JP2006506455A - ウイルス感染症の治療のための１−アシル−ピロリジン誘導体 - Google Patents
ウイルス感染症の治療のための１−アシル−ピロリジン誘導体 Download PDFInfo
- Publication number
- JP2006506455A JP2006506455A JP2005501534A JP2005501534A JP2006506455A JP 2006506455 A JP2006506455 A JP 2006506455A JP 2005501534 A JP2005501534 A JP 2005501534A JP 2005501534 A JP2005501534 A JP 2005501534A JP 2006506455 A JP2006506455 A JP 2006506455A
- Authority
- JP
- Japan
- Prior art keywords
- tert
- pyrrolidine
- butylbenzoyl
- methoxy
- isobutyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 0 CC(C)C[C@@](C[C@@](C[U]C)C1)(*1C(c1cc(OC)c(C(C)(C)C)cc1)=O)C(OC(C)(C)C)=O Chemical compound CC(C)C[C@@](C[C@@](C[U]C)C1)(*1C(c1cc(OC)c(C(C)(C)C)cc1)=O)C(OC(C)(C)C)=O 0.000 description 5
- GKKCTWFJWBMGID-UHFFFAOYSA-N CC(C)(C)c(ccc(C(C)=O)c1)c1OC Chemical compound CC(C)(C)c(ccc(C(C)=O)c1)c1OC GKKCTWFJWBMGID-UHFFFAOYSA-N 0.000 description 1
- OPCHAFVNDOZOBO-RQZCQDPDSA-N CC(C)CC(C(OC(C)(C)C)=O)/N=C/c1ncc(COC)[s]1 Chemical compound CC(C)CC(C(OC(C)(C)C)=O)/N=C/c1ncc(COC)[s]1 OPCHAFVNDOZOBO-RQZCQDPDSA-N 0.000 description 1
- COKUCCIHPJIDAE-QVWGJOIVSA-N CC(C)C[C@](CC(C1)C(C)C)(C(OC(C)(C)C)=O)N1C(c1ccc(C(C)(C)C)c(OC)c1)=O Chemical compound CC(C)C[C@](CC(C1)C(C)C)(C(OC(C)(C)C)=O)N1C(c1ccc(C(C)(C)C)c(OC)c1)=O COKUCCIHPJIDAE-QVWGJOIVSA-N 0.000 description 1
- BSBUQUPCVMXAIX-ZHCYEPILSA-N CCOC[C@@H](C[C@@]1(CC(C)C)C(O)=O)[C@H](c2ncc[s]2)N1C(c1cc(OC)c(C(C)(C)C)cc1)=O Chemical compound CCOC[C@@H](C[C@@]1(CC(C)C)C(O)=O)[C@H](c2ncc[s]2)N1C(c1cc(OC)c(C(C)(C)C)cc1)=O BSBUQUPCVMXAIX-ZHCYEPILSA-N 0.000 description 1
- ZOWPXBXFINYLBU-VDALTMKYSA-N CCOC[C@@H](C[C@@]1(CC(C)C)[IH](OC(C)(C)C)=O)[C@H](c2n[o]c(C)c2)N1C(c1cc(OC)c(C(C)(C)C)cc1)=O Chemical compound CCOC[C@@H](C[C@@]1(CC(C)C)[IH](OC(C)(C)C)=O)[C@H](c2n[o]c(C)c2)N1C(c1cc(OC)c(C(C)(C)C)cc1)=O ZOWPXBXFINYLBU-VDALTMKYSA-N 0.000 description 1
- ZUPJLZIMMUBGDT-UHFFFAOYSA-N COCc([s]1)cnc1Br Chemical compound COCc([s]1)cnc1Br ZUPJLZIMMUBGDT-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Virology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Tropical Medicine & Parasitology (AREA)
- AIDS & HIV (AREA)
- Gastroenterology & Hepatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyrrole Compounds (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0224774A GB0224774D0 (en) | 2002-10-24 | 2002-10-24 | Compounds |
| GB0229470A GB0229470D0 (en) | 2002-12-18 | 2002-12-18 | Compounds |
| GB0317141A GB0317141D0 (en) | 2003-07-22 | 2003-07-22 | Compounds |
| PCT/EP2003/011813 WO2004037818A1 (en) | 2002-10-24 | 2003-10-22 | 1-acyl-pyrrolidine derivatives for the treatment of viral infections |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2006506455A true JP2006506455A (ja) | 2006-02-23 |
| JP2006506455A5 JP2006506455A5 (https=) | 2006-12-07 |
Family
ID=32180212
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2005501534A Withdrawn JP2006506455A (ja) | 2002-10-24 | 2003-10-22 | ウイルス感染症の治療のための１−アシル−ピロリジン誘導体 |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US7304087B2 (https=) |
| EP (1) | EP1554274B1 (https=) |
| JP (1) | JP2006506455A (https=) |
| KR (1) | KR20050057670A (https=) |
| AR (1) | AR041816A1 (https=) |
| AT (1) | ATE418554T1 (https=) |
| AU (1) | AU2003276172A1 (https=) |
| BR (1) | BR0315417A (https=) |
| CA (1) | CA2503471A1 (https=) |
| CO (1) | CO5550450A2 (https=) |
| DE (1) | DE60325498D1 (https=) |
| IS (1) | IS7851A (https=) |
| MA (1) | MA27524A1 (https=) |
| MX (1) | MXPA05004435A (https=) |
| NO (1) | NO20052472L (https=) |
| PL (1) | PL376454A1 (https=) |
| TW (1) | TW200418848A (https=) |
| WO (1) | WO2004037818A1 (https=) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0304494D0 (en) * | 2003-02-27 | 2003-04-02 | Glaxo Group Ltd | Compounds |
| GB0408995D0 (en) * | 2004-04-22 | 2004-05-26 | Glaxo Group Ltd | Compounds |
| GB0423673D0 (en) * | 2004-10-25 | 2004-11-24 | Glaxo Group Ltd | Compounds |
| GB0423672D0 (en) * | 2004-10-25 | 2004-11-24 | Glaxo Group Ltd | Compounds |
| JP4663733B2 (ja) * | 2004-10-29 | 2011-04-06 | シェーリング コーポレイション | 抗ウイルス物質としての置換５−オキソピラゾールおよび置換［１，２，４］トリアゾール |
| GB0519478D0 (en) * | 2005-09-23 | 2005-11-02 | Glaxo Group Ltd | Compounds |
| GB0519488D0 (en) * | 2005-09-23 | 2005-11-02 | Glaxo Group Ltd | Compounds |
| GB0519486D0 (en) * | 2005-09-23 | 2005-11-02 | Glaxo Group Ltd | Compounds |
| GB0519485D0 (en) * | 2005-09-23 | 2005-11-02 | Glaxo Group Ltd | Compounds |
| PT2144604E (pt) | 2007-02-28 | 2011-10-19 | Conatus Pharmaceuticals Inc | Métodos para o tratamento da hepatite c viral crónica utilizando ro-113-0830 |
| ES2381410T3 (es) | 2007-05-04 | 2012-05-28 | Vertex Pharmceuticals Incorporated | Terapia de combinación paa el tratamiento de infecciones por VHC |
| US20090053175A1 (en) * | 2007-08-24 | 2009-02-26 | Yat Sun Or | Substitute pyrrolidine derivatives |
| EP2272832A4 (en) | 2008-04-28 | 2011-09-07 | Asahi Kasei Pharma Corp | PHENYLPROPIONIC ACID DERIVATIVE AND USE THEREOF |
| JP2011530562A (ja) | 2008-08-11 | 2011-12-22 | グラクソスミスクライン エルエルシー | アレルギー性、炎症性及び感染性疾患治療用のプリン誘導体 |
| UA103195C2 (uk) | 2008-08-11 | 2013-09-25 | Глаксосмитклайн Ллк | Похідні пурину для застосування у лікуванні алергій, запальних та інфекційних захворювань |
| SI2320905T1 (sl) | 2008-08-11 | 2017-10-30 | Glaxosmithkline Llc Corporation Service Company | Novi adeninski derivati |
| EP2534149B1 (en) | 2010-02-10 | 2014-10-15 | GlaxoSmithKline LLC | 6-amino-2-{[(1s)-1-methylbutyl]oxy}-9-[5-(1-piperidinyl)pentyl]-7,9-dihydro-8h-purin-8-one maleate |
| US8575340B2 (en) | 2010-02-10 | 2013-11-05 | Glaxosmithkline Llc | Purine derivatives and their pharmaceutical uses |
| WO2013134012A1 (en) | 2012-03-06 | 2013-09-12 | Merck Sharp & Dohme Corp. | Preparation and use of bicyclic himbacine derivatives as par-receptor antagonists |
| KR20160124157A (ko) | 2014-02-20 | 2016-10-26 | 글락소스미스클라인 인털렉츄얼 프로퍼티 (넘버 2) 리미티드 | 인간 인터페론의 유도인자로서의 피롤로[3,2]피리미딘 유도체 |
| MX2017006302A (es) | 2014-11-13 | 2018-02-16 | Glaxosmithkline Biologicals Sa | Derivados de adenina que son utiles en el tratamiento de enfermedades alergicas u otras afecciones inflamatorias. |
| TWI704154B (zh) | 2015-12-03 | 2020-09-11 | 英商葛蘭素史克智慧財產發展有限公司 | 新穎化合物 |
| HRP20220936T1 (hr) | 2016-04-07 | 2022-10-28 | Glaxosmithkline Intellectual Property Development Limited | Heterociklički amidi korisni kao modulatori proteina |
| JP2019510802A (ja) | 2016-04-07 | 2019-04-18 | グラクソスミスクライン、インテレクチュアル、プロパティー、ディベロップメント、リミテッドＧｌａｘｏｓｍｉｔｈｋｌｉｎｅ Ｉｎｔｅｌｌｅｃｔｕａｌ Ｐｒｏｐｅｒｔｙ Ｄｅｖｅｌｏｐｍｅｎｔ Ｌｉｍｉｔｅｄ | タンパク質調節物質として有用な複素環アミド |
| US20210238172A1 (en) | 2017-10-05 | 2021-08-05 | Glaxosmithkline Intellectual Property Development Limited | Heterocyclic amides useful as protein modulators and methods of using the same |
| CA3077337A1 (en) | 2017-10-05 | 2019-04-11 | Glaxosmithkline Intellectual Property Development Limited | Modulators of stimulator of interferon genes (sting) |
| GB201807924D0 (en) | 2018-05-16 | 2018-06-27 | Ctxt Pty Ltd | Compounds |
| JP2022533194A (ja) | 2019-05-16 | 2022-07-21 | スティングセラ インコーポレイテッド | ベンゾ［ｂ］［１，８］ナフチリジン酢酸誘導体および使用方法 |
| US20220227761A1 (en) | 2019-05-16 | 2022-07-21 | Stingthera, Inc. | Oxoacridinyl acetic acid derivatives and methods of use |
| GB201910304D0 (en) | 2019-07-18 | 2019-09-04 | Ctxt Pty Ltd | Compounds |
| GB201910305D0 (en) | 2019-07-18 | 2019-09-04 | Ctxt Pty Ltd | Compounds |
| CN114981265B (zh) | 2019-12-18 | 2025-01-03 | Ctxt私人有限公司 | 化合物 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU5687396A (en) | 1995-04-21 | 1996-11-07 | Novarits Ag | N-aroylamino acid amides as endothelin inhibitors |
| AU1804299A (en) | 1997-12-08 | 1999-06-28 | Glycomed Incorporated | Sialyl lewis x and sialyl lewis a glycomimetics |
| ATE391451T1 (de) | 1998-01-26 | 2008-04-15 | Massachusetts Inst Technology | Endoskop zur erfassung von fluoreszenzbilder |
| EP1315698A1 (en) | 1998-04-23 | 2003-06-04 | Abbott Laboratories | Pyrrolidines as inhibitors of neuraminidases |
| US6323180B1 (en) | 1998-08-10 | 2001-11-27 | Boehringer Ingelheim (Canada) Ltd | Hepatitis C inhibitor tri-peptides |
| EP1118287B1 (de) * | 2000-01-21 | 2004-11-24 | Alois Ing. Sampl | Steckbares Regalsystem |
| EP1278743A4 (en) * | 2000-05-05 | 2003-05-14 | Smithkline Beecham Corp | NEW ANTI-INFECTIOUS ACTIVE SUBSTANCES |
| WO2002044168A2 (en) | 2000-11-20 | 2002-06-06 | Scios Inc. | Indole-type inhibitors of p38 kinase |
| BR0213760A (pt) | 2001-10-26 | 2004-10-19 | Upjohn Co | Composto, composição farmacêutica, uso do composto e método para tratamento de doença ou condição |
| JP2005511572A (ja) | 2001-11-02 | 2005-04-28 | グラクソ グループ リミテッド | Ｈｃｖ阻害剤としてのアシルジヒドロピロール誘導体 |
| CA2490385C (en) | 2002-10-28 | 2014-05-06 | Marquage Antivol Sherlock, Inc. | Method of preventing theft of vehicles using intensive marking |
-
2003
- 2003-10-22 MX MXPA05004435A patent/MXPA05004435A/es unknown
- 2003-10-22 AR ARP030103852A patent/AR041816A1/es not_active Application Discontinuation
- 2003-10-22 US US10/531,884 patent/US7304087B2/en not_active Expired - Fee Related
- 2003-10-22 WO PCT/EP2003/011813 patent/WO2004037818A1/en not_active Ceased
- 2003-10-22 EP EP03809322A patent/EP1554274B1/en not_active Expired - Lifetime
- 2003-10-22 AU AU2003276172A patent/AU2003276172A1/en not_active Abandoned
- 2003-10-22 PL PL03376454A patent/PL376454A1/xx not_active Application Discontinuation
- 2003-10-22 AT AT03809322T patent/ATE418554T1/de not_active IP Right Cessation
- 2003-10-22 DE DE60325498T patent/DE60325498D1/de not_active Expired - Fee Related
- 2003-10-22 TW TW092129213A patent/TW200418848A/zh unknown
- 2003-10-22 CA CA002503471A patent/CA2503471A1/en not_active Abandoned
- 2003-10-22 KR KR1020057006957A patent/KR20050057670A/ko not_active Withdrawn
- 2003-10-22 BR BR0315417-3A patent/BR0315417A/pt not_active IP Right Cessation
- 2003-10-22 JP JP2005501534A patent/JP2006506455A/ja not_active Withdrawn
-
2005
- 2005-04-25 CO CO05038997A patent/CO5550450A2/es not_active Application Discontinuation
- 2005-05-06 MA MA28263A patent/MA27524A1/fr unknown
- 2005-05-19 IS IS7851A patent/IS7851A/is unknown
- 2005-05-23 NO NO20052472A patent/NO20052472L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| AR041816A1 (es) | 2005-06-01 |
| DE60325498D1 (de) | 2009-02-05 |
| PL376454A1 (en) | 2005-12-27 |
| ATE418554T1 (de) | 2009-01-15 |
| KR20050057670A (ko) | 2005-06-16 |
| CO5550450A2 (es) | 2005-08-31 |
| US20060258720A1 (en) | 2006-11-16 |
| EP1554274A1 (en) | 2005-07-20 |
| MA27524A1 (fr) | 2005-09-01 |
| US7304087B2 (en) | 2007-12-04 |
| TW200418848A (en) | 2004-10-01 |
| AU2003276172A1 (en) | 2004-05-13 |
| EP1554274B1 (en) | 2008-12-24 |
| NO20052472L (no) | 2005-05-23 |
| WO2004037818A1 (en) | 2004-05-06 |
| CA2503471A1 (en) | 2004-05-06 |
| MXPA05004435A (es) | 2005-07-26 |
| BR0315417A (pt) | 2005-08-16 |
| IS7851A (is) | 2005-05-19 |
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