JP2006510037A - 高速クロマトグラフィカラムフロー分配器 - Google Patents
高速クロマトグラフィカラムフロー分配器 Download PDFInfo
- Publication number
- JP2006510037A JP2006510037A JP2005518145A JP2005518145A JP2006510037A JP 2006510037 A JP2006510037 A JP 2006510037A JP 2005518145 A JP2005518145 A JP 2005518145A JP 2005518145 A JP2005518145 A JP 2005518145A JP 2006510037 A JP2006510037 A JP 2006510037A
- Authority
- JP
- Japan
- Prior art keywords
- flow distributor
- flow
- distributor
- ribs
- column
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/10—Selective adsorption, e.g. chromatography characterised by constructional or operational features
- B01D15/14—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to the introduction of the feed to the apparatus
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/60—Construction of the column
- G01N30/6004—Construction of the column end pieces
- G01N30/6017—Fluid distributors
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/60—Construction of the column
- G01N30/6004—Construction of the column end pieces
- G01N30/6026—Fluid seals
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- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Physics & Mathematics (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Treatment Of Liquids With Adsorbents In General (AREA)
- Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
Abstract
Description
Claims (10)
- 上面および底面と、貫通する入口と、ベッド支持体が固定される底面とを有するフロー分配器を備えるクロマトグラフィカラム用のフロー分配器であって、底面が底面の中心部分から半径方向に外に向かって延びる1つまたは複数の一連のリブを有し、ベッド支持体がフロー分配器底面に近接してフロー分配器にその外周端部周囲で固定され、分配ディスクが入口の上に配置され、フロー分配器の底面積の約1〜約30%にわたって延在し、かつ入口の中心部分に最も近い1つまたは複数の一連のリブの内端部のちょうど手前で終端しており、リブと実質的に同じ高さになるようにディスクが2本以上の脚上に配置され、ディスクが目立った分離を生じさせることなく360°の半径方向に分配するように入口からの流体の流れを放出するフロー分配器。
- ベッド支持体を固定するのに用いられるフロー分配器の底面の表面積の大きさが約10%未満である請求項1に記載のフロー分配器。
- フロー分配器にわたってその完全性および標準的な流れを維持しながら、かつカラムにわたって低い圧力低下しか起こさないで、カラムが最大1500cm/時の速度で動作することをフロー分配器が可能にする請求項1に記載のフロー分配器。
- 有効フロー分配器表面積とその下にあるカラムベッドの全表面積との比が少なくとも0.9%、好適には少なくとも約0.9〜約0.95%である請求項1に記載のフロー分配器。
- ディスクが底面の全表面積の約1%〜約4%である請求項1に記載のフロー分配器。
- ディスクが底面の全表面積の約2%〜約3%である請求項1に記載のフロー分配器。
- ディスクが底面の全表面積の約2.4%である請求項1に記載のフロー分配器。
- 1つまたは複数の一連のリブが表面の中心部に最も近い先端を有し、かつ先端が表面の中心から表面の半径の約19%の距離だけ離間している請求項1に記載のフロー分配器。
- 1つまたは複数の一連のリブが表面の中心部に最も近い先端を有し、かつ先端が表面の中心から表面の半径の約10%〜約30%の距離だけ離間している請求項1に記載のフロー分配器。
- 1つまたは複数の一連のリブが表面の中心部に最も近い先端を有し、かつ先端が表面の中心から表面の半径の約16%〜約22%の距離だけ離間している請求項1に記載のフロー分配器。
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US45672003P | 2003-03-21 | 2003-03-21 | |
PCT/US2004/004587 WO2004095019A1 (en) | 2003-03-21 | 2004-02-17 | High velocity chromatography column flow distributor |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2006510037A true JP2006510037A (ja) | 2006-03-23 |
JP4166789B2 JP4166789B2 (ja) | 2008-10-15 |
Family
ID=33310662
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2005518145A Expired - Fee Related JP4166789B2 (ja) | 2003-03-21 | 2004-02-17 | 高速クロマトグラフィカラムフロー分配器 |
Country Status (7)
Country | Link |
---|---|
US (1) | US6942794B2 (ja) |
EP (1) | EP1606615B1 (ja) |
JP (1) | JP4166789B2 (ja) |
AT (1) | ATE337548T1 (ja) |
DE (1) | DE602004002102T2 (ja) |
ES (1) | ES2267052T3 (ja) |
WO (1) | WO2004095019A1 (ja) |
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2012501439A (ja) * | 2008-08-27 | 2012-01-19 | ジーイー・ヘルスケア・バイオサイエンス・バイオプロセス・コーポレイション | クロマトグラフィーカラム用のベッド支持体の製造システム及び方法 |
JP2013011601A (ja) * | 2011-06-29 | 2013-01-17 | Agilent Technologies Inc | 液体クロマトグラフィ用の微細加工されたフリットおよび流れ分配デバイス |
JP2013522591A (ja) * | 2010-03-12 | 2013-06-13 | ジーイー・ヘルスケア・バイオサイエンス・アクチボラグ | プラスチックメッシュ用固定具を備えるクロマトグラフィーカラムアセンブリ |
KR20140008340A (ko) * | 2011-02-02 | 2014-01-21 | 에프. 호프만-라 로슈 아게 | 크로마토그래피 칼럼 지지체 |
JP2015034816A (ja) * | 2013-08-07 | 2015-02-19 | ポール・コーポレーションPallCorporation | クロマトグラフィーカラム |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB0322144D0 (en) | 2003-09-23 | 2003-10-22 | Amersham Biosciences Ab | Chromatography column distribution system |
US7588683B2 (en) | 2005-08-03 | 2009-09-15 | Agilent Technologies, Inc. | Column for liquid chromatography with adjustable compression |
KR101477871B1 (ko) | 2009-07-30 | 2014-12-30 | 에프. 호프만-라 로슈 아게 | 이동식 크로마토그래피 컬럼 세퍼레이터 |
ES2392973B1 (es) * | 2012-10-11 | 2013-11-26 | David TEIXIDO RAMIREZ | Trampa para insectos y procedimiento correspondiente. |
CN104436757B (zh) * | 2014-11-26 | 2017-10-27 | 源创精科生物科技(长沙)有限公司 | 压力耦合式层析柱流体分配器 |
EP4299156A1 (en) | 2022-06-29 | 2024-01-03 | Sartorius Stedim Biotech GmbH | Tangential flow filtration/chromatography systems, use thereof, and methods of separation |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS59199032A (ja) * | 1983-04-26 | 1984-11-12 | Asahi Chem Ind Co Ltd | 圧力吸収機構 |
US4582608A (en) * | 1985-02-15 | 1986-04-15 | Separations Technology, Inc. | HPLC column |
US4737292A (en) * | 1986-06-05 | 1988-04-12 | Separations Technology, Inc. | HPLC column and a column packing method |
US4894152A (en) * | 1987-08-13 | 1990-01-16 | Cerex Corporation | Fluid control device |
US4891133A (en) * | 1987-09-15 | 1990-01-02 | Cerex Corporation | Chromatography apparatus |
FR2632206B1 (fr) * | 1988-06-03 | 1990-10-26 | Kodak Pathe | Repartiteur de fluide, et dispositif de traitement de fluide, tel qu'un chromatographe, equipe d'un tel repartiteur |
GB2248097A (en) | 1990-09-19 | 1992-03-25 | Amicon Ltd | Piston for chromatography column |
GB2248027A (en) * | 1990-09-19 | 1992-03-25 | Amicon Ltd | End cell for chromatography column. |
US5324426A (en) * | 1992-03-20 | 1994-06-28 | Kontes Glass Corp. | Chromatography column |
US5423982A (en) * | 1994-05-31 | 1995-06-13 | Biosepra Inc. | Liquid chromatography column adapted for in situ chemical sterilization |
SE9702169D0 (sv) * | 1997-06-06 | 1997-06-06 | Pharmacia Biotech Ab | Chromatography column end arrangements |
US6139732A (en) | 1998-03-16 | 2000-10-31 | Hodge Bioseparation, Ltd. | Chromatography column |
-
2004
- 2004-02-17 US US10/779,995 patent/US6942794B2/en not_active Expired - Lifetime
- 2004-02-17 JP JP2005518145A patent/JP4166789B2/ja not_active Expired - Fee Related
- 2004-02-17 DE DE602004002102T patent/DE602004002102T2/de not_active Expired - Lifetime
- 2004-02-17 WO PCT/US2004/004587 patent/WO2004095019A1/en active IP Right Grant
- 2004-02-17 ES ES04711834T patent/ES2267052T3/es not_active Expired - Lifetime
- 2004-02-17 AT AT04711834T patent/ATE337548T1/de not_active IP Right Cessation
- 2004-02-17 EP EP04711834A patent/EP1606615B1/en not_active Expired - Lifetime
Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2012501439A (ja) * | 2008-08-27 | 2012-01-19 | ジーイー・ヘルスケア・バイオサイエンス・バイオプロセス・コーポレイション | クロマトグラフィーカラム用のベッド支持体の製造システム及び方法 |
JP2013522591A (ja) * | 2010-03-12 | 2013-06-13 | ジーイー・ヘルスケア・バイオサイエンス・アクチボラグ | プラスチックメッシュ用固定具を備えるクロマトグラフィーカラムアセンブリ |
KR20140008340A (ko) * | 2011-02-02 | 2014-01-21 | 에프. 호프만-라 로슈 아게 | 크로마토그래피 칼럼 지지체 |
KR101951965B1 (ko) | 2011-02-02 | 2019-02-25 | 에프. 호프만-라 로슈 아게 | 크로마토그래피 칼럼 지지체 |
JP2013011601A (ja) * | 2011-06-29 | 2013-01-17 | Agilent Technologies Inc | 液体クロマトグラフィ用の微細加工されたフリットおよび流れ分配デバイス |
JP2015034816A (ja) * | 2013-08-07 | 2015-02-19 | ポール・コーポレーションPallCorporation | クロマトグラフィーカラム |
Also Published As
Publication number | Publication date |
---|---|
US20040184957A1 (en) | 2004-09-23 |
ATE337548T1 (de) | 2006-09-15 |
WO2004095019A1 (en) | 2004-11-04 |
EP1606615A1 (en) | 2005-12-21 |
DE602004002102D1 (de) | 2006-10-05 |
JP4166789B2 (ja) | 2008-10-15 |
EP1606615B1 (en) | 2006-08-23 |
US6942794B2 (en) | 2005-09-13 |
ES2267052T3 (es) | 2007-03-01 |
WO2004095019A8 (en) | 2004-12-23 |
DE602004002102T2 (de) | 2007-03-15 |
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