JP2006503819A5 - - Google Patents
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- Publication number
- JP2006503819A5 JP2006503819A5 JP2004531921A JP2004531921A JP2006503819A5 JP 2006503819 A5 JP2006503819 A5 JP 2006503819A5 JP 2004531921 A JP2004531921 A JP 2004531921A JP 2004531921 A JP2004531921 A JP 2004531921A JP 2006503819 A5 JP2006503819 A5 JP 2006503819A5
- Authority
- JP
- Japan
- Prior art keywords
- hydroxycholesterol
- group
- mammalian
- cells
- oxysterol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US40671502P | 2002-08-29 | 2002-08-29 | |
| PCT/US2003/027105 WO2004019884A2 (en) | 2002-08-29 | 2003-08-28 | Agents and methods for enhancing bone formation |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2006503819A JP2006503819A (ja) | 2006-02-02 |
| JP2006503819A5 true JP2006503819A5 (https=) | 2006-10-19 |
Family
ID=31978345
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004531921A Pending JP2006503819A (ja) | 2002-08-29 | 2003-08-28 | 骨形成を増進するための作用剤および方法 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US7897588B2 (https=) |
| EP (1) | EP1556057A4 (https=) |
| JP (1) | JP2006503819A (https=) |
| AU (1) | AU2003268260B2 (https=) |
| CA (1) | CA2495882A1 (https=) |
| WO (1) | WO2004019884A2 (https=) |
Families Citing this family (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7897588B2 (en) | 2002-08-29 | 2011-03-01 | The Regents Of The University Of California | Agents and methods for enhancing bone formation |
| CA2529558A1 (en) * | 2003-07-01 | 2005-01-13 | Astellas Pharma Inc. | Agent inducing increase in bone mass |
| US7318925B2 (en) | 2003-08-08 | 2008-01-15 | Amgen Fremont, Inc. | Methods of use for antibodies against parathyroid hormone |
| WO2005016111A2 (en) | 2003-08-08 | 2005-02-24 | Abgenix, Inc. | Antibodies directed to parathyroid hormone (pth) and uses thereof |
| US9532994B2 (en) * | 2003-08-29 | 2017-01-03 | The Regents Of The University Of California | Agents and methods for enhancing bone formation by oxysterols in combination with bone morphogenic proteins |
| US8188219B2 (en) * | 2004-01-28 | 2012-05-29 | The Regents Of The University Of California | Bone morphogenic protein binding peptide |
| US8415302B2 (en) | 2004-01-28 | 2013-04-09 | The Regents Of The University Of California | Surgical applications for BMP binding protein |
| US8193312B2 (en) | 2004-01-28 | 2012-06-05 | The Regents Of The University Of California | Bone morphogenic protein binding peptide |
| EP1758651A2 (en) * | 2004-06-24 | 2007-03-07 | Galapagos N.V. | Lxr agonists to promote bone homeostasis |
| US8753660B2 (en) * | 2004-11-29 | 2014-06-17 | The Regents Of The University Of California | Activating extraction of demineralized bone matrix |
| US20090202660A1 (en) * | 2005-04-07 | 2009-08-13 | The Regents Of The University Of California | Agents and Methods for Osteogenic Oxysterols Inhibition of Oxidative Stress on Osteogenic Cellular Differentiation |
| DE502006002752D1 (de) * | 2005-04-23 | 2009-03-19 | Ixetic Mac Gmbh | Axialkolbenmaschine |
| CA2621157A1 (en) * | 2005-09-02 | 2007-03-08 | The Regents Of The University Of California | Osteogenic and anti-adipogenic oxysterols |
| US9670244B2 (en) | 2006-02-27 | 2017-06-06 | The Regents Of The University Of California | Oxysterol compounds and the hedgehog pathway |
| US20100048944A1 (en) * | 2006-07-19 | 2010-02-25 | Farhad Parhami | Interactions of hedgehog and liver x receptor signaling pathways |
| AU2007339325A1 (en) | 2006-12-19 | 2008-07-10 | The Regents Of The University Of California | Inhibition of PPAR gamma expression by specific osteogenic oxysterols |
| US20100112030A1 (en) * | 2007-03-16 | 2010-05-06 | The Regents Of The University Of California | Role of hedgehog signaling in atherosclerosis and cardiovascular disease |
| WO2009073186A1 (en) * | 2007-12-03 | 2009-06-11 | The Regents Of The University Of California | Oxsterols for activation of hedgehog signaling, osteoinduction, antiadipogenesis, and wnt signaling |
| US8574567B2 (en) | 2007-05-03 | 2013-11-05 | The Brigham And Women's Hospital, Inc. | Multipotent stem cells and uses thereof |
| US20100291042A1 (en) | 2007-05-03 | 2010-11-18 | The Brigham And Women's Hospital, Inc. | Multipotent stem cells and uses thereof |
| MX2012000214A (es) | 2009-06-23 | 2012-01-25 | Univ California | Aumento de retencion de bmp. |
| US9707318B2 (en) * | 2009-10-29 | 2017-07-18 | Shaker A. Mousa | Compositions of novel bone patch in bone and vascular regeneration |
| US8882740B2 (en) * | 2009-12-23 | 2014-11-11 | Stryker Trauma Gmbh | Method of delivering a biphosphonate and/or strontium ranelate below the surface of a bone |
| KR20150013232A (ko) | 2012-05-07 | 2015-02-04 | 더 리전트 오브 더 유니버시티 오브 캘리포니아 | 골형성 및 헤지호그 신호전달을 유도하고 지방생성을 억제하는 옥시스테롤 유사체 oxy133 |
| CN105263500A (zh) | 2013-05-02 | 2016-01-20 | 加利福尼亚大学董事会 | 骨选择性成骨性氧固醇-骨靶向剂 |
| US9657052B2 (en) | 2014-12-09 | 2017-05-23 | Warsaw Orthopedic, Inc. | Compounds and methods of making sterols using diols |
| US9987289B2 (en) | 2015-07-10 | 2018-06-05 | Warsaw Orthopedic, Inc. | Slow release oxysterols and methods of use |
| US10632230B2 (en) | 2015-07-10 | 2020-04-28 | Warsaw Orthopedic, Inc. | Implants having a high drug load of an oxysterol and methods of use |
| US9878070B2 (en) | 2015-06-17 | 2018-01-30 | Warsaw Orthopedic, Inc. | Malleable implants including an oxysterol and methods of use |
| US9877836B2 (en) | 2015-07-10 | 2018-01-30 | Warsaw Orthopedic, Inc. | Compression resistant implants including an oxysterol and methods of use |
| US12171909B2 (en) | 2015-07-10 | 2024-12-24 | Warsaw Orthopedic, Inc. | Implants having a drug load of an oxysterol and methods of use |
| US9637514B1 (en) | 2015-10-26 | 2017-05-02 | MAX BioPharma, Inc. | Oxysterols and hedgehog signaling |
| US10688222B2 (en) | 2016-11-21 | 2020-06-23 | Warsaw Orthopedic, Inc. | Lyophilized moldable implants containing an oxysterol |
| US11384114B2 (en) | 2016-12-09 | 2022-07-12 | Warsaw Orthopedic, Inc. | Polymorphic forms of an oxysterol and methods of making them |
| US10434106B2 (en) | 2017-05-19 | 2019-10-08 | Warsaw Orthopedic, Inc. | Oxysterol-statin compounds for bone growth |
| KR102081230B1 (ko) * | 2017-06-01 | 2020-02-25 | 연세대학교 산학협력단 | 골 관련 질환의 예방 또는 치료를 위한 약학 조성물 |
| US11464888B2 (en) | 2017-06-12 | 2022-10-11 | Warsaw Orthopedic, Inc. | Moldable formulations containing an oxysterol in an acellular tissue matrix |
| CN110917397A (zh) * | 2018-09-20 | 2020-03-27 | 天津大学 | 基于病毒载体投递MicroRNA与骨粉的复合材料及其制备方法 |
| CN114507638B (zh) * | 2021-12-31 | 2024-01-02 | 浙江大学 | 一种抑制间充质干细胞衰老的优化培养基及其应用 |
Family Cites Families (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3887545A (en) * | 1973-11-12 | 1975-06-03 | Hoffmann La Roche | Synthesis of 1{60 -hydroxylated cholesterol derivatives |
| US4183852A (en) * | 1977-07-18 | 1980-01-15 | Kaiser Emil T | Process for preparing 25-hydroxycholesterol |
| US4743597A (en) * | 1986-01-27 | 1988-05-10 | Javitt Norman B | Composition comprising an oxygenated cholesterol and use thereof for topical treatment of diseases |
| CA2160930A1 (en) * | 1995-10-19 | 1997-04-20 | Lloyd Cuttress | Pet feeder |
| EP0954317B1 (en) * | 1996-04-09 | 2007-06-06 | The University Of Edinburgh | Use of 7 apha-substituted steroids to treat neuropsychiatric disorders |
| ES2329953T3 (es) | 1996-04-19 | 2009-12-02 | Osiris Therapeutics, Inc. | Regeneracion e incremento de hueso utilizando celulas madre mesenquimales. |
| US6893830B1 (en) * | 1996-09-27 | 2005-05-17 | The Board Of Regents Of The University Of Texas System | Method of screening oxysterol activation of LXRα |
| US5855920A (en) | 1996-12-13 | 1999-01-05 | Chein; Edmund Y. M. | Total hormone replacement therapy |
| US6080779A (en) | 1996-12-13 | 2000-06-27 | Osteoscreen, Inc. | Compositions and methods for stimulating bone growth |
| WO1998032444A1 (en) * | 1997-01-24 | 1998-07-30 | The Regents Of The University Of California | USE OF FXR, PPARα AND LXRα ACTIVATORS TO RESTORE BARRIER FUNCTION, PROMOTE EPIDERMAL DIFFERENTIATION AND INHIBIT PROLIFERATION |
| US5929062A (en) * | 1997-06-19 | 1999-07-27 | University Of Western Ontario | Oxysterol inhibition of dietary cholesterol uptake |
| WO1999000117A2 (en) * | 1997-06-27 | 1999-01-07 | Ontogeny, Inc. | Neuroprotective methods and reagents |
| US20030153541A1 (en) * | 1997-10-31 | 2003-08-14 | Robert Dudley | Novel anticholesterol compositions and method for using same |
| JP2002506030A (ja) * | 1998-03-13 | 2002-02-26 | メルク エンド カムパニー インコーポレーテッド | 骨再吸収の阻害方法 |
| EP0943332A1 (en) * | 1998-03-19 | 1999-09-22 | Nederlandse Organisatie Voor Toegepast-Natuurwetenschappelijk Onderzoek Tno | Prevention and treatment of adhesions |
| US6316503B1 (en) | 1999-03-15 | 2001-11-13 | Tularik Inc. | LXR modulators |
| US6586189B2 (en) * | 1999-06-18 | 2003-07-01 | City Of Hope | Screening method for PPAR-γ ligands |
| JP2003520780A (ja) | 1999-09-01 | 2003-07-08 | ユニバーシティ オブ ブリティッシュ コロンビア | Ｈｄｌコレステロールとトリグリセリド水準を調節する組成物と方法 |
| US20020161026A1 (en) * | 2000-11-07 | 2002-10-31 | Paralkar Vishwas M. | Combination therapies for the stimulation of bone growth |
| AU2002247847A1 (en) | 2001-04-09 | 2002-10-21 | Lorantis Limited | Therapeutic use and identification of modulators of a hedgehog signalling pathway or one of its target pathways |
| US7897588B2 (en) | 2002-08-29 | 2011-03-01 | The Regents Of The University Of California | Agents and methods for enhancing bone formation |
| WO2005028616A2 (en) | 2003-07-24 | 2005-03-31 | Caritas St. Elizabeth's Medical Center Of Boston, Inc. | Morphogen compositions and methods of use thereof to treat heart disorders |
| CA2534567A1 (en) * | 2003-08-18 | 2005-03-03 | Wyeth | Novel human lxr alpha variants |
| US9532994B2 (en) | 2003-08-29 | 2017-01-03 | The Regents Of The University Of California | Agents and methods for enhancing bone formation by oxysterols in combination with bone morphogenic proteins |
| WO2006012902A2 (en) | 2004-08-02 | 2006-02-09 | Novozymes A/S | Creation of diversity in polypeptides |
| US20090202660A1 (en) | 2005-04-07 | 2009-08-13 | The Regents Of The University Of California | Agents and Methods for Osteogenic Oxysterols Inhibition of Oxidative Stress on Osteogenic Cellular Differentiation |
| CA2621157A1 (en) | 2005-09-02 | 2007-03-08 | The Regents Of The University Of California | Osteogenic and anti-adipogenic oxysterols |
| US9670244B2 (en) | 2006-02-27 | 2017-06-06 | The Regents Of The University Of California | Oxysterol compounds and the hedgehog pathway |
| GB0619860D0 (en) | 2006-10-06 | 2006-11-15 | Birkeland Innovasjon As | Treatment of insulin resistance and disorders associated therewith |
| US20100112030A1 (en) | 2007-03-16 | 2010-05-06 | The Regents Of The University Of California | Role of hedgehog signaling in atherosclerosis and cardiovascular disease |
-
2003
- 2003-08-28 US US10/524,945 patent/US7897588B2/en not_active Expired - Lifetime
- 2003-08-28 EP EP03749213A patent/EP1556057A4/en not_active Withdrawn
- 2003-08-28 AU AU2003268260A patent/AU2003268260B2/en not_active Ceased
- 2003-08-28 WO PCT/US2003/027105 patent/WO2004019884A2/en not_active Ceased
- 2003-08-28 JP JP2004531921A patent/JP2006503819A/ja active Pending
- 2003-08-28 CA CA002495882A patent/CA2495882A1/en not_active Abandoned
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