JP2006502160A - 水安定化エアゾル薬剤組成 - Google Patents
水安定化エアゾル薬剤組成 Download PDFInfo
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- JP2006502160A JP2006502160A JP2004534386A JP2004534386A JP2006502160A JP 2006502160 A JP2006502160 A JP 2006502160A JP 2004534386 A JP2004534386 A JP 2004534386A JP 2004534386 A JP2004534386 A JP 2004534386A JP 2006502160 A JP2006502160 A JP 2006502160A
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- aerosol
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- 229940079593 drug Drugs 0.000 title claims abstract description 231
- 239000000203 mixture Substances 0.000 title claims abstract description 202
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- 239000003380 propellant Substances 0.000 claims abstract description 68
- 239000008194 pharmaceutical composition Substances 0.000 claims abstract description 58
- 239000003381 stabilizer Substances 0.000 claims abstract description 39
- 239000000725 suspension Substances 0.000 claims abstract description 10
- -1 cromoline Chemical compound 0.000 claims description 87
- 238000000034 method Methods 0.000 claims description 75
- 239000003246 corticosteroid Substances 0.000 claims description 45
- 150000003839 salts Chemical class 0.000 claims description 43
- 239000000048 adrenergic agonist Substances 0.000 claims description 39
- 150000002617 leukotrienes Chemical class 0.000 claims description 35
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- 239000012453 solvate Substances 0.000 claims description 33
- 150000002148 esters Chemical class 0.000 claims description 32
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- 239000006184 cosolvent Substances 0.000 claims description 28
- VOVIALXJUBGFJZ-KWVAZRHASA-N Budesonide Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@@H]2[C@@H]1[C@@H]1C[C@H]3OC(CCC)O[C@@]3(C(=O)CO)[C@@]1(C)C[C@@H]2O VOVIALXJUBGFJZ-KWVAZRHASA-N 0.000 claims description 25
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- BPZSYCZIITTYBL-UHFFFAOYSA-N formoterol Chemical compound C1=CC(OC)=CC=C1CC(C)NCC(O)C1=CC=C(O)C(NC=O)=C1 BPZSYCZIITTYBL-UHFFFAOYSA-N 0.000 claims description 24
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- YNDXUCZADRHECN-JNQJZLCISA-N triamcinolone acetonide Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@H]3OC(C)(C)O[C@@]3(C(=O)CO)[C@@]1(C)C[C@@H]2O YNDXUCZADRHECN-JNQJZLCISA-N 0.000 claims description 23
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- MGNNYOODZCAHBA-GQKYHHCASA-N fluticasone Chemical compound C1([C@@H](F)C2)=CC(=O)C=C[C@]1(C)[C@]1(F)[C@@H]2[C@@H]2C[C@@H](C)[C@@](C(=O)SCF)(O)[C@@]2(C)C[C@@H]1O MGNNYOODZCAHBA-GQKYHHCASA-N 0.000 claims description 20
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- KEWHKYJURDBRMN-ZEODDXGYSA-M ipratropium bromide hydrate Chemical compound O.[Br-].O([C@H]1C[C@H]2CC[C@@H](C1)[N@@+]2(C)C(C)C)C(=O)C(CO)C1=CC=CC=C1 KEWHKYJURDBRMN-ZEODDXGYSA-M 0.000 claims description 15
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- VQDBNKDJNJQRDG-UHFFFAOYSA-N Pirbuterol Chemical compound CC(C)(C)NCC(O)C1=CC=C(O)C(CO)=N1 VQDBNKDJNJQRDG-UHFFFAOYSA-N 0.000 claims description 14
- RKUNBYITZUJHSG-SPUOUPEWSA-N atropine Chemical compound O([C@H]1C[C@H]2CC[C@@H](C1)N2C)C(=O)C(CO)C1=CC=CC=C1 RKUNBYITZUJHSG-SPUOUPEWSA-N 0.000 claims description 14
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- KWGRBVOPPLSCSI-UHFFFAOYSA-N d-ephedrine Natural products CNC(C)C(O)C1=CC=CC=C1 KWGRBVOPPLSCSI-UHFFFAOYSA-N 0.000 claims description 14
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- 229960005139 epinephrine Drugs 0.000 claims description 14
- 125000001301 ethoxy group Chemical group [H]C([H])([H])C([H])([H])O* 0.000 claims description 14
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- 229960000676 flunisolide Drugs 0.000 claims description 14
- 125000004051 hexyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 claims description 14
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- OIGNJSKKLXVSLS-VWUMJDOOSA-N prednisolone Chemical compound O=C1C=C[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 OIGNJSKKLXVSLS-VWUMJDOOSA-N 0.000 claims description 14
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 14
- MIXMJCQRHVAJIO-TZHJZOAOSA-N qk4dys664x Chemical compound O.C1([C@@H](F)C2)=CC(=O)C=C[C@]1(C)[C@@H]1[C@@H]2[C@@H]2C[C@H]3OC(C)(C)O[C@@]3(C(=O)CO)[C@@]2(C)C[C@@H]1O.C1([C@@H](F)C2)=CC(=O)C=C[C@]1(C)[C@@H]1[C@@H]2[C@@H]2C[C@H]3OC(C)(C)O[C@@]3(C(=O)CO)[C@@]2(C)C[C@@H]1O MIXMJCQRHVAJIO-TZHJZOAOSA-N 0.000 claims description 14
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- 150000004677 hydrates Chemical class 0.000 claims description 13
- 239000002245 particle Substances 0.000 claims description 13
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- 229960000289 fluticasone propionate Drugs 0.000 claims description 10
- WMWTYOKRWGGJOA-CENSZEJFSA-N fluticasone propionate Chemical compound C1([C@@H](F)C2)=CC(=O)C=C[C@]1(C)[C@]1(F)[C@@H]2[C@@H]2C[C@@H](C)[C@@](C(=O)SCF)(OC(=O)CC)[C@@]2(C)C[C@@H]1O WMWTYOKRWGGJOA-CENSZEJFSA-N 0.000 claims description 10
- JYGXADMDTFJGBT-VWUMJDOOSA-N hydrocortisone Chemical compound O=C1CC[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 JYGXADMDTFJGBT-VWUMJDOOSA-N 0.000 claims description 10
- XBDQKXXYIPTUBI-UHFFFAOYSA-M Propionate Chemical compound CCC([O-])=O XBDQKXXYIPTUBI-UHFFFAOYSA-M 0.000 claims description 9
- 230000003287 optical effect Effects 0.000 claims description 9
- WVDDGKGOMKODPV-UHFFFAOYSA-N Benzyl alcohol Chemical compound OCC1=CC=CC=C1 WVDDGKGOMKODPV-UHFFFAOYSA-N 0.000 claims description 8
- 206010061218 Inflammation Diseases 0.000 claims description 8
- GIIZNNXWQWCKIB-UHFFFAOYSA-N Serevent Chemical compound C1=C(O)C(CO)=CC(C(O)CNCCCCCCOCCCCC=2C=CC=CC=2)=C1 GIIZNNXWQWCKIB-UHFFFAOYSA-N 0.000 claims description 8
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- 230000004054 inflammatory process Effects 0.000 claims description 8
- 229960004017 salmeterol Drugs 0.000 claims description 8
- 125000000143 2-carboxyethyl group Chemical group [H]OC(=O)C([H])([H])C([H])([H])* 0.000 claims description 7
- JHIIPMNJGTTZQF-UHFFFAOYSA-N cyclopentyl n-[1-(diphenylcarbamoyl)-3-[[2-methoxy-6-[(2-methylphenyl)sulfonylcarbamoyl]phenyl]methyl]indol-5-yl]carbamate Chemical compound C=1N(C(=O)N(C=2C=CC=CC=2)C=2C=CC=CC=2)C2=CC=C(NC(=O)OC3CCCC3)C=C2C=1CC=1C(OC)=CC=CC=1C(=O)NS(=O)(=O)C1=CC=CC=C1C JHIIPMNJGTTZQF-UHFFFAOYSA-N 0.000 claims description 7
- JCSUFOPUYUYANB-UHFFFAOYSA-N cyclopentyl n-[1-carbamoyl-3-[[2-methoxy-6-[(2-methylphenyl)sulfonylcarbamoyl]phenyl]methyl]indol-5-yl]carbamate Chemical compound C=1N(C(N)=O)C2=CC=C(NC(=O)OC3CCCC3)C=C2C=1CC=1C(OC)=CC=CC=1C(=O)NS(=O)(=O)C1=CC=CC=C1C JCSUFOPUYUYANB-UHFFFAOYSA-N 0.000 claims description 7
- IXVQHPKKDLCTHC-UHFFFAOYSA-N cyclopentyl n-[1-formyl-3-[[2-methoxy-6-[(2-methylphenyl)sulfonylcarbamoyl]phenyl]methyl]indol-5-yl]carbamate Chemical group C=1N(C=O)C2=CC=C(NC(=O)OC3CCCC3)C=C2C=1CC=1C(OC)=CC=CC=1C(=O)NS(=O)(=O)C1=CC=CC=C1C IXVQHPKKDLCTHC-UHFFFAOYSA-N 0.000 claims description 7
- FPACABIHUTXCLO-UHFFFAOYSA-N cyclopentyl n-[3-[[2-methoxy-6-[(2-methylphenyl)sulfonylcarbamoyl]phenyl]methyl]-1-[methyl(phenyl)carbamoyl]indol-5-yl]carbamate Chemical compound C=1N(C(=O)N(C)C=2C=CC=CC=2)C2=CC=C(NC(=O)OC3CCCC3)C=C2C=1CC=1C(OC)=CC=CC=1C(=O)NS(=O)(=O)C1=CC=CC=C1C FPACABIHUTXCLO-UHFFFAOYSA-N 0.000 claims description 7
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- QLIIKPVHVRXHRI-CXSFZGCWSA-N mometasone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(Cl)[C@@H]1[C@@H]1C[C@@H](C)[C@@](C(=O)CCl)(O)[C@@]1(C)C[C@@H]2O QLIIKPVHVRXHRI-CXSFZGCWSA-N 0.000 claims description 7
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- XSDQTOBWRPYKKA-UHFFFAOYSA-N amiloride Chemical compound NC(=N)NC(=O)C1=NC(Cl)=C(N)N=C1N XSDQTOBWRPYKKA-UHFFFAOYSA-N 0.000 claims description 6
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/008—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy comprising drug dissolved or suspended in liquid propellant for inhalation via a pressurized metered dose inhaler [MDI]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
- A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
Landscapes
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Otolaryngology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10/234,825 US7074388B2 (en) | 1998-12-10 | 2002-09-03 | Water stabilized medicinal aerosol formulation |
| PCT/US2003/027245 WO2004022035A1 (en) | 2002-09-03 | 2003-09-03 | Water stabilized medicinal aerosol formulation related applications |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2006502160A true JP2006502160A (ja) | 2006-01-19 |
| JP2006502160A5 JP2006502160A5 (https=) | 2006-03-02 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004534386A Pending JP2006502160A (ja) | 2002-09-03 | 2003-09-03 | 水安定化エアゾル薬剤組成 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US7074388B2 (https=) |
| EP (1) | EP1569617A4 (https=) |
| JP (1) | JP2006502160A (https=) |
| AU (1) | AU2003272251A1 (https=) |
| CA (1) | CA2497171C (https=) |
| DE (1) | DE03754425T1 (https=) |
| ES (1) | ES2247959T1 (https=) |
| MX (1) | MXPA05002337A (https=) |
| WO (1) | WO2004022035A1 (https=) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2006520797A (ja) * | 2003-03-20 | 2006-09-14 | ベーリンガー インゲルハイム ファーマシューティカルズ インコーポレイテッド | 推進剤としてヒドロフルオロアルカンを用いる計量式吸入器のための調合物 |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EA006384B1 (ru) * | 2000-07-31 | 2005-12-29 | Нюкомед Данмарк А/С | Композиция фентанила для интраназального введения |
| EP1415647A1 (en) * | 2002-10-23 | 2004-05-06 | CHIESI FARMACEUTICI S.p.A. | "Long-acting beta-2 agonists ultrafine formulations" |
| CA2522231A1 (en) * | 2003-04-14 | 2004-10-21 | Vectura Ltd | Pharmaceutical compositions comprising apomorphine for pulmonary inhalation |
| US20040204439A1 (en) * | 2003-04-14 | 2004-10-14 | Staniforth John Nicholas | Composition, device, and method for treating sexual dysfunction via inhalation |
| AR041873A1 (es) * | 2003-10-30 | 2005-06-01 | Pablo Cassara Srl Lab | Una formulacion farmaceutica en aerosol adecuada para la inhalacion oral o nasal que contienen glucocorticoides en solucion estable al almacenamiento; un metodo para estabilzar formulaciones y uso de un agente estabilizante |
| GB0501956D0 (en) * | 2005-01-31 | 2005-03-09 | Arrow Internat | Nebulizer formulation |
| GB0604141D0 (en) * | 2006-03-01 | 2006-04-12 | Arrow Int Ltd | Nebulizer formulation |
| US8551534B2 (en) | 2007-10-10 | 2013-10-08 | Parion Sciences, Inc. | Inhaled hypertonic saline delivered by a heated nasal cannula |
| EP2477601B1 (en) * | 2009-09-15 | 2017-09-13 | Union Carbide Chemicals & Plastics Technology LLC | Personal care compositions with ethylene acrylic acid copolymer aqueous dispersions |
| GB0918149D0 (en) * | 2009-10-16 | 2009-12-02 | Jagotec Ag | Improved medicinal aerosol formulation |
| WO2012061195A2 (en) | 2010-11-04 | 2012-05-10 | Union Carbide Chemicals & Plastics Technology Llc | Skin care compositions |
| US8778383B2 (en) | 2011-06-07 | 2014-07-15 | Parion Sciences, Inc. | Methods of treatment |
| US8945605B2 (en) | 2011-06-07 | 2015-02-03 | Parion Sciences, Inc. | Aerosol delivery systems, compositions and methods |
| PL3104853T3 (pl) | 2014-02-10 | 2020-05-18 | Respivant Sciences Gmbh | Leczenie stabilizatorami komórek tucznych zaburzeń ogólnoustrojowych |
| ES2792682T3 (es) | 2014-02-10 | 2020-11-11 | Respivant Sciences Gmbh | Métodos para el tratamiento de enfermedades pulmonares con estabilizadores de mastocitos |
| WO2017027402A1 (en) | 2015-08-07 | 2017-02-16 | Patara Pharma, LLC | Methods for the treatment of systemic disorders treatable with mast cell stabilizers, including mast cell related disorders |
| US10238625B2 (en) | 2015-08-07 | 2019-03-26 | Respivant Sciences Gmbh | Methods for the treatment of mast cell related disorders with mast cell stabilizers |
| WO2018044942A1 (en) | 2016-08-31 | 2018-03-08 | Patara Pharma, LLC | Cromolyn compositions for treatment of chronic cough due to idiopathic pulmonary fibrosis |
| EP3522983A4 (en) | 2016-10-07 | 2020-06-03 | Respivant Sciences GmbH | CROMOLYN COMPOSITION FOR TREATING LUNG FIBROSIS |
| CA3100679A1 (en) | 2018-06-08 | 2019-12-12 | Toko Yakuhin Kogyo Co., Ltd. | Fluticasone furoate nasal preparation composition |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2000033892A1 (en) * | 1998-12-10 | 2000-06-15 | Aeropharm Technology Incorporated | A medicinal aerosol formulation |
| WO2002005784A1 (en) * | 2000-07-17 | 2002-01-24 | Aeropharm Technology, Inc. | A medicinal aerosol formulation |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9202519D0 (en) * | 1992-02-06 | 1992-03-25 | Glaxo Group Ltd | Medicaments |
| DE4446891A1 (de) * | 1994-12-27 | 1996-07-04 | Falk Pharma Gmbh | Stabile wäßrige Budesonid-Lösung |
| DE19847969A1 (de) * | 1998-10-17 | 2000-04-20 | Boehringer Ingelheim Pharma | Lagerfähig flüssige Formulierung mit Formoterol |
| US6540983B1 (en) * | 2000-01-25 | 2003-04-01 | Aeropharm Technology Incorporated | Medical aerosol formulation |
| US6447750B1 (en) * | 2000-05-01 | 2002-09-10 | Aeropharm Technology Incorporated | Medicinal aerosol formulation |
| US6565833B1 (en) * | 2000-05-01 | 2003-05-20 | Aeropharm Technology Incorporated | Medicinal aerosol formulation |
| US6548049B1 (en) * | 2000-05-01 | 2003-04-15 | Aeropharm Technology Incorporated | Medicinal aerosol formulation |
-
2002
- 2002-09-03 US US10/234,825 patent/US7074388B2/en not_active Expired - Fee Related
-
2003
- 2003-09-03 ES ES03754425T patent/ES2247959T1/es active Pending
- 2003-09-03 JP JP2004534386A patent/JP2006502160A/ja active Pending
- 2003-09-03 DE DE03754425T patent/DE03754425T1/de active Pending
- 2003-09-03 WO PCT/US2003/027245 patent/WO2004022035A1/en not_active Ceased
- 2003-09-03 CA CA002497171A patent/CA2497171C/en not_active Expired - Fee Related
- 2003-09-03 MX MXPA05002337A patent/MXPA05002337A/es unknown
- 2003-09-03 AU AU2003272251A patent/AU2003272251A1/en not_active Abandoned
- 2003-09-03 EP EP03754425A patent/EP1569617A4/en not_active Withdrawn
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2000033892A1 (en) * | 1998-12-10 | 2000-06-15 | Aeropharm Technology Incorporated | A medicinal aerosol formulation |
| WO2002005784A1 (en) * | 2000-07-17 | 2002-01-24 | Aeropharm Technology, Inc. | A medicinal aerosol formulation |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2006520797A (ja) * | 2003-03-20 | 2006-09-14 | ベーリンガー インゲルハイム ファーマシューティカルズ インコーポレイテッド | 推進剤としてヒドロフルオロアルカンを用いる計量式吸入器のための調合物 |
Also Published As
| Publication number | Publication date |
|---|---|
| US20030091512A1 (en) | 2003-05-15 |
| US7074388B2 (en) | 2006-07-11 |
| WO2004022035A1 (en) | 2004-03-18 |
| EP1569617A1 (en) | 2005-09-07 |
| DE03754425T1 (de) | 2006-03-09 |
| ES2247959T1 (es) | 2006-03-16 |
| CA2497171A1 (en) | 2004-03-18 |
| AU2003272251A1 (en) | 2004-03-29 |
| CA2497171C (en) | 2009-04-28 |
| EP1569617A4 (en) | 2010-10-27 |
| MXPA05002337A (es) | 2005-12-05 |
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