|
US7569342B2
(en)
|
1997-12-10 |
2009-08-04 |
Sierra Molecular Corp. |
Removal of molecular assay interferences
|
|
IL146508A0
(en)
|
1999-06-01 |
2002-07-25 |
Biogen Inc |
A blocking monoclonal antibody to vla-1 and its use for the treatment of inflammatory disorders
|
|
GEP20074252B
(en)
|
2001-04-13 |
2007-12-10 |
Biogen Idec Inc |
Antibodies to vla-1
|
|
US7591994B2
(en)
|
2002-12-13 |
2009-09-22 |
Immunomedics, Inc. |
Camptothecin-binding moiety conjugates
|
|
US8877901B2
(en)
|
2002-12-13 |
2014-11-04 |
Immunomedics, Inc. |
Camptothecin-binding moiety conjugates
|
|
US20160279239A1
(en)
|
2011-05-02 |
2016-09-29 |
Immunomedics, Inc. |
Subcutaneous administration of anti-cd74 antibody for systemic lupus erythematosus and autoimmune disease
|
|
CA2494310A1
(en)
*
|
2002-08-01 |
2004-02-12 |
Immunomedics, Inc. |
Alpha-fetoprotein immu31 antibodies and fusion proteins and methods of use thereof
|
|
US8946387B2
(en)
|
2002-08-14 |
2015-02-03 |
Macrogenics, Inc. |
FcγRIIB specific antibodies and methods of use thereof
|
|
US8044180B2
(en)
*
|
2002-08-14 |
2011-10-25 |
Macrogenics, Inc. |
FcγRIIB specific antibodies and methods of use thereof
|
|
US8193318B2
(en)
*
|
2002-08-14 |
2012-06-05 |
Macrogenics, Inc. |
FcγRIIB specific antibodies and methods of use thereof
|
|
ES2655912T3
(es)
*
|
2002-11-08 |
2018-02-22 |
Ablynx N.V. |
Anticuerpos de dominio simple dirigidos contra factor de necrosis tumoral-alfa y usos para los mismos
|
|
US20100003253A1
(en)
*
|
2002-11-08 |
2010-01-07 |
Ablynx N.V. |
Single domain antibodies directed against epidermal growth factor receptor and uses therefor
|
|
CA2505316C
(en)
*
|
2002-11-08 |
2014-08-05 |
Ablynx N.V. |
Single domain antibodies directed against tumour necrosis factor-alpha and uses therefor
|
|
WO2004041867A2
(en)
*
|
2002-11-08 |
2004-05-21 |
Ablynx N.V. |
Camelidae antibodies against imminoglobulin e and use thereof for the treatment of allergic disorders
|
|
US20060034845A1
(en)
|
2002-11-08 |
2006-02-16 |
Karen Silence |
Single domain antibodies directed against tumor necrosis factor alpha and uses therefor
|
|
WO2005044858A1
(en)
*
|
2003-11-07 |
2005-05-19 |
Ablynx N.V. |
Camelidae single domain antibodies vhh directed against epidermal growth factor receptor and uses therefor
|
|
US9320792B2
(en)
|
2002-11-08 |
2016-04-26 |
Ablynx N.V. |
Pulmonary administration of immunoglobulin single variable domains and constructs thereof
|
|
JP2006524039A
(ja)
|
2003-01-09 |
2006-10-26 |
マクロジェニクス,インコーポレーテッド |
変異型Fc領域を含む抗体の同定および作製ならびにその利用法
|
|
US7960512B2
(en)
|
2003-01-09 |
2011-06-14 |
Macrogenics, Inc. |
Identification and engineering of antibodies with variant Fc regions and methods of using same
|
|
WO2005016970A2
(en)
*
|
2003-05-01 |
2005-02-24 |
Imclone Systems Incorporated |
Fully human antibodies directed against the human insulin-like growth factor-1 receptor
|
|
CA2529027C
(en)
*
|
2003-06-13 |
2013-09-10 |
Immunomedics, Inc. |
D-amino acid peptides
|
|
WO2005080586A1
(en)
*
|
2004-02-13 |
2005-09-01 |
Immunomedics, Inc. |
Fusion proteins containing recombinant cytotoxic rnases
|
|
CN1961003B
(zh)
*
|
2004-03-31 |
2013-03-27 |
健泰科生物技术公司 |
人源化抗TGF-β抗体
|
|
US20050227289A1
(en)
*
|
2004-04-09 |
2005-10-13 |
Reilly Edward B |
Antibodies to erythropoietin receptor and uses thereof
|
|
WO2005110474A2
(en)
*
|
2004-05-10 |
2005-11-24 |
Macrogenics, Inc. |
HUMANIZED FcϜRIIB SPECIFIC ANTIBODIES AND METHODS OF USE THEREOF
|
|
EP1810035A4
(en)
*
|
2004-11-10 |
2010-03-17 |
Macrogenics Inc |
GENERATION OF FC ANTIBODY REGIONS FOR EFFECTOR FUNCTION
|
|
US20160355591A1
(en)
|
2011-05-02 |
2016-12-08 |
Immunomedics, Inc. |
Subcutaneous anti-hla-dr monoclonal antibody for treatment of hematologic malignancies
|
|
JP2006248978A
(ja)
|
2005-03-10 |
2006-09-21 |
Mebiopharm Co Ltd |
新規なリポソーム製剤
|
|
CA2612449A1
(en)
|
2005-06-17 |
2006-12-28 |
Imclone Systems Incorporated |
Receptor antagonists for treatment of metastatic bone cancer
|
|
HUE029465T2
(en)
*
|
2005-08-10 |
2017-02-28 |
Macrogenics Inc |
Identification and engineering of antibodies with variant Fc regions and methods of using same
|
|
JP5198289B2
(ja)
*
|
2006-02-03 |
2013-05-15 |
イムクローン・リミテッド・ライアビリティ・カンパニー |
前立腺癌の治療用アジュバントとしてのigf−irアンタゴニスト
|
|
CA2644903A1
(en)
*
|
2006-03-10 |
2007-09-20 |
Macrogenics, Inc. |
Identification and engineering of antibodies with variant heavy chains and methods of using same
|
|
MX2008014793A
(es)
*
|
2006-05-25 |
2008-12-02 |
Biogen Idec Inc |
Metodos para tratar la apoplejia.
|
|
US7786270B2
(en)
|
2006-05-26 |
2010-08-31 |
Macrogenics, Inc. |
Humanized FcγRIIB-specific antibodies and methods of use thereof
|
|
WO2008002933A2
(en)
|
2006-06-26 |
2008-01-03 |
Macrogenics, Inc. |
Combination of fcgammariib antibodies and cd20-specific antibodies and methods of use thereof
|
|
HUE030269T2
(en)
|
2006-06-26 |
2017-04-28 |
Macrogenics Inc |
FC RIIB-specific antibodies and methods for their use
|
|
US20080112961A1
(en)
*
|
2006-10-09 |
2008-05-15 |
Macrogenics, Inc. |
Identification and Engineering of Antibodies with Variant Fc Regions and Methods of Using Same
|
|
WO2008140603A2
(en)
|
2006-12-08 |
2008-11-20 |
Macrogenics, Inc. |
METHODS FOR THE TREATMENT OF DISEASE USING IMMUNOGLOBULINS HAVING FC REGIONS WITH ALTERED AFFINITIES FOR FCγR ACTIVATING AND FCγR INHIBITING
|
|
AU2009258063B2
(en)
*
|
2007-06-21 |
2014-09-25 |
Macrogenics, Inc. |
BCR-complex-specific antibodies and methods of using same
|
|
US20090074780A1
(en)
|
2007-06-25 |
2009-03-19 |
David Urech |
Methods of modifying antibodies, and modified antibodies with improved functional properties
|
|
CN107325182A
(zh)
|
2008-04-02 |
2017-11-07 |
宏观基因有限公司 |
HER2/neu‑特异性抗体和其使用方法
|
|
CA2739663A1
(en)
*
|
2008-10-10 |
2010-05-15 |
Anaphore, Inc. |
Polypeptides that bind trail-r1 and trail-r2
|
|
BRPI0919879A2
(pt)
|
2008-10-29 |
2016-02-16 |
Wyeth Llc |
métodos para purificação de moléculas de ligação a antígeno de domínio único
|
|
EP2362767B1
(en)
|
2008-10-29 |
2017-12-06 |
Ablynx N.V. |
Formulations of single domain antigen binding molecules
|
|
EP3912643B8
(en)
|
2009-02-13 |
2023-08-23 |
Immunomedics, Inc. |
Immunoconjugates with an intracellularly-cleavable linkage
|
|
BR112012003983A2
(pt)
*
|
2009-08-31 |
2021-09-14 |
Roche Glycart Ag |
Molecula de ligação abm moleculas de ligação de antigenos abm variante polipeptideo isolado molecula de ligação de antigeneos humanizada anticorpo polinucleotideo isolado composição vetor celula hospedeira metodo de produção de abm metodo de indução da lise celular de tumor, metodo de diagnostico de doença em pacientes que possuem um cancer metodo de aumento de tempo de sobrevivencia em pacientes que possuem um cancer metodo de indução em pacientes de regressão de um motor uso abm e invenção
|
|
EP3009455A1
(en)
|
2009-09-16 |
2016-04-20 |
Immunomedics Inc. |
Class i anti-cea antibodies and uses thereof
|
|
WO2011044368A1
(en)
|
2009-10-07 |
2011-04-14 |
Macrogenics, Inc. |
Fc region-containing polypeptides that exhibit improved effector function due to alterations of the extent of fucosylation, and methods for their use
|
|
US20110086806A1
(en)
*
|
2009-10-09 |
2011-04-14 |
Anaphore, Inc. |
Polypeptides that Bind IL-23R
|
|
ES2978177T3
(es)
|
2009-12-02 |
2024-09-06 |
Immunomedics Inc |
Combinación de radio inmunoterapia y conjugados anticuerpo-fármaco para mejorar la terapia contra el cáncer
|
|
PH12012501751A1
(en)
|
2010-03-04 |
2012-11-12 |
Macrogenics Inc |
Antibodies reactive with b7-h3, immunologically active fragments thereof and uses thereof
|
|
JP5998060B2
(ja)
|
2010-03-04 |
2016-09-28 |
マクロジェニクス,インコーポレーテッド |
B7−h3と反応性のある抗体、その免疫学的に活性なフラグメントおよびその使用
|
|
FR2960974B1
(fr)
|
2010-06-03 |
2016-12-30 |
Biosynex |
Procede de detection de rupture de membranes
|
|
CN103298489A
(zh)
*
|
2010-10-29 |
2013-09-11 |
伊缪诺金公司 |
新型egfr结合分子及其免疫偶联物
|
|
AU2012250924B2
(en)
|
2011-05-02 |
2017-05-25 |
Immunomedics, Inc. |
Ultrafiltration concentration of allotype selected antibodies for small-volume administration
|
|
CA2858315C
(en)
|
2011-12-13 |
2020-05-12 |
Engeneic Molecular Delivery Pty Ltd |
Bacterially derived, intact minicells for delivery of therapeutic agents to brain tumors
|
|
CN103215255B
(zh)
*
|
2012-01-19 |
2015-06-17 |
深圳华大基因科技有限公司 |
用于扩增免疫球蛋白轻链cdr3序列的引物集及其用途
|
|
CA2864539C
(en)
|
2012-02-16 |
2022-06-07 |
Santarus, Inc. |
Antibody formulations
|
|
AU2013302696B9
(en)
|
2012-08-14 |
2018-08-09 |
Ibc Pharmaceuticals, Inc. |
T-cell redirecting bispecific antibodies for treatment of disease
|
|
SI2900277T1
(sl)
|
2012-12-13 |
2022-05-31 |
Immunomedics, Inc. |
Odmerki imunokonjugatov protiteles in SN-38 za boljšo učinkovitost in zmanjšano toksičnost
|
|
US9487587B2
(en)
|
2013-03-05 |
2016-11-08 |
Macrogenics, Inc. |
Bispecific molecules that are immunoreactive with immune effector cells of a companion animal that express an activating receptor and cells that express B7-H3 and uses thereof
|
|
EP2774930A1
(en)
|
2013-03-07 |
2014-09-10 |
Aptenia S.R.L. |
Metallocene compounds and labeled molecules comprising the same for in vivo imaging.
|
|
EP3933384A1
(en)
|
2013-03-15 |
2022-01-05 |
Hycor Biomedical, LLC |
Device and associated method for performing luminescence and fluorescence measurements of a sample
|
|
WO2015126548A1
(en)
|
2014-02-21 |
2015-08-27 |
Ibc Pharmaceuticals, Inc. |
Disease therapy by inducing immune response to trop-2 expressing cells
|
|
US9139649B2
(en)
|
2014-02-25 |
2015-09-22 |
Immunomedics, Inc. |
Humanized anti-CD22 antibody
|
|
IL292311A
(en)
|
2014-04-03 |
2022-06-01 |
Igm Biosciences Inc |
J-chain qualified
|
|
WO2015200260A1
(en)
|
2014-06-24 |
2015-12-30 |
Immunomedics, Inc. |
Anti-histone therapy for vascular necrosis in severe glomerulonephritis
|
|
WO2016037985A1
(en)
|
2014-09-08 |
2016-03-17 |
Ruprecht-Karls-Universität Heidelberg |
Construct for the delivery of a molecule into the cytoplasm of a cell
|
|
CN117138060A
(zh)
|
2014-10-07 |
2023-12-01 |
免疫医疗公司 |
抗体-药物缀合物的新辅助剂用途
|
|
AU2016243026B2
(en)
|
2015-04-03 |
2022-03-31 |
Eureka Therapeutics, Inc. |
Constructs targeting AFP peptide/MHC complexes and uses thereof
|
|
WO2016172427A1
(en)
|
2015-04-22 |
2016-10-27 |
Immunomedics, Inc. |
Isolation, detection, diagnosis and/or characterization of circulating trop-2-positive cancer cells
|
|
EP4257134A3
(en)
|
2015-06-25 |
2024-01-24 |
Immunomedics, Inc. |
Combining anti-hla-dr or anti-trop-2 antibodies with microtubule inhibitors, parp inhibitors, bruton kinase inhibitors or phosphoinositide 3-kinase inhibitors significantly improves therapeutic outcome in cancer
|
|
PL3316885T3
(pl)
|
2015-07-01 |
2021-12-06 |
Immunomedics, Inc. |
Immunokoniugaty przeciwciało-sn-38 z linkerem cl2a
|
|
EP3356401B1
(en)
|
2015-09-30 |
2020-06-24 |
IGM Biosciences, Inc. |
Binding molecules with modified j-chain
|
|
EP3824903A1
(en)
|
2015-09-30 |
2021-05-26 |
IGM Biosciences Inc. |
Binding molecules with modified j-chain
|
|
CN106810609A
(zh)
*
|
2015-11-27 |
2017-06-09 |
苏州君盟生物医药科技有限公司 |
抗pcsk9抗体及其应用
|
|
TWI781098B
(zh)
|
2016-04-15 |
2022-10-21 |
美商宏觀基因股份有限公司 |
新穎的b7-h3-結合分子、其抗體藥物綴合物及其使用方法
|
|
WO2018187074A1
(en)
|
2017-04-03 |
2018-10-11 |
Immunomedics, Inc. |
Subcutaneous administration of antibody-drug conjugates for cancer therapy
|
|
CN111295394B
(zh)
|
2017-08-11 |
2024-06-11 |
豪夫迈·罗氏有限公司 |
抗cd8抗体及其用途
|
|
WO2020064847A1
(en)
|
2018-09-26 |
2020-04-02 |
Ascendis Pharma A/S |
Degradable hyaluronic acid hydrogels
|
|
CN110865416A
(zh)
*
|
2019-11-15 |
2020-03-06 |
南华大学 |
一种放射性胁迫下的植物生化指征测量方法
|
|
EP4178624A2
(en)
|
2020-07-07 |
2023-05-17 |
Bionecure Therapeutics, Inc. |
Maytansinoids as adc payloads and their use for the treatment of cancer
|
|
EP4178530A1
(en)
|
2020-07-09 |
2023-05-17 |
F. Hoffmann-La Roche AG |
Concentrated compositions of proteins, their preparation and use thereof
|
|
US20250073349A1
(en)
|
2021-05-10 |
2025-03-06 |
Kawasaki Institute Of Industrial Promotion |
Antibody having reduced binding affinity for antigen
|
|
CN113416729B
(zh)
*
|
2021-05-18 |
2022-11-22 |
遵义医科大学附属医院 |
一种肝脏靶向调控甲胎蛋白基因的shRNA和cDNA及其应用
|
|
US20240279318A1
(en)
*
|
2021-05-31 |
2024-08-22 |
Nanjing Legend Biotech Co., Ltd. |
Antibodies targeting afp peptide/mhc complexes and uses thereof
|
|
EP4385522A1
(en)
|
2021-08-13 |
2024-06-19 |
Kunshan Xinyunda Biotech Co., Ltd. |
Microtubule inhibitor-based antibody-drug conjugate
|
|
CN116120455B
(zh)
*
|
2021-08-23 |
2023-11-07 |
东莞市朋志生物科技有限公司 |
一种抗ca15-3蛋白的重组抗体
|
|
CN117881431A
(zh)
|
2021-08-24 |
2024-04-12 |
昆山新蕴达生物科技有限公司 |
一种由可断裂连接子偶联的抗体偶联药物
|
|
CN118541392A
(zh)
|
2021-09-28 |
2024-08-23 |
准星生物医药有限公司 |
多种形式的分子复合物
|
|
CN118401258A
(zh)
|
2021-12-09 |
2024-07-26 |
昆山新蕴达生物科技有限公司 |
一种亲和力改善的抗体-药物偶联物、其制备方法及应用
|
|
IL318865A
(en)
|
2022-08-10 |
2025-04-01 |
Kowa Co |
New drug complex
|
|
PE20260306A1
(es)
|
2023-06-12 |
2026-02-11 |
Amgen Inc |
Proteinas de union a receptor de linfotoxina beta agonistas
|
|
EP4731758A2
(en)
*
|
2023-06-20 |
2026-04-29 |
The Methodist Hospital |
Antigen-specific t cell receptors and chimeric antigen receptors, and methods of use in immune signaling modulation for cancer immunotherapy
|
|
WO2025149667A1
(en)
|
2024-01-12 |
2025-07-17 |
Pheon Therapeutics Ltd |
Antibody drug conjugates and uses thereof
|