JP2009512422A5 - - Google Patents
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- Publication number
- JP2009512422A5 JP2009512422A5 JP2008529347A JP2008529347A JP2009512422A5 JP 2009512422 A5 JP2009512422 A5 JP 2009512422A5 JP 2008529347 A JP2008529347 A JP 2008529347A JP 2008529347 A JP2008529347 A JP 2008529347A JP 2009512422 A5 JP2009512422 A5 JP 2009512422A5
- Authority
- JP
- Japan
- Prior art keywords
- hydroxycholesterol
- differentiation
- acetate
- 4beta
- diol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US71406305P | 2005-09-02 | 2005-09-02 | |
| PCT/US2006/034374 WO2007028101A2 (en) | 2005-09-02 | 2006-09-05 | Osteogenic and anti-adiogenic oxysterols |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2009512422A JP2009512422A (ja) | 2009-03-26 |
| JP2009512422A5 true JP2009512422A5 (https=) | 2009-11-05 |
Family
ID=37809619
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008529347A Pending JP2009512422A (ja) | 2005-09-02 | 2006-09-05 | 骨形成及び抗脂肪細胞形成オキシステロール類 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20090220562A1 (https=) |
| EP (1) | EP1931353A4 (https=) |
| JP (1) | JP2009512422A (https=) |
| AU (1) | AU2006284650A1 (https=) |
| CA (1) | CA2621157A1 (https=) |
| WO (1) | WO2007028101A2 (https=) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1556057A4 (en) | 2002-08-29 | 2009-07-15 | Univ California | MEDIUM AND METHOD FOR REINFORCING BONE TRAINING |
| WO2005020928A2 (en) | 2003-08-29 | 2005-03-10 | The Regents Of The University Of California | Agents and methods for enhancing bone formation by oxysterols in combination with bone morphogenic proteins |
| CA2643732C (en) | 2006-02-27 | 2012-08-21 | The Regents Of The University Of California | Oxysterol compounds and the hedgehog pathway |
| EP2111225A4 (en) | 2006-12-19 | 2010-02-10 | Univ California | INHIBITION OF PPAR GAMMA EXPRESSION BY SPECIFIC OSTEOGENIC OXYSTEROLE |
| WO2008115469A2 (en) * | 2007-03-16 | 2008-09-25 | The Regents Of The University Of California | Role of hedgehog signaling in atherosclerosis and cardiovascular disease |
| CN101951915A (zh) * | 2007-12-03 | 2011-01-19 | 加利福尼亚大学董事会 | 用于刺猬蛋白信号、骨诱导、抗脂肪形成和wnt信号的激活的氧固醇 |
| CA2872751A1 (en) | 2012-05-07 | 2013-11-14 | The Regents Of The University Of California | Oxysterol analogue oxy133 induces osteogenesis and hedgehog signaling and inhibits adipogenesis |
| JP2016517888A (ja) | 2013-05-02 | 2016-06-20 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | 骨選択的骨形成のオキシステロール骨標的薬剤 |
| US9657052B2 (en) | 2014-12-09 | 2017-05-23 | Warsaw Orthopedic, Inc. | Compounds and methods of making sterols using diols |
| US9987289B2 (en) | 2015-07-10 | 2018-06-05 | Warsaw Orthopedic, Inc. | Slow release oxysterols and methods of use |
| US9877836B2 (en) | 2015-07-10 | 2018-01-30 | Warsaw Orthopedic, Inc. | Compression resistant implants including an oxysterol and methods of use |
| US10632230B2 (en) | 2015-07-10 | 2020-04-28 | Warsaw Orthopedic, Inc. | Implants having a high drug load of an oxysterol and methods of use |
| US9878070B2 (en) | 2015-06-17 | 2018-01-30 | Warsaw Orthopedic, Inc. | Malleable implants including an oxysterol and methods of use |
| US12171909B2 (en) | 2015-07-10 | 2024-12-24 | Warsaw Orthopedic, Inc. | Implants having a drug load of an oxysterol and methods of use |
| US9637514B1 (en) | 2015-10-26 | 2017-05-02 | MAX BioPharma, Inc. | Oxysterols and hedgehog signaling |
| ITUA20162556A1 (it) * | 2016-04-13 | 2017-10-13 | Massimo Dominici | Metodo per analizzare le potenzialita' di cellule staminali/stromali mesenchimali nella rigenerazione tessutale |
| US11384114B2 (en) | 2016-12-09 | 2022-07-12 | Warsaw Orthopedic, Inc. | Polymorphic forms of an oxysterol and methods of making them |
| US10434106B2 (en) | 2017-05-19 | 2019-10-08 | Warsaw Orthopedic, Inc. | Oxysterol-statin compounds for bone growth |
| US11464888B2 (en) | 2017-06-12 | 2022-10-11 | Warsaw Orthopedic, Inc. | Moldable formulations containing an oxysterol in an acellular tissue matrix |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3887545A (en) * | 1973-11-12 | 1975-06-03 | Hoffmann La Roche | Synthesis of 1{60 -hydroxylated cholesterol derivatives |
| US4183852A (en) * | 1977-07-18 | 1980-01-15 | Kaiser Emil T | Process for preparing 25-hydroxycholesterol |
| US4743597A (en) * | 1986-01-27 | 1988-05-10 | Javitt Norman B | Composition comprising an oxygenated cholesterol and use thereof for topical treatment of diseases |
| US6893830B1 (en) * | 1996-09-27 | 2005-05-17 | The Board Of Regents Of The University Of Texas System | Method of screening oxysterol activation of LXRα |
| US6080779A (en) * | 1996-12-13 | 2000-06-27 | Osteoscreen, Inc. | Compositions and methods for stimulating bone growth |
| CN1248916A (zh) * | 1997-01-24 | 2000-03-29 | 加利福尼亚大学董事会 | FXR、PPARα和LXRα激活剂恢复屏障功能、促进表皮分化和抑制增生的用途 |
| US5929062A (en) * | 1997-06-19 | 1999-07-27 | University Of Western Ontario | Oxysterol inhibition of dietary cholesterol uptake |
| AU8173098A (en) * | 1997-06-27 | 1999-01-19 | Ontogeny, Inc. | Neuroprotective methods and reagents |
| US20030153541A1 (en) * | 1997-10-31 | 2003-08-14 | Robert Dudley | Novel anticholesterol compositions and method for using same |
| US6586189B2 (en) * | 1999-06-18 | 2003-07-01 | City Of Hope | Screening method for PPAR-γ ligands |
| US20020161026A1 (en) * | 2000-11-07 | 2002-10-31 | Paralkar Vishwas M. | Combination therapies for the stimulation of bone growth |
| EP1556057A4 (en) * | 2002-08-29 | 2009-07-15 | Univ California | MEDIUM AND METHOD FOR REINFORCING BONE TRAINING |
| AU2004267067A1 (en) * | 2003-08-18 | 2005-03-03 | Wyeth | Human LXR alpha variants |
| WO2005020928A2 (en) * | 2003-08-29 | 2005-03-10 | The Regents Of The University Of California | Agents and methods for enhancing bone formation by oxysterols in combination with bone morphogenic proteins |
| WO2006110490A2 (en) * | 2005-04-07 | 2006-10-19 | The Regents Of The University Of California | Agents and methods for osteogenic oxysterols inhibition of oxidative stress on osteogenic cellular differentiation |
| CA2643732C (en) * | 2006-02-27 | 2012-08-21 | The Regents Of The University Of California | Oxysterol compounds and the hedgehog pathway |
-
2006
- 2006-09-05 JP JP2008529347A patent/JP2009512422A/ja active Pending
- 2006-09-05 CA CA002621157A patent/CA2621157A1/en not_active Abandoned
- 2006-09-05 WO PCT/US2006/034374 patent/WO2007028101A2/en not_active Ceased
- 2006-09-05 AU AU2006284650A patent/AU2006284650A1/en not_active Abandoned
- 2006-09-05 EP EP06824888A patent/EP1931353A4/en not_active Withdrawn
- 2006-09-05 US US11/991,322 patent/US20090220562A1/en not_active Abandoned
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