JP2006516195A5 - - Google Patents
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- Publication number
- JP2006516195A5 JP2006516195A5 JP2006500864A JP2006500864A JP2006516195A5 JP 2006516195 A5 JP2006516195 A5 JP 2006516195A5 JP 2006500864 A JP2006500864 A JP 2006500864A JP 2006500864 A JP2006500864 A JP 2006500864A JP 2006516195 A5 JP2006516195 A5 JP 2006516195A5
- Authority
- JP
- Japan
- Prior art keywords
- cell
- vector
- bacterial
- mammalian
- sequence
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 210000004027 cell Anatomy 0.000 claims 31
- 230000001580 bacterial effect Effects 0.000 claims 28
- 229920001184 polypeptide Polymers 0.000 claims 15
- 108090000765 processed proteins & peptides Proteins 0.000 claims 15
- 102000004196 processed proteins & peptides Human genes 0.000 claims 15
- 108010076504 Protein Sorting Signals Proteins 0.000 claims 12
- 239000000427 antigen Substances 0.000 claims 11
- 102000036639 antigens Human genes 0.000 claims 11
- 108091007433 antigens Proteins 0.000 claims 11
- 230000027455 binding Effects 0.000 claims 10
- 210000004962 mammalian cell Anatomy 0.000 claims 10
- 239000002773 nucleotide Substances 0.000 claims 9
- 125000003729 nucleotide group Chemical group 0.000 claims 9
- 108090000623 proteins and genes Proteins 0.000 claims 8
- 239000000203 mixture Substances 0.000 claims 7
- 230000004927 fusion Effects 0.000 claims 6
- 238000000034 method Methods 0.000 claims 5
- 241000588724 Escherichia coli Species 0.000 claims 4
- 239000003814 drug Substances 0.000 claims 4
- 230000028327 secretion Effects 0.000 claims 4
- 229940124597 therapeutic agent Drugs 0.000 claims 4
- 108091026890 Coding region Proteins 0.000 claims 2
- 108020004705 Codon Proteins 0.000 claims 2
- 108091006020 Fc-tagged proteins Proteins 0.000 claims 2
- 241000724791 Filamentous phage Species 0.000 claims 2
- 108700028146 Genetic Enhancer Elements Proteins 0.000 claims 2
- 108020005091 Replication Origin Proteins 0.000 claims 2
- 210000001322 periplasm Anatomy 0.000 claims 2
- 102000004169 proteins and genes Human genes 0.000 claims 2
- DLZKEQQWXODGGZ-KCJUWKMLSA-N 2-[[(2r)-2-[[(2s)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]propanoyl]amino]acetic acid Chemical compound OC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)CC1=CC=C(O)C=C1 DLZKEQQWXODGGZ-KCJUWKMLSA-N 0.000 claims 1
- 108010011170 Ala-Trp-Arg-His-Pro-Gln-Phe-Gly-Gly Proteins 0.000 claims 1
- 101100136076 Aspergillus oryzae (strain ATCC 42149 / RIB 40) pel1 gene Proteins 0.000 claims 1
- 108010001857 Cell Surface Receptors Proteins 0.000 claims 1
- 230000004568 DNA-binding Effects 0.000 claims 1
- HVLSXIKZNLPZJJ-TXZCQADKSA-N HA peptide Chemical compound C([C@@H](C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C(C)C)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H](C)C(O)=O)NC(=O)[C@H]1N(CCC1)C(=O)[C@@H](N)CC=1C=CC(O)=CC=1)C1=CC=C(O)C=C1 HVLSXIKZNLPZJJ-TXZCQADKSA-N 0.000 claims 1
- 108010093488 His-His-His-His-His-His Proteins 0.000 claims 1
- 102000001706 Immunoglobulin Fab Fragments Human genes 0.000 claims 1
- 108010054477 Immunoglobulin Fab Fragments Proteins 0.000 claims 1
- 241001529936 Murinae Species 0.000 claims 1
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 1
- 108091000080 Phosphotransferase Proteins 0.000 claims 1
- 206010035226 Plasma cell myeloma Diseases 0.000 claims 1
- 108091023040 Transcription factor Proteins 0.000 claims 1
- 102000040945 Transcription factor Human genes 0.000 claims 1
- 239000007801 affinity label Substances 0.000 claims 1
- 210000004102 animal cell Anatomy 0.000 claims 1
- 210000004978 chinese hamster ovary cell Anatomy 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 230000002255 enzymatic effect Effects 0.000 claims 1
- 210000005260 human cell Anatomy 0.000 claims 1
- 102000006240 membrane receptors Human genes 0.000 claims 1
- 201000000050 myeloid neoplasm Diseases 0.000 claims 1
- 108700026679 orbivirus VP7 Proteins 0.000 claims 1
- 101150040383 pel2 gene Proteins 0.000 claims 1
- 101150050446 pelB gene Proteins 0.000 claims 1
- 102000020233 phosphotransferase Human genes 0.000 claims 1
- 229920002704 polyhistidine Polymers 0.000 claims 1
- 230000004850 protein–protein interaction Effects 0.000 claims 1
- 102000005962 receptors Human genes 0.000 claims 1
- 230000010076 replication Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US43949203P | 2003-01-09 | 2003-01-09 | |
| US60/439,492 | 2003-01-09 | ||
| PCT/US2004/000462 WO2004063343A2 (en) | 2003-01-09 | 2004-01-08 | Dual expression vector system for antibody expression in bacterial and mammalian cells |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2006516195A JP2006516195A (ja) | 2006-06-29 |
| JP2006516195A5 true JP2006516195A5 (enExample) | 2007-02-22 |
| JP4773947B2 JP4773947B2 (ja) | 2011-09-14 |
Family
ID=32713489
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006500864A Expired - Fee Related JP4773947B2 (ja) | 2003-01-09 | 2004-01-08 | 細菌細胞及び哺乳動物細胞における抗体発現のための二重発現ベクター系 |
Country Status (8)
| Country | Link |
|---|---|
| US (3) | US7112439B2 (enExample) |
| EP (1) | EP1588166A4 (enExample) |
| JP (1) | JP4773947B2 (enExample) |
| AU (1) | AU2004204462B2 (enExample) |
| BR (1) | BRPI0406662A (enExample) |
| CA (1) | CA2513025A1 (enExample) |
| IL (1) | IL169604A (enExample) |
| WO (1) | WO2004063343A2 (enExample) |
Families Citing this family (48)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1495055B1 (en) * | 2002-04-18 | 2013-08-14 | Genencor International, Inc. | Production of functional antibodies in filamentous fungi |
| US20040067532A1 (en) | 2002-08-12 | 2004-04-08 | Genetastix Corporation | High throughput generation and affinity maturation of humanized antibody |
| JP4773947B2 (ja) * | 2003-01-09 | 2011-09-14 | マクロジェニクス，インコーポレーテッド | 細菌細胞及び哺乳動物細胞における抗体発現のための二重発現ベクター系 |
| WO2006028480A1 (en) * | 2004-09-07 | 2006-03-16 | Clonex Development, Inc. | Cell lines for use in increasing protein yield form a cell culture |
| SG149071A1 (en) * | 2004-12-07 | 2009-01-29 | Lonza Ag | Rhamnose promoter expression system |
| CA2606576A1 (en) | 2005-05-20 | 2006-11-23 | Lonza Biologics Plc. | High-level expression of recombinant antibody in a mammalian host cell |
| DK2061891T3 (da) * | 2006-08-24 | 2012-07-23 | Virovek Inc | Ekspression i insektceller af gener med overlappende åbne læserammer, fremgangsmåder og sammensætninger hertil |
| EP2078075B1 (en) | 2006-10-30 | 2015-09-02 | Eli Lilly and Company | Random homozygous gene perturbation to enhance antibody production |
| US8877688B2 (en) | 2007-09-14 | 2014-11-04 | Adimab, Llc | Rationally designed, synthetic antibody libraries and uses therefor |
| CA2697193C (en) | 2007-09-14 | 2017-06-06 | Adimab, Inc. | Rationally designed, synthetic antibody libraries and uses therefor |
| CN102089324B (zh) | 2007-11-12 | 2014-04-16 | 特罗科隆科学有限公司 | 用于对流行性感冒进行治疗以及诊断的组合物以及方法 |
| US20110033476A1 (en) * | 2007-11-12 | 2011-02-10 | Theraclone Sciences Inc. | Compositions and methods for the therapy and diagnosis of influenza |
| US20090162845A1 (en) * | 2007-12-20 | 2009-06-25 | Elazar Rabbani | Affinity tag nucleic acid and protein compositions, and processes for using same |
| JP5785490B2 (ja) | 2008-04-02 | 2015-09-30 | マクロジェニクス，インコーポレーテッド | Ｂｃｒ複合体特異的抗体およびその使用方法 |
| SG189730A1 (en) | 2008-04-02 | 2013-05-31 | Macrogenics Inc | Her2/neu-specific antibodies and methods of using same |
| ES2675730T3 (es) | 2008-06-04 | 2018-07-12 | Macrogenics, Inc. | Anticuerpos con unión alterada a FcRn y métodos de uso de los mismos |
| US8546307B2 (en) | 2008-10-03 | 2013-10-01 | Xoma Technology, Ltd. | Triple tag sequence and methods of use thereof |
| WO2010096394A2 (en) | 2009-02-17 | 2010-08-26 | Redwood Biosciences, Inc. | Aldehyde-tagged protein-based drug carriers and methods of use |
| SI3260136T1 (sl) | 2009-03-17 | 2021-05-31 | Theraclone Sciences, Inc. | Humani imunodeficientni virus (HIV)-nevtralizirajoča protitelesa |
| US8609101B2 (en) * | 2009-04-23 | 2013-12-17 | Theraclone Sciences, Inc. | Granulocyte-macrophage colony-stimulating factor (GM-CSF) neutralizing antibodies |
| EP2432803A2 (en) | 2009-05-20 | 2012-03-28 | Theraclone Sciences, Inc. | Compositions and methods for the therapy and diagnosis of influenza |
| CA2765418A1 (en) * | 2009-06-26 | 2010-12-29 | Five Prime Therapeutics, Inc. | Therapeutic antibody target validation and screening in vivo |
| AU2011289275A1 (en) | 2010-08-12 | 2013-02-21 | Theraclone Sciences, Inc. | Anti-hemagglutinin antibody compositions and methods of use thereof |
| EP2611465A4 (en) | 2010-08-31 | 2014-06-04 | Theraclone Sciences Inc | ANTIBODIES FOR NEUTRALIZING THE HUMAN IMMUNODICITY VIRUS (HIV) |
| US9540438B2 (en) | 2011-01-14 | 2017-01-10 | Redwood Bioscience, Inc. | Aldehyde-tagged immunoglobulin polypeptides and methods of use thereof |
| CA2827301A1 (en) | 2011-02-14 | 2012-08-23 | Theraclone Sciences, Inc. | Compositions and methods for the therapy and diagnosis of influenza |
| AU2012229188A1 (en) | 2011-03-15 | 2013-09-26 | Theraclone Sciences, Inc. | Compositions and methods for the therapy and diagnosis of influenza |
| WO2013033069A1 (en) | 2011-08-30 | 2013-03-07 | Theraclone Sciences, Inc. | Human rhinovirus (hrv) antibodies |
| SG11201404991YA (en) | 2012-02-23 | 2014-09-26 | Stage Cell Therapeutics Gmbh | Chromatographic isolation of cells and other complex biological materials |
| CN104428416B (zh) | 2012-07-05 | 2019-01-29 | 弗·哈夫曼-拉罗切有限公司 | 表达和分泌系统 |
| WO2014100073A2 (en) * | 2012-12-21 | 2014-06-26 | Merck Sharp & Dohme Corp. | Expression vectors for recombinant protein production in mammalian cells |
| JP6554473B2 (ja) | 2013-12-24 | 2019-07-31 | アルゲン−エックス ビーブイビーエー | ＦｃＲｎアンタゴニスト及び使用方法 |
| HRP20192243T1 (hr) * | 2014-07-03 | 2020-03-06 | F. Hoffmann - La Roche Ag | Polipeptidni ekspresijski sustavi |
| TWI870335B (zh) | 2015-06-12 | 2025-01-21 | 美商宏觀基因股份有限公司 | 變異的嵌合4d5抗體及其與抗pd-1抗體聯合用於治療癌症的應用 |
| EP3307786B1 (en) | 2015-06-12 | 2020-08-05 | AxioMx, Inc. | Methods and compositions for producing a chimeric polypeptide |
| MA45489A (fr) | 2015-10-22 | 2018-08-29 | Juno Therapeutics Gmbh | Procédés de culture de cellules, kits et appareil associés |
| KR20180108567A (ko) | 2015-10-22 | 2018-10-04 | 주노 테라퓨틱스 게엠베하 | 형질도입을 위한 방법, 키트, 제제 및 장치 |
| JP2019515677A (ja) | 2016-04-26 | 2019-06-13 | アール．ピー．シェーラー テクノロジーズ エルエルシー | 抗体複合体ならびにそれを作製および使用する方法 |
| GB201617270D0 (en) | 2016-10-11 | 2016-11-23 | Argen-X N V And Fairjourney Biologics | Triple vector for expressing antibody molecules in full therapeutic format |
| IL270142B2 (en) | 2017-04-27 | 2025-05-01 | Juno Therapeutics Gmbh | Oligomeric particle reagents and methods of use thereof |
| KR20200096786A (ko) | 2017-12-08 | 2020-08-13 | 아르제넥스 비브이비에이 | 전신 중증 근무력증의 치료를 위한 FcRn 길항제의 용도 |
| AU2018383600B2 (en) | 2017-12-11 | 2025-10-02 | Abalone Bio, Inc. | Yeast display of proteins in the periplasmic space |
| US12202900B2 (en) | 2018-06-08 | 2025-01-21 | argenx BV | Compositions and methods for treating immune thrombocytopenia |
| JP7565951B2 (ja) | 2019-06-07 | 2024-10-11 | アルジェニクス ビーブイ | 皮下投与に好適なＦｃＲｎインヒビターの医薬製剤 |
| BR112022000876A2 (pt) | 2019-07-19 | 2022-04-26 | Oncoresponse Inc | Anticorpos imunomoduladores e métodos de uso destes |
| CA3163172A1 (en) | 2020-01-08 | 2021-07-15 | Peter Verheesen | Methods for treating pemphigus disorders |
| US20240092926A1 (en) | 2021-01-20 | 2024-03-21 | Oncoresponse, Inc. | Immunomodulatory antibodies and uses thereof |
| CN119630697A (zh) | 2022-06-15 | 2025-03-14 | 阿根思有限公司 | Ph依赖性hsa结合分子及使用方法 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4816567A (en) * | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| US4703004A (en) * | 1984-01-24 | 1987-10-27 | Immunex Corporation | Synthesis of protein with an identification peptide |
| US5807715A (en) * | 1984-08-27 | 1998-09-15 | The Board Of Trustees Of The Leland Stanford Junior University | Methods and transformed mammalian lymphocyte cells for producing functional antigen-binding protein including chimeric immunoglobulin |
| DE4237113B4 (de) * | 1992-11-03 | 2006-10-12 | "Iba Gmbh" | Peptide und deren Fusionsproteine, Expressionsvektor und Verfahren zur Herstellung eines Fusionsproteins |
| US6627436B2 (en) * | 1997-10-31 | 2003-09-30 | Stratagene | Vector for gene expression in prokaryotic and eukaryotic systems |
| EP1133523A1 (en) * | 1998-11-16 | 2001-09-19 | Genway Biotech, Inc. | Generation of antibodies using polynucleotide vaccination in avian species |
| US7244592B2 (en) * | 2002-03-07 | 2007-07-17 | Dyax Corp. | Ligand screening and discovery |
| JP4773947B2 (ja) * | 2003-01-09 | 2011-09-14 | マクロジェニクス，インコーポレーテッド | 細菌細胞及び哺乳動物細胞における抗体発現のための二重発現ベクター系 |
-
2004
- 2004-01-08 JP JP2006500864A patent/JP4773947B2/ja not_active Expired - Fee Related
- 2004-01-08 BR BR0406662-6A patent/BRPI0406662A/pt not_active IP Right Cessation
- 2004-01-08 AU AU2004204462A patent/AU2004204462B2/en not_active Expired - Fee Related
- 2004-01-08 WO PCT/US2004/000462 patent/WO2004063343A2/en not_active Ceased
- 2004-01-08 EP EP04700895A patent/EP1588166A4/en not_active Withdrawn
- 2004-01-08 CA CA002513025A patent/CA2513025A1/en not_active Abandoned
- 2004-01-08 US US10/753,309 patent/US7112439B2/en not_active Expired - Lifetime
-
2005
- 2005-07-07 IL IL169604A patent/IL169604A/en not_active IP Right Cessation
-
2006
- 2006-08-10 US US11/503,399 patent/US7906327B2/en not_active Expired - Fee Related
-
2011
- 2011-01-26 US US13/014,422 patent/US20110136689A1/en not_active Abandoned
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