JP2006500996A5 - - Google Patents

Info

Publication number

JP2006500996A5

JP2006500996A5 JP2004540244A JP2004540244A JP2006500996A5 JP 2006500996 A5 JP2006500996 A5 JP 2006500996A5 JP 2004540244 A JP2004540244 A JP 2004540244A JP 2004540244 A JP2004540244 A JP 2004540244A JP 2006500996 A5 JP2006500996 A5 JP 2006500996A5

Authority

JP

Japan

Prior art keywords

drug

biocompatible

mitomycin

release matrix

medical device

Prior art date

2003-09-26

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

• Espacenet
• Global Dossier
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• 229940079593 drug Drugs 0.000 claims description 40
• 239000003814 drug Substances 0.000 claims description 40
• NWIBSHFKIJFRCO-WUDYKRTCSA-N Mytomycin Chemical compound C1N2C(C(C(C)=C(N)C3=O)=O)=C3[C@@H](COC(N)=O)[C@@]2(OC)[C@@H]2[C@H]1N2 NWIBSHFKIJFRCO-WUDYKRTCSA-N 0.000 claims description 26
• 239000011159 matrix material Substances 0.000 claims description 25
• 229960004857 mitomycin Drugs 0.000 claims description 18
• 229930192392 Mitomycin Natural products 0.000 claims description 10
• 229940100198 alkylating agent Drugs 0.000 claims description 10
• 239000002168 alkylating agent Substances 0.000 claims description 10
• 229920000249 biocompatible polymer Polymers 0.000 claims description 6
• 230000002792 vascular Effects 0.000 claims description 4
• 208000037803 restenosis Diseases 0.000 claims description 3
• 238000010828 elution Methods 0.000 claims description 2
• 238000002513 implantation Methods 0.000 claims description 2
• AZQWKYJCGOJGHM-UHFFFAOYSA-N 1,4-benzoquinone Chemical compound O=C1C=CC(=O)C=C1 AZQWKYJCGOJGHM-UHFFFAOYSA-N 0.000 claims 6
• 239000002904 solvent Substances 0.000 claims 3
• 230000008878 coupling Effects 0.000 claims 1
• 238000010168 coupling process Methods 0.000 claims 1
• 238000005859 coupling reaction Methods 0.000 claims 1
• HYFMSAFINFJTFH-NGSRAFSJSA-N mitomycin A Chemical compound O=C1C(OC)=C(C)C(=O)C2=C1[C@@H](COC(N)=O)[C@]1(OC)N2C[C@@H]2N[C@@H]21 HYFMSAFINFJTFH-NGSRAFSJSA-N 0.000 description 3
• HYFMSAFINFJTFH-UHFFFAOYSA-N Mitomycin-A Natural products O=C1C(OC)=C(C)C(=O)C2=C1C(COC(N)=O)C1(OC)N2CC2NC21 HYFMSAFINFJTFH-UHFFFAOYSA-N 0.000 description 2
• 230000001028 anti-proliverative effect Effects 0.000 description 2
• 230000003115 biocidal effect Effects 0.000 description 2
• 230000002401 inhibitory effect Effects 0.000 description 2
• 238000000034 method Methods 0.000 description 2
• 239000000126 substance Substances 0.000 description 2
• ZRPXANWPZVSJIZ-UHFFFAOYSA-N 3,4,6-tri-o-acetyl-2-(acetylamino)-n-[4-({8-[(carbamoyloxy)methyl]-8a-methoxy-5-methyl-4,7-dioxo-1,1a,2,4,7,8,8a,8b-octahydroazireno[2',3':3,4]pyrrolo[1,2-a]indol-6-yl}amino)butanoyl]-2-deoxyhexopyranosylamine Chemical compound NC(=O)OCC1C2(OC)C3NC3CN2C(C(C=2C)=O)=C1C(=O)C=2NCCCC(=O)NC1OC(COC(C)=O)C(OC(C)=O)C(OC(C)=O)C1NC(C)=O ZRPXANWPZVSJIZ-UHFFFAOYSA-N 0.000 description 1
• WZMFNIVNLYRDDE-QJIICXBUSA-N C1N2C(C(C(C)=C(N=CN(C)C)C3=O)=O)=C3[C@@H](COC(N)=O)[C@@]2(OC)[C@@H]2[C@H]1N2 Chemical compound C1N2C(C(C(C)=C(N=CN(C)C)C3=O)=O)=C3[C@@H](COC(N)=O)[C@@]2(OC)[C@@H]2[C@H]1N2 WZMFNIVNLYRDDE-QJIICXBUSA-N 0.000 description 1
• UZUUQCBCWDBYCG-UHFFFAOYSA-N Mitomycin B Natural products O=C1C(OC)=C(C)C(=O)C2=C1C(COC(N)=O)C1(O)N2CC2C1N2C UZUUQCBCWDBYCG-UHFFFAOYSA-N 0.000 description 1
• YJHYHDSHHWKEIS-CJUKMMNNSA-N [(4S,6S,7R,8S)-11-(2-hydroxyethoxy)-7-methoxy-12-methyl-10,13-dioxo-2,5-diazatetracyclo[7.4.0.02,7.04,6]trideca-1(9),11-dien-8-yl]methyl carbamate Chemical compound CO[C@]12[C@H]3N[C@H]3CN1C1=C([C@H]2COC(N)=O)C(=O)C(OCCO)=C(C)C1=O YJHYHDSHHWKEIS-CJUKMMNNSA-N 0.000 description 1
• OONKIOWWPLCSQD-NPHOOMDASA-N ac1l2zne Chemical compound C([C@@H]1N[C@@H]1[C@@]1([C@@H]2COC(N)=O)OC)N1C(C(C=1C)=O)=C2C(=O)C=1NC(C=C1)=CC=C1O[C@@H]1O[C@H](COC(C)=O)[C@@H](OC(C)=O)[C@H](OC(C)=O)[C@H]1OC(C)=O OONKIOWWPLCSQD-NPHOOMDASA-N 0.000 description 1
• 210000004204 blood vessel Anatomy 0.000 description 1
• ZNDJOCJUBZZAMN-USYHLRJESA-N bmy-25067 Chemical compound C([C@@H]1N[C@@H]1[C@@]1([C@@H]2COC(N)=O)OC)N1C(C(C=1C)=O)=C2C(=O)C=1NCCSSC1=CC=C([N+]([O-])=O)C=C1 ZNDJOCJUBZZAMN-USYHLRJESA-N 0.000 description 1
• 239000011248 coating agent Substances 0.000 description 1
• 238000000576 coating method Methods 0.000 description 1
• BIOSTZMAOGCGSC-CYUGEGSCSA-N kt6149 Chemical compound C1N2C(C(C(C)=C(NCCSSCCNC(=O)CC[C@H](N)C(O)=O)C3=O)=O)=C3[C@@H](COC(N)=O)[C@@]2(OC)[C@@H]2[C@H]1N2 BIOSTZMAOGCGSC-CYUGEGSCSA-N 0.000 description 1
• UZUUQCBCWDBYCG-DQRAMIIBSA-N mitomycin B Chemical compound O=C1C(OC)=C(C)C(=O)C2=C1[C@H](COC(N)=O)[C@]1(O)N2C[C@H]2[C@@H]1N2C UZUUQCBCWDBYCG-DQRAMIIBSA-N 0.000 description 1
• 238000006467 substitution reaction Methods 0.000 description 1