JP2006520797A5 - - Google Patents
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- Publication number
- JP2006520797A5 JP2006520797A5 JP2006507344A JP2006507344A JP2006520797A5 JP 2006520797 A5 JP2006520797 A5 JP 2006520797A5 JP 2006507344 A JP2006507344 A JP 2006507344A JP 2006507344 A JP2006507344 A JP 2006507344A JP 2006520797 A5 JP2006520797 A5 JP 2006520797A5
- Authority
- JP
- Japan
- Prior art keywords
- formulation
- propellant
- ethanol
- water
- mass
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 claims 15
- 238000009472 formulation Methods 0.000 claims 11
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 8
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims 6
- 239000003380 propellant Substances 0.000 claims 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 4
- 229940057282 albuterol sulfate Drugs 0.000 claims 2
- BNPSSFBOAGDEEL-UHFFFAOYSA-N albuterol sulfate Chemical compound OS(O)(=O)=O.CC(C)(C)NCC(O)C1=CC=C(O)C(CO)=C1.CC(C)(C)NCC(O)C1=CC=C(O)C(CO)=C1 BNPSSFBOAGDEEL-UHFFFAOYSA-N 0.000 claims 2
- 239000012141 concentrate Substances 0.000 claims 2
- KEWHKYJURDBRMN-ZEODDXGYSA-M ipratropium bromide hydrate Chemical compound O.[Br-].O([C@H]1C[C@H]2CC[C@@H](C1)[N@@+]2(C)C(C)C)C(=O)C(CO)C1=CC=CC=C1 KEWHKYJURDBRMN-ZEODDXGYSA-M 0.000 claims 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims 2
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims 2
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims 2
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims 2
- LVGUZGTVOIAKKC-UHFFFAOYSA-N 1,1,1,2-tetrafluoroethane Chemical group FCC(F)(F)F LVGUZGTVOIAKKC-UHFFFAOYSA-N 0.000 claims 1
- 239000004480 active ingredient Substances 0.000 claims 1
- 229960001361 ipratropium bromide Drugs 0.000 claims 1
- 229960002630 ipratropium bromide monohydrate Drugs 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 229940071648 metered dose inhaler Drugs 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US45611303P | 2003-03-20 | 2003-03-20 | |
| US60/456,113 | 2003-03-20 | ||
| PCT/US2004/008375 WO2004084858A2 (en) | 2003-03-20 | 2004-03-19 | Formulation for a metered dose inhaler using hydro-fluoro-alkanes as propellants |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2006520797A JP2006520797A (ja) | 2006-09-14 |
| JP2006520797A5 true JP2006520797A5 (https=) | 2007-05-17 |
| JP4708332B2 JP4708332B2 (ja) | 2011-06-22 |
Family
ID=33098086
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006507344A Expired - Lifetime JP4708332B2 (ja) | 2003-03-20 | 2004-03-19 | 推進剤としてヒドロフルオロアルカンを用いる計量式吸入器のための調合物 |
Country Status (28)
| Country | Link |
|---|---|
| US (1) | US7914770B2 (https=) |
| EP (1) | EP1608336B1 (https=) |
| JP (1) | JP4708332B2 (https=) |
| KR (1) | KR101113003B1 (https=) |
| CN (1) | CN1761455A (https=) |
| AT (1) | ATE390125T1 (https=) |
| AU (1) | AU2004224367B2 (https=) |
| BR (1) | BRPI0408547A (https=) |
| CA (1) | CA2519523C (https=) |
| CO (1) | CO5640070A2 (https=) |
| CY (1) | CY1108137T1 (https=) |
| DE (1) | DE602004012718T2 (https=) |
| DK (1) | DK1608336T3 (https=) |
| EA (1) | EA009087B1 (https=) |
| EC (1) | ECSP056029A (https=) |
| ES (1) | ES2304616T3 (https=) |
| HR (1) | HRP20050822B1 (https=) |
| ME (1) | ME00420B (https=) |
| MX (1) | MXPA05009920A (https=) |
| NO (1) | NO336457B1 (https=) |
| NZ (1) | NZ542957A (https=) |
| PL (1) | PL1608336T3 (https=) |
| PT (1) | PT1608336E (https=) |
| RS (1) | RS51663B (https=) |
| SI (1) | SI1608336T1 (https=) |
| UA (1) | UA89751C2 (https=) |
| WO (1) | WO2004084858A2 (https=) |
| ZA (1) | ZA200506463B (https=) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102004011381A1 (de) * | 2004-03-05 | 2005-09-15 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Impaktionsdüse für treibgasbetriebene Dosieraerosole |
| NZ552869A (en) * | 2004-07-02 | 2010-06-25 | Boehringer Ingelheim Int | Aerosol suspension formulations containing TG 227 ea as a propellant, an ipratropium or tiotropium salt and a small amount of free water to stabilise the composition |
| US20060140873A1 (en) * | 2004-12-27 | 2006-06-29 | Chang Heng W | Aerosol pharmaceutical compositions |
| GB0501956D0 (en) * | 2005-01-31 | 2005-03-09 | Arrow Internat | Nebulizer formulation |
| GB0518769D0 (en) * | 2005-09-14 | 2005-10-19 | Medpharm Ltd | Topical formulations |
| DE102006053374A1 (de) * | 2006-02-09 | 2007-08-16 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Pharmazeutische Formulierung für Aerosole mit zwei oder mehr Wirkstoffen und mindestens einer oberflächenaktiven Substanz |
| DE102006014433A1 (de) | 2006-03-27 | 2007-10-04 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Dosieraerosole für die Verabreichung von pharmazeutischen Zubereitungen |
| DE102006017320A1 (de) | 2006-04-11 | 2007-10-18 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Aerosolsuspensionsformulierungen mit TG 227 ea oder TG 134 a als Treibmittel |
| WO2008047239A2 (en) * | 2006-09-21 | 2008-04-24 | Medispray Laboratories Pvt. Ltd. | Stable aerosol pharmaceutical formulations |
| JP5358574B2 (ja) * | 2007-08-17 | 2013-12-04 | アルション セラピューティクス， インコーポレイテッド | 高濃度の局所麻酔薬調合物 |
| EP2077132A1 (en) | 2008-01-02 | 2009-07-08 | Boehringer Ingelheim Pharma GmbH & Co. KG | Dispensing device, storage device and method for dispensing a formulation |
| US8119694B2 (en) | 2008-08-15 | 2012-02-21 | Arcion Therapeutics, Inc. | High concentration local anesthetic formulations |
| US10011906B2 (en) | 2009-03-31 | 2018-07-03 | Beohringer Ingelheim International Gmbh | Method for coating a surface of a component |
| WO2010133294A2 (de) | 2009-05-18 | 2010-11-25 | Boehringer Ingelheim International Gmbh | Adapter, inhalationseinrichtung und zerstäuber |
| US10016568B2 (en) | 2009-11-25 | 2018-07-10 | Boehringer Ingelheim International Gmbh | Nebulizer |
| JP5658268B2 (ja) | 2009-11-25 | 2015-01-21 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | ネブライザ |
| EA026241B1 (ru) | 2009-11-25 | 2017-03-31 | Бёрингер Ингельхайм Интернациональ Гмбх | Распылитель |
| WO2011160932A1 (en) | 2010-06-24 | 2011-12-29 | Boehringer Ingelheim International Gmbh | Nebulizer |
| US20120204871A1 (en) * | 2011-02-10 | 2012-08-16 | Julio Cesar Vega | Stable, non-corrosive formulations for pressurized metered dose inhalers |
| WO2012130757A1 (de) | 2011-04-01 | 2012-10-04 | Boehringer Ingelheim International Gmbh | Medizinisches gerät mit behälter |
| US9827384B2 (en) | 2011-05-23 | 2017-11-28 | Boehringer Ingelheim International Gmbh | Nebulizer |
| WO2013152894A1 (de) | 2012-04-13 | 2013-10-17 | Boehringer Ingelheim International Gmbh | Zerstäuber mit kodiermitteln |
| CN102798044B (zh) * | 2012-08-02 | 2014-09-10 | 深圳市华星光电技术有限公司 | 侧入式背光模组 |
| PL2835146T3 (pl) | 2013-08-09 | 2021-04-06 | Boehringer Ingelheim International Gmbh | Nebulizator |
| EP3030298B1 (en) | 2013-08-09 | 2017-10-11 | Boehringer Ingelheim International GmbH | Nebulizer |
| HUE055604T2 (hu) | 2014-05-07 | 2021-12-28 | Boehringer Ingelheim Int | Porlasztó |
| EA035261B1 (ru) | 2014-05-07 | 2020-05-21 | Бёрингер Ингельхайм Интернациональ Гмбх | Небулайзер и контейнер |
| AU2015257878B2 (en) | 2014-05-07 | 2019-08-08 | Boehringer Ingelheim International Gmbh | Container, nebulizer and use |
| WO2016164508A1 (en) * | 2015-04-10 | 2016-10-13 | 3M Innovative Properties Company | Formulation and aerosol canisters, inhalers, and the like containing the formulation |
| GB2573297A (en) * | 2018-04-30 | 2019-11-06 | Mexichem Fluor Sa De Cv | Pharmaceutical composition |
| US20230271770A1 (en) * | 2020-04-21 | 2023-08-31 | Amphastar Pharmaceuticals, Inc. | Anti-Viral Pharmaceutical Formulations Administered Via Devices for Lung Targeted Delivery |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4405598A (en) * | 1976-01-30 | 1983-09-20 | Fisons, Limited | Composition for treating asthma |
| GB8824804D0 (en) | 1988-10-22 | 1988-11-30 | Fisons Plc | Device |
| US5225183A (en) | 1988-12-06 | 1993-07-06 | Riker Laboratories, Inc. | Medicinal aerosol formulations |
| US5919435A (en) | 1990-11-09 | 1999-07-06 | Glaxo Group Limited | Aerosol formulation containing a particulate medicament |
| GB9202519D0 (en) * | 1992-02-06 | 1992-03-25 | Glaxo Group Ltd | Medicaments |
| SK280911B6 (sk) | 1992-12-09 | 2000-09-12 | Boehringer Ingelheim Pharmaceuticals, Inc. | Farmaceutický prostriedok |
| DE69701051T2 (de) | 1993-04-30 | 2000-08-31 | Minnesota Mining And Mfg. Co., Saint Paul | Abdichtung an Aerosolbehältern |
| ES2119219T5 (es) | 1993-07-15 | 2011-05-11 | Minnesota Mining And Manufacturing Company | Cierres estancos para uso en un dispositivo para suministrar un aerosol. |
| KR19980703850A (ko) * | 1995-04-14 | 1998-12-05 | 그레이엄브레레톤 | 베클로메타손 디프로피오네이트용 계량 흡입기 |
| GB9513084D0 (en) | 1995-06-27 | 1995-08-30 | Bespak Plc | Dispensing apparatus |
| SE9701750D0 (sv) | 1997-05-12 | 1997-05-12 | Astra Pharma Prod | Inhalation device and method of manufacture thereof |
| US20010031244A1 (en) | 1997-06-13 | 2001-10-18 | Chiesi Farmaceutici S.P.A. | Pharmaceutical aerosol composition |
| GB2326334A (en) | 1997-06-13 | 1998-12-23 | Chiesi Farma Spa | Pharmaceutical aerosol compositions |
| US6423298B2 (en) * | 1998-06-18 | 2002-07-23 | Boehringer Ingelheim Pharmaceuticals, Inc. | Pharmaceutical formulations for aerosols with two or more active substances |
| CN1150890C (zh) * | 1998-08-04 | 2004-05-26 | 杰格研究股份公司 | 药用气溶胶制剂 |
| IT1303788B1 (it) | 1998-11-25 | 2001-02-23 | Chiesi Farma Spa | Formulazioni di aerosol medicinali. |
| DZ2947A1 (fr) | 1998-11-25 | 2004-03-15 | Chiesi Farma Spa | Inhalateur à compteur de dose sous pression. |
| US7074388B2 (en) * | 1998-12-10 | 2006-07-11 | Kos Life Science, Inc. | Water stabilized medicinal aerosol formulation |
| US6261539B1 (en) * | 1998-12-10 | 2001-07-17 | Akwete Adjei | Medicinal aerosol formulation |
| US20030008369A1 (en) * | 1999-03-03 | 2003-01-09 | Board Of Regents, The University Of Texas System | Genetic and epigenetic manipulation of ABC transporters and ecto-phosphatases |
| GB0002798D0 (en) | 2000-02-09 | 2000-03-29 | Glaxo Group Ltd | Actuator nozzle for metered dose inhaler |
| EP1241113A1 (en) | 2001-03-12 | 2002-09-18 | CHIESI FARMACEUTICI S.p.A. | Inhaler with means for improving chemical stability of medicinal aerosol solution contained therein |
| US20070089735A1 (en) | 2001-06-26 | 2007-04-26 | Alan Langford | Aerosol actuator |
-
2004
- 2004-03-19 WO PCT/US2004/008375 patent/WO2004084858A2/en not_active Ceased
- 2004-03-19 JP JP2006507344A patent/JP4708332B2/ja not_active Expired - Lifetime
- 2004-03-19 DK DK04757846T patent/DK1608336T3/da active
- 2004-03-19 CA CA2519523A patent/CA2519523C/en not_active Expired - Fee Related
- 2004-03-19 AT AT04757846T patent/ATE390125T1/de active
- 2004-03-19 BR BRPI0408547-7A patent/BRPI0408547A/pt not_active Application Discontinuation
- 2004-03-19 MX MXPA05009920A patent/MXPA05009920A/es active IP Right Grant
- 2004-03-19 AU AU2004224367A patent/AU2004224367B2/en not_active Ceased
- 2004-03-19 ES ES04757846T patent/ES2304616T3/es not_active Expired - Lifetime
- 2004-03-19 UA UAA200509733A patent/UA89751C2/ru unknown
- 2004-03-19 DE DE602004012718T patent/DE602004012718T2/de not_active Expired - Lifetime
- 2004-03-19 HR HRP20050822AA patent/HRP20050822B1/hr not_active IP Right Cessation
- 2004-03-19 EA EA200501363A patent/EA009087B1/ru unknown
- 2004-03-19 CN CNA200480007545XA patent/CN1761455A/zh active Pending
- 2004-03-19 NZ NZ542957A patent/NZ542957A/en not_active IP Right Cessation
- 2004-03-19 KR KR1020057017414A patent/KR101113003B1/ko not_active Expired - Fee Related
- 2004-03-19 EP EP04757846A patent/EP1608336B1/en not_active Expired - Lifetime
- 2004-03-19 ME MEP-2008-626A patent/ME00420B/me unknown
- 2004-03-19 PL PL04757846T patent/PL1608336T3/pl unknown
- 2004-03-19 SI SI200430720T patent/SI1608336T1/sl unknown
- 2004-03-19 PT PT04757846T patent/PT1608336E/pt unknown
- 2004-03-19 RS YU20050705A patent/RS51663B/sr unknown
- 2004-03-19 US US10/804,710 patent/US7914770B2/en active Active
-
2005
- 2005-08-12 ZA ZA200506463A patent/ZA200506463B/en unknown
- 2005-09-20 EC EC2005006029A patent/ECSP056029A/es unknown
- 2005-10-19 CO CO05106413A patent/CO5640070A2/es not_active Application Discontinuation
- 2005-10-19 NO NO20054839A patent/NO336457B1/no not_active IP Right Cessation
-
2008
- 2008-06-11 CY CY20081100626T patent/CY1108137T1/el unknown
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