JP2006527722A - Ａｌｋ−５受容体の阻害剤としての４−（ヘテロサイクル−縮合フェニル）−３−（フェニルまたはピリド−２−イル）ピラゾール - Google Patents

Ａｌｋ−５受容体の阻害剤としての４−（ヘテロサイクル−縮合フェニル）−３−（フェニルまたはピリド−２−イル）ピラゾール Download PDF

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Publication number
JP2006527722A
JP2006527722A JP2006515936A JP2006515936A JP2006527722A JP 2006527722 A JP2006527722 A JP 2006527722A JP 2006515936 A JP2006515936 A JP 2006515936A JP 2006515936 A JP2006515936 A JP 2006515936A JP 2006527722 A JP2006527722 A JP 2006527722A
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JP
Japan
Prior art keywords
compound
methyl
pyrazol
pyrazole
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
JP2006515936A
Other languages
English (en)
Japanese (ja)
Inventor
ネリナ・ドディック
フレデリック・ドンシュ
フランソワーズ・ジャンヌ・ジェリベール
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SmithKline Beecham Corp
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SmithKline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SmithKline Beecham Corp filed Critical SmithKline Beecham Corp
Publication of JP2006527722A publication Critical patent/JP2006527722A/ja
Withdrawn legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Urology & Nephrology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2006515936A 2003-06-16 2004-06-14 Ａｌｋ−５受容体の阻害剤としての４−（ヘテロサイクル−縮合フェニル）−３−（フェニルまたはピリド−２−イル）ピラゾール Withdrawn JP2006527722A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0313915.1A GB0313915D0 (en) 2003-06-16 2003-06-16 Compounds
PCT/EP2004/006427 WO2004111036A1 (fr) 2003-06-16 2004-06-14 4-(heterocyclyle-phenyle fusionne)-3-phenyle ou pyrid-2-yle)pyrazoles utilises comme inhibiteurs du recepteur de alk-5

Publications (1)

Publication Number Publication Date
JP2006527722A true JP2006527722A (ja) 2006-12-07

Family

ID=27636631

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2006515936A Withdrawn JP2006527722A (ja) 2003-06-16 2004-06-14 Ａｌｋ−５受容体の阻害剤としての４−（ヘテロサイクル−縮合フェニル）−３−（フェニルまたはピリド−２−イル）ピラゾール

Country Status (4)

Country Link
EP (1) EP1656367A1 (fr)
JP (1) JP2006527722A (fr)
GB (1) GB0313915D0 (fr)
WO (1) WO2004111036A1 (fr)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20170045348A (ko) * 2014-10-07 2017-04-26 일라이 릴리 앤드 캄파니 아미노피리딜옥시피라졸 화합물
JP2019522038A (ja) * 2016-07-29 2019-08-08 シャンハイ インリ ファーマシューティカル カンパニー リミティド 窒素含有芳香族複素環式化合物、その製造方法、薬物組成物および使用

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CL2004000234A1 (es) * 2003-02-12 2005-04-15 Biogen Idec Inc Compuestos derivados 3-(piridin-2-il)-4-heteroaril-pirazol sustituidos, antagonistas de aik5 y/o aik4; composicion farmaceutica y uso del compuesto en el tratamiento de desordenes fibroticos como esclerodermia, lupus nefritico, cicatrizacion de herid
TW200639163A (en) * 2005-02-04 2006-11-16 Genentech Inc RAF inhibitor compounds and methods
US20100056505A1 (en) * 2005-11-21 2010-03-04 Biogen Idec Ma Inc. Substituted Pyrazalones
RU2008136657A (ru) * 2006-03-28 2010-05-10 Вайет (Us) Модуляторы gdf-9/bmp-15 для лечения заболеваний костей
WO2008006583A1 (fr) * 2006-07-14 2008-01-17 Novartis Ag Dérivés de la pyrimidine en tant qu'inhibiteurs d'alk-5
EP1878733A1 (fr) * 2006-07-14 2008-01-16 Novartis AG Dérivés de pyrimidine comme inhibiteurs de ALK-5
UY32656A (es) * 2009-05-27 2010-12-31 Sanofi Aventis Procedimiento para producir benzofuranos
EP3894401A2 (fr) 2018-12-11 2021-10-20 Theravance Biopharma R&D IP, LLC Dérivés naphthyridine et quinoléine en tant qu'inhibiteurs de alk5
CN114728941A (zh) * 2019-11-22 2022-07-08 施万生物制药研发Ip有限责任公司 作为alk5抑制剂的经取代的1,5-萘啶或喹啉
EP4173675A1 (fr) * 2021-10-26 2023-05-03 Perha Pharmaceuticals Dérivés d'imidazolone d'en tant qu'inhibiteurs de kinases de protéine en particulier, dyrk1a, clk1 et/ou clk4

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3734180B2 (ja) * 1994-12-28 2006-01-11 エーザイ株式会社 新規ピラゾール誘導体
GB0027987D0 (en) * 2000-11-16 2001-01-03 Smithkline Beecham Plc Compounds
GB0102672D0 (en) * 2001-02-02 2001-03-21 Glaxo Group Ltd Compounds
CA2440211A1 (fr) * 2001-03-09 2002-09-19 Pfizer Products Inc. Composes de benzimidazole anti-inflammatoires
ATE374753T1 (de) * 2001-12-21 2007-10-15 Vernalis Cambridge Ltd 3-(2,4)dihydroxyphenyl-4-phenylpyrazole und deren medizinische verwendung
MXPA05002376A (es) * 2002-09-18 2005-05-23 Pfizer Prod Inc Nuevos compuestos de pirazol como inhibidores del factor de crecimiento transformante (tgf).
CL2004000234A1 (es) * 2003-02-12 2005-04-15 Biogen Idec Inc Compuestos derivados 3-(piridin-2-il)-4-heteroaril-pirazol sustituidos, antagonistas de aik5 y/o aik4; composicion farmaceutica y uso del compuesto en el tratamiento de desordenes fibroticos como esclerodermia, lupus nefritico, cicatrizacion de herid

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20170045348A (ko) * 2014-10-07 2017-04-26 일라이 릴리 앤드 캄파니 아미노피리딜옥시피라졸 화합물
KR101921847B1 (ko) 2014-10-07 2018-11-23 일라이 릴리 앤드 캄파니 아미노피리딜옥시피라졸 화합물
JP2019522038A (ja) * 2016-07-29 2019-08-08 シャンハイ インリ ファーマシューティカル カンパニー リミティド 窒素含有芳香族複素環式化合物、その製造方法、薬物組成物および使用
JP7007359B2 (ja) 2016-07-29 2022-01-24 シャンハイ インリ ファーマシューティカル カンパニー リミティド 窒素含有芳香族複素環式化合物、その製造方法、薬物組成物および使用
US11466003B2 (en) 2016-07-29 2022-10-11 Shanghai Yingli Pharmaceutical Co., Ltd Nitrogenous heterocyclic aromatic compound, preparation method therefor, pharmaceutical composition thereof, and application thereof

Also Published As

Publication number Publication date
EP1656367A1 (fr) 2006-05-17
WO2004111036A1 (fr) 2004-12-23
GB0313915D0 (en) 2003-07-23

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Effective date: 20070904