JP2006520611A5 - - Google Patents
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- JP2006520611A5 JP2006520611A5 JP2006509126A JP2006509126A JP2006520611A5 JP 2006520611 A5 JP2006520611 A5 JP 2006520611A5 JP 2006509126 A JP2006509126 A JP 2006509126A JP 2006509126 A JP2006509126 A JP 2006509126A JP 2006520611 A5 JP2006520611 A5 JP 2006520611A5
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- JP
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- Prior art keywords
- pharmaceutical composition
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- apoptosis
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- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 108020004459 Small interfering RNA Proteins 0.000 claims description 15
- 230000006907 apoptotic process Effects 0.000 claims description 14
- 230000000692 anti-sense effect Effects 0.000 claims description 12
- 239000002773 nucleotide Substances 0.000 claims description 10
- 125000003729 nucleotide group Chemical group 0.000 claims description 10
- 230000000295 complement effect Effects 0.000 claims description 9
- 239000003795 chemical substances by application Substances 0.000 claims description 8
- 108010074105 Factor Va Proteins 0.000 claims description 4
- 108091033319 polynucleotide Proteins 0.000 claims description 3
- 239000002157 polynucleotide Substances 0.000 claims description 3
- 102000040430 polynucleotide Human genes 0.000 claims description 3
- 239000008194 pharmaceutical composition Substances 0.000 claims 44
- 108091034117 Oligonucleotide Proteins 0.000 claims 15
- 239000000074 antisense oligonucleotide Substances 0.000 claims 11
- 238000012230 antisense oligonucleotides Methods 0.000 claims 11
- 102000016614 Autophagy-Related Protein 5 Human genes 0.000 claims 8
- 108010092776 Autophagy-Related Protein 5 Proteins 0.000 claims 8
- 210000004027 cell Anatomy 0.000 claims 7
- 102000004127 Cytokines Human genes 0.000 claims 6
- 108090000695 Cytokines Proteins 0.000 claims 6
- 239000003814 drug Substances 0.000 claims 5
- 229940079593 drug Drugs 0.000 claims 5
- GOZMBJCYMQQACI-UHFFFAOYSA-N 6,7-dimethyl-3-[[methyl-[2-[methyl-[[1-[3-(trifluoromethyl)phenyl]indol-3-yl]methyl]amino]ethyl]amino]methyl]chromen-4-one;dihydrochloride Chemical compound Cl.Cl.C=1OC2=CC(C)=C(C)C=C2C(=O)C=1CN(C)CCN(C)CC(C1=CC=CC=C11)=CN1C1=CC=CC(C(F)(F)F)=C1 GOZMBJCYMQQACI-UHFFFAOYSA-N 0.000 claims 3
- 102100025064 Cellular tumor antigen p53 Human genes 0.000 claims 3
- 101000721661 Homo sapiens Cellular tumor antigen p53 Proteins 0.000 claims 3
- 210000001130 astrocyte Anatomy 0.000 claims 3
- MZOFCQQQCNRIBI-VMXHOPILSA-N (3s)-4-[[(2s)-1-[[(2s)-1-[[(1s)-1-carboxy-2-hydroxyethyl]amino]-4-methyl-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-3-[[2-[[(2s)-2,6-diaminohexanoyl]amino]acetyl]amino]-4-oxobutanoic acid Chemical compound OC[C@@H](C(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@@H](N)CCCCN MZOFCQQQCNRIBI-VMXHOPILSA-N 0.000 claims 2
- 108010002352 Interleukin-1 Proteins 0.000 claims 2
- 108090001005 Interleukin-6 Proteins 0.000 claims 2
- 108060008682 Tumor Necrosis Factor Proteins 0.000 claims 2
- 102000000852 Tumor Necrosis Factor-alpha Human genes 0.000 claims 2
- 230000004069 differentiation Effects 0.000 claims 2
- 230000002401 inhibitory effect Effects 0.000 claims 2
- 210000001616 monocyte Anatomy 0.000 claims 2
- 210000000056 organ Anatomy 0.000 claims 2
- 210000003994 retinal ganglion cell Anatomy 0.000 claims 2
- 230000008685 targeting Effects 0.000 claims 2
- 108020000948 Antisense Oligonucleotides Proteins 0.000 claims 1
- 102100021569 Apoptosis regulator Bcl-2 Human genes 0.000 claims 1
- 208000023328 Basedow disease Diseases 0.000 claims 1
- 206010009900 Colitis ulcerative Diseases 0.000 claims 1
- 208000011231 Crohn disease Diseases 0.000 claims 1
- 201000003883 Cystic fibrosis Diseases 0.000 claims 1
- 201000004624 Dermatitis Diseases 0.000 claims 1
- 208000010412 Glaucoma Diseases 0.000 claims 1
- 208000015023 Graves' disease Diseases 0.000 claims 1
- 101000971171 Homo sapiens Apoptosis regulator Bcl-2 Proteins 0.000 claims 1
- 206010020751 Hypersensitivity Diseases 0.000 claims 1
- 108090000171 Interleukin-18 Proteins 0.000 claims 1
- 201000002287 Keratoconus Diseases 0.000 claims 1
- 208000034578 Multiple myelomas Diseases 0.000 claims 1
- 208000023715 Ocular surface disease Diseases 0.000 claims 1
- 206010035226 Plasma cell myeloma Diseases 0.000 claims 1
- 201000004681 Psoriasis Diseases 0.000 claims 1
- 206010063837 Reperfusion injury Diseases 0.000 claims 1
- 206010040047 Sepsis Diseases 0.000 claims 1
- 206010052779 Transplant rejections Diseases 0.000 claims 1
- 201000006704 Ulcerative Colitis Diseases 0.000 claims 1
- 208000026935 allergic disease Diseases 0.000 claims 1
- 230000007815 allergy Effects 0.000 claims 1
- 206010003230 arteritis Diseases 0.000 claims 1
- 208000006673 asthma Diseases 0.000 claims 1
- 208000010668 atopic eczema Diseases 0.000 claims 1
- 230000030833 cell death Effects 0.000 claims 1
- 208000029078 coronary artery disease Diseases 0.000 claims 1
- 206010012601 diabetes mellitus Diseases 0.000 claims 1
- 210000002919 epithelial cell Anatomy 0.000 claims 1
- 210000005260 human cell Anatomy 0.000 claims 1
- 208000028867 ischemia Diseases 0.000 claims 1
- 210000003734 kidney Anatomy 0.000 claims 1
- 206010025135 lupus erythematosus Diseases 0.000 claims 1
- 208000002780 macular degeneration Diseases 0.000 claims 1
- 201000006417 multiple sclerosis Diseases 0.000 claims 1
- 201000008482 osteoarthritis Diseases 0.000 claims 1
- 230000001575 pathological effect Effects 0.000 claims 1
- 208000028169 periodontal disease Diseases 0.000 claims 1
- 230000000770 proinflammatory effect Effects 0.000 claims 1
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US45167703P | 2003-03-05 | 2003-03-05 | |
| US10/383,614 US7381708B2 (en) | 2001-07-23 | 2003-03-10 | Suppression of eIF5A1 expression by the use of antisense oligonucleotides for the prevention of retinal cell death in the glaucomatous eye |
| US47619403P | 2003-06-06 | 2003-06-06 | |
| US50473103P | 2003-09-22 | 2003-09-22 | |
| PCT/US2004/006598 WO2004078940A2 (en) | 2003-03-05 | 2004-03-05 | USE OF ANTISENSE OLIGONUCLEOTIDES OR siRNA TO SUPPRESS EXPRESSION OF eIF-5A1 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010229103A Division JP5566250B2 (ja) | 2003-03-05 | 2010-10-08 | ｅＩＦ−５Ａ１の発現を抑制するための、アンチセンス・オリゴヌクレオチド又はｓｉＲＮＡの使用 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2006520611A JP2006520611A (ja) | 2006-09-14 |
| JP2006520611A5 true JP2006520611A5 (https=) | 2007-05-31 |
Family
ID=32966688
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006509126A Pending JP2006520611A (ja) | 2003-03-05 | 2004-03-05 | ｅＩＦ−５Ａ１の発現を抑制するための、アンチセンス・オリゴヌクレオチド又はｓｉＲＮＡの使用 |
Country Status (9)
| Country | Link |
|---|---|
| US (5) | US20100168047A9 (https=) |
| EP (1) | EP1601767B1 (https=) |
| JP (1) | JP2006520611A (https=) |
| KR (1) | KR20050098954A (https=) |
| AU (1) | AU2004217437B2 (https=) |
| CA (1) | CA2517974A1 (https=) |
| NZ (1) | NZ542665A (https=) |
| TW (1) | TW200427695A (https=) |
| WO (1) | WO2004078940A2 (https=) |
Families Citing this family (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7381708B2 (en) | 2001-07-23 | 2008-06-03 | Sensco Technologies, Inc. | Suppression of eIF5A1 expression by the use of antisense oligonucleotides for the prevention of retinal cell death in the glaucomatous eye |
| CN101014708B (zh) * | 2003-03-05 | 2011-11-02 | 森尼斯科技术公司 | 反义寡核苷酸或siRNA在抑制eIF-5A1表达中的应用 |
| AU2004217437B2 (en) | 2003-03-05 | 2009-11-19 | Senesco Technologies, Inc. | Use of antisense oligonucleotides or siRNA to suppress expression of eIF-5A1 |
| CA2528372A1 (en) * | 2003-06-06 | 2005-01-27 | Senesco Technologies, Inc. | Inhibition of apoptosis-specific elf-5a ("eif-5a1") with antisense oligonucleotides and sirnas as anti-inflammatory therapeutics |
| US8193158B2 (en) * | 2006-03-20 | 2012-06-05 | Senesco Technologies, Inc. | Use of apoptosis-specific eIF-5A siRNA to down regulate expression of proinflammatory cytokines to treat sepsis |
| US20140371299A1 (en) * | 2004-06-07 | 2014-12-18 | Senesco Technologies, Inc. | Use of Apoptosis-Specific elF-5A siRNA to Down Regulate Expression of Proinflammatory Cytokines to Treat Sepsis |
| AU2005269647B2 (en) * | 2004-07-20 | 2009-11-12 | Senesco Technologies, Inc. | Use of apoptosis-specific eIF-5A siRNAs and antisense polynucleotides to inhibit/suppress an inflammatory response |
| EP1824982A2 (en) * | 2004-12-03 | 2007-08-29 | Senesco Technologies, Inc. | Methods of increasing seed yield |
| CA2588129A1 (en) * | 2004-12-03 | 2006-06-08 | Senesco Technologies, Inc. | Apoptosis-specific eif-5a and polynucleotides encoding same |
| JP5139083B2 (ja) | 2005-01-25 | 2013-02-06 | プロレキシーズ ファーマシューティカルズ インコーポレイテッド | 抗腫瘍剤としてのキノキサリン誘導体 |
| DE102005005528A1 (de) * | 2005-01-30 | 2006-08-03 | Eberhard-Karls-Universität Tübingen Universitätsklinikum | Injizierbares Mittel zur zielgerichteten Behandlung von retinalen Ganglienzellen |
| US8105611B2 (en) * | 2005-06-17 | 2012-01-31 | Allergan, Inc. | Treatment of autoimmune disorder with a neurotoxin |
| KR20080075552A (ko) * | 2005-12-13 | 2008-08-18 | 세네스코 테크놀로지스 인코포레이티드 | 다발성 골수종 세포를 사멸시키기 위한 ｅＩＦ-５Ａ의 용도 |
| AU2007226878A1 (en) * | 2006-03-20 | 2007-09-27 | Senesco Technologies, Inc. | A novel method of protecting islet cells from apoptosis during the donor harvesting process |
| WO2007115047A2 (en) * | 2006-03-29 | 2007-10-11 | Senesco Technologies, Inc. | Inhibition of hiv replication and expression of p24 with eif-5a |
| ATE508191T1 (de) | 2006-11-01 | 2011-05-15 | Medical Res And Infrastructure Fund Of The Tel Aviv Sourasky Medical Ct | Adipozytenspezifische konstrukte und verfahren zur hemmung der expression von blutplättchen-typ- 12-lipoxygenase |
| WO2008065429A1 (en) * | 2006-11-30 | 2008-06-05 | Ucl Business Plc | Method for delivering gene therapy vectors to the optic nerve head |
| CN101126098B (zh) * | 2007-07-05 | 2012-07-11 | 深圳市第二人民医院 | 特异性抑制gfap蛋白表达的小干扰rna分子表达载体及其构建方法与用途 |
| EP2265717A4 (en) | 2008-03-07 | 2012-09-12 | Senesco Technologies Inc | USE OF RNSI TO OBTAIN NEGATIVE REGULATION OF ENDOGENOUS GENE IN COMBINATION WITH THE USE OF SENS BUILDING PRODUCT TO OBTAIN EXPRESSION OF DESIRED POLYNUCLEOTIDE |
| JP5578522B2 (ja) | 2008-05-27 | 2014-08-27 | 義規 世古 | アポトーシス誘導薬 |
| US8946239B2 (en) | 2008-07-10 | 2015-02-03 | Duquesne University Of The Holy Spirit | Substituted pyrrolo, -furano, and cyclopentylpyrimidines having antimitotic and/or antitumor activity and methods of use thereof |
| US8445638B2 (en) | 2008-09-03 | 2013-05-21 | Senesco Technologies, Inc. | Use of a truncated eIF-5A1 polynucleotide to induce apoptosis in cancer cells |
| CA2962219C (en) * | 2008-10-22 | 2020-08-25 | Quark Pharmaceuticals, Inc. | Methods for treating eye disorders |
| US20120196918A1 (en) * | 2009-04-08 | 2012-08-02 | Mirmira Raghavendra G | PREVENTING ISLET INFLAMMATION AND DYSFUNCTION AND MAINTAINING PROPER GLUCOSE LEVELS BY CONTROLLING eIF5A AND ITS HYPUSINATION |
| EP3318248B1 (en) | 2009-12-01 | 2019-04-10 | Translate Bio, Inc. | Delivery of mrna for the augmentation of proteins and enzymes in human genetic diseases |
| RU2013154295A (ru) | 2011-06-08 | 2015-07-20 | Шир Хьюман Дженетик Терапис, Инк. | КОМПОЗИЦИИ ЛИПИДНЫХ НАНОЧАСТИЦ И СПОСОБЫ ДЛЯ ДОСТАВКИ мРНК |
| WO2013185067A1 (en) * | 2012-06-08 | 2013-12-12 | Shire Human Genetic Therapies, Inc. | Nuclease resistant polynucleotides and uses thereof |
| RS57739B1 (sr) | 2013-03-14 | 2018-12-31 | Translate Bio Inc | Kompozicije cftr irnk i postupci i upotrebe u vezi sa njima |
| JP6586075B2 (ja) | 2013-03-14 | 2019-10-02 | トランスレイト バイオ， インコーポレイテッド | メッセンジャーｒｎａの精製方法 |
| EP2986599A1 (en) | 2013-04-17 | 2016-02-24 | Pfizer Inc. | N-piperidin-3-ylbenzamide derivatives for treating cardiovascular diseases |
| CN103421791B (zh) * | 2013-06-24 | 2015-04-15 | 广西医科大学 | 一种抑制人-单核巨噬细胞TLR2表达的siRNA及其应用 |
| CN106413811A (zh) | 2013-10-22 | 2017-02-15 | 夏尔人类遗传性治疗公司 | 精氨基琥珀酸合成酶缺乏症的mrna疗法 |
| JP6506749B2 (ja) | 2013-10-22 | 2019-04-24 | シャイアー ヒューマン ジェネティック セラピーズ インコーポレイテッド | フェニルケトン尿症のためのｍＲＮＡ療法 |
| US9850269B2 (en) | 2014-04-25 | 2017-12-26 | Translate Bio, Inc. | Methods for purification of messenger RNA |
| EA201991747A1 (ru) | 2017-02-27 | 2020-06-04 | Транслейт Био, Инк. | НОВАЯ КОДОН-ОПТИМИЗИРОВАННАЯ мРНК CFTR |
| MX2019013752A (es) | 2017-05-16 | 2020-07-20 | Translate Bio Inc | Tratamiento de la fibrosis quística mediante el suministro de arnm que codifica cftr optimizado en codones. |
| JP7429639B2 (ja) | 2017-11-18 | 2024-02-08 | マガリャエス，ンゾラ デ | 抗体薬物複合体またはその薬学的に許容される塩 |
| KR102950141B1 (ko) | 2018-08-24 | 2026-04-07 | 트랜슬레이트 바이오 인코포레이티드 | 전령 rna의 정제 방법 |
| WO2020106946A1 (en) | 2018-11-21 | 2020-05-28 | Translate Bio, Inc. | TREATMENT OF CYSTIC FIBROSIS BY DELIVERY OF NEBULIZED mRNA ENCODING CFTR |
| EP4031662A1 (en) | 2019-09-20 | 2022-07-27 | Translate Bio, Inc. | Mrna encoding engineered cftr |
| CN114231551B (zh) * | 2021-12-24 | 2023-09-29 | 云南大学 | 蛋白在促进昆虫淋巴细胞凋亡和/或防治害虫中的应用 |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU4665196A (en) | 1995-02-13 | 1996-09-04 | Novartis Ag | Eukaryotic initiation factor 5A (eIF-5A) mutants |
| CA2264745C (en) * | 1996-09-13 | 2003-11-11 | University Of Florida Research Foundation, Inc. | Method of inhibiting biosynthesis of eif5a |
| CA2296105A1 (en) | 1997-06-30 | 1999-01-14 | Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften E.V. | Novel inhibitor of cellular proliferation |
| US6506559B1 (en) * | 1997-12-23 | 2003-01-14 | Carnegie Institute Of Washington | Genetic inhibition by double-stranded RNA |
| US7358418B2 (en) | 1999-07-06 | 2008-04-15 | Senesco Technologies, Inc. | Isoforms of eIF-5A: senescence-induced eLF5A; wounding-induced eIF-4A; growth eIF-5A; and DHS |
| CA2376065A1 (en) | 1999-08-06 | 2001-02-15 | Pharmacia & Upjohn Company | Crystallization and structure determination of staphylococcus aureus elongation factor p |
| ES2336887T5 (es) * | 2000-03-30 | 2019-03-06 | Whitehead Inst Biomedical Res | Mediadores de interferencia por ARN específicos de secuencias de ARN |
| CA2429814C (en) * | 2000-12-01 | 2014-02-18 | Thomas Tuschl | Rna interference mediating small rna molecules |
| US7217517B2 (en) * | 2001-07-23 | 2007-05-15 | Senesco Technologies, Inc. | Nucleic acids, polypeptides, and methods for modulating apoptosis |
| US7381708B2 (en) * | 2001-07-23 | 2008-06-03 | Sensco Technologies, Inc. | Suppression of eIF5A1 expression by the use of antisense oligonucleotides for the prevention of retinal cell death in the glaucomatous eye |
| JP2003037457A (ja) * | 2001-07-23 | 2003-02-07 | Niigata Seimitsu Kk | 増幅回路 |
| US7166467B2 (en) * | 2001-07-23 | 2007-01-23 | Senesco Technologies, Inc. | Nucleic acids, polypeptides, compositions, and methods for modulating apoptosis |
| US7968523B2 (en) * | 2001-07-23 | 2011-06-28 | Senesco Technologies, Inc. | Method for inducing apoptosis using apoptosis-specific EIF5-A |
| WO2003016572A1 (en) * | 2001-08-17 | 2003-02-27 | Eli Lilly And Company | Oligonucleotide therapeutics for treating hepatitis c virus infections |
| EP1572902B1 (en) * | 2002-02-01 | 2014-06-11 | Life Technologies Corporation | HIGH POTENCY siRNAS FOR REDUCING THE EXPRESSION OF TARGET GENES |
| AU2003295600A1 (en) * | 2002-11-14 | 2004-06-15 | Dharmacon, Inc. | Functional and hyperfunctional sirna |
| AU2004217437B2 (en) * | 2003-03-05 | 2009-11-19 | Senesco Technologies, Inc. | Use of antisense oligonucleotides or siRNA to suppress expression of eIF-5A1 |
| CA2528372A1 (en) | 2003-06-06 | 2005-01-27 | Senesco Technologies, Inc. | Inhibition of apoptosis-specific elf-5a ("eif-5a1") with antisense oligonucleotides and sirnas as anti-inflammatory therapeutics |
-
2004
- 2004-03-05 AU AU2004217437A patent/AU2004217437B2/en not_active Ceased
- 2004-03-05 KR KR1020057015276A patent/KR20050098954A/ko not_active Ceased
- 2004-03-05 JP JP2006509126A patent/JP2006520611A/ja active Pending
- 2004-03-05 WO PCT/US2004/006598 patent/WO2004078940A2/en not_active Ceased
- 2004-03-05 EP EP04717933A patent/EP1601767B1/en not_active Expired - Lifetime
- 2004-03-05 CA CA002517974A patent/CA2517974A1/en not_active Abandoned
- 2004-03-05 NZ NZ542665A patent/NZ542665A/en unknown
- 2004-03-05 TW TW093105908A patent/TW200427695A/zh unknown
-
2005
- 2005-05-23 US US11/134,445 patent/US20100168047A9/en not_active Abandoned
- 2005-11-28 US US11/287,460 patent/US7662796B2/en not_active Expired - Fee Related
-
2009
- 2009-12-17 US US12/640,148 patent/US8242256B2/en not_active Expired - Fee Related
-
2011
- 2011-05-02 US US13/099,171 patent/US8754057B2/en not_active Expired - Fee Related
-
2012
- 2012-08-10 US US13/572,123 patent/US20130066058A1/en not_active Abandoned
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