JP2006525372A5 - - Google Patents
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- Publication number
- JP2006525372A5 JP2006525372A5 JP2006514309A JP2006514309A JP2006525372A5 JP 2006525372 A5 JP2006525372 A5 JP 2006525372A5 JP 2006514309 A JP2006514309 A JP 2006514309A JP 2006514309 A JP2006514309 A JP 2006514309A JP 2006525372 A5 JP2006525372 A5 JP 2006525372A5
- Authority
- JP
- Japan
- Prior art keywords
- compound
- hydroxy
- mmol
- alkyl
- added
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 0 CN(*)c1cc(*)c(*)c(*)c1 Chemical compound CN(*)c1cc(*)c(*)c(*)c1 0.000 description 8
- KOAAQKRFVXJXAO-UHFFFAOYSA-N Brc1ccc(CCNCc2ccccc2)cc1 Chemical compound Brc1ccc(CCNCc2ccccc2)cc1 KOAAQKRFVXJXAO-UHFFFAOYSA-N 0.000 description 1
- CZQDKXWZNXASHB-UHFFFAOYSA-N CC(C)(C)OC(NCCc(cc1)ccc1Nc(cc1-c2ccccc2)ccc1OC)=O Chemical compound CC(C)(C)OC(NCCc(cc1)ccc1Nc(cc1-c2ccccc2)ccc1OC)=O CZQDKXWZNXASHB-UHFFFAOYSA-N 0.000 description 1
- GWGAWPNKXNYQLT-UHFFFAOYSA-N CC(C)(OC1)Oc(cc2)c1cc2C(C)=O Chemical compound CC(C)(OC1)Oc(cc2)c1cc2C(C)=O GWGAWPNKXNYQLT-UHFFFAOYSA-N 0.000 description 1
- SJYXUPGLQCUYJS-UHFFFAOYSA-N CC(C)(OC1)Oc(cc2)c1cc2C(CBr)=O Chemical compound CC(C)(OC1)Oc(cc2)c1cc2C(CBr)=O SJYXUPGLQCUYJS-UHFFFAOYSA-N 0.000 description 1
- RPBPDPNLDMMFDY-UHFFFAOYSA-N CC(C)Oc(cc1)ccc1Nc1ccc(CCNCC(c(cc2)cc(CO)c2O)O)cc1 Chemical compound CC(C)Oc(cc1)ccc1Nc1ccc(CCNCC(c(cc2)cc(CO)c2O)O)cc1 RPBPDPNLDMMFDY-UHFFFAOYSA-N 0.000 description 1
- BUABDFLRWABIHW-UHFFFAOYSA-N COc(c(-c1ccccc1)c1)ccc1Nc1ccc(CCN)cc1 Chemical compound COc(c(-c1ccccc1)c1)ccc1Nc1ccc(CCN)cc1 BUABDFLRWABIHW-UHFFFAOYSA-N 0.000 description 1
- OFBRKDXLBOTZNB-UHFFFAOYSA-N COc(ccc(N)c1)c1-c1ccccc1 Chemical compound COc(ccc(N)c1)c1-c1ccccc1 OFBRKDXLBOTZNB-UHFFFAOYSA-N 0.000 description 1
- OBCDOWSEHUFWHD-UHFFFAOYSA-N COc1cnc(NS(c(cc2)ccc2Nc2ccc(CCNCC(c(cc3)cc(CO)c3O)O)cc2)(=O)=O)nc1 Chemical compound COc1cnc(NS(c(cc2)ccc2Nc2ccc(CCNCC(c(cc3)cc(CO)c3O)O)cc2)(=O)=O)nc1 OBCDOWSEHUFWHD-UHFFFAOYSA-N 0.000 description 1
- VGLFTCULMFKTSG-UHFFFAOYSA-N CS(c(cc1)ccc1Nc1ccc(CCNC(c(cc2CO)ccc2O)O)cc1)(=O)=O Chemical compound CS(c(cc1)ccc1Nc1ccc(CCNC(c(cc2CO)ccc2O)O)cc1)(=O)=O VGLFTCULMFKTSG-UHFFFAOYSA-N 0.000 description 1
- JZSIMIKTELGWQK-UHFFFAOYSA-N Cc(cc1)ccc1Sc(cc1)ccc1Nc1ccc(CCNC(c(cc2)cc(CO)c2O)O)cc1 Chemical compound Cc(cc1)ccc1Sc(cc1)ccc1Nc1ccc(CCNC(c(cc2)cc(CO)c2O)O)cc1 JZSIMIKTELGWQK-UHFFFAOYSA-N 0.000 description 1
- ZQWSAGBTQROFSW-UHFFFAOYSA-N Cc(cccc1C)c1NS(c(cc1)ccc1Nc1ccc(CCNCC(c(cc2)cc(CO)c2O)O)cc1)(=O)=O Chemical compound Cc(cccc1C)c1NS(c(cc1)ccc1Nc1ccc(CCNCC(c(cc2)cc(CO)c2O)O)cc1)(=O)=O ZQWSAGBTQROFSW-UHFFFAOYSA-N 0.000 description 1
- BNVARRDONLHGIA-UHFFFAOYSA-N Cc1cc(C)nc(NS(c(cc2)ccc2Nc2ccc(CCNCC(c(cc3)cc(CO)c3O)O)cc2)(=O)=O)n1 Chemical compound Cc1cc(C)nc(NS(c(cc2)ccc2Nc2ccc(CCNCC(c(cc3)cc(CO)c3O)O)cc2)(=O)=O)n1 BNVARRDONLHGIA-UHFFFAOYSA-N 0.000 description 1
- ZSZCXAOQVBEPME-UHFFFAOYSA-N NCCc(cc1)ccc1Br Chemical compound NCCc(cc1)ccc1Br ZSZCXAOQVBEPME-UHFFFAOYSA-N 0.000 description 1
- RVHSDLUBNZBRMH-UHFFFAOYSA-N O=C(CBr)c(c(C=C1)c2NC1=O)ccc2OCc1ccccc1 Chemical compound O=C(CBr)c(c(C=C1)c2NC1=O)ccc2OCc1ccccc1 RVHSDLUBNZBRMH-UHFFFAOYSA-N 0.000 description 1
- DQPSWBUUOUGNDP-UHFFFAOYSA-N OCc(cc(C(CNCCc(cc1)ccc1Nc(cc1)ccc1S(Nc1ccccc1C(F)(F)F)(=O)=O)O)cc1)c1O Chemical compound OCc(cc(C(CNCCc(cc1)ccc1Nc(cc1)ccc1S(Nc1ccccc1C(F)(F)F)(=O)=O)O)cc1)c1O DQPSWBUUOUGNDP-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10/431,762 US20030229058A1 (en) | 2001-11-13 | 2003-05-08 | Aryl aniline beta2 adrenergic receptor agonists |
| PCT/US2004/014168 WO2005025555A2 (en) | 2003-05-08 | 2004-05-07 | Combinations of an aryl aniline beta-2 adrenergic receptor agonist and a corticosteroid |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2006525372A JP2006525372A (ja) | 2006-11-09 |
| JP2006525372A5 true JP2006525372A5 (https=) | 2007-06-14 |
Family
ID=34312096
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006514309A Withdrawn JP2006525372A (ja) | 2003-05-08 | 2004-05-07 | アリールアニリンβ−２アドレナリン作用性レセプタアゴニストおよびコルチコステロイドの組み合わせ |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US20030229058A1 (https=) |
| EP (1) | EP1641465B1 (https=) |
| JP (1) | JP2006525372A (https=) |
| AT (1) | ATE447408T1 (https=) |
| DE (1) | DE602004023946D1 (https=) |
| WO (1) | WO2005025555A2 (https=) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR028948A1 (es) | 2000-06-20 | 2003-05-28 | Astrazeneca Ab | Compuestos novedosos |
| US6653323B2 (en) | 2001-11-13 | 2003-11-25 | Theravance, Inc. | Aryl aniline β2 adrenergic receptor agonists |
| WO2004101525A1 (en) * | 2003-05-08 | 2004-11-25 | Theravance, Inc. | Crystalline form of aryl aniline beta-2 adrenergic receptor agonist |
| US7504401B2 (en) * | 2003-08-29 | 2009-03-17 | Locus Pharmaceuticals, Inc. | Anti-cancer agents and uses thereof |
| TW200526547A (en) * | 2003-09-22 | 2005-08-16 | Theravance Inc | Amino-substituted ethylamino β2 adrenergic receptor agonists |
| TW200531692A (en) * | 2004-01-12 | 2005-10-01 | Theravance Inc | Aryl aniline derivatives as β2 adrenergic receptor agonists |
| EP1708991B1 (en) * | 2004-01-22 | 2007-10-17 | Pfizer Limited | Sulfonamide derivatives for the treatment of diseases |
| KR100794844B1 (ko) * | 2004-01-22 | 2008-01-15 | 화이자 인코포레이티드 | 질병 치료용 설폰아마이드 유도체 |
| PT1708992E (pt) * | 2004-01-22 | 2007-11-16 | Pfizer | Derivados de sulfonamida para o tratamento de doenças |
| EP1730103B1 (en) | 2004-03-23 | 2010-05-26 | Pfizer Limited | Formamide derivatives useful as adrenoceptor |
| BRPI0511695A (pt) * | 2004-06-03 | 2008-01-08 | Theravance Inc | agonistas de receptor (beta)2 adrenérgico diamina |
| WO2006014704A1 (en) * | 2004-07-21 | 2006-02-09 | Theravance, Inc. | DIARYL ETHER β2 ADRENERGIC RECEPTOR AGONISTS |
| JP2008510014A (ja) * | 2004-08-16 | 2008-04-03 | セラヴァンス， インコーポレーテッド | β２アドレナリン作用性レセプターアゴニスト活性およびムスカリン性レセプターアンタゴニスト活性を有する化合物 |
| EP1786762A2 (en) * | 2004-09-10 | 2007-05-23 | Theravance, Inc. | Amidine substituted aryl aniline compounds |
| AU2006205933A1 (en) * | 2005-01-11 | 2006-07-20 | Glaxo Group Limited | Cinnamate salts of a beta-2 adrenergic agonist |
| TW200738658A (en) * | 2005-08-09 | 2007-10-16 | Astrazeneca Ab | Novel compounds |
| TW200744612A (en) * | 2005-08-26 | 2007-12-16 | Astrazeneca Ab | New combination |
| TW200738659A (en) * | 2005-08-29 | 2007-10-16 | Astrazeneca Ab | Novel compounds |
| TW200745067A (en) * | 2006-03-14 | 2007-12-16 | Astrazeneca Ab | Novel compounds |
| BRPI0714463A2 (pt) | 2006-07-19 | 2013-04-02 | Astrazeneca Ab | compostos de espiropiperidina tricÍclicos, sua sÍntese e seus usos como moduladores de atividade receptora de quimiocina |
| TW200825084A (en) | 2006-11-14 | 2008-06-16 | Astrazeneca Ab | New compounds 521 |
| AU2007336054A1 (en) | 2006-12-19 | 2008-06-26 | Astrazeneca Ab | Quinuclidinol derivatives as muscarinic receptor antagonists |
| TW200833670A (en) * | 2006-12-20 | 2008-08-16 | Astrazeneca Ab | Novel compounds 569 |
| GB0702458D0 (en) * | 2007-02-08 | 2007-03-21 | Astrazeneca Ab | Salts 668 |
| EA017627B1 (ru) | 2008-05-13 | 2013-01-30 | Астразенека Аб | Хинуклидиновые производные в качестве антагонистов мускаринового м3 рецептора |
| EP2297106B1 (en) | 2008-05-27 | 2014-07-16 | AstraZeneca AB | Phenoxypyridinylamide derivatives and their use in the treatment of pde4 mediated disease states |
| WO2009154557A1 (en) | 2008-06-18 | 2009-12-23 | Astrazeneca Ab | Benzoxazinone derivatives acting as beta2-adrenoreceptor agonist for the treatment of respiratory disorders |
| WO2010067102A1 (en) | 2008-12-09 | 2010-06-17 | Astrazeneca Ab | Diazaspiro [5.5] undecane derivatives and related compounds as muscarinic-receptor antagonists and beta-adrenoreceptor agonists for the treatment of pulmonary disorders |
Family Cites Families (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AT310146B (de) | 1971-04-26 | 1973-09-25 | Boehringer Sohn Ingelheim | Verfahren zur Herstellung von neuen N,N'-Bis-(β-hydroxyaryläthyl)-diaminoalkanen und deren Säureadditionssalzen |
| CH545764A (https=) | 1971-07-27 | 1974-02-15 | ||
| BE794414A (fr) | 1972-01-25 | 1973-07-23 | Sandoz Sa | Nouveaux amino-alcools, leur preparation et leur application comme medicament |
| JPS5913510B2 (ja) | 1975-12-26 | 1984-03-30 | オオツカセイヤク カブシキガイシヤ | カルボスチリルユウドウタイノセイゾウホウ |
| JPS609713B2 (ja) | 1976-10-08 | 1985-03-12 | 大塚製薬株式会社 | カルボスチリル誘導体 |
| US4460581A (en) | 1982-10-12 | 1984-07-17 | Boehringer Ingelheim Kg | (1-Hydroxy-2-amino-alkyl)-substituted benzoxazinones and benzoxazolinones |
| US4480581A (en) * | 1982-12-27 | 1984-11-06 | Usm Corporation | Deposition apparatus |
| ZW6584A1 (en) | 1983-04-18 | 1985-04-17 | Glaxo Group Ltd | Phenethanolamine derivatives |
| CA1262729A (en) | 1983-10-19 | 1989-11-07 | Leo Alig | Phenoxypropanolamines |
| GB8334494D0 (en) | 1983-12-24 | 1984-02-01 | Tanabe Seiyaku Co | Carbostyril derivatives |
| US5223614A (en) | 1987-12-19 | 1993-06-29 | Boehringer Ingelheim Gmbh | New quaternary ammonium compounds, their preparation and use |
| US4894219A (en) | 1988-03-29 | 1990-01-16 | University Of Florida | Beta-agonist carbostyril derivatives, assay method and pharmacological composition |
| FR2639166B1 (fr) * | 1988-11-14 | 1990-12-14 | Cit Alcatel | Systeme d'echange de messages en temps reel entre stations reliees par une liaison en boucle, notamment entre stations d'un central de telecommunications |
| US5434304A (en) | 1990-09-26 | 1995-07-18 | Aktiebolaget Astra | Process for preparing formoterol and related compounds |
| ES2172510T3 (es) * | 1991-12-18 | 2002-10-01 | Astrazeneca Ab | Nueva combinacion de formoterol y budesonida. |
| US5524613A (en) * | 1993-08-25 | 1996-06-11 | Habley Medical Technology Corporation | Controlled multi-pharmaceutical inhaler |
| GB9405019D0 (en) | 1994-03-15 | 1994-04-27 | Smithkline Beecham Plc | Novel compounds |
| US6075040A (en) | 1996-09-05 | 2000-06-13 | Eli Lilly And Company | Selective β3 adrenergic agonists |
| US6040344A (en) | 1996-11-11 | 2000-03-21 | Sepracor Inc. | Formoterol process |
| US6541669B1 (en) | 1998-06-08 | 2003-04-01 | Theravance, Inc. | β2-adrenergic receptor agonists |
| US6673908B1 (en) * | 1999-02-22 | 2004-01-06 | Nuvelo, Inc. | Tumor necrosis factor receptor 2 |
| US6432966B2 (en) * | 1999-10-29 | 2002-08-13 | Smithkline Beecham Corporation | Antiviral combinations |
| UA73965C2 (en) | 1999-12-08 | 2005-10-17 | Theravance Inc | b2 ADRENERGIC RECEPTOR ANTAGONISTS |
| US6285581B1 (en) * | 1999-12-13 | 2001-09-04 | Motorola, Inc. | MRAM having semiconductor device integrated therein |
| BR0110331A (pt) | 2000-04-27 | 2003-01-07 | Boehringer Ingelheim Pharma | Substâncias que mimetizam beta que têm uma atividade de longa duração, processos para prepará-las e o uso das mesmas como medicamentos |
| WO2002012266A1 (en) * | 2000-08-05 | 2002-02-14 | Glaxo Group Limited | 17.beta.-carbothioate 17.alpha.-arylcarbonyloxyloxy androstane derivative as anti-inflammatory agents |
| US6759398B2 (en) * | 2000-08-05 | 2004-07-06 | Smithkline Beecham Corporation | Anti-inflammatory androstane derivative |
| US6578793B2 (en) * | 2001-02-13 | 2003-06-17 | Sikorsky Aircraft Corporation | Method and apparatus for fiber strap termination |
| GB0103630D0 (en) | 2001-02-14 | 2001-03-28 | Glaxo Group Ltd | Chemical compounds |
| EP1366025B1 (en) | 2001-03-08 | 2007-06-27 | Glaxo Group Limited | Agonists of beta-adrenoreceptors |
| JP4143413B2 (ja) | 2001-03-22 | 2008-09-03 | グラクソ グループ リミテッド | β２−アドレナリン受容体アゴニストとしてのホルムアニリド誘導体 |
| UA77656C2 (en) * | 2001-04-07 | 2007-01-15 | Glaxo Group Ltd | S-fluoromethyl ester of 6-alpha, 9-alpha-difluoro-17-alpha-[(2-furanylcarbonyl)oxy]-11-beta-hydroxy-16- alpha-methyl-3-oxoandrosta-1,4-dien-17-beta-carbothioacid as anti-inflammatory agent |
| US6653323B2 (en) * | 2001-11-13 | 2003-11-25 | Theravance, Inc. | Aryl aniline β2 adrenergic receptor agonists |
| TWI249515B (en) | 2001-11-13 | 2006-02-21 | Theravance Inc | Aryl aniline beta2 adrenergic receptor agonists |
| WO2004101525A1 (en) * | 2003-05-08 | 2004-11-25 | Theravance, Inc. | Crystalline form of aryl aniline beta-2 adrenergic receptor agonist |
-
2003
- 2003-05-08 US US10/431,762 patent/US20030229058A1/en not_active Abandoned
-
2004
- 2004-05-07 JP JP2006514309A patent/JP2006525372A/ja not_active Withdrawn
- 2004-05-07 WO PCT/US2004/014168 patent/WO2005025555A2/en not_active Ceased
- 2004-05-07 AT AT04809361T patent/ATE447408T1/de not_active IP Right Cessation
- 2004-05-07 DE DE602004023946T patent/DE602004023946D1/de not_active Expired - Fee Related
- 2004-05-07 EP EP04809361A patent/EP1641465B1/en not_active Expired - Lifetime
-
2007
- 2007-05-22 US US11/805,101 patent/US7582765B2/en not_active Expired - Lifetime
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