JP2006523704A - ケモカイン受容体活性ヘテロサイクリックシクロペンチルテトラヒドロイソキノリンおよびテトラヒドロピリドピリジンのモジュレーター - Google Patents

ケモカイン受容体活性ヘテロサイクリックシクロペンチルテトラヒドロイソキノリンおよびテトラヒドロピリドピリジンのモジュレーター Download PDF

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JP2006523704A
JP2006523704A JP2006510018A JP2006510018A JP2006523704A JP 2006523704 A JP2006523704 A JP 2006523704A JP 2006510018 A JP2006510018 A JP 2006510018A JP 2006510018 A JP2006510018 A JP 2006510018A JP 2006523704 A JP2006523704 A JP 2006523704A
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JP2006523704A5 (enExample
Inventor
ブートラ，ガボール
ゴーブル，ステイーブン・デイ
パスターナク，アレクサンダー
ヤン，リフー
チヨウ，チヤンユウ
モイーズ，クリストフアー・アール
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Merck and Co Inc
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Merck and Co Inc
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Publication of JP2006523704A publication Critical patent/JP2006523704A/ja
Publication of JP2006523704A5 publication Critical patent/JP2006523704A5/ja
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    • C07D401/08—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing alicyclic rings
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  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Physical Education & Sports Medicine (AREA)
  • Oncology (AREA)
  • Diabetes (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Communicable Diseases (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Rheumatology (AREA)
  • Hematology (AREA)
  • Dermatology (AREA)
  • Neurology (AREA)
  • Molecular Biology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Endocrinology (AREA)
  • Urology & Nephrology (AREA)
  • Emergency Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Biotechnology (AREA)
  • Transplantation (AREA)
  • Vascular Medicine (AREA)
  • Obesity (AREA)
  • AIDS & HIV (AREA)
JP2006510018A 2003-04-17 2004-04-14 ケモカイン受容体活性ヘテロサイクリックシクロペンチルテトラヒドロイソキノリンおよびテトラヒドロピリドピリジンのモジュレーター Pending JP2006523704A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US46367303P 2003-04-17 2003-04-17
PCT/US2004/011463 WO2004094371A2 (en) 2003-04-17 2004-04-14 Heterocyclic cyclopentyl tetrahydroisoquinoline and tetrahydropyridopyridine modulators of chemokine receptor activity

Publications (2)

Publication Number Publication Date
JP2006523704A true JP2006523704A (ja) 2006-10-19
JP2006523704A5 JP2006523704A5 (enExample) 2007-05-10

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JP2006510018A Pending JP2006523704A (ja) 2003-04-17 2004-04-14 ケモカイン受容体活性ヘテロサイクリックシクロペンチルテトラヒドロイソキノリンおよびテトラヒドロピリドピリジンのモジュレーター

Country Status (6)

Country Link
EP (1) EP1622916A4 (enExample)
JP (1) JP2006523704A (enExample)
CN (1) CN100384856C (enExample)
AU (1) AU2004232939A1 (enExample)
CA (1) CA2521625A1 (enExample)
WO (1) WO2004094371A2 (enExample)

Cited By (1)

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JP2021512098A (ja) * 2018-01-31 2021-05-13 アプティニックス インコーポレイテッド スピロラクタム系ｎｍｄａ受容体修飾因子およびその使用

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AU2004232939A1 (en) * 2003-04-17 2004-11-04 Merck Sharp & Dohme Corp. Heterocyclic cyclopentyl tetrahydroisoquinoline and tetrahydropyridopyridine modulators of chemokine receptor activity
US7598243B2 (en) 2003-04-17 2009-10-06 Merck & Co., Inc. Heterocyclic cyclopentyl tetrahydroisoquinoline and tetrahydropyridopyridine modulators of chemokine receptor activity
TWI350168B (en) 2004-05-07 2011-10-11 Incyte Corp Amido compounds and their use as pharmaceuticals
US8067415B2 (en) 2005-11-01 2011-11-29 Millennium Pharmaceuticals, Inc. Compounds useful as antagonists of CCR2
US8067457B2 (en) 2005-11-01 2011-11-29 Millennium Pharmaceuticals, Inc. Compounds useful as antagonists of CCR2
CA2649636A1 (en) * 2006-04-20 2007-11-01 F. Hoffmann-La Roche Ag Diazepan derivatives modulators of chemokine receptors
EP2123644B1 (en) 2007-03-07 2014-12-17 Takeda Pharmaceutical Company Limited Benzoxazepine derivatives and use thereof
SMT201700456T1 (it) 2009-07-27 2017-11-15 Gilead Sciences Inc Composti eterociclici fusi come modulatori dei canali ionici
AR080375A1 (es) 2010-03-05 2012-04-04 Sanofi Aventis Procedimiento para la preparacion de 2-(cicloheximetil)-n-{2-[(2s)-1-metilpirrolidin-2-il] etil}-1,2,3,4-tetrahidroisoquinolina- 7-sulfonamida
JP5858586B2 (ja) 2010-07-02 2016-02-10 ギリアード サイエンシーズ， インコーポレイテッド イオンチャネルモジュレーターとしての縮合複素環式化合物
TWI577670B (zh) 2011-05-10 2017-04-11 基利科學股份有限公司 充當離子通道調節劑之稠合雜環化合物
TWI478908B (zh) 2011-07-01 2015-04-01 Gilead Sciences Inc 作為離子通道調節劑之稠合雜環化合物
NO3175985T3 (enExample) 2011-07-01 2018-04-28
RS62809B1 (sr) 2015-05-21 2022-02-28 Chemocentryx Inc Modulatori ccr2
WO2018026763A1 (en) 2016-08-01 2018-02-08 Aptinyx Inc. Spiro-lactam nmda receptor modulators and uses thereof
SG11201900554YA (en) 2016-08-01 2019-02-27 Aptinyx Inc Spiro-lactam nmda modulators and methods of using same
MX383650B (es) 2016-08-01 2025-03-14 Aptinyx Inc Moduladores del receptor nmda espiro-lactam y uso de los mismos.
US11304952B2 (en) 2017-09-25 2022-04-19 Chemocentryx, Inc. Combination therapy using a chemokine receptor 2 (CCR2) antagonist and a PD-1/PD-L1 inhibitor
US20190269664A1 (en) 2018-01-08 2019-09-05 Chemocentryx, Inc. Methods of treating solid tumors with ccr2 antagonists
EP3737367B1 (en) 2018-01-08 2024-10-02 ChemoCentryx, Inc. Ccr2 antagonists for the treatment of cutaneous t-cell lymphoma
CN111056955B (zh) * 2019-12-16 2021-05-25 中国科学院大连化学物理研究所 一种环己烯制备己二胺的方法
CN117342958B (zh) * 2023-09-12 2025-12-16 武汉理工大学 一种埋底界面材料及其制备得到的柔性钙钛矿太阳能电池

Citations (3)

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Publication number Priority date Publication date Assignee Title
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