過時，由於高濃度酒精難滲入細 過鱗’不能殺死—部份_，兩者皆殺菌能力過低故不能 1284523 二^此配製消毒酒精時，以容積計算酒精濃度_，以重量 濃度會逐漸下降且岭水量她上;揮發，減叫緊密，則其 ㈣h 水相對增因而_—長就會失去殺菌功能。 中十分鐘後即會失去殺菌作用，而即使置於瓶中 故 於㈣關，崎濃度也會因此下降至有效濃度以下， 瓶裝的酒精棉球於一週後需全部更新。 ?麻醉劑，如亂A，通常使狀後需至少—小時以上方見麻 酉fir般使用後一小時以上，藥物才深入皮膚約Μ公分；經過兩小時 L ’日冰人皮膚約G·6公分左右。冗長的等辦間造成醫療品質的耗損。本 二t酒精赫棉球（片）内含促進吸收之吸收促進劑，可大大地縮短等 1、+ 1增加麟及時錄。當制者於賴之後絲分鐘即可有效地產 ^皮膚的麻醉效果，再辭-般的打針或抽血，可有效的止痛且完全避免 其所帶來的不適。故本發明具有新穎性與進步性。 【發明内容】 本發明係縣具麻醉止痛功能的酒精消毒棉球（片）裝置，包 括·基材、消毒劑、麻醉劑及促進吸收之吸收促進劑。其作用為以此棉球 於皮膚上擦拭後，除有滅菌消毒功能外，内含吸收促進劑可快速使所含的 麻醉止痛藥物進入皮膚達到快速局部麻醉止痛的效果。隨後之打針或抽血 4均可減少疼痛，甚至無疼痛的感覺。 、皮膚是-個很好的保護層，-般藥物並不容練由皮膚滲人到皮内。 為了要增進麻醉劑經由皮膚滲人到皮内的量及速率，我們於劑型中加入 =進吸收之吸收促進劑。凡是能幫助藥物穿過皮膚角f層和表皮擴散的物 質即為减促進劑及吸收促輔，總稱為促賴。經皮促進劑是通過打開 新的渗透祕，增進皮膚最表層之肖質層巾_骨架無序性而增加皮膚的 非均句性’從而促進藥物渗透。早期的研究多限於有機溶劑如丙二醇、二 曱基甲酸肢、二甲基亞辦，其巾以二甲基频（Dimethyl Sulfoxide，dms〇) 及二曱基f醯胺亞微果不錯。另外雜氮卓酮（疆e)的效果也不錯· 可以說是經皮促·的-個典錢表。服氮卓酿轉透個强·有效 1284523 濃度低，性質穩定，毒性低·無副作用·可廣泛用於透皮给藥系统。研究 顯示月挂氮卓酮對藥物的透皮促進作用，只有在最佳濃度時才發揮最佳的 促進作用，最佳渗透作用的濃度在2%〜6%之間，但因藥而異。其他的吸 收促進劑還包括膽鹽類(Bile salts):膽酸納(Sodium Cholate)、去氧膽酸鈉 (Sodium Deoxycholate)、烏索去氧膽酸(urs〇deoxycholic acid)、鵝去氧膽 (chenodeoxycholic acid)、等；非離子型界面活性劑··聚氧乙烯烷基醚 (Polyoxyethylene alkyl ethers)、聚氧乙烯烷基酯（p〇lyOXyethylene alkyl esters)、聚氧乙烯烧基酯（P〇lyOXyethylene alkyl esters)、聚山梨醇酯 (Polysorbates)、Span®系列、Tween'系列等；離子型界面活性劑：月桂酸鈉 或硫酸月桂酸鈉(Sodium lauryl sulfate)、硫化丁二酸鈉(Dioctyl sodium sulfosuccinate)等；脂肪酸及其酯類··癸酸鈉(S〇dium caprate)、油酸(Oleic acid)、亞油酸、月挂酸及其酯等；化合物··甘油醋(Glycerides)、天然油⑺伽㈤ oils)，中鏈甘油醋（Medium-chain glycerides):碟g旨質或構脂類 (Phospholipids):印磷脂、豆磷脂等、聚氧乙烯甘油醋(p〇]ly〇xyethyiene glyceryl esters)、醯基肉驗及膽驗(Acyl carnitines and cholines)、棕櫚醯肉驗 (Palmitoyl carnitine棕櫚醯肉鹼）、月桂膽鹼(Laur〇yi ch〇iine)等；水楊酸鹽 (Salicylates):水揚酸納（Sodium salicylate)、曱氧基水楊酸納（Sodium methoxysahcylate);螯合劑(Chelatingagents):乙烯二胺四醋酸(edTA)等； 其他·杯檬酸(Citric acid)、可膨脹高分子(Swellable polymers)、殺粉(Starch)、 氰基_6·曱基冰(3-确’苯基)-1，4_二氫啶-3，5-二羧酸5-異丙脂3-甲酯等。 值得注意的是，經皮吸收促進劑配合使用有協調作用的藥物即可减少 促進劑的使用量，降低不必要的毒副作用，又可使主藥量少而效倍。經皮 吸收促進劑也可以組合使用，有時藥物經皮透入速度可大於不同經皮促進 劑單獨應用時的促渗效果。 ' 【實施例一】具麻醉止痛功能的酒精消毒棉球的製備： -、含有麻醉藥物之酒精容易的配製：取10 cc的無菌水，加人〇·25克利 多卡因(Lidocaine)及加入〇·25克的普羅卡因(Pril〇caine)，使其濃度成為 2.5%與2.5%。另外加入吸收促進劑h〇%，均勻混合後即可。又 1284523 、取滅菌過的棉球或不織布，與 【實施例二】 -、選取試驗者靠近手_面，選擇—平坦處，以傳統酒 後，於該紅疼糾進行勤«試驗:當 繼者感見賴祕絲法駿時’鱗料賴計上碰力值。 步驟’域財闕—帽_具_止痛魏的酒精消毒 棉求於皮膚上⑽嫌拭，雌經過不同時間後，於該處以疼 力疼痛試驗。當試驗者感覺疼痛或疼痛無法,£、受時，紀 = 的壓力值。 丁令涌砟上 、比較上述兩種不同棉球後，疼痛計上壓力值的變化。 圖一、使用上述具麻醉止痛功能的酒精消毒棉球後，以疼痛計量測手 臂承党的壓力變化 PSM>§Si ^ ^ ^ low 3 Μ -) rise _ rate and inhibit sensory nerve rush, special ¥. The progress of anesthesia and the diameter of the nerve fibers, the presence or absence of myelin and the rate of conduction. The order of loss of nerve function is: pain, temperature, touch, autonomic sensation and skeletal muscle tension. Local anesthetics can be divided into pure and noodles. · The former such as cocaine and =〇came 'we are quickly hydrolyzed and inactivated in the liver and blood; the latter is like 1 〇C_e(Xyl〇cain# Inferior mouth (5) In addition, the local σ anesthetic belongs to the test amine. Berxzocaine is insoluble in water, so the use of the anesthetic contained in this service, such as EMLA (Eutectic Mixture of Local 1284523 ^nesttocs), is a kind of A decade of white creamy ointment in Europe and the United States. It is a mixture of two commonly used amine-based local anesthetics, lidocaine (Udocaine®) and procaine (pril〇caine 2), suspended in water. It is a mixture containing two kinds of drugs, which produces a type of mound, which causes the charm to decrease and is oily at room temperature. Further, it forms an emulsification with water and strongly recognizes the acidity and alkalinity of the aqueous solution of the chlorinated sodium. Sex, then add the excipient to make the money penetrating the skin less f _ Yi the following two pieces of jujube · · silk ^ water - for its basis ( (4) that is not charged state. And this advantage is currently used clinically The bureau has no supplements. In addition, it is currently clinically It shows that the safety of Hidden Eight is very high. The concentration of t^d〇eaine or MGeaine is low. If the skin on the smear is erythema and sputum, these reactions are short-lived and harmless, and are not of clinical importance. After the anesthetic drug makes the secret skin strong, it takes at least -hours to consume the cotton when it passes through the gamma. The alcohol disinfection rate of the present invention and the absorption enhancer for the daily absorption of the Hi-di can greatly shorten the waiting time and increase the utility. The skin can be effectively anesthetized in about five minutes after wiping. In addition, the two injections or blood draw can effectively relieve pain and completely avoid the discomfort caused by it. Skin or shallow ^1_于In addition to blood and injection, it can also provide non-domain table surgery, skin grafting: sputum smear for traumatic disinfection and analgesic function, spinal fluid extraction, epidermal piercing, etc. Disinfection, pain relief, skin tissue sectioning, fatigue The invention is industrially usable. [Previous technique] The function of the toxic function and the sputum is: after the cotton ball is wiped on the skin, it is sterilized and eliminated. Keep sterile and non-staining The state container also needs to be fixed weekly _ main flf ' or in a sterile container. And the alcohol-sterilized cotton ball with cotton ball is placed in water and boiled for 15 to 20 minutes. Because of its bactericidal effect There is a system. It must be in the alcohol concentration of 6G%,% 'bacterial cells, and if the right, more than the right, when the high concentration of alcohol is difficult to penetrate into the fine scales can not kill - part _, both sterilization If the ability is too low, it can't be 1284523. When this formula is used to disinfect alcohol, the alcohol concentration will be calculated by volume. The weight concentration will gradually decrease and the amount of water will be on her. Volatilization and reduction will be close, then (4) h water will increase relatively. Will lose the sterilization function. After ten minutes, the bactericidal effect will be lost, and even if it is placed in the bottle, the concentration of sag will drop below the effective concentration, and the bottled alcohol cotton ball will need to be renewed after one week. Anesthetic, such as chaotic A, usually after the use of at least - hour to see the paralysis of the above-mentioned use of more than an hour after the use of the drug, the drug only penetrated into the skin about Μ centimeters; after two hours L 'Ice ice skin about G · 6 cm about. The lengthy of the work caused the loss of medical quality. The two t-alcoholic cotton balls (tablets) contain absorption enhancers for promoting absorption, which can be greatly shortened, etc. 1. When the makers are in the market for a few minutes, they can effectively use the skin's anesthetic effect, and then re-examine the injection or blood, which can effectively relieve the pain and completely avoid the discomfort caused by it. Therefore, the present invention is novel and progressive. SUMMARY OF THE INVENTION The present invention relates to an alcohol-sterilized cotton ball (sheet) device having an anesthetic and analgesic function, including a substrate, a disinfectant, an anesthetic, and an absorption enhancer for promoting absorption. Its function is to wipe the cotton ball on the skin, in addition to the sterilization and disinfection function, the absorption enhancer can quickly make the anesthesia and analgesic drugs contained in the skin to achieve rapid local anesthesia and analgesic effect. Subsequent injections or blood draws 4 can reduce pain or even painless feeling. The skin is a good protective layer, and the general medicine is not allowed to infiltrate into the skin by the skin. In order to increase the amount and rate of penetration of the anesthetic into the skin via the skin, we add an absorption enhancer to the absorption in the dosage form. Any substance that can help the drug to diffuse through the skin layer f and the epidermis is a reduction accelerator and absorption auxiliary, which is generally called promotion. The percutaneous enhancer promotes drug penetration by opening a new osmotic secret and enhancing the outermost layer of the skin, the skeleton disorder, which increases the heterogeneity of the skin. Early studies were mostly limited to organic solvents such as propylene glycol, dimercapto formate, and dimethyl arsenic. The towels were good with Dimethyl Sulfoxide (dms 〇) and Dimercapto amide. In addition, the effect of azapineone (E.g.) is also good. It can be said that it is a percutaneous version of the money. Nitrogen is a strong and effective 1284523 Low concentration, stable nature, low toxicity, no side effects, and can be widely used in transdermal drug delivery systems. Studies have shown that the transdermal promoting effect of azide on the drug is only optimal at the optimal concentration. The optimal osmotic concentration is between 2% and 6%, but varies from drug to drug. Other absorption enhancers include Bile salts: Sodium Cholate, Sodium Deoxycholate, urs〇deoxycholic acid, and goose deoxycholate. (chenodeoxycholic acid), etc.; nonionic surfactants··Polyoxyethylene alkyl ethers, p〇lyOXyethylene alkyl esters, polyoxyethylene alkyl esters (P〇 lyOXyethylene alkyl esters), Polysorbates, Span® series, Tween' series, etc.; ionic surfactant: sodium laurate or sodium lauryl sulfate, sodium disulfate sodium Sulfosuccinate); fatty acids and their esters · S〇dium caprate, oleic acid, linoleic acid, lauric acid and their esters; compounds · glycerol (Glycerides), natural Oil (7) gamma (5) oils), medium-chain glycerides: Phospholipids: imprinted phospholipids, soybean phospholipids, etc., polyoxyethylene glycerin (p〇]ly〇xyethyiene glyceryl Esters), thiol test and biliary test (Acyl ca Rnitines and cholines), palmitosin (Palmitoyl carnitine), laurylcholine (Laur〇yi ch〇iine), etc.; Salicylates: Sodium salicylate, 曱 oxygen Sodium methoxysahcylate; Chelating agents: ethylene diamine tetraacetic acid (edTA); others · Citric acid, Swellable polymers, Starch And cyano-6-indolyl ice (3- sure 'phenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid 5-isopropyl 3-methyl ester. It is worth noting that the use of a percutaneous absorption enhancer in combination with a coordinated drug can reduce the amount of accelerator used, reduce unnecessary side effects, and reduce the amount of main drug. Transdermal absorption enhancers may also be used in combination, and sometimes the transdermal penetration rate of the drug may be greater than the permeation effect of the different transdermal enhancers alone. [Example 1] Preparation of alcohol-sterilized cotton balls with anesthesia and analgesic function: - Easy preparation of alcohol containing anesthetic drugs: Take 10 cc of sterile water, add 〇25 Lidocaine and join 25·25g of procaine (Pril〇caine), the concentration of which is 2.5% and 2.5%. In addition, an absorption enhancer h〇% is added, and the mixture can be uniformly mixed. 1284523, take the sterilized cotton ball or non-woven fabric, and [Example 2] -, select the tester close to the hand _ face, select - flat, to the traditional drunk, in the red pain correction work «test: when I feel that when I look at the secrets of the silk, I feel the impact of the scales. Step ‘domain 阙 阙 — Cap _ _ 止 痛 Wei's alcohol disinfection Cotton on the skin (10) suspected swab, after the female after different time, where the pain test. When the tester feels pain or pain can not, £, subject to time, the pressure value of Ji =. After Ding Lingyong squatted and compared the above two different cotton balls, the pressure value on the pain gauge changed. Figure 1. After using the above-mentioned alcohol with anesthesia and analgesic function to sterilize the cotton ball, measure the pressure change of the hand arm by the pain measurement PSM>
1284523 圖二、使用傳統酒精消毒棉球後，以疼痛計量測手臂承受的壓力變化1284523 Figure 2. Pressure changes in the arm measured by pain after disinfecting the cotton ball with conventional alcohol
10 15 20 Time(min) 試驗 者財發狀具料止痛魏的崎赫棉球後， ίί、、Γί 達到麻醉的魏，手f可以承受的疼痛壓力比使用傳統 ζίΓϊίί 受的賴壓力高出很多，顯示本剌之具麻醉止痛 力月匕的，酉精消f棉球使用後可快速產生其功效。 【實施例三】一般使用 二將本發明之酒精棉球（片）於需要注射的皮膚部位上以其為中心點 向外約略半徑零點五公分呈®形擦拭塗抹，之後待五分鐘左右。 ^在=本發明之酒精棉球⑷五分鐘後，即可進行注射或抽血，並 、广射或抽血完成後使用本發明之酒精棉S(片注射S，即可在 / 主射全各中達到麻醉止痛的效果。10 15 20 Time(min) After the tester's wealthy hair is used to relieve the painful Wei's cotton ball, ίί, Γί reach the anesthetic Wei, the pain pressure that the hand f can bear is much higher than the pressure of using the traditional ζίΓϊίί It shows that the sputum has an anesthetic and analgesic force, and the sputum can quickly produce its effect after being used. [Embodiment 3] General use 2 The alcohol cotton ball (sheet) of the present invention is applied to the skin portion to be injected as a center point, and is applied to the outer shape with a radius of about 0.5 cm, and then waited for about five minutes. ^ After 5 minutes of the alcohol cotton ball (4) of the present invention, the injection or blood can be taken, and the alcoholic cotton S of the present invention can be used after the wide shot or the blood is drawn (the tablet injection S can be used in the main shot) The effect of anesthesia and pain relief is achieved in each.