JP2006505788A - 無希釈の全血における凝固時間の光度判定 - Google Patents
無希釈の全血における凝固時間の光度判定 Download PDFInfo
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- JP2006505788A JP2006505788A JP2004551138A JP2004551138A JP2006505788A JP 2006505788 A JP2006505788 A JP 2006505788A JP 2004551138 A JP2004551138 A JP 2004551138A JP 2004551138 A JP2004551138 A JP 2004551138A JP 2006505788 A JP2006505788 A JP 2006505788A
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Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US42530002P | 2002-11-12 | 2002-11-12 | |
| PCT/IL2003/000958 WO2004044560A1 (en) | 2002-11-12 | 2003-11-12 | Photometric determination of coagulation time in undiluted whole blood |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2006505788A true JP2006505788A (ja) | 2006-02-16 |
| JP2006505788A5 JP2006505788A5 (enExample) | 2006-12-28 |
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Country Status (6)
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|---|---|
| US (1) | US20060110283A1 (enExample) |
| EP (1) | EP1561094A4 (enExample) |
| JP (1) | JP2006505788A (enExample) |
| AU (1) | AU2003282351A1 (enExample) |
| CA (1) | CA2492486A1 (enExample) |
| WO (1) | WO2004044560A1 (enExample) |
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Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1209604B (it) * | 1984-11-27 | 1989-08-30 | Instrumentation Lab Spa | Metodo ed apparecchiatura per la misura di parametri di coagulazione. |
| US5164598A (en) * | 1985-08-05 | 1992-11-17 | Biotrack | Capillary flow device |
| DE3610429A1 (de) * | 1986-03-27 | 1987-10-01 | Boehringer Mannheim Gmbh | Gerinnungsneutrale, hydrophile glasfasern |
| JPS62226057A (ja) * | 1986-03-28 | 1987-10-05 | Minoru Tomita | 全血用赤血球の凝集率測定方法及びその装置 |
| US4849340A (en) * | 1987-04-03 | 1989-07-18 | Cardiovascular Diagnostics, Inc. | Reaction system element and method for performing prothrombin time assay |
| US5039617A (en) * | 1989-04-20 | 1991-08-13 | Biotrack, Inc. | Capillary flow device and method for measuring activated partial thromboplastin time |
| WO1993007492A1 (en) * | 1991-10-04 | 1993-04-15 | Baxter Diagnostics Inc. | Preparation of prothrombin time reagents from recombinant human tissue factor and purified natural and synthetic phospholipids |
| US5522255A (en) * | 1993-08-31 | 1996-06-04 | Boehringer Mannheim Corporation | Fluid dose, flow and coagulation sensor for medical instrument |
| US5418141A (en) * | 1994-05-06 | 1995-05-23 | Avocet Medical, Inc. | Test articles for performing dry reagent prothrombin time assays |
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-
2003
- 2003-11-12 US US10/516,053 patent/US20060110283A1/en not_active Abandoned
- 2003-11-12 EP EP03773964A patent/EP1561094A4/en not_active Withdrawn
- 2003-11-12 WO PCT/IL2003/000958 patent/WO2004044560A1/en not_active Ceased
- 2003-11-12 CA CA002492486A patent/CA2492486A1/en not_active Abandoned
- 2003-11-12 JP JP2004551138A patent/JP2006505788A/ja not_active Withdrawn
- 2003-11-12 AU AU2003282351A patent/AU2003282351A1/en not_active Abandoned
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Also Published As
| Publication number | Publication date |
|---|---|
| US20060110283A1 (en) | 2006-05-25 |
| EP1561094A4 (en) | 2008-11-19 |
| EP1561094A1 (en) | 2005-08-10 |
| AU2003282351A1 (en) | 2004-06-03 |
| CA2492486A1 (en) | 2004-05-27 |
| WO2004044560A1 (en) | 2004-05-27 |
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