JP2006508665A - 化学療法剤の活性を変化させるブチリルコリンエステラーゼ変異体 - Google Patents
化学療法剤の活性を変化させるブチリルコリンエステラーゼ変異体 Download PDFInfo
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- JP2006508665A JP2006508665A JP2004557611A JP2004557611A JP2006508665A JP 2006508665 A JP2006508665 A JP 2006508665A JP 2004557611 A JP2004557611 A JP 2004557611A JP 2004557611 A JP2004557611 A JP 2004557611A JP 2006508665 A JP2006508665 A JP 2006508665A
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- butyrylcholinesterase
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
- C12N9/18—Carboxylic ester hydrolases (3.1.1)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
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Applications Claiming Priority (2)
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| US31066602A | 2002-12-04 | 2002-12-04 | |
| PCT/US2003/038684 WO2004050041A2 (en) | 2002-12-04 | 2003-12-04 | Butyrylcholinesterase variants that alter the activity of chemotherapeutic agents |
Publications (2)
| Publication Number | Publication Date |
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| JP2006508665A true JP2006508665A (ja) | 2006-03-16 |
| JP2006508665A5 JP2006508665A5 (enExample) | 2007-02-01 |
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| JP2004557611A Pending JP2006508665A (ja) | 2002-12-04 | 2003-12-04 | 化学療法剤の活性を変化させるブチリルコリンエステラーゼ変異体 |
Country Status (9)
| Country | Link |
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| US (1) | US20080213281A1 (enExample) |
| EP (1) | EP1581253A4 (enExample) |
| JP (1) | JP2006508665A (enExample) |
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| AU (1) | AU2003298920A1 (enExample) |
| BR (1) | BR0316865A (enExample) |
| CA (1) | CA2507626A1 (enExample) |
| MX (1) | MXPA05005996A (enExample) |
| WO (1) | WO2004050041A2 (enExample) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6989261B2 (en) * | 2001-12-20 | 2006-01-24 | Eli Lilly And Company | Butyrylcholinesterase variant polypeptides with increased catalytic efficiency and methods of use |
| AR044388A1 (es) * | 2003-05-20 | 2005-09-07 | Applied Molecular Evolution | Moleculas de union a cd20 |
| EP2049661A4 (en) * | 2006-08-04 | 2012-07-04 | Pharmathene Inc | RECOMBINANT BUTYRYLCHOLINESTERASE WITH LONG HALF-LIFE |
| US20100008978A1 (en) * | 2008-05-09 | 2010-01-14 | The Regents Of The University Of California | Nanoparticles effective for internalization into cells |
| US20100009390A1 (en) * | 2008-05-09 | 2010-01-14 | The Regents Of The University Of California | Mutant antibodies with high affinity for egfr |
| KR20110008075A (ko) * | 2008-05-16 | 2011-01-25 | 넥타르 테라퓨틱스 | 콜린에스테라아제 부분 및 폴리머의 콘쥬게이트 |
| WO2011084145A2 (en) * | 2009-12-21 | 2011-07-14 | Pharmathene, Inc. | Recombinant butyrylcholinesterases and truncates thereof |
| CN103898101B (zh) * | 2012-12-27 | 2017-08-08 | 上海桀蒙生物技术有限公司 | 利用转基因动物乳腺生物平台大规模生产重组人丁酰胆碱酯酶的方法 |
| CN104630177A (zh) * | 2013-11-08 | 2015-05-20 | 中国农业大学 | 一种利用人丁酰胆碱酯酶迷你基因在乳腺中表达重组人丁酰胆碱脂酶的方法 |
| EP3137098A4 (en) | 2014-04-29 | 2017-11-01 | Mayo Foundation for Medical Education and Research | Butyrylcholinesterases having an enhanced ability to hydrolyze acyl ghrelin |
| WO2018053216A1 (en) * | 2016-09-15 | 2018-03-22 | Mayo Foundation For Medical Education And Research | Methods and materials for using butyrylcholinesterases to treat cancer |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2002518022A (ja) * | 1998-06-16 | 2002-06-25 | ノヴァ モレキュラー インク． | Ｂｃｈｅ遺伝子型の決定による神経疾患の治療法 |
| US20020119489A1 (en) * | 2000-12-26 | 2002-08-29 | Oksana Lockridge | Butyrylcholinesterase variants and methods of use |
| US20030153062A1 (en) * | 2001-12-20 | 2003-08-14 | Watkins Jeffry D. | Butyrylcholinesterase variant polypeptides with increased catalytic efficiency and methods of use |
| JP2004535155A (ja) * | 2000-12-26 | 2004-11-25 | アプライド モレキュラー エボリューション，インコーポレイテッド | 増大した触媒効率を有するブチリルコリンエステラーゼポリペプチド改変体およびその使用方法 |
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| EP0633318A1 (en) * | 1987-09-11 | 1995-01-11 | Whitehead Institute For Biomedical Research | Transduced fibroblasts and uses therefor |
| US5703055A (en) * | 1989-03-21 | 1997-12-30 | Wisconsin Alumni Research Foundation | Generation of antibodies through lipid mediated DNA delivery |
| US5399346A (en) * | 1989-06-14 | 1995-03-21 | The United States Of America As Represented By The Department Of Health And Human Services | Gene therapy |
| US5264563A (en) * | 1990-08-24 | 1993-11-23 | Ixsys Inc. | Process for synthesizing oligonucleotides with random codons |
| US5643578A (en) * | 1992-03-23 | 1997-07-01 | University Of Massachusetts Medical Center | Immunization by inoculation of DNA transcription unit |
| US5620896A (en) * | 1992-03-23 | 1997-04-15 | University Of Massachusetts Medical Center | DNA vaccines against rotavirus infections |
| US5506125A (en) * | 1993-12-22 | 1996-04-09 | Agracetus, Inc. | Gene delivery instrument with replaceable cartridges |
| US5605793A (en) * | 1994-02-17 | 1997-02-25 | Affymax Technologies N.V. | Methods for in vitro recombination |
| US5656465A (en) * | 1994-05-04 | 1997-08-12 | Therion Biologics Corporation | Methods of in vivo gene delivery |
| US6001625A (en) * | 1995-05-19 | 1999-12-14 | The United States Of America As Represented By The Secretary Of The Army | Site-directed mutagenesis of esterases |
| CN1331339A (zh) * | 2000-06-26 | 2002-01-16 | 上海博德基因开发有限公司 | 一种新的多肽——人dna拓扑异构酶i11.44和编码这种多肽的多核苷酸 |
| US7049121B2 (en) * | 2001-12-20 | 2006-05-23 | Applied Molecular Evolution | Butyrylcholinesterase variant polypeptides with increased catalytic efficiency and methods of use |
| US6989261B2 (en) * | 2001-12-20 | 2006-01-24 | Eli Lilly And Company | Butyrylcholinesterase variant polypeptides with increased catalytic efficiency and methods of use |
-
2003
- 2003-12-04 EP EP03796682A patent/EP1581253A4/en not_active Withdrawn
- 2003-12-04 US US10/535,441 patent/US20080213281A1/en not_active Abandoned
- 2003-12-04 WO PCT/US2003/038684 patent/WO2004050041A2/en not_active Ceased
- 2003-12-04 MX MXPA05005996A patent/MXPA05005996A/es not_active Application Discontinuation
- 2003-12-04 CN CNB2003801050807A patent/CN100341568C/zh not_active Expired - Fee Related
- 2003-12-04 CA CA002507626A patent/CA2507626A1/en not_active Abandoned
- 2003-12-04 AU AU2003298920A patent/AU2003298920A1/en not_active Abandoned
- 2003-12-04 JP JP2004557611A patent/JP2006508665A/ja active Pending
- 2003-12-04 BR BR0316865-4A patent/BR0316865A/pt not_active IP Right Cessation
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2002518022A (ja) * | 1998-06-16 | 2002-06-25 | ノヴァ モレキュラー インク． | Ｂｃｈｅ遺伝子型の決定による神経疾患の治療法 |
| US20020119489A1 (en) * | 2000-12-26 | 2002-08-29 | Oksana Lockridge | Butyrylcholinesterase variants and methods of use |
| JP2004535155A (ja) * | 2000-12-26 | 2004-11-25 | アプライド モレキュラー エボリューション，インコーポレイテッド | 増大した触媒効率を有するブチリルコリンエステラーゼポリペプチド改変体およびその使用方法 |
| US20030153062A1 (en) * | 2001-12-20 | 2003-08-14 | Watkins Jeffry D. | Butyrylcholinesterase variant polypeptides with increased catalytic efficiency and methods of use |
Also Published As
| Publication number | Publication date |
|---|---|
| BR0316865A (pt) | 2005-10-25 |
| CA2507626A1 (en) | 2004-06-17 |
| MXPA05005996A (es) | 2006-04-18 |
| EP1581253A2 (en) | 2005-10-05 |
| AU2003298920A1 (en) | 2004-06-23 |
| CN1720063A (zh) | 2006-01-11 |
| WO2004050041A3 (en) | 2004-10-28 |
| US20080213281A1 (en) | 2008-09-04 |
| WO2004050041A2 (en) | 2004-06-17 |
| EP1581253A4 (en) | 2007-02-14 |
| CN100341568C (zh) | 2007-10-10 |
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