JP2006514991A5 - - Google Patents
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- Publication number
- JP2006514991A5 JP2006514991A5 JP2005509699A JP2005509699A JP2006514991A5 JP 2006514991 A5 JP2006514991 A5 JP 2006514991A5 JP 2005509699 A JP2005509699 A JP 2005509699A JP 2005509699 A JP2005509699 A JP 2005509699A JP 2006514991 A5 JP2006514991 A5 JP 2006514991A5
- Authority
- JP
- Japan
- Prior art keywords
- retinoic acid
- compound
- cis
- cra
- general formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP02090431 | 2002-12-27 | ||
| EP03090061 | 2003-03-12 | ||
| PCT/EP2003/014071 WO2004058234A2 (en) | 2002-12-27 | 2003-12-11 | Pharmaceutical combinations of phthalazine vegf inhibitors and benzamide hdac inhibitors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2006514991A JP2006514991A (ja) | 2006-05-18 |
| JP2006514991A5 true JP2006514991A5 (https=) | 2006-12-07 |
Family
ID=32683819
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2005509699A Pending JP2006514991A (ja) | 2002-12-27 | 2003-12-11 | 新規医薬組合せ |
Country Status (4)
| Country | Link |
|---|---|
| EP (2) | EP1641458A2 (https=) |
| JP (1) | JP2006514991A (https=) |
| AU (1) | AU2003292888A1 (https=) |
| WO (1) | WO2004058234A2 (https=) |
Families Citing this family (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6897220B2 (en) | 2001-09-14 | 2005-05-24 | Methylgene, Inc. | Inhibitors of histone deacetylase |
| EP1429765A2 (en) | 2001-09-14 | 2004-06-23 | Methylgene, Inc. | Inhibitors of histone deacetylase |
| US7868204B2 (en) | 2001-09-14 | 2011-01-11 | Methylgene Inc. | Inhibitors of histone deacetylase |
| CA2531485C (en) * | 2003-07-07 | 2013-03-26 | Merck Patent Gmbh | Malonamide derivatives |
| KR101153335B1 (ko) | 2003-09-24 | 2012-07-05 | 메틸진 인코포레이티드 | 히스톤 데아세틸라제의 억제제 |
| US7253204B2 (en) | 2004-03-26 | 2007-08-07 | Methylgene Inc. | Inhibitors of histone deacetylase |
| SE0401790D0 (sv) * | 2004-07-07 | 2004-07-07 | Forskarpatent I Syd Ab | Tamoxifen response in pre- and postmenopausal breast cancer patients |
| JP2008524246A (ja) * | 2004-12-16 | 2008-07-10 | タケダ サン ディエゴ インコーポレイテッド | ヒストンデアセチラーゼ阻害剤 |
| AU2006240246A1 (en) | 2005-04-20 | 2006-11-02 | Merck Sharp & Dohme Corp. | Benzothiophene hydroxamic acid derivatives with carbamate, urea, amide and sulfonamide substitutions |
| CA2605110A1 (en) | 2005-04-20 | 2006-11-02 | Merck & Co., Inc. | Benzothiophene derivatives |
| AU2006240248A1 (en) | 2005-04-20 | 2006-11-02 | Merck Sharp & Dohme Corp. | Benzothiophene hydroxamic acid derivatives |
| US7642253B2 (en) | 2005-05-11 | 2010-01-05 | Takeda San Diego, Inc. | Histone deacetylase inhibitors |
| JP2008546793A (ja) | 2005-06-24 | 2008-12-25 | メルク エンド カムパニー インコーポレーテッド | 修飾マロン酸誘導体 |
| EA200800321A1 (ru) * | 2005-07-14 | 2008-06-30 | Такеда Сан Диего, Инк. | Ингибиторы гистондеацетилазы |
| AR057579A1 (es) | 2005-11-23 | 2007-12-05 | Merck & Co Inc | Compuestos espirociclicos como inhibidores de histona de acetilasa (hdac) |
| JP2009120486A (ja) * | 2005-12-05 | 2009-06-04 | Mitsubishi Pharma Corp | 核内オーファン受容体の新規活性化剤及びその用途 |
| JP2009528354A (ja) | 2006-02-28 | 2009-08-06 | メルク エンド カムパニー インコーポレーテッド | ヒストン脱アセチル化酵素のインヒビター |
| KR101495611B1 (ko) | 2006-04-07 | 2015-02-25 | 메틸진 인코포레이티드 | 히스톤 데아세틸라아제의 억제제 |
| CA2649861A1 (en) | 2006-04-26 | 2007-11-08 | Merck & Co., Inc. | Disubstituted aniline compounds |
| CA2651681A1 (en) | 2006-05-18 | 2007-11-29 | Merck & Co., Inc. | Aryl-fused spirocyclic compounds |
| EP2049124A4 (en) | 2006-07-20 | 2010-02-10 | Merck & Co Inc | PHOSPHOR DERIVATIVES AS HISTONDEACETYLASE HEMMER |
| WO2009005638A2 (en) | 2007-06-27 | 2009-01-08 | Merck & Co., Inc. | Pyridyl and pyrimidinyl derivatives as histone deacetylase inhibitors |
| EP3103791B1 (en) | 2007-06-27 | 2018-01-31 | Merck Sharp & Dohme Corp. | 4-carboxybenzylamino derivatives as histone deacetylase inhibitors |
| EP2060565A1 (en) | 2007-11-16 | 2009-05-20 | 4Sc Ag | Novel bifunctional compounds which inhibit protein kinases and histone deacetylases |
| EP2330894B8 (en) | 2008-09-03 | 2017-04-19 | BioMarin Pharmaceutical Inc. | Compositions including 6-aminohexanoic acid derivatives as hdac inhibitors |
| US8716326B2 (en) * | 2009-05-15 | 2014-05-06 | Korea Research Institute Of Chemical Technology | Isoindolinone derivatives, preparation method thereof and a pharmaceutical composition comprising same |
| US8912184B1 (en) | 2010-03-01 | 2014-12-16 | Alzheimer's Institute Of America, Inc. | Therapeutic and diagnostic methods |
| US10059723B2 (en) | 2011-02-28 | 2018-08-28 | Biomarin Pharmaceutical Inc. | Histone deacetylase inhibitors |
| US9540395B2 (en) | 2011-02-28 | 2017-01-10 | Biomarin Pharmaceutical Inc. | Histone deacetylase inhibitors |
| US8957066B2 (en) | 2011-02-28 | 2015-02-17 | Biomarin Pharmaceutical Inc. | Histone deacetylase inhibitors |
| WO2014160221A1 (en) | 2013-03-13 | 2014-10-02 | The General Hospital Corporation | Photoswitchable hdac inhibitors |
| WO2014143666A1 (en) | 2013-03-15 | 2014-09-18 | Biomarin Pharmaceutical Inc. | Hdac inhibitors |
| TWI635077B (zh) * | 2016-08-11 | 2018-09-11 | 行政院原子能委員會核能研究所 | 針對腫瘤診斷與治療之組織蛋白去乙醯酶抑制劑（ＨＤＡＣｉ）ＰＥＴ造影化合物與類似物，及其製造方法 |
| US11208382B2 (en) * | 2017-07-28 | 2021-12-28 | Hangzhou Solipharma Co., Ltd. | Entinostat-containing compound, crystal form of compound thereof, and preparation method therefor and pharmaceutical composition thereof |
| KR102831570B1 (ko) | 2018-05-04 | 2025-07-10 | 레미디 플랜, 인크. | 암 줄기 세포를 표적화하는 암 치료 |
| EP3982968A4 (en) * | 2019-06-13 | 2023-07-05 | Dana-Farber Cancer Institute, Inc. | DEVELOPMENT OF HDAC3 CATALYTIC INHIBITOR AND USES THEREOF |
| JP7748392B2 (ja) | 2020-04-30 | 2025-10-02 | グレート ノベル セラピューティクス バイオテック アンド メディカルズ コーポレイション | 腫瘍微小環境における免疫調節のためのヒストンデアセチラーゼ阻害剤 |
| CN114957132A (zh) * | 2021-02-20 | 2022-08-30 | 中国科学院上海药物研究所 | 含s构型的氨基苯甲酰胺基哒嗪酮类化合物、其制备方法、药物组合物及应用 |
| CN113200908B (zh) * | 2021-04-09 | 2022-07-19 | 南华大学 | 一种含叔胺的邻氨基苯甲酰胺类化合物及其制备与应用 |
| CN115703736B (zh) * | 2021-08-04 | 2025-05-16 | 中国海洋大学 | 靶向于hdac和nad合成的多靶点抑制剂及其用途 |
| KR102743956B1 (ko) * | 2021-10-08 | 2024-12-17 | 아주대학교산학협력단 | 히스톤 탈아세틸화효소 억제제를 포함하는 대사성 질환의 예방, 개선 또는 치료용 조성물 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU555658B2 (en) | 1981-04-03 | 1986-10-02 | Eli Lilly And Company | Benzothiophene compounds |
| DE3121152A1 (de) | 1981-05-22 | 1982-12-09 | Schering Ag, 1000 Berlin Und 4619 Bergkamen | "verwendung der kombination eines aromatase-hemmers mit einem antiandrogen zur prophylaxe und therapie der prostatahyperplasie" |
| US5053405A (en) | 1990-06-21 | 1991-10-01 | Sterling Drug Inc. | Antiandrogenic sulfonylsteroidothiazoles |
| SE9300971D0 (sv) * | 1993-03-24 | 1993-03-24 | Jan Wadstein | Hudvaardskomposition |
| US6174905B1 (en) * | 1996-09-30 | 2001-01-16 | Mitsui Chemicals, Inc. | Cell differentiation inducer |
| CO4950519A1 (es) * | 1997-02-13 | 2000-09-01 | Novartis Ag | Ftalazinas, preparaciones farmaceuticas que las comprenden y proceso para su preparacion |
| GB0111078D0 (en) * | 2001-05-04 | 2001-06-27 | Novartis Ag | Organic compounds |
| DE60231068D1 (de) * | 2001-09-12 | 2009-03-19 | Novartis Ag | Die Verwendung von 4-Pyridylmethylphthalazinen zur Behandlung von Nierentumoren |
| JP4130179B2 (ja) * | 2001-09-27 | 2008-08-06 | ノバルティス アクチエンゲゼルシャフト | 骨髄腫を処置するためのｃ−ｋｉｔ阻害剤の使用 |
| MXPA04005561A (es) * | 2001-12-21 | 2004-12-06 | Bayer Pharmaceuticals Corp | Terapias de combinacion anti-angiogenesis que comprenden derivados de piridazina o piridina. |
-
2003
- 2003-12-11 AU AU2003292888A patent/AU2003292888A1/en not_active Abandoned
- 2003-12-11 EP EP03782372A patent/EP1641458A2/en not_active Withdrawn
- 2003-12-11 WO PCT/EP2003/014071 patent/WO2004058234A2/en not_active Ceased
- 2003-12-11 EP EP06090154A patent/EP1738752A1/en not_active Withdrawn
- 2003-12-11 JP JP2005509699A patent/JP2006514991A/ja active Pending
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